R. Barbuch

发表

Cloning and characterization of ERG25, the Saccharomyces cerevisiae gene encoding C-4 sterol methyl oxidase.

D. A. Bruner, M. Bard, N. Lees, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Characterization of the Saccharomyces cerevisiae ERG27 gene encoding the 3-keto reductase involved in C-4 sterol demethylation.

M. Bard, M. Krieger, J. Eckstein, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Evidence for a lysine-specific fragmentation in fast-atom bombardment mass spectra of peptides.

B. Ackermann, R. Barbuch, T. J. Owen, 1992, Rapid communications in mass spectrometry : RCM.

Characterization of a cytochrome P450 deficient mutant of Candida albicans.

M. Bard, D. Sanglard, N. Lees, 1987, Biochemical and biophysical research communications.

The use of thermospray liquid chromatography/tandem mass spectrometry for the class identification and structural verification of phytoestrogens in soy protein preparations.

R. Barbuch, J. Coutant, K. Setchell, 1989, Biomedical & environmental mass spectrometry.

Pharmacokinetics, Metabolism, and Excretion of the Glycogen Synthase Kinase-3 Inhibitor LY2090314 in Rats, Dogs, and Humans: A Case Study in Rapid Clearance by Extensive Metabolism with Low Circulating Metabolite Exposure

K. Cassidy, P. Kulanthaivel, R. Barbuch, 2013, Drug Metabolism and Disposition.

Genome-wide expression profiling reveals genes associated with amphotericin B and fluconazole resistance in experimentally induced antifungal resistant isolates of Candida albicans.

M. Bard, K. Barker, P. D. Rogers, 2004, The Journal of antimicrobial chemotherapy.

Ergosterol gene expression in wild-type and ergosterol-deficient mutants of Candida albicans.

M. Bard, J. Eckstein, C. Pierson, 2004, Medical mycology.

Cloning and disruption of the yeast C-8 sterol isomerase gene

M. Bard, H. Jarrett, R. Barbuch, 1991, Lipids.

A yeast sterol auxotroph (erg25) is rescued by addition of azole antifungals and reduced levels of heme.

M. Bard, N. Lees, C. Pierson, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Disposition and Metabolism of Semagacestat, a γ-Secretase Inhibitor, in Humans

B. Ring, P. Kulanthaivel, P. Yi, 2010, Drug Metabolism and Disposition.

Ping Yi, Chad Hadden, Palaniappan Kulanthaivel, Nathan Calvert, William Annes, Thomas

B. Ring, R. Barbuch, A. Chaudhary, 2010 .

Metabolism of LY654322, a Growth Hormone Secretagogue, to an Unusual Diimidazopyridine Metabolite

P. Kulanthaivel, W. J. Wheeler, V. Klimkowski, 2011, Drug Metabolism and Disposition.

Candida albicans Sterol C-14 Reductase, Encoded by the ERG24 Gene, as a Potential Antifungal Target Site

M. Bard, N. Lees, J. Eckstein, 2002, Antimicrobial Agents and Chemotherapy.

Characterization of the Saccharomyces cerevisiae ERG26 gene encoding the C-3 sterol dehydrogenase (C-4 decarboxylase) involved in sterol biosynthesis.

M. Bard, R. Barbuch, D. Gachotte, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Sterol synthesis and viability oferg11 (cytochrome P450 lanosterol demethylase) mutations inSaccharomyces cerevisiae andCandida albicans

M. Bard, N. Lees, C. Koegel, 1993, Lipids.

Cloning and sequencing of the Candida albicans C-4 sterol methyl oxidase gene (ERG25) and expression of an ERG25 conditional lethal mutation in Saccharomyces cerevisiae

M. Bard, N. Lees, J. Eckstein, 2000, Lipids.

A simple method for the isolation of zymosterol from a sterol mutant of Saccharomyces cerevisiae

M. Bard, R. Barbuch, E. Parish, 1992, The Journal of Steroid Biochemistry and Molecular Biology.

Cloning, disruption and sequence of the gene encoding yeast C-5 sterol desaturase.

M. Bard, P. Skatrud, R. Barbuch, 1991, Gene.

Differences in membrane order parameter and antibiotic sensitivity in ergosterol-producing strains of Saccharomyces cerevisiae

Michael A. Smith, M. Bard, M. D. Kemple, 1984 .

Disposition of [14C]Ruboxistaurin in Humans

R. Barbuch, C. Benson, J. Burkey, 2006, Drug Metabolism and Disposition.

Disposition of [ 14 C] Ruboxistaurin in Humans

James, R. Barbuch, C. Benson, 2006 .

Sequencing, Disruption, and Characterization of the Candida albicans Sterol Methyltransferase (ERG6) Gene: Drug Susceptibility Studies in erg6 Mutants

M. Bard, N. Lees, K. Jensen-Pergakes, 1998, Antimicrobial Agents and Chemotherapy.

Evidence for a novel pentyl radical adduct of the cyclic nitrone spin trap MDL 101,002.

J. Dage, B. Ackermann, R. Barbuch, 1997, Free radical biology & medicine.

Selective reduction of N-oxides to amines: application to drug metabolism.

Lawrence A. Goodwin, P. Kulanthaivel, P. Yi, 2004, Drug metabolism and disposition: the biological fate of chemicals.

Mechanistic observations in the Gewald syntheses of 2-aminothiophenes

N. Peet, R. Barbuch, S. Sunder, 1986 .

3-CHLORO-2-(PHENYLSULFINYL)-1-PROPENE AND 3-CHLORO-2-(PHENYLSULFONYL)-1-PROPENE: PREPARATION AND UTILITY AS REAGENTS FOR α,α′-ANNELATION OF CYCLIC KETONES

R. Barbuch, D. Matthews, P. Anzeveno, 1984 .

A NOVEL OXAMIDE REARRANGEMENT

R. Barbuch, S. Sunder, P. PeetNorton, 1980 .

Sulfonylcarbamimidic azides from sulfonyl chlorides and 5‐aminotetrazole

E. Huber, R. Barbuch, S. Sunder, 1987 .

Synthesis of thiazolotriazepinones

N. Peet, R. Barbuch, S. Sunder, 1982 .

Transcriptional regulation of the squalene synthase gene (ERG9) in the yeast Saccharomyces cerevisiae.

M. Bard, R. Barbuch, M. Kennedy, 1999, Biochimica et biophysica acta.

Sterol uptake in Candida glabrata: rescue of sterol auxotrophic strains.

M. Bard, N. Lees, J. Eckstein, 2005, Diagnostic microbiology and infectious disease.

Disruption of the Candida albicans CYB5 Gene Results in Increased Azole Sensitivity

M. Bard, N. Lees, J. Eckstein, 2004, Antimicrobial Agents and Chemotherapy.

Cloning and characterization of the Saccharomyces cerevisiae C-22 sterol desaturase gene, encoding a second cytochrome P-450 involved in ergosterol biosynthesis.

M. Bard, C. Pierson, C. Koegel, 1996, Gene.

SELECTIVE METABOLISM OF VINCRISTINE IN VITRO BY CYP3A5

Jennifer B Dennison, P. Kulanthaivel, S. Hall, 2006, Drug Metabolism and Disposition.

A Sterol-Regulatory Element Binding Protein Is Required for Cell Polarity, Hypoxia Adaptation, Azole Drug Resistance, and Virulence in Aspergillus fumigatus

Martin Bard, Christopher B. Lawrence, M. Bard, 2008, PLoS pathogens.

A one step synthesis of 4‐substituted imidazoles. An important observation when N‐alkylating imidazoles

R. Barbuch, D. Matthews, J. Mccarthy, 1988 .

A One-Step Synthesis of 4-Substituted Imidazoles (III). An Important Observation When N-Alkylating Imidazoles (I).

R. Barbuch, D. Matthews, J. Whitten, 1989 .

Thermal dealkylations of quaternized methoxyquinolinium and methoxyisoquinolinium iodides in the mass spectrometer

N. Peet, R. Barbuch, G. Karrick, 1987 .

A mass spectral rearrangement of 2-(alkylamino)benzoic acid derivatives and related heterocyclic systems

N. Peet, R. Barbuch, 1988 .

Tandem mass spectrometry study of 1-methylisatin

N. Peet, R. Barbuch, J. Coutant, 1986 .

Mass spectral fragmentation and rearrangement of isatin derivatives

N. Peet, R. Barbuch, 1984 .

Stereospecific syntheses of the four diastereomeric 2-amino-5-phenoxycyclopentanols

P. Wiedeman, J. Huffman, R. Barbuch, 1985 .

Spectral analysis and structural identification of a major deflazacort metabolite in man.

E. Huber, R. Barbuch, 1995, Xenobiotica; the fate of foreign compounds in biological systems.

Apparent High CYP3A5 Expression Is Required for Significant Metabolism of Vincristine by Human Cryopreserved Hepatocytes

Jennifer B Dennison, S. Wrighton, M. Mohutsky, 2008, Journal of Pharmacology and Experimental Therapeutics.

The Relative Contributions of CYP3A4 and CYP3A5 to the Metabolism of Vinorelbine

Jennifer B Dennison, S. Hall, C. Hadden, 2013, Drug Metabolism and Disposition.

Dap1/PGRMC1 binds and regulates cytochrome P450 enzymes.

M. Bard, A. Link, P. Espenshade, 2007, Cell metabolism.

Dap 1 / PGRMC 1 Binds and Regulates Cytochrome P 450 Enzymes

M. Bard, A. Link, P. Espenshade, 2022 .

Disposition and metabolic fate of atomoxetine hydrochloride: pharmacokinetics, metabolism, and excretion in the Fischer 344 rat and beagle dog.

John-Michael Sauer, F. Kuo, W. J. Wheeler, 2003, Drug metabolism and disposition: the biological fate of chemicals.

Cumulative Mutations Affecting Sterol Biosynthesis in the Yeast Saccharomyces cerevisiae Result in Synthetic Lethality That Is Suppressed by Alterations in Sphingolipid Profiles

Martin Bard, M. Bard, S. Sturley, 2006, Genetics.

A novel gene conserved from yeast to humans is involved in sterol biosynthesis.

M. Bard, J. Eckstein, R. Barbuch, 2001, Journal of lipid research.

Genetic analyses involving interactions between the ergosterol biosynthetic enzymes, lanosterol synthase (Erg7p) and 3-ketoreductase (Erg27p), in the yeast Saccharomyces cerevisiae.

M. Bard, B. Teske, S. Randall, 2008, Biochimica et biophysica acta.

Synthesis of 6H-pyrazolo[2,3-a][1,3,5]benzotriazepines: 6H-Pyrazolo[2,3-a][1,3,5]benzotriazepines

N. Peet, R. Barbuch, S. Sunder, 1983 .

Synthesis of 6H‐pyrazolo[2,3‐a][1,3,5]benzotriazepines

N. Peet, R. Barbuch, S. Sunder, 1983 .

Reinvestigation of the condensation of 2‐hydrazinobenzothiazole with ethyl acetoacetate

N. Peet, J. Huffman, R. Barbuch, 1988 .

IN VIVO METABOLISM OF [14C]RUBOXISTAURIN IN DOGS, MICE, AND RATS FOLLOWING ORAL ADMINISTRATION AND THE STRUCTURE DETERMINATION OF ITS METABOLITES BY LIQUID CHROMATOGRAPHY/MASS SPECTROMETRY AND NMR SPECTROSCOPY

P. Kulanthaivel, P. Yi, M. Zmijewski, 2006, Drug Metabolism and Disposition.

IN VIVO METABOLISM OF [ 14 C ] RUBOXISTAURIN IN DOGS , MICE , AND RATS FOLLOWING ORAL ADMINISTRATION AND THE STRUCTURE DETERMINATION OF ITS METABOLITES BY LIQUID CHROMATOGRAPHY / MASS SPECTROMETRY AND NMR SPECTROSCOPY

P. Kulanthaivel, P. Yi, M. Zmijewski, 2006 .

Ruboxistaurin in Dogs , Mice , and Rats Following Oral Administration and the Structure Determination of Its Metabolites by LC / MS and NMR Spectroscopy

P. Kulanthaivel, P. Yi, M. Zmijewski, 2005 .

Identification in man of urinary metabolites of a new bronchodilator, MDL 257, using triple stage quadrupole mass spectrometry-mass spectrometry.

R. J. Cregge, R. Barbuch, D. Satonin, 1987, Biomedical & environmental mass spectrometry.

Reinvestigation of a 5H‐dibenzo[d,h][1,3,6]triazonine synthesis

N. Peet, E. Huber, J. Huffman, 2009 .

Characterization of a mutation that results in independence of oxidosqualene cyclase (Erg7) activity from the downstream 3-ketoreductase (Erg27) in the yeast ergosterol biosynthetic pathway.

M. Bard, R. Barbuch, Liangtao Li, 2013, Biochimica et biophysica acta.

A reinvestigation of the cyclodesulfurization of thiosemicarbazides

N. Peet, R. Barbuch, S. Sunder, 1981 .

Investigation into the yellowing on aging of sabril® tablet cores

E. Huber, R. Barbuch, R. George, 1994 .

Synthetically Lethal Interactions Involving Loss of the Yeast ERG24: The Sterol C-14 Reductase Gene

Martin Bard, M. Bard, J. Eckstein, 2007, Lipids.

Genome-wide expression profiling reveals genes associated with amphotericin B and fluconazole resistance in experimentally induced antifungal resistant isolates of Candida albicans.

M. Bard, K. Barker, J. Eckstein, 2004, The Journal of antimicrobial chemotherapy.