L. Hua

发表

Stereoselective ketone reduction by a carbonyl reductase from Sporobolomyces salmonicolor. Substrate specificity, enantioselectivity and enzyme-substrate docking studies.

Dunming Zhu, Yan Yang, J. Buynak, 2006, Organic & biomolecular chemistry.

A molecular modeling study on the enantioselectivity of aryl alkyl ketone reductions by a NADPH-dependent carbonyl reductase

Dunming Zhu, T. Cundari, L. Hua, 2007, Journal of molecular modeling.

Exploring the Synthetic Applicability of a Cyanobacterium Nitrilase as Catalyst for Nitrile Hydrolysis

Dunming Zhu, L. Hua, E. Biehl, 2006 .

Enzymatic nitrile hydrolysis catalyzed by nitrilase ZmNIT2 from maize. An unprecedented β-hydroxy functionality enhanced amide formation

Dunming Zhu, L. Hua, E. Biehl, 2006 .

Specialty Enzymes for Chemical Needs

Dunming Zhu, L. Hua, 2016 .

WITHDRAWN: CRISPR/Cas9 mediated HPV and PD1 inhibition produces a synergistic anti-tumor effect on cervical cancer.

L. Hua, Xu Li, Wei Chen, 2018, Archives of biochemistry and biophysics.

Bufalin attenuates the proliferation of breast cancer MCF-7 cells in vitro and in vivo by inhibiting the PI 3 K / Akt pathway

L. Hua, Shuai Zhen, Wenjuan Luo, 2016 .

Site-saturation mutagenesis of formate dehydrogenase from Candida bodinii creating effective NADP + -dependent FDH enzymes

Dunming Zhu, Weihua Wu, L. Hua, 2009 .

How carbonyl reductases control stereoselectivity: Approaching the goal of rational design

Dunming Zhu, L. Hua, 2010 .

Alpha-amylase issue de promicromonospora vindobonensis

M. Kolkman, L. Hua, D. Song, 2014 .

Cloning, Protein Sequence Clarification, and Substrate Specificity of a Leucine Dehydrogenase from Bacillus sphaericus ATCC4525

Dunming Zhu, L. Hua, Hongmei Li, 2009, Applied biochemistry and biotechnology.

Biocatalytic asymmetric amination of carbonyl functional groups – a synthetic biology approach to organic chemistry

Dunming Zhu, L. Hua, 2009, Biotechnology journal.

A recombinant ketoreductase tool-box. Assessing the substrate selectivity and stereoselectivity toward the reduction of β-ketoesters

Dunming Zhu, J. Rozzell, S. Kambourakis, 2006 .

Synthesis of oxazolidines using DMSO/P4O10 as a formaldehyde equivalent

Yan Yang, L. Hua, M. Kayser, 2007 .

Unexpected stereorecognition in nitrilase-catalyzed hydrolysis of beta-hydroxy nitriles.

Dunming Zhu, L. Hua, E. Biehl, 2006, Organic letters.

Asymmetric synthesis of both antipodes of beta-hydroxy nitriles and beta-hydroxy carboxylic acids via enzymatic reduction or sequential reduction/hydrolysis.

Haribabu Ankati, Dunming Zhu, Dunming Zhu, 2009, The Journal of organic chemistry.

Overexpression of Serratia marcescens lipase in Escherichia coli for efficient bioresolution of racemic ketoprofen

Jiang Pan, Jiang Pan, Jian‐He Xu, 2007 .

Enantioselective Reduction of Diaryl Ketones Catalyzed by a Carbonyl Reductase from Sporobolomyces salmonicolor and its Mutant Enzymes

Dunming Zhu, L. Hua, Hongmei Li, 2009 .

Synthesis of optically pure 2-azido-1-arylethanols with isolated enzymes and conversion to triazole-containing beta-blocker analogues employing click chemistry.

Dunming Zhu, Yan Yang, L. Hua, 2008, The Journal of organic chemistry.

The synthesis and lactamase inhibitory activity of 6-(carboxymethylene)penicillins and 7-(carboxymethylene)cephalosporins

B. Bachmann, J. Buynak, L. Hua, 1995 .

Synthesis and biological activity of 7-alkylidenecephems.

B. Bachmann, J. Buynak, L. Hua, 1995, Journal of medicinal chemistry.

Enzymatic hydrogen transfer reduction of α-chloro aromatic ketones catalyzed by a hyperthermophilic alcohol dehydrogenase

Dunming Zhu, L. Hua, B. Hyatt, 2009 .

Enzymatic enantioselective reduction of α-ketoesters by a thermostable 7α-hydroxysteroid dehydrogenase from Bacteroides fragilis

Dunming Zhu, Dunming Zhu, L. Hua, 2006 .

Asymmetric ketone reduction by a hyperthermophilic alcohol dehydrogenase. The substrate specificity, enantioselectivity and tolerance of organic solvents

Dunming Zhu, L. Hua, Hiba T. Malik, 2006 .

Stereoselective enzymatic synthesis of chiral alcohols with the use of a carbonyl reductase from Candida magnoliae with anti-Prelog enantioselectivity.

Dunming Zhu, Yan Yang, L. Hua, 2006, The Journal of organic chemistry.

The molecular cloning of 8-epicedrol synthase from Artemisia annua.

S. Matsuda, L. Hua, 1999, Archives of biochemistry and biophysics.

Inhibition of long non-coding RNA UCA1 by CRISPR/Cas9 attenuated malignant phenotypes of bladder cancer

L. Hua, Xu Li, Wei Chen, 2016, Oncotarget.

Lanosterol biosynthesis in plants.

Q. Xiong, M. Kolesnikova, S. Matsuda, 2006, Archives of biochemistry and biophysics.

Highly enantioselective mutant carbonyl reductases created via structure-based site-saturation mutagenesis.

K. Kantardjieff, Dunming Zhu, Yan Yang, 2010, The Journal of organic chemistry.

Inverting the enantioselectivity of a carbonyl reductase via substrate-enzyme docking-guided point mutation.

K. Kantardjieff, Dunming Zhu, Yan Yang, 2008, Organic letters.

Enzymatic Enantioselective Reduction of α-Ketoesters by a Thermostable 7α-Hydroxysteroid Dehydrogenase from Bacteroides fragilis.

Dunming Zhu, L. Hua, J. E. Stearns, 2006 .

How carbonyl reductases control stereoselectivity: Approaching the goal of rational design*

Dunming Zhu, L. Hua, 2008 .

Influence of Cofactor Regeneration Strategies on Preparative-Scale, Asymmetric Carbonyl Reductions by Engineered Escherichia coli

J. Rozzell, J. Stewart, S. Kambourakis, 2014, Organic process research & development.

‘Green’ synthesis of important pharmaceutical building blocks: enzymatic access to enantiomerically pure α-chloroalcohols

Dunming Zhu, L. Hua, Chandrani Mukherjee, 2005 .

Enantioselective enzymatic reductions of sterically bulky aryl alkyl ketones catalyzed by a NADPH-dependent carbonyl reductase.

Dunming Zhu, L. Hua, 2006, The Journal of organic chemistry.

Asymmetric reduction of beta-ketonitriles with a recombinant carbonyl reductase and enzymatic transformation to optically pure beta-hydroxy carboxylic acids.

Dunming Zhu, Yan Yang, L. Hua, 2007, Organic letters.

One-Pot Multienzymatic Synthesis of 12-Ketoursodeoxycholic Acid: Subtle Cofactor Specificities Rule the Reaction Equilibria of Five Biocatalysts Working in a Row

Sergio Riva, Daniela Monti, Giacomo Carrea, 2009 .

A Novel meso-Diaminopimelate Dehydrogenase from Symbiobacterium thermophilum: Overexpression, Characterization, and Potential for d-Amino Acid Synthesis

Qiaqing Wu, Dunming Zhu, Xiuzhen Gao, 2012, Applied and Environmental Microbiology.

Directed Evolution To Investigate Steric Control of Enzymatic Oxidosqualene Cyclization. An Isoleucine-to-Valine Mutation in Cycloartenol Synthase Allows Lanosterol and Parkeol Biosynthesis

W. K. Wilson, S. Matsuda, L. Hua, 1999 .

Highly efficient production of peptides: N-glycosidase F for N-glycomics analysis.

Haifeng Song, Jiyue Cao, L. Hua, 2014, Protein expression and purification.

In vitro and in vivo growth suppression of human papillomavirus 16-positive cervical cancer cells by CRISPR/Cas9.

Yoshimitsu Takahashi, Y. Takahashi, Yan Li, 2014, Biochemical and biophysical research communications.

Alpha-amylase provenant de streptomyces umbrinus

M. Kolkman, L. Hua, D. Song, 2014 .

Steric bulk at position 454 in Saccharomyces cerevisiae lanosterol synthase influences B-ring formation but not deprotonation.

S. Matsuda, L. Hua, B. M. Joubert, 2000, Organic letters.

Discovery of a mandelonitrile hydrolase from Bradyrhizobium japonicum USDA110 by rational genome mining.

Dunming Zhu, Dunming Zhu, L. Hua, 2007, Journal of biotechnology.

Mechanism of Arctigenin-Induced Specific Cytotoxicity against Human Hepatocellular Carcinoma Cell Lines: Hep G2 and SMMC7721

Jiyue Cao, Hongbo Zhou, S. Cao, 2015, PloS one.

Evaluation of substituent effects on activity and enantioselectivity in the enzymatic reduction of aryl ketones

Dunming Zhu, J. Rozzell, L. Hua, 2005 .

A new nitrilase from Bradyrhizobium japonicum USDA 110. Gene cloning, biochemical characterization and substrate specificity.

Dunming Zhu, D. Gallagher, Dunming Zhu, 2008, Journal of biotechnology.

Scale‐up of enzymatic production of lactobionic acid using the rotary jet head system

John Villadsen, Mikkel Nordkvist, Per Munk Nielsen, 2007, Biotechnology and bioengineering.

Enzymatic ketone reduction: mapping the substrate profile of a short-chain alcohol dehydrogenase (YMR226c) from Saccharomyces cerevisiae

Dunming Zhu, Yan Yang, L. Hua, 2007 .

Asymmetric Synthesis of Both Antipodes of β-Hydroxy Nitriles and β-Hydroxy Carboxylic Acids via Enzymatic Reduction or Sequential Reduction/Hydrolysis.

Dunming Zhu, Yan Yang, L. Hua, 2009 .

Expression and biochemical characterization of recombinant human epididymis protein 4.

Yunhui Liu, Jiyue Cao, L. Hua, 2014, Protein expression and purification.

Prokaryotic expression and identification of scavenger receptor B2.

T. Xu, L. Hua, B. Zhu, 2018, Acta virologica.

Purification and Identification of a Novel Antimicrobial Protein from the Rabbit Sacculus Rotundus and its Effect on Cellular Immune Function in Mice

Juan Liu, L. Hua, Guangwei Zhao, 2015, International Journal of Peptide Research and Therapeutics.

Nitrilase-catalyzed selective hydrolysis of dinitriles and green access to the cyanocarboxylic acids of pharmaceutical importance

Dunming Zhu, Dunming Zhu, L. Hua, 2007 .