Chirag H. Patel

发表

Developing a pro-regenerative biomaterial scaffold microenvironment requires T helper 2 cells

J. Elisseeff, Hao Wang, D. Pardoll, 2016, Science.

PKG-Modified TSC2 Regulates mTORC1 Activity to Counter Adverse Cardiac Stress

Dong Ik Lee, David A. Kass, Jennifer E. Van Eyk, 2018, Nature.

mTOR Complex 1 Signaling Regulates the Generation and Function of Central and Effector Foxp3+ Regulatory T Cells

Wei Xu, J. Powell, Jiayu Wen, 2018, The Journal of Immunology.

Targeting glutamine metabolism enhances tumor specific immunity by modulating suppressive myeloid cells.

M. Horton, J. Powell, S. Collins, 2020, The Journal of clinical investigation.

Targeting glutamine metabolism enhances tumor specific immunity by inhibiting the generation of MDSCs and reprogramming tumor associated macrophages

M. Horton, J. Powell, S. Collins, 2019, bioRxiv.

Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion

J. Powell, Jiayu Wen, Liang Zhao, 2019, Science.

Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR

D. Welsh, A. Weeraratna, R. Gillies, 2018, Cell.

Cytosolic Branched Chain Aminotransferase (BCATc) Regulates mTORC1 Signaling and Glycolytic Metabolism in CD4+ T Cells*

J. Powell, S. Hutson, Chirag H. Patel, 2014, The Journal of Biological Chemistry.

Discovery of CPI-1612: A Potent, Selective, and Orally Bioavailable EP300/CBP Histone Acetyltransferase Inhibitor.

R. Sims, R. Cummings, F. Poy, 2020, ACS medicinal chemistry letters.

Early Drug‐Discovery Efforts towards the Identification of EP300/CBP Histone Acetyltransferase (HAT) Inhibitors

R. Cummings, R. Sims, J. Audia, 2020, ChemMedChem.

mTORC2 Signaling Selectively Regulates the Generation and Function of Tissue-Resident Peritoneal Macrophages.

M. Horton, J. Powell, S. Collins, 2017, Cell reports.

The AGC kinase SGK1 regulates TH1 and TH2 differentiation downstream of the mTORC2 complex

M. Horton, P. Illei, A. Waickman, 2014, Nature Immunology.

Discovery of CPI-1612: A Potent, Selective, and Orally Bioavailable EP300/CBP Histone Acetyltransferase Inhibitor.

R. Sims, R. Cummings, F. Poy, 2020, ACS medicinal chemistry letters.

Synthesis and biochemical evaluation of a range of potent benzyl imidazole-based compounds as potential inhibitors of the enzyme complex 17α-hydroxylase/17,20-lyase (P45017α)

I. Shahid, Chirag H. Patel, C. Owen, 2006 .

Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of 4-substituted phenyl alkyl imidazole-based inhibitors of the enzyme complex 17alpha-hydroxylase/17,20-lyase (P450(17alpha)).

Chirag H. Patel, C. Owen, Sabbir Ahmed, 2006, Bioorganic & medicinal chemistry letters.

Asymmetric inheritance of mTORC1 kinase activity during division dictates CD8 T cell differentiation

Greg M. Delgoffe, Kristen N. Pollizzi, A. Waickman, 2016, Nature Immunology.

Targeting metabolism to regulate immune responses in autoimmunity and cancer

M. Horton, J. Powell, R. Leone, 2019, Nature Reviews Drug Discovery.

mTORC 1 and mTORC 2 selectively regulate CD 8 + T cell differentiation

Greg M. Delgoffe, Kristen N. Pollizzi, A. Waickman, 2018 .

mTORC1 and mTORC2 selectively regulate CD8⁺ T cell differentiation.

Greg M. Delgoffe, Kristen N. Pollizzi, A. Waickman, 2015, The Journal of clinical investigation.

Cutting Edge: mTORC2 Regulates CD8+ Effector and Memory T Cell Differentiation through Serum and Glucocorticoid Kinase 1.

Emily B. Heikamp, J. Powell, Jiayu Wen, 2022, Journal of immunology.

The AGC kinase serum- and glucocorticoid-regulated kinase 1 (SGK1) regulates TH1 and TH2 differentiation downstream of mTORC2

M. Horton, P. Illei, A. Waickman, 2014, Nature immunology.

Targeting Metabolism as a Platform for Inducing Allograft Tolerance in the Absence of Long-Term Immunosuppression

J. Powell, G. Brandacher, Chirag H. Patel, 2020, Frontiers in Immunology.

Targeting T cell metabolism to regulate T cell activation, differentiation and function in disease.

J. Powell, Chirag H. Patel, 2017, Current opinion in immunology.

Warburg meets epigenetics

J. Powell, Chirag H. Patel, 2016, Science.

GOT1 regulates CD8+ effector and memory T cell generation

Liang Zhao, J. Powell, Jiayu Wen, 2023, Cell reports.

PKG-Modified TSC2 Regulates mTORC1 Activity to Counter Adverse Cardiac Stress

Dong I. Lee, D. Kass, J. V. Van Eyk, 2018, Nature.

Cellular Size as a Means of Tracking mTOR Activity and Cell Fate of CD4+ T Cells upon Antigen Recognition

Kristen N. Pollizzi, A. Waickman, J. Powell, 2015, PloS one.

650 Target the activin receptor 1c on CD4+ T cells to achieve anti-tumor therapeutic effects

Ying Zheng, Chirag H. Patel, Xiaoxu Wang, 2021, Journal for ImmunoTherapy of Cancer.

Serendipitous Discovery of T Cell-Produced KLK1b22 as a Regulator of Systemic Metabolism.

Liang Zhao, A. Waickman, J. Powell, 2023, ImmunoHorizons.

Signaling Node at TSC2 S1365 Potently Regulates T-Cell Differentiation and Improves Adoptive Cellular Cancer Therapy

D. Kass, J. Powell, Jiayu Wen, 2023, bioRxiv.

T cell metabolic reprogramming in acute kidney injury and protection by glutamine blockade

P. Pierorazio, H. Rabb, L. Arend, 2023, JCI Insight.

The AGC kinase serum- and glucocorticoid-regulated kinase 1 (SGK1) regulates TH1 and TH2 differentiation downstream of mTORC2

M. Horton, P. Illei, A. Waickman, 2014, Nature Immunology.

GOT1 constrains T_H17 cell differentiation, while promoting iT_reg cell differentiation

Liang Zhao, A. Tam, Chirag H. Patel, 2023, Nature.