S. Soisson

发表

Structural basis for ligand-regulated oligomerization of AraC.

C. Wolberger, R. Schleif, S. Soisson, 1997, Science.

The 1.6 A crystal structure of the AraC sugar-binding and dimerization domain complexed with D-fucose.

C. Wolberger, R. Schleif, S. Soisson, 1997, Journal of molecular biology.

Outcome of the First wwPDB/CCDC/D3R Ligand Validation Workshop.

Haruki Nakamura, Evan Bolton, Zukang Feng, 2016, Structure.

The discovery and synthesis of potent zwitterionic inhibitors of renin.

J. Falgueyret, M. Percival, S. Gagné, 2011, Bioorganic & medicinal chemistry letters.

Structure and Function of the Hypertension Variant A486V of G Protein-coupled Receptor Kinase 4*

P. Darke, S. Munshi, D. Hall, 2015, The Journal of Biological Chemistry.

Structural understanding of non-nucleoside inhibition in an elongating herpesvirus polymerase

A. W. Shaw, Mee Ra Heo, I. Raheem, 2021, Nature Communications.

Isolation, enzyme-bound structure, and activity of platensimycin A1 from Streptomyces platensis

J. W. Becker, S. Soisson, Sheo B. Singh, 2009 .

Synthesis and biological evaluation of platensimycin analogs.

M. Maccoss, Hong C Shen, S. Soisson, 2009, Bioorganic & medicinal chemistry letters.

Isolation, enzyme-bound structure and antibacterial activity of platencin A1 from Streptomyces platensis.

J. W. Becker, S. Soisson, Sheo B. Singh, 2009, Bioorganic & medicinal chemistry letters.

A potent broadly neutralizing human RSV antibody targets conserved site IV of the fusion glycoprotein

H. Su, K. Vora, M. Eddins, 2019, Nature Communications.

Mechanism of action of the cell-division inhibitor PC190723: modulation of FtsZ assembly cooperativity.

Sujata Sharma, K. Lumb, S. Soisson, 2012, Journal of the American Chemical Society.

Identification of an allosteric binding site for RORγt inhibition

C. Ottmann, Sujata Sharma, H. van Eenennaam, 2015, Nature Communications.

From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9.

Sujata Sharma, J. Lisnock, P. Orth, 2019, Cell chemical biology.

Expression, purification and crystallization of human prolylcarboxypeptidase.

Sujata Sharma, D. Hall, R. Diehl, 2010, Acta crystallographica. Section F, Structural biology and crystallization communications.

Development of a robust crystallization platform for immune receptor TREM2 using a crystallization chaperone strategy.

S. So, H. Su, A. Brooun, 2020, Protein expression and purification.

Structure of the Bacterial Deacetylase LpxC Bound to the Nucleotide Reaction Product Reveals Mechanisms of Oxyanion Stabilization and Proton Transfer

Sujata Sharma, D. Klein, K. Lumb, 2013, The Journal of Biological Chemistry.

Insights into activity and inhibition from the crystal structure of human O-GlcNAcase.

Sujata Sharma, D. Klein, D. Hall, 2017, Nature chemical biology.

Discovery of a highly potent, selective, and bioavailable soluble epoxide hydrolase inhibitor with excellent ex vivo target engagement.

J. Berger, Gaochao Zhou, Sanjeev Kumar, 2009, Journal of medicinal chemistry.

Design and optimization of a substituted amino propanamide series of renin inhibitors for the treatment of hypertension.

C. Bayly, S. Gagné, S. Soisson, 2010, Bioorganic & medicinal chemistry letters.

Platensimycin is a selective FabF inhibitor with potent antibiotic properties

Jun Wang, Olga Genilloud, Sang Ho Lee, 2006, Nature.

Structures of kibdelomycin bound to Staphylococcus aureus GyrB and ParE showed a novel U-shaped binding mode.

N. Sharma, K. Lumb, Sangita Patel, 2014, ACS chemical biology.

Discovery of a 5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one (MK-2461) inhibitor of c-Met kinase for the treatment of cancer.

K. Kunii, M. Altman, A. Szewczak, 2011, Journal of medicinal chemistry.

Reducing the peptidyl features of caspase-3 inhibitors: a structural analysis.

C. Bayly, Yongxin Han, R. Zamboni, 2004, Journal of medicinal chemistry.

Identification of potent inhibitors of the sortilin-progranulin interaction.

Gregory T O'Donnell, P. Coleman, M. Ziebell, 2020, Bioorganic & medicinal chemistry letters.

Crystal Structure of the Dbl and Pleckstrin Homology Domains from the Human Son of Sevenless Protein

D. Bar-Sagi, J. Kuriyan, Marc Uy, 1998, Cell.

Structural insights on ligand recognition at the human leukotriene B4 receptor 1

V. Katritch, G. Han, V. Cherezov, 2021, Nature Communications.

Tandem histone folds in the structure of the N-terminal segment of the ras activator Son of Sevenless.

Holger Sondermann, John Kuriyan, H. Sondermann, 2003, Structure.

Structural definition and substrate specificity of the S28 protease family: the crystal structure of human prolylcarboxypeptidase

Sujata Sharma, D. Hall, R. Diehl, 2010, BMC Structural Biology.

Structural characterization of nonactive site, TrkA-selective kinase inhibitors

D. Henze, H. Su, M. Ziebell, 2016, Proceedings of the National Academy of Sciences.

Structural Basis for Selective Small Molecule Kinase Inhibition of Activated c-Met

P. Darke, S. Munshi, D. Hall, 2011, The Journal of Biological Chemistry.

Structural Analysis of Autoinhibition in the Ras Activator Son of Sevenless

Holger Sondermann, John Kuriyan, Sean Boykevisch, 2004, Cell.

Structures of active-state orexin receptor 2 rationalize peptide and small-molecule agonist recognition and receptor activation

M. Rudd, T. Mcdonald, S. Stachel, 2021, Nature Communications.

Lead Optimization of Cathepsin K Inhibitors for the Treatment of Osteoarthritis.

K. K. Nanda, B. Ma, G. Wesolowski, 2022, Bioorganic & medicinal chemistry letters.

Tricyclic 1,5-naphthyridinone oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents-SAR of left-hand-side moiety (Part-2).

Leo A. Joyce, E. Sherer, R. Nargund, 2015, Bioorganic & medicinal chemistry letters.

Oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad spectrum antibacterial agents.

Sangita Patel, Jin Wu, P. Meinke, 2014, ACS medicinal chemistry letters.

Identification of a potent synthetic FXR agonist with an unexpected mode of binding and activation

J. W. Becker, S. Soisson, Alan D. Adams, 2008, Proceedings of the National Academy of Sciences.

Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40

Sujata Sharma, G. Bricogne, C. Vonrhein, 2017, Nature Structural &Molecular Biology.

Structural Basis for Selectivity and Diversity in Angiotensin II Receptors

M. Rudd, R. Stevens, M. Hunter, 2017, Nature.

Discovery of 1-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-(pyridin-2-ylmethyl)methanesulfonamide (MK-8033): A Specific c-Met/Ron dual kinase inhibitor with preferential affinity for the activated state of c-Met.

Wei Lu, Michael D Altman, Craig Rosenstein, 2013, Journal of medicinal chemistry.

A rapid and quantitative microtiter assay for eukaryotic topoisomerase II.

M. Muller, S. Soisson, J. Spitzner, 1989, Nucleic acids research.

The identification of a novel lead class for phosphodiesterase 2 inhibition by fragment-based drug design.

Deping Wang, Sujata Sharma, W. Shipe, 2017, Bioorganic & medicinal chemistry letters.

A non-canonical mechanism of GPCR activation

Naomi R. Latorraca, Joseph M. Paggi, S. Soisson, 2023, bioRxiv.

From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9.

Sujata Sharma, P. Orth, J. Shipman, 2021, Cell chemical biology.

Oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad spectrum antibacterial agents.

Sangita Patel, Jin Wu, P. Meinke, 2014, ACS medicinal chemistry letters.