I. Paterson

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The total synthesis of swinholide A. Part 3: A stereocontrolled synthesis of (−)-pre-swinholide A.

K. Yeung, J. G. Cumming, I. Paterson, 1995 .

The total synthesis of swinholide A. Part 4: Synthesis of swinholide A and isoswinholide A from the protected monomeric seco acid, pre-swinholide A

K. Yeung, I. Paterson, R. Ward, 1995 .

Attention to detail?

David I. Perrett, Ian Paterson, D. Perrett, 1989, Behavioral and Brain Sciences.

Stereocontrolled total synthesis of (+)-leucascandrolide A.

Ian Paterson, I. Paterson, M. Tudge, 2003, Angewandte Chemie.

Advances in the total synthesis of biologically important marine macrolides.

Ian Paterson, K. Yeung, I. Paterson, 2005, Chemical reviews.

The impact of the Mukaiyama aldol reaction in total synthesis.

S. Kan, I. Paterson, K. Ng, 2013, Angewandte Chemie.

Total synthesis of the marine macrolide (+)-neopeltolide.

I. Paterson, N. A. Miller, 2008, Chemical communications.

The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: the CD-spiroacetal segment.

K. Gibson, I. Paterson, M. J. Coster, 2005, Organic & biomolecular chemistry.

Stereocontrolled Total Synthesis of (+)‐Leucascandrolide A

I. Paterson, M. Tudge, 2003 .

Stereocontrolled Synthesis as an Enabling Tool for the Configurational Assignment of Marine Polyketide Natural Products

I. Paterson, Nelson Y. S. Lam, 2020, European Journal of Organic Chemistry.

Challenges and discoveries in the total synthesis of complex polyketide natural products

I. Paterson, Nelson Y. S. Lam, 2017, The Journal of Antibiotics.

Toward the total synthesis of patellazole B: synthesis of an advanced C1-C25 fragment corresponding to the macrocyclic skeleton.

I. Paterson, Nelson Y. S. Lam, Andrew W. Phillips, 2018, Organic & biomolecular chemistry.

Strategy Evolution in the Total Synthesis of (−)‐Leiodermatolide

I. Paterson, Simon R Williams, 2017 .

Synthetic studies toward the brasilinolides: controlled assembly of a protected C1-C38 polyol based on fragment union by complex aldol reactions.

C. Cordier, I. Paterson, O. Loiseleur, 2015, Organic & biomolecular chemistry.

Total Synthesis of the Antimitotic Marine Macrolide (−)-Leiodermatolide

I. Paterson, K. Ng, Simon R Williams, 2014, Angewandte Chemie.

The stereocontrolled total synthesis of spirastrellolide A methyl ester. Fragment coupling studies and completion of the synthesis.

E. Anderson, I. Paterson, S. M. Dalby, 2012, Organic & biomolecular chemistry.

The stereocontrolled total synthesis of spirastrellolide A methyl ester. Expedient construction of the key fragments.

E. Anderson, I. Paterson, O. Loiseleur, 2012, Organic & biomolecular chemistry.

Strategy Evolution in the Total Synthesis of Spirastrellolide A Methyl Ester

I. Paterson, S. M. Dalby, P. Maltas, 2011 .

Stereocontrolled total synthesis of (+)-concanamycin F: the strategic use of boron-mediated aldol reactions of chiral ketones

I. Paterson, M. McLeod, Thomas Trieselmann, 2011 .

Total synthesis of (-)-dictyostatin, a microtubule-stabilising anticancer macrolide of marine sponge origin

Ó. Delgado, I. Paterson, Arndt Meyer, 2010 .

The chemical synthesis of discodermolide.

I. Paterson, G. J. Florence, 2010, Topics in current chemistry.

Synthesis and stereochemical determination of the spirastrellolides.

I. Paterson, S. M. Dalby, 2009, Natural product reports.

Total synthesis of spirastrellolide A methyl ester--part 1: Synthesis of an advanced C17-C40 bis-spiroacetal subunit.

E. Anderson, I. Paterson, Julien Genovino, 2008, Angewandte Chemie.

Development of practical syntheses of the marine anticancer agents discodermolide and dictyostatin.

I. Paterson, G. J. Florence, N. Gardner, 2008, Natural product reports.

Total synthesis of (-)-reidispongiolide A, an actin-targeting macrolide isolated from the marine sponge Reidispongia coerulea.

I. Paterson, G. J. Florence, R. Britton, 2008, Chemistry, an Asian journal.

Total synthesis of (-)-reidispongiolide A, an actin-targeting marine macrolide.

I. Paterson, G. J. Florence, R. Britton, 2007, Angewandte Chemie.

Synthesis of two diastereomeric C1-C22 fragments of spirastrellolide A.

E. Anderson, I. Paterson, Julien Genovino, 2007, Chemical communications.

Synthesis of the DEF-bis-spiroacetal of spirastrellolide A exploiting a double asymmetric dihydroxylation/spiroacetalisation strategy.

E. Anderson, I. Paterson, S. M. Dalby, 2006, Chemical communications.

Advances in the Total Synthesis of Biologically Important Marine Macrolides

K. Yeung, I. Paterson, 2006 .

Total synthesis and stereochemical reassignment of (+)-dolastatin 19.

I. Paterson, G. J. Florence, A. Findlay, 2006, Organic letters.

Remote, 1,5-anti stereoinduction in the boron-mediated aldol reactions of β-oxygenated methyl ketones

R. Oballa, K. Gibson, I. Paterson, 1996 .

The Horner-Wadsworth-Emmons Reaction in Natural Products Synthesis: Expedient Construction of Complex (E)-Enones Using Barium Hydroxide

J. Smaill, K. Yeung, I. Paterson, 1993 .

The stereochemical assignment of acyclic polyols: a computational study of the NMR data of a library of stereopentad sequences from polyketide natural products

J. Goodman, I. Paterson, Steven G Smith, 2010 .

Total Synthesis of Bioactive Marine Macrolides

I. Paterson, R. Norcross, 1995 .

Synergistic Effects of Peloruside A and Laulimalide with Taxoid Site Drugs, but Not with Each Other, on Tubulin Assembly

Arun K. Ghosh, K. Nicolaou, J. Miller, 2006, Molecular Pharmacology.

Total synthesis of the microtubule-stabilizing agent (-)-laulimalide.

C. De Savi, I. Paterson, M. Tudge, 2001, Organic letters.

Total synthesis of spirastrellolide A methyl ester--part 2: Subunit union and completion of the synthesis.

E. Anderson, I. Paterson, Julien Genovino, 2008, Angewandte Chemie.

Total synthesis and biological evaluation of potent analogues of dictyostatin: modification of the C2-C6 dienoate region.

A. Wright, I. Paterson, E. Guzmán, 2008, Bioorganic & Medicinal Chemistry Letters.

Studies in marine cembranolide synthesis: A synthesis of 2,3,5-trisubstituted furan intermediates for lophotoxin and pukalide

I. Paterson, G. Mark, B. J. Banks, 1989 .

Tetrahedron report number 190

I. Paterson, M. Mansuri, 1985 .

Synthesis of antimicrofilament marine macrolides: synthesis and configurational assignment of a C5-C16 degradation fragment of reidispongiolide A.

I. Paterson, R. Britton, K. Ashton, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Studies in marine macrolide synthesis: A stereocontrolled synthesis of a C17-C32 subunit of scytophycin C.

I. Paterson, Yeung Kap-Sun, 1993 .

Toward the synthesis of reidispongiolide a: stereocontrolled synthesis of the C17-C22 and C23-C35 degradation fragments.

I. Paterson, R. Britton, K. Ashton, 2003, Organic letters.

Best Practices for Message Threads

Peter Saint-Andre, Kevin Smith, Ian Paterson, 2010 .

Evaluation of the brain-penetrant microtubule-stabilizing agent, dictyostatin, in the PS19 tau transgenic mouse model of tauopathy

J. Trojanowski, V. Lee, Amos B. Smith, 2016, Acta Neuropathologica Communications.

Synergistic interactions between peloruside A and other microtubule-stabilizing and destabilizing agents in cultured human ovarian carcinoma cells and murine T cells

J. Miller, A. Wilmes, P. Northcote, 2011, Cancer Chemotherapy and Pharmacology.

Total synthesis of a library of designed hybrids of the microtubule-stabilising anticancer agents taxol, discodermolide and dictyostatin.

A. Wright, I. Paterson, E. Guzmán, 2010, Chemical communications.

Towards the total synthesis of phorboxazoles A and B: Stereocontrolled synthesis of a C20C32 subunit

I. Paterson, E. A. Arnott, 1998 .

MT-Stabilizer, Dictyostatin, Exhibits Prolonged Brain Retention and Activity: Potential Therapeutic Implications.

J. Trojanowski, V. Lee, Amos B. Smith, 2013, ACS medicinal chemistry letters.

Total synthesis of (-)-spirangien A, an antimitotic polyketide isolated from the myxobacterium Sorangium cellulosum.

I. Paterson, C. Noti, A. Findlay, 2009, Chemistry, an Asian journal.

Total synthesis of (-)-spirangien A and its methyl ester.

I. Paterson, C. Noti, A. Findlay, 2008, Chemical communications.

Synthesis of an advanced C10-C32 spiroacetal fragment and assignment of the absolute configuration of spirangien A.

E. Anderson, I. Paterson, A. Findlay, 2007, Angewandte Chemie.

Lattice defects induced by microtubule-stabilizing agents exert a long-range effect on microtubule growth by promoting catastrophes

A. Akhmanova, E. Katrukha, C. Moores, 2021, Proceedings of the National Academy of Sciences.

Microtubule lattice defects promote catastrophes

A. Akhmanova, E. Katrukha, C. Moores, 2021 .

Toward the synthesis of peloruside a: fragment synthesis and coupling studies.

M. D. Di Francesco, I. Paterson, T. Kuehn, 2003, Organic letters.

Synthesis of the macrocyclic core of laulimalide.

I. Paterson, M. Tudge, C. De savi, 2001, Organic letters.

Total synthesis and biological evaluation of a series of macrocyclic hybrids and analogues of the antimitotic natural products dictyostatin, discodermolide, and taxol.

A. Wright, I. Paterson, E. Guzmán, 2011, Chemistry, an Asian journal.

Large-Scale Synthesis of the Anti-Cancer Marine Natural Product (+)-Discodermolide. Part 4: Preparation of Fragment C7-24

T. Ramsey, S. Xue, I. Paterson, 2004 .

Structural Basis of Microtubule Stabilization by Discodermolide

M. Steinmetz, M. Redondo-Horcajo, A. Prota, 2017, Chembiochem : a European journal of chemical biology.

Total synthesis of (+)-discodermolide: an improved endgame exploiting a Still-Gennari-type olefination with a C1-C8 beta-ketophosphonate fragment.

I. Paterson, I. Lyothier, 2004, Organic letters.

Toward the combinatorial synthesis of polyketide libraries: asymmetric aldol reactions with alpha-chiral aldehydes on solid support.

I. Paterson, Taoues Temal-Laïb, 2002, Organic letters.

A highly enantioselective catalyst for the asymmetric Nozaki-Hiyama-Kishi reaction of allylic and vinylic halides.

I. Paterson, A. Berkessel, D. Menche, 2003, Angewandte Chemie.

Structural Determinants of the Dictyostatin Chemotype for Tubulin Binding Affinity and Antitumor Activity Against Taxane- and Epothilone-Resistant Cancer Cells

M. Steinmetz, A. Nogales, F. Gago, 2016, ACS omega.

Towards the combinatorial synthesis of spongistatin fragment libraries by using asymmetric aldol reactions on solid support.

I. Paterson, D. Menche, D. Gottschling, 2005, Chemical communications.

Induction of accelerated senescence by the microtubule-stabilizing agent peloruside A

J. Miller, P. Northcote, I. Paterson, 2017, Investigational New Drugs.

Total Synthesis of Bioactive Marine Macrolides

I. Paterson, R. Norcross, 1995 .

Total synthesis of (-)-rhizopodin.

I. Paterson, S. M. Dalby, J. Goodwin-Tindall, 2012, Angewandte Chemie.

Total synthesis of the actinoallolides and a designed photoaffinity probe for target identification.

I. Paterson, Matthew J Anketell, Theodore M. Sharrock, 2020, Organic & biomolecular chemistry.

Asymmetric Aldol Reactions Using Boron Enolates

I. Paterson, Cameron J. Cowden, C. Cowden, 1998 .

Toward aplyronine payloads for antibody-drug conjugates: total synthesis of aplyronines A and D.

I. Paterson, Simon R Williams, M. P. Housden, 2018, Organic & biomolecular chemistry.

Chemical modulation of microtubule structure through the laulimalide/peloruside site.

M. Steinmetz, K. Altmann, F. Gago, 2022, Structure.

Recent developments in asymmetric aldol methodology

I. Paterson, A. Franklin, 1995 .

Studies in Macrolide Synthesis: A Stereocontrolled Synthesis of Oleandolide Employing Reagent- and Substrate-Controlled Aldol Reactions of (S)-1-(Benzyloxy)-2-methylpentan-3-one

I. Paterson, R. Ward, P. Romea, 1994 .

A synthesis-enabled relative stereochemical assignment of the C1-C28 region of hemicalide.

J. Goodman, I. Paterson, Nelson Y. S. Lam, 2018, Chemical Communications.

An Expedient Total Synthesis of Chivosazole F: an Actin‐Binding Antimitotic Macrolide from the Myxobacterium Sorangium Cellulosum

S. Kan, I. Paterson, Simon R Williams, 2016, Angewandte Chemie.

Total synthesis of (+)-spirastrellolide A methyl ester: Challenges and discoveries

E. Anderson, I. Paterson, P. Maltas, 2013 .

Synthesis of the macrocyclic core of leiodermatolide.

I. Paterson, S. M. Dalby, Tanya Paquet, 2011, Organic Letters.

Strategy Evolution in the Total Synthesis of Spirastrellolide A Methyl Ester

I. Paterson, S. M. Dalby, P. Maltas, 2011 .

Studies in macrolide synthesis: A novel cyclodimerisation approach to the synthesis of elaiophylin using a double Stille cross-coupling reaction

I. Paterson, J. Man, 1997 .

Polyketide Synthesis Using the Boron-Mediated, anti-Aldol Reactions of Lactate-Derived Ketones: Total Synthesis of (-)-ACRL Toxin IIIB

I. Paterson, 1998 .

O-silylated enolate phenylthialkylation: A synthesis of α,β-unsaturated 5- and 6-membered lactones.

I. Paterson, H. A. Khan, 1982 .

New methods and strategies for the stereocontrolled synthesis of polypropionate-derived natural products

I. Paterson, 1992 .

Enantio- and diastereoselective aldol reactions of achiral ethyl and methyl ketones with aldehydes: the use of enol diisopinocampheylborinates

J. Goodman, R. Schumann, I. Paterson, 1990 .

γ-Sulphenylation of αβ-unsaturated aldehydes, ketones, and esters: the use of O-silylated dienolates

I. Fleming, I. Paterson, J. Goldhill, 1979 .

Studies in macrolide synthesis: A sequential aldol/glycosylation approach to the synthesis of concanamycin A

I. Paterson, M. McLeod, 1995 .

Recent Progress in the Chemical Synthesis of Antibiotics and Related Microbial Products

I. Paterson, 1994 .

Two Complimentary Methods for the Synthesis of the Terminal N-Alkenyl-N-methylformamide Group Found in Cytotoxic Marine Macrolides

I. Paterson, Cameron J. Cowden, Christine A L Watson, 1996 .

Allylsilanes in Organic Synthesis: A Method for the Introduction of Two Carbon Substituents in Place of Carbonyl Oxygen

I. Fleming, I. Paterson, 1979 .

Boron-mediated aldol reactions of ethyl α-( N , N )-dibenzylamino ketones: control of enolisation geometry and aldehyde π-facial selectivity

I. Paterson, A. Mackay, 2001 .

Computer-assisted design of chiral boron enolates: The role of ate complexes in determining aldol stereoselectivity.

Jonathan M. Goodman, Angiolina Comotti, Ian Paterson, 1994 .

Studies in marine macrolide synthesis: Boron and silicon-mediated coupling strategies for Swinholide A

J. G. Cumming, I. Paterson, R. Ward, 1994 .

13-Asymmetric induction in the aldol reactions of α-methylene-β-alkoxy aldehydes

I. Paterson, R. Tillyer, S. Bower, 1993 .

Developing a force field for the transition state of the aldol reaction of enolborinates: Evaluation of the use of fixed point charges.

J. Goodman, M. Gardner, A. Bernardi, 2010 .

Enolisation of ketones by dialkylboron chlorides and trifiates: A model for the effect of reagent leaving group substrate structure and amine base.

J. Goodman, I. Paterson, 1992 .

Origins of stereoselectivity in chiral boron enolate aldol reactions: A computational study using transition state modellings☆

Jonathan M. Goodman, Angiolina Comotti, Anna Maria Capelli, 1991 .

Stereoselective aldol reactions of β-chlorovinyl ketones using dienol borinates: A new synthesis of dihydropyrones.

S. Osborne, I. Paterson, 1990 .

Total synthesis of the esterase inhibitor (±)-ebelactone a using an aldol-claisen strategy

I. Paterson, A. Hulme, 1990 .

Aldol reactions in polypropionate synthesis: High π-face selectivity of enol borinates from α-chiral methyl and ethyl ketones under substrate control

J. Goodman, M. Isaka, I. Paterson, 1989 .

Studies in macrolide synthesis: aldol condensations of chiral ethylketones via boron enolates.

I. Paterson, C. Mcclure, 1987 .

Enantioselective aldol condensations: The use of ketone boron enolates with chiral ligands attached to boron.

I. Paterson, C. Mcclure, M. Lister, 1987 .

Total Synthesis of (-)-Ebelactone A and B

I. Paterson, A. Hulme, 1995 .

High π-face selectivity in anti aldol reactions of E-enol borinates from chiral alkoxymethyl ketones : stereocontrolled synthesis of a C24-C32 polyol subunit of rapamycin

I. Paterson, R. Tillyer, 1993 .

Studies in polyether synthesis using polyepoxide cyclisations.

I. Paterson, I. Boddy, I. Mason, 1987 .

Total Synthesis of (+)‐Concanamycin F

I. Paterson, M. McLeod, Thomas Trieselmann, 2000 .

Total Synthesis of Elaiolide Using a Copper(I)-Promoted Stille Cyclodimerization Reaction

I. Paterson, C. Allerton, and Henry-Georges Lombart, 1999 .

The Aldol Reaction: Transition Metal Enolates

Ian Paterson, I. Paterson, 1991 .

The rational design and systematic analysis of asymmetric aldol reactions using enol borinates: Applications of transition state computer modelling

J. Goodman, A. Bernardi, I. Paterson, 1995 .

Diastereofacial selectivity in the aldol reactions of chiral α-methyl aldehydes: a computer modelling approach.☆

Anna Vulpetti, Jonathan M. Goodman, Angiolina Comotti, 1992 .

Diastereofacial Selectivity in the Aldol Reactions of Chiral α‐ Methyl Aldehydes: A Computer Modelling Approach.

J. Goodman, A. Vulpetti, A. Comotti, 1992 .

Stereocontrolled Total Synthesis of (+)-Altohyrtin A/Spongistatin 1.

A. P. Hodgson, R. Oballa, K. Gibson, 2001, Angewandte Chemie.

Studies in macrolide synthesis: A concise asymmetric synthesis of a macrolide intermediate for the erythronolides.

D. Laffan, I. Paterson, D. Rawson, 1988 .

Studies in marine macrolide synthesis: Stereocontrolled synthesis of the F-ring subunit of spongistatin 1 (altohyrtin A)

I. Paterson, L. Keown, L. E. Keown, 1997 .

Studies in polypropionate synthesis: High π-face selectivity in syn and anti aldol reactions of chiral boron enolates of lactate-derived ketones

I. Paterson, D. J. Wallace, Silvia M. Velázquez, 1994 .

Origins of π-face selectivity in the aldol reactions of chiral E-enol borinates: a computational study using transition state modelling.

Anna Vulpetti, Jonathan M. Goodman, Ian Paterson, 1993 .

Actin-binding marine macrolides: total synthesis and biological importance.

K. Yeung, I. Paterson, 2002, Angewandte Chemie.

O-Silylated dienolates in organic synthesis: γ-Selective alkylation of unsaturated carbonyl compounds by 1,5-dithienium fluoroborate.

I. Paterson, L. G. Price, 1981 .

O-Silylated enolates in organic synthesis: α-Alkylation of carbonyl compounds by 1,3-dithienium fluoroborate.

I. Paterson, L. G. Price, 1981 .

THEORETICAL STUDIES OF ALDOL STEREOSELECTIVITY : THE DEVELOPMENT OF A FORCE FIELD MODEL FOR ENOL BORINATES AND THE INVESTIGATION OF CHIRAL ENOLATE PI -FACE SELECTIVITY

Jonathan M. Goodman, Scott D. Kahn, Ian Paterson, 1990 .

Total Synthesis of (-)-Preswinholide A

J. G. Cumming, I. Paterson, R. Ward, 1994 .

Studies in biomimetic polyether synthesis: Construction of an ABCD-ring subunit of etheromycin using polyepoxide cascade cyclisations.

J. Smaill, I. Paterson, R. Tillyer, 1993 .

Studies in marine macrolide synthesis: Asymmetric synthesis of C1-C15/C16 subunits of swinholide A and scytophycin C.

I. Paterson, J. D. Smith, 1993 .

Total synthesis of (-)-saliniketals A and B.

E. Anderson, I. Paterson, M. Razzak, 2008, Organic letters.

Design, synthesis and biological evaluation of novel, simplified analogues of laulimalide: modification of the side chain.

I. Barasoain, R. Buey, I. Paterson, 2005, Bioorganic & medicinal chemistry letters.

Total synthesis and stereochemical reassignment of (+)-dolastatin 19, a cytotoxic marine macrolide isolated from Dolabella auricularia

I. Paterson, G. J. Florence, A. Findlay, 2007 .

Stereocontrolled total synthesis of (-)-callipeltoside A.

Robert D. M. Davies, I. Paterson, Arndt Meyer, 2003, Organic letters.

Phorboxazole B synthetic studies: construction of C(1-32) and C(33-46) subtargets.

I. Paterson, A. Steven, C. Luckhurst, 2004, Organic & biomolecular chemistry.

Stereocontrolled synthesis of a C(1)-C(15) segment for the marine macrolides swinholide A and scytophycin C: use of a vinylogous Mukaiyama aldol reaction

I. Paterson, J. D. Smith, 1992 .

Toward the total synthesis of phorboxazole A: synthesis of an advanced C4–C32 subunit using the Jacobsen hetero Diels–Alder reaction

I. Paterson, C. Luckhurst, 2003 .

γ-Alkylation of unsaturated ketones and esters: zinc bromide-catalysed alkylation of O-silylated dienolates

I. Fleming, I. Paterson, J. Goldhill, 1979 .

Studies Towards the Total Synthesis of the Marine-Derived Immunosuppressant Discodermolide: Stereoselective Synthesis of a C9-C24 Subunit

I. Paterson, A. Schlapbach, 1995 .

Stereocontrolled total synthesis of (-)-aurisides A and B.

I. Paterson, G. J. Florence, A. Mackay, 2005, Angewandte Chemie.

TRANSITION-STATE MODELING OF THE ALDOL REACTION OF BORON ENOLATES - A FORCE-FIELD APPROACH

Jonathan M. Goodman, Anna Maria Capelli, Ian Paterson, 1990 .

Stereoselective synthesis of the chiral sequence of erythronolide A

I. Paterson, G. Stork, Ferdinand K. C. Lee, 1982 .

A short asymmetric synthesis of a C19-C27 segment of rifamycin S. kinetic resolution in the aldol reactions of ethylketones using chiral boron reagents

R. Schumann, I. Paterson, C. Mcclure, 1989 .

Total Synthesis of Aplyronine C

S. Atkinson, I. Paterson, S. Blakey, 2013, Organic letters.

Studies in marine macrolide synthesis: Construction of a 24-membered macrocyclic intermediate for aplyronine A

Michael D. Woodrow, I. Paterson, Cameron J. Cowden, 1998 .

Studies in marine macrolide synthesis: Stereocontrolled synthesis of the C1C11 and C15C27 subunits of aplyronine A

Michael D. Woodrow, I. Paterson, Cameron J. Cowden, 1998 .

Studies in marine macrolide synthesis: stereocontrolled synthesis of a C21–C34 subunit of the aplyronines

I. Paterson, S. Blakey, Cameron J. Cowden, 2002 .

Total Synthesis of (−)-Denticulatins A and B Using Efficient Methods of Acyclic Stereocontrol.

I. Paterson, M. Perkins, 1996 .

Manipulation of the aldol adducts from lactate-derived ketones. A versatile chiral auxiliary for the asymmetric synthesis of β-hydroxy carbonyl compounds

I. Paterson, D. J. Wallace, 1994 .

Total synthesis and configurational validation of (+)-phorbaside A.

I. Paterson, Tanya Paquet, 2010, Organic letters.

Total Synthesis of the Callipeltoside Aglycon.

Robert D. M. Davies, I. Paterson, R. Marquez, 2001, Angewandte Chemie.

A Simple Synthesis of Carvone Using Silyl Enol Ethers

I. Fleming, I. Paterson, 1979 .

Stereochemical determination of dictyostatin, a novel microtubule-stabilising macrolide from the marine sponge Corallistidae sp.

Ó. Delgado, A. Wright, I. Paterson, 2004, Chemical communications.

Stereoselective Aldol Reactions in the Synthesis of Polyketide Natural Products

I. Paterson, D. J. Wallace, Cameron J. Cowden, 2007 .

Stereocontrolled Total Synthesis of (+)-Altohyrtin A/Spongistatin 1.

A. P. Hodgson, R. Oballa, K. Gibson, 2001, Angewandte Chemie.

Studies in macrolide synthesis: A stereocontrolled synthesis of a (9S)-macrolide intermediate for oleandomycin using chiral boron reagents.

I. Paterson, R. Norcross, M. Lister, 1992 .

Aldol condensations of chiral ethylketones: Control by chiral boron reagents.

I. Paterson, M. Lister, 1988 .

Synthesis of novel 11-desmethyl analogues of laulimalide by Nozaki-Kishi coupling.

H. Bergmann, I. Paterson, A. Berkessel, 2004, Organic letters.

A Unified Total Synthesis of the Actinoallolides, a Family of Potent Anti‐Trypanosomal Macrolides

I. Paterson, Matthew J Anketell, Theodore M. Sharrock, 2019, Angewandte Chemie.

A Unified Total Synthesis of the Actinoallolides, a Family of Potent Anti-trypanosomal Macrolides.

I. Paterson, Matthew J Anketell, Theodore M. Sharrock, 2019, Angewandte Chemie.

meso Epoxides in Asymmetric Synthesis: Enantioselective Opening by Nucleophiles in the Presence of Chiral Lewis Acids

D. J. Berrisford, I. Paterson, 1992 .

Recent Advances in the Total Synthesis of Polyketide Natural Products as Promising Anticancer Agents

I. Paterson, A. Findlay, 2009 .

Anti Aldol reactions of α-alkoxymethyl ketones: Application to the total synthesis of (+)-restricticin

I. Paterson, T. Nowak, 1996 .

Studies towards the total synthesis of the marine-derived immunosuppressant discodermolide; asymmetric synthesis of a C1–C8δ-lactone subunit

S. Wren, I. Paterson, 1993 .

Stereocontrolled, Two-Directional, Chain Synthesis Using the Boron Aldol Reaction and Double Ireland-Claisen Rearrangement.

I. Paterson, A. Hulme, D. J. Wallace, 1991 .

Toward the synthesis of spirastrellolide A: construction of two C1-C25 diastereomers containing the BC-spiroacetal.

E. Anderson, I. Paterson, O. Loiseleur, 2005, Organic letters.

Total Synthesis of Spongistatin 1 (Altohyrtin A): A Tale of Ten Aldols

I. Paterson, M. J. Coster, 2004 .

Remote 1,5-stereoinduction in boron aldol reactions of methyl ketones: application to the convergent assembly of the 1,3-polyol sequence of (+)-roxaticin

L. A. Collett, I. Paterson, 2001 .

Studies in marine macrolide synthesis: Synthesis of a C16C28 subunit of spongistatin 1 (altohyrtin A) incorporating the CD-spiroacetal moiety

K. Gibson, I. Paterson, D. J. Wallace, 1997 .

Studies towards the synthesis of the zaragozic acids: Synthesis of the bicyclic acetal core of zaragozic acid C

I. Paterson, M. Finlay, K. Feßner, 1997 .

Conquering peaks and illuminating depths: developing stereocontrolled organic reactions to unlock nature's macrolide treasure trove.

I. Paterson, Nelson Y. S. Lam, Tegan P. Stockdale, 2021, Chemical communications.

Stereocontrolled synthesis of polyketide libraries: Boron-mediated aldol reactions with aldehydes on solid support

S. Ceccarelli, M. Donghi, I. Paterson, 1998 .

The total synthesis of scytophycin C. Part 1: stereocontrolled synthesis of the C1C32 protected seco acid

P. A. Wallace, K. Yeung, I. Paterson, 1998 .

The total synthesis of swinholide A. Part 1: A stereocontrolled synthesis of a C19-C32 segment

J. G. Cumming, I. Paterson, R. Ward, 1995 .

Stereocontrolled aldol additions to α-methylene-β-alkoxy aldehydes: Application to the synthesis of a C13C25 segment of bafilomycin A1

I. Paterson, M. McLeod, S. Bower, 1995 .

Assignment of the absolute configuration of the siphonarins and baconipyrones. Enantiocontrolled synthesis of a γ-pyrone subunit

I. Paterson, A. Franklin, 1994 .

Studies in biomimetic polyether synthesis: Synthesis of an A-ring subunit of etheromycin

I. Paterson, R. Tillyer, G. R. Ryan, 1993 .

Synthesis of the C1-C11 western fragment of madeirolide A.

I. Paterson, G. W. Haslett, 2013, Organic letters.

Synthesis of novel discodermolide analogues with modified hydrogen-bonding donor/acceptor sites

Ó. Delgado, I. Paterson, 2003 .

Total synthesis of altohyrtin A (spongistatin 1): an alternative synthesis of the CD-spiroacetal subunit

I. Paterson, M. J. Coster, 2002 .

Total synthesis of siphonarin B and dihydrosiphonarin B.

I. Paterson, D. Y. Chen, A. Franklin, 2002, Organic letters.

Synthesis of (+)-discodermolide and analogues by control of asymmetric induction in aldol reactions of γ-chiral (Z)-enals

I. Paterson, G. J. Florence, 2000 .

Studies in marine polypropionate synthesis: total synthesis of (-)-baconipyrone C.

I. Paterson, J. L. Aceña, A. Franklin, 2000, Organic letters.

Synthesis of Cytotoxic Marine Macrolides: An Aldol-Based Approach to Spongistatin 1 (Altohyrtin A)

R. Oballa, K. Gibson, I. Paterson, 1999 .

Studies in marine macrolide synthesis: Synthesis of the C1C15 subunit of spongistatin 1 (altohyrtin A) and 15,16-anti aldol coupling reactions

R. Oballa, I. Paterson, 1997 .

Mechanistic insights from ab initio calculations on a nitrogen analogue of the boron-mediated aldol reaction

J. Goodman, A. Bernardi, I. Paterson, 1995 .

Studies in polypropionate synthesis: high π-face selectivity in syn aldol reactions of tin(II) enolates from (R)- and (S)-1-benzyloxy-2-methylpentan-3-one.

I. Paterson, R. Tillyer, 1992 .

Asymmetric aldol reactions using chiral boron reagents: Application to the synthesis of tirandamycin A

I. Paterson, M. Lister, G. R. Ryan, 1991 .

Enantio- and diastereoselective aldol reactions of achiral ethyl and methyl ketones with aldehydes: the use of enol diisopinocampheylborinates

J. Goodman, R. Schumann, I. Paterson, 1990 .

Aldol reactions of methylketones using chiral boron reagents: a reversal in aldehyde enantioface selectivity

J. Goodman, I. Paterson, 1989 .

Studies in macrolide synthesis: aldol condensations of chiral ethylketones via boron enolates.

I. Paterson, C. Mcclure, 1987 .

A force field model for boron enolates

J. Goodman, I. Paterson, S. S. Kahn, 1987 .

Toward the synthesis of spirastrellolide a: construction of a tetracyclic C26-C40 subunit containing the DEF-bis-spiroacetal.

E. Anderson, I. Paterson, O. Loiseleur, 2005, Organic letters.

Total Synthesis of Swinholide A and Hemiswinholide A

K. Yeung, J. G. Cumming, I. Paterson, 1994 .

A fully stereocontrolled total synthesis of (+)-leucascandrolide A

I. Paterson, M. Tudge, Matthew T. Tudge, 2003 .

Synthesis of the C1-C13 tetraenoate subunit of the chivosazoles.

S. Kan, I. Paterson, Lisa Gibson, 2010, Organic letters.

Development of a third-generation total synthesis of (+)-discodermolide: an expedient Still-Gennari-type fragment coupling utilizing an advanced beta-ketophosphonate.

I. Paterson, I. Lyothier, 2005, The Journal of organic chemistry.

anti-Aldol reactions of lactate-derived ketones. Application to the synthesis of (−)-tetrahydrolipstatin

I. Paterson, V. A. Doughty, 1999 .

Total synthesis of the marine polypropionate (+)-muamvatin. A configurational model for siphonariid metabolites

I. Paterson, M. Perkins, 1993 .

Studies in polypropionate synthesis: stereoselective synthesis of (−)-denticulatins A and B

I. Paterson, M. Perkins, 1992 .

Studies in polyether synthesis: Controlled bisepoxide cyclisation using a β-diketone group

I. Paterson, P. A. Craw, 1989 .

α-Alkylation of ketones, esters, and lactones: zinc bromide-catalysed alkylation of o-silylated enolates, a synthesis of (±)-ar-turmerone☆

Ian Paterson, I. Paterson, 1979 .

Recent developments in the total synthesis od macrolide antibiotics

I. Paterson, M. Mansuri, 1985 .

Substrate-Controlled Aldol Reactions of Chiral Ethyl Ketones: Application to the Total Synthesis of Oleandomycin

I. Paterson, R. Ward, P. Romea, 1994 .

Studies in macrolide synthesis: A highly stereoselective synthesis of (+)-(9S)-dihydroerythronolide a using macrocyclic stereocontrol

I. Paterson, D. Rawson, 1989 .

α-methylenation of lactones and esters zinc bromide-catalysed phenylthiomethylation of o-silylated enolates☆

I. Fleming, I. Paterson, 1979 .

A stereocontrolled synthesis of a C19-C32 / C17-C30 Segment for swinholide A and misakinolide A, Cytotoxic dimeric macrolides from theonella swinhoei.

J. G. Cumming, I. Paterson, 1992 .

The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: the southern hemisphere EF segment.

I. Paterson, M. J. Coster, J. L. Aceña, 2005, Organic & biomolecular chemistry.

α-alkylation and α-alkylidenation of carbonyl compounds by o-silylated enolate phenylthioalkylation

I. Paterson, 1988 .

Alkene carbosulphenylation and carboselenylation: The use of allyltrimethylsilane and o-silylated enolates.

I. Paterson, R. Alexander, 1983 .

α-t-Butylation of aldehydes and ketones by the Friedel-Crafts alkylation of trimethylsilyl enol ethers

I. Paterson, T. Chan, J. Pinsonnault, 1977 .

Studies in polyether synthesis: Spiroacetal formation by directed bisepoxide cyclisation.

I. Paterson, I. Boddy, 1988 .

A second-generation total synthesis of spirastrellolide A methyl ester.

E. Anderson, I. Paterson, S. M. Dalby, 2012, Angewandte Chemie.

The formation of allyl sulphides by phenylthio-migration: control by silicon

I. Fleming, I. Paterson, A. Pearce, 1981 .

Total Synthesis of Jiadifenolide**

I. Paterson, S. M. Dalby, Meng Xuan, 2014, Angewandte Chemie.

Total Synthesis of Pteridic Acids A and B

C. Knappy, E. Anderson, I. Paterson, 2008 .

The Renaissance of Natural Products as Drug Candidates

Ian Paterson, Edward A Anderson, E. Anderson, 2005, Science.

Studies towards the synthesis of lophotoxin and pukalide: Synthesis of the 14-membered macrocyclic core and some acyclic structural analogues

C. Urch, I. Paterson, Rebecca E. Brown, 1999 .

Laboratory emulation of polyketide biosynthesis: an iterative, aldol-based, synthetic entry to polyketide libraries using (R)- and (S)-1-(benzyloxy)-2-methylpentan-3-one, and conformational aspects of extended polypropionates

Jeremy P. Scott, I. Paterson, 1999 .

Studies in macrolide synthesis: Stereocontrolled synthesis of a C1C13 segment of concanamycin A

I. Paterson, M. McLeod, 1997 .

Total synthesis of alotaketal A.

I. Paterson, S. M. Dalby, Meng Xuan, 2012, Organic letters.

Polyketide Library Synthesis: Iterative Assembly of Extended Polypropionates Using (R)- and (S)-1-(Benzyloxy)-2-methylpentan-3-one

Jeremy P. Scott, I. Paterson, 1997 .

Studies in Macrolide Synthesis: Stereocontrolled Synthesis of a C1-C13 Segment of Concanamycin A.

I. Paterson, M. McLeod, 1997 .

A configurational model for siphonariid polypropionates derived from structural and biosynthetic considerations

J. Goodman, M. Garson, I. Paterson, 1994 .

Enol Borinates in Organic Synthesis: Regioselective α-Sulphenylation and α-Selenenylation of Ketones

S. Osborne, I. Paterson, 1991 .

A counterintuitive stereochemical outcome from a chelation-controlled vinylmetal aldehyde addition leads to the configurational reassignment of phormidolide A.

I. Paterson, Nelson Y. S. Lam, R. Britton, 2019, Chemical communications.

O-silylated enolates in organic synthesis: sulphur-mediated alkylation of esters with alkenes.

S. K. Patel, I. Paterson, 1983 .

O-silylated enolate phenylthioalkylation: a new synthesis of unsaturated 1,5-dicarbonyl compounds.

I. Paterson, H. A. Khan, 1982 .

Synergism of anisotropic and computational NMR methods reveals the likely configuration of phormidolide A.

Kelsey L. Alexander, Kelsey L Alexander, J. Goodman, 2020, Chemical communications.

Total synthesis and biological evaluation of simplified aplyronine analogues as synthetically tractable anticancer agents.

Stephen J. Walsh, J. Carroll, D. Spring, 2020, Chemical communications.

Toward the stereochemical assignment and synthesis of hemicalide: DP4f GIAO-NMR analysis and synthesis of a reassigned C16-C28 subunit.

J. Goodman, I. Paterson, B. Han, 2016, Chemical communications.

Total synthesis and configurational assignment of (-)-dictyostatin, a microtubule-stabilizing macrolide of marine sponge origin.

Ó. Delgado, I. Paterson, Arndt Meyer, 2004, Angewandte Chemie.

Epoxides in Asymmetric Synthesis: Enantioselective Opening by Nucleophiles Promoted by Chiral Transition Metal Complexes

D. J. Berrisford, I. Paterson, 2003 .

α-Alkylation and α-alkylidenation of carbonyl compounds: Lewis acid-promoted phenylthioalkylation of o-silylated enolates

I. Fleming, I. Paterson, 1979 .

The bound conformation of microtubule-stabilizing agents: NMR insights into the bioactive 3D structure of discodermolide and dictyostatin.

Jesús Jiménez-Barbero, Ian Paterson, I. Paterson, 2008, Chemistry.

The tubulin-bound conformation of discodermolide derived by NMR studies in solution supports a common pharmacophore model for epothilone and discodermolide.

Jens Meiler, Ian Paterson, Karel Kubicek, 2006, Angewandte Chemie.

Microtubule interactions with chemically diverse stabilizing agents: thermodynamics of binding to the paclitaxel site predicts cytotoxicity.

I. Barasoain, P. Giannakakou, R. Buey, 2005, Chemistry & biology.

Large-Scale Synthesis of the Anti-Cancer Marine Natural Product (+)-Discodermolide. Part 5: Linkage of Fragments C1-6 and C7-24 and Finale

Ian Paterson, T. Ramsey, I. Paterson, 2004 .

The Development of a Practical Total Synthesis of Discodermolide, a Promising Microtubule-Stabilizing Anticancer Agent

Ian Paterson, I. Paterson, Gordon J. Florence, 2003 .

A practical synthesis of (+)-discodermolide and analogues: fragment union by complex aldol reactions.

I. Paterson, G. J. Florence, K. Gerlach, 2001, Journal of the American Chemical Society.

A second-generation total synthesis of (+)-discodermolide: the development of a practical route using solely substrate-based stereocontrol.

Ian Paterson, Jeremy P. Scott, Ó. Delgado, 2005, The Journal of organic chemistry.

Synthesis of the C1-C21 Southern Hemisphere of the Originally Proposed Structure of Spirastrellolide A

E. Anderson, I. Paterson, S. M. Dalby, 2005 .

Structure-activity studies of the pelorusides: new congeners and semi-synthetic analogues.

J. Goodman, J. Miller, A. Wilmes, 2011, Organic & biomolecular chemistry.

Structural and Biochemical Studies of Actin in Complex with Synthetic Macrolide Tail Analogues

J. H. Pereira, P. Adams, N. Moriarty, 2014, ChemMedChem.

Synthetic mimetics of actin-binding macrolides: rational design of actin-targeted drugs.

Ian Paterson, Giuseppe Cecere, G. Marriott, 2008, Chemistry & biology.

Studies towards the synthesis of the zaragozic acids: A novel epoxide cyclisation approach to the formation of the bicyclic acetal core

I. Paterson, M. Finlay, M. F. Jacobs, 1996 .

Towards the synthesis of swinholide A and scytophycin C. A highly stereocontrolled synthesis of (−)-pre-swinholide A

K. Yeung, J. G. Cumming, I. Paterson, 1994 .

The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: fragment couplings, completion of the synthesis, analogue generation and biological evaluation.

I. Paterson, M. J. Coster, J. L. Aceña, 2005, Organic & biomolecular chemistry.

Synthesis and biological evaluation of spongistatin/altohyrtin analogues: E-ring dehydration and C46 side-chain truncation.

I. Paterson, M. J. Coster, J. L. Aceña, 2003, Chemical communications.

Synthetic chemistry. Cancer drugs better than taxol?

I. Paterson, Cameron J. Cowden, 1997, Nature.

Zampanolide, a Microtubule-Stabilizing Agent, Is Active in Resistant Cancer Cells and Inhibits Cell Migration

K. Altmann, J. Miller, P. Northcote, 2017, International journal of molecular sciences.

A Facile Oxidation/Deprotection of Electron Rich Silyl Ethers Using DDQ

Michael D. Woodrow, I. Paterson, Cameron J. Cowden, 1998 .

Synthesis of polyketide natural products and analogs as promising anticancer agents.

I. Paterson, S. M. Dalby, 2011, Current opinion in drug discovery & development.

Synthesis of Spirastrellolide A Methyl Ester

E. Anderson, I. Paterson, Julien Genovino, 2008 .

Progress toward a total synthesis of spirastrellolide A

E. Anderson, I. Paterson, O. Loiseleur, 2007 .

Synthesis of the C15-C35 northern hemisphere subunit of the chivosazoles.

S. Kan, I. Paterson, Lisa Gibson, 2010, Organic letters.

Leiodermatolide, a potent antimitotic macrolide from the marine sponge Leiodermatium sp.

R. Isbrucker, D. Divlianska, A. Wright, 2011, Angewandte Chemie.

Stereochemical Determination of Dictyostatin, a Novel Microtubule‐Stabilizing Macrolide from the Marine Sponge Corallistidae sp.

Ó. Delgado, A. Wright, I. Paterson, 2004 .

Insights into the interaction of discodermolide and docetaxel with tubulin. Mapping the binding sites of microtubule-stabilizing agents by using an integrated NMR and computational approach.

I. Paterson, C. Trigili, Á. Canales, 2011, ACS chemical biology.

Total synthesis and biological evaluation of novel C2-C6 region analogues of dictyostatin.

A. Wright, I. Paterson, E. Guzmán, 2009, Bioorganic & medicinal chemistry.

Total synthesis of a potent hybrid of the anticancer natural products dictyostatin and discodermolide.

A. Wright, I. Paterson, Guy J. Naylor, 2008, Chemical communications.

Synthesis and biological evaluation of novel analogues of dictyostatin.

A. Wright, I. Paterson, N. Gardner, 2007, Bioorganic & medicinal chemistry letters.

Molecular recognition of epothilones by microtubules and tubulin dimers revealed by biochemical and NMR approaches.

K. Altmann, F. Gago, T. Carlomagno, 2014, ACS chemical biology.

Molecular Recognition of Peloruside A by Microtubules. The C24 Primary Alcohol is Essential for Biological Activity

I. Barasoain, J. Díaz, P. Northcote, 2010, Chembiochem : a European journal of chemical biology.

Evaluation of the brain-penetrant microtubule-stabilizing agent, dictyostatin, in the PS19 tau transgenic mouse model of tauopathy

J. Trojanowski, V. Lee, Amos B. Smith, 2016, Acta neuropathologica communications.

Synthetic Studies towards Iriomoteolide1a: Stereocontrolled Construction of C1-C9 and C11-C23Segments Using Lactate Aldol Chemistry

I. Paterson, P. Rubenbauer, 2010 .

Conformational studies and solution structure of laulimalide and simplified analogues using NMR spectroscopy and molecular modelling

I. Paterson, D. Menche, R. Britton, 2005 .

Aldol Reactions of Methyl Ketones Using Chiral Boron Reagents: A Reversal in Aldehyde Enantioface Selectivity.

J. Goodman, I. Paterson, 1989 .

Laboratory Emulation of Polyketide Biosynthesis: An Iterative, Aldol-Based, Synthetic Entry to Polyketide Libraries Using (R)- and (S)-1-(Benzyloxy)-2-methylpentan-3-one, and Conformational Aspects of Extended Polypropionates.

Jeremy P. Scott, I. Paterson, 1999 .

Polyketide library synthesis: Conformational control in extended polypropionates

Jeremy P. Scott, I. Paterson, 1997 .

Total Synthesis of Scytophycin C.

P. A. Wallace, K. Yeung, I. Paterson, 1997, The Journal of organic chemistry.

Design, synthesis and biological evaluation of a macrocyclic discodermolide/dictyostatin hybrid.

I. Paterson, N. Gardner, 2007, Chemical communications.

A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin

M. Steinmetz, K. Altmann, D. Lucena‐Agell, 2018, Nature Communications.

1,6-asymmetric induction in boron-mediated aldol reactions: application to a practical total synthesis of (+)-discodermolide.

Jeremy P. Scott, Ó. Delgado, I. Paterson, 2003, Organic letters.

Synthesis and biological evaluation of 10,11-dihydrodictyostatin, a potent analogue of the marine anticancer agent dictyostatin.

Ian Paterson, A. Wright, I. Paterson, 2008, Journal of natural products.

Discodermolide interferes with the binding of tau protein to microtubules

Ian Paterson, L. Amos, Santwana Kar, 2003, FEBS letters.

Polyketide Synthesis Using the Boron-Mediated, anti-Aldol Reactions of Lactate-Derived Ketones: Total Synthesis of (-)-ACRL Toxin IIIB

I. Paterson, 1998 .

Asymmetric alkylation and sulphenylation of chiral O-silylated imide enolates.

I. Paterson, R. Alexander, 1986 .

A quantitative evaluation of the effects of inhibitors of tubulin assembly on polymerization induced by discodermolide, epothilone B, and paclitaxel

Ian Paterson, Ernest Hamel, E. Hamel, 2004, Cancer Chemotherapy and Pharmacology.

The total synthesis of scytophycin C. Part 2: synthesis of scytophycin C from the protected seco acid

P. A. Wallace, K. Yeung, I. Paterson, 1998 .

Total Synthesis of the Antimicrotubule Agent (+)-Discodermolide Using Boron-Mediated Aldol Reactions of Chiral Ketones.

Gerlach, I. Paterson, Scott, 2000, Angewandte Chemie.

Molecular Recognition of Peloruside A by Microtubules. The C24 Primary Alcohol is Essential for Biological Activity

I. Barasoain, J. Díaz, P. Northcote, 2010, Chembiochem : a European journal of chemical biology.

Insights into the interaction of discodermolide and docetaxel with tubulin. Mapping the binding sites of microtubule-stabilizing agents by using an integrated NMR and computational approach.

I. Paterson, C. Trigili, Á. Canales, 2011, ACS chemical biology.

Total Synthesis of the Callipeltoside Aglycon.

Robert D. M. Davies, I. Paterson, R. Marquez, 2001, Angewandte Chemie.

The impact of the Mukaiyama aldol reaction in total synthesis.

S. Kan, I. Paterson, K. Ng, 2013, Angewandte Chemie.

Synthesis of the C1-C13 tetraenoate subunit of the chivosazoles.

I. Paterson, Lisa J. Gibson, S. Kan, 2010, Organic letters.