N. Shibata

发表

Biological evaluation of both enantiomers of fluoro-thalidomide using human myeloma cell line H929 and others

H. Hara, V. Soloshonok, Etsuko Tokunaga, 2017, PloS one.

Synthesis and application of trifluoroethoxy-substituted phthalocyanines and subphthalocyanines

N. Shibata, Satoru Mori, 2017, Beilstein journal of organic chemistry.

Trifluoroethoxy-Coated Phthalocyanine Catalyzes Perfluoroalkylation of Alkenes under Visible-Light Irradiation †

H. Amii, N. Shibata, Kohei Matsuzaki, 2017, Molecules.

Synthesis, photophysical and electrochemical properties of perfluoroisopropyl substituted binuclear phthalocyanine conjugated with a butadiyne linker

N. Shibata, Shuichi Nakamura, Banibrata Das, 2009 .

Cinchona alkaloid/Ti(IV)-catalyzed enantioselective enamine-trifluoropyruvate condensation-cyclization reaction and its application to drug-like heterocycles.

Etsuko Tokunaga, N. Shibata, M. Shiro, 2010, Chemistry.

Diastereodivergent Asymmetric 1,3‐Dipolar Cycloaddition of Azomethine Ylides and β‐Fluoroalkyl Vinylsulfones: Low Copper(II) Catalyst Loading and Theoretical Studies

Yan Zhao, Yiyong Huang, N. Shibata, 2019, Angewandte Chemie.

Diastereodivergent Asymmetric 1,3-Dipolar Cycloaddition of Azomethine Ylides and β-Fluoroalkyl Vinylsulfones: Low Cu(II) Catalyst Loading and Theoretical Studies.

Yan Zhao, Yiyong Huang, N. Shibata, 2019, Angewandte Chemie.

A proximity biotinylation-based approach to identify protein-E3 ligase interactions induced by PROTACs and molecular glues

H. Kosako, T. Sawasaki, N. Shibata, 2022, Nature communications.

An IMiD-induced SALL4 degron system for selective degradation of target proteins

T. Sawasaki, N. Shibata, Hisayo Nishida-Fukuda, 2020, Communications biology.

Synthesis of Aryl Triflones through the Trifluoromethanesulfonylation of Benzynes

Etsuko Tokunaga, N. Shibata, Yuji Sumii, 2018, ChemistryOpen.

Fluorothalidomide: a characterization of maternal and developmental toxicity in rabbits and mice.

P. G. Wells, M. Wiley, N. Shibata, 2011, Toxicological sciences : an official journal of the Society of Toxicology.

Chiral discrimination between thalidomide enantiomers using a solid surface with two-dimensional chirality.

T. Osaka, B. Ohtani, T. Asahi, 2004, Chirality.

Trifluoroethoxy-Coated Subphthalocyanines Attract Small Arenes in Their π-Concave Cavity.

S. Tsuzuki, Etsuko Tokunaga, N. Shibata, 2018, ChemPlusChem.

Current Contributions of Organofluorine Compounds to the Agrochemical Industry

K. Hirai, Etsuko Tokunaga, N. Shibata, 2020, iScience.

The Dihydroxy Metabolite of the Teratogen Thalidomide Causes Oxidative DNA Damage.

H. Yamazaki, F. Guengerich, G. Chowdhury, 2017, Chemical research in toxicology.

Direct Enantioselective Three‐Component Kabachnik–Fields Reaction Catalyzed by Chiral Bis(imidazoline)‐Zinc(II) Catalysts

N. Shibata, Shuichi Nakamura, M. Ohara, 2011 .

Catalytic enantioselective hydrophosphonylation of ketimines using cinchona alkaloids.

Y. Funahashi, N. Shibata, Shuichi Nakamura, 2009, Journal of the American Chemical Society.

Organocatalytic Enantioselective Hydrophosphonylation of Sulfonylimines having a Heteroarenesulfonyl Group as a Novel Stereocontroller

N. Shibata, Shuichi Nakamura, T. Toru, 2008 .

Asymmetric synthesis of α-deuterated α-amino acids.

H. Moriwaki, V. Soloshonok, N. Shibata, 2017, Organic & biomolecular chemistry.

Design, synthesis, spectral investigations and biological activity of fluorinated phthalocyanine conjugated with galactose and comparison to its non-fluorinated counterpart

Etsuko Tokunaga, N. Shibata, Satoru Mori, 2015 .

Fundamental Study on Organic Solar Cells Based on Soluble Zinc Phthalocyanine

Y. Hayashi, T. Soga, N. Shibata, 2012 .

Self-disproportionation of enantiomers of heterocyclic compounds having a tertiary trifluoromethyl alcohol center on chromatography with a non-chiral system

Etsuko Tokunaga, N. Shibata, Shuichi Nakamura, 2010 .

IF5 affects the final stage of the Cl-F exchange fluorination in the synthesis of pentafluoro-λ6-sulfanyl-pyridines, pyrimidines and benzenes with electron-withdrawing substituents.

Etsuko Tokunaga, N. Shibata, Kohei Matsuzaki, 2017, Chemical communications.

Synthesis of Diaryliodonium Salts Having Pentafluorosulfanylarenes and Their Application to Electrophilic Pentafluorosulfanylarylation of C-, O-, N-, and S-Nucleophiles.

Etsuko Tokunaga, N. Shibata, M. Shiro, 2015, Organic letters.

Enantioselective synthesis of AG-041R by using N-heteroarenesulfonyl cinchona alkaloid amides as organocatalysts.

Y. Funahashi, N. Shibata, Shuichi Nakamura, 2012, Chemistry.

2-Fluoro-1,3-benzodithiole-1,1,3,3-tetraoxide: a reagent for nucleophilic monofluoromethylation of aldehydes.

Etsuko Tokunaga, N. Shibata, M. Shiro, 2010, Angewandte Chemie.

Catalytic and highly enantioselective reactions of alpha-sulfonyl carbanions with chiral bis(oxazoline)s.

N. Shibata, Shuichi Nakamura, T. Toru, 2008, Chemistry.

Asymmetric Mannich reaction between (S)-N-(tert-butanesulfinyl)-3,3,3-trifluoroacetaldimine and malonic acid derivatives. Stereodivergent synthesis of (R)- and (S)-3-amino-4,4,4-trifluorobutanoic acids.

V. Soloshonok, Etsuko Tokunaga, N. Shibata, 2014, Organic & biomolecular chemistry.

Phthalocyanine with Trifluoroethoxy Substituents for Organic Solar Cells

Y. Hayashi, T. Soga, N. Shibata, 2013 .

Ionic liquids as media for nucleophilic ring opening fluorination of aziridines

N. Shibata, Shuichi Nakamura, T. Toru, 2009 .

Solkane® 365mfc is an environmentally benign alternative solvent for trifluoromethylation reactions

N. Shibata, Shuichi Nakamura, Hiroyuki Kawai, 2009 .

Suzuki–Miyaura Cross‐Coupling Reactions in a Solkane365/227/Ethanol Blend at Ambient Temperature

Etsuko Tokunaga, N. Shibata, Akihiro Kusuda, 2012 .

Human liver microsomal cytochrome P450 3A enzymes involved in thalidomide 5-hydroxylation and formation of a glutathione conjugate.

M. Shimizu, H. Yamazaki, F. Guengerich, 2010, Chemical research in toxicology.

Synthesis of Sulfur Perfluorophenyl Compounds Using a Pentafluorobenzenesulfonyl Hypervalent Iodonium Ylide.

Etsuko Tokunaga, N. Shibata, Yuji Sumii, 2017, The Journal of organic chemistry.

Redox chemistry of trifluoromethyl sulfonium salts as CF3 radical sources

M. Médebielle, N. Shibata, V. Gouverneur, 2013 .

An eccentric rod-like linear connection of two heterocycles: synthesis of pyridine trans-tetrafluoro-λ6-sulfanyl triazoles† †Electronic supplementary information (ESI) available. CCDC 1823578 and 1823581. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c8sc01216d

Etsuko Tokunaga, N. Shibata, Tomoya Hiromura, 2018, Chemical science.

Shelf-stable electrophilic trifluoromethylating reagents: A brief historical perspective

N. Shibata, D. Cahard, Andrej V Matsnev, 2010, Beilstein journal of organic chemistry.

Enantiomerization of Allylic Trifluoromethyl Sulfoxides Studied by HPLC Analysis and DFT Calculations.

O. Trapp, N. Shibata, I. Chataigner, 2016, Chirality.

Triple‐Bond Directed Csp 2 −N Bond Formation with N ‐Fluorobenzenesulfonimide as Aminating Source: One‐Step Transformation of Aldehydes into Amines

N. Shibata, T. Aggarwal, Sushmita, 2019 .

Synthesis and spectral investigations of covalently linked phthalocyanine-C60 dyad via flexible carbon linker

Y. Hayashi, T. Soga, S. Singh, 2009 .

Synthesis and spectroscopic investigation of trifluoroethoxy-coated phthalocyanine linked with fullerene

Y. Hayashi, T. Soga, N. Shibata, 2009 .

Design, synthesis and optical properties of unsymmetrical subphthalocyanine trimer connected by phloroglucinol via axial positions.

S. Tsuzuki, Etsuko Tokunaga, N. Shibata, 2016, Dalton transactions.

Activation of Trifluoromethylthio Moiety by Appending Iodonium Ylide under Copper Catalysis for Electrophilic Trifluoromethylation Reaction

Shugo Suzuki, Etsuko Tokunaga, N. Shibata, 2016 .

Reactions of allyl alcohols and boronic acids with trifluoromethanesulfonyl hypervalent iodonium ylide under copper-catalysis.

N. Shibata, Masahiro Takada, S. Arimori, 2015, Dalton transactions.

Trifluoroethoxy-coating improves the axial ligand substitution of subphthalocyanine.

Etsuko Tokunaga, N. Shibata, M. Shiro, 2010, Chemistry.

Organocatalytic Enantioselective Nucleophilic Alkynylation of Allyl Fluorides Affording Chiral Skipped Ene-ynes.

V. Soloshonok, Etsuko Tokunaga, N. Shibata, 2016, Angewandte Chemie.

Bis(pentafluorosulfanyl)phenyl Azide as an Expeditious Tool for Click Chemistry toward Antitumor Pharmaceuticals

Etsuko Tokunaga, H. Akiyama, N. Shibata, 2014, ChemMedChem.

Design, synthesis, and spectroscopic investigation of zinc dodecakis(trifluoroethoxy)phthalocyanines conjugated with deoxyribonucleosides.

Yuki Kondo, N. Shibata, Shuichi Nakamura, 2006, Angewandte Chemie.

Regioisomer-Free C4h β-Tetrakis(tert-butyl)metallo-phthalocyanines: Regioselective Synthesis and Spectral Investigations

Kenta Tanaka, Etsuko Tokunaga, N. Shibata, 2014, ChemistryOpen.

Synthesis and property of novel phthalocyanine having a 3,5-bis-pentafluorosulfanylphenyl group on the α-peripheral position ☆

Etsuko Tokunaga, N. Shibata, Norihito Iida, 2014 .

Solubility of trifluoroethoxyphthalocyanines and -subphthalocyanines in liquid and supercritical carbon dioxide

Etsuko Tokunaga, N. Shibata, N. Kobayashi, 2010 .

Synthesis of trifluoroethoxy-coated binuclear phthalocyanines with click spacers and investigation of their clamshell behaviour.

N. Shibata, Shuichi Nakamura, T. Toru, 2009, Organic & biomolecular chemistry.

Synthesis of covalently linked binuclear clamshell phthalocyanine by double-click reaction.

N. Shibata, Shuichi Nakamura, T. Toru, 2008, Organic & biomolecular chemistry.

The story of SF5-substituted pyridines

N. Shibata, Benqiang Cui, 2019, Phosphorus, Sulfur, and Silicon and the Related Elements.

The CF3-DAST-induced deacylative trifluoromethylthiolation of cyclic 1,3-diketones/lactams/lactones and its extension to deacylative pentafluorophenylthiolation.

Etsuko Tokunaga, N. Shibata, Yumeng Liang, 2018, Chemical communications.

Fluolead (Ar-SF 3 ) Deoxofluorination

N. Shibata, Benqiang Cui, 2018 .

Synthesis of fluoro-functionalized diaryl-λ3-iodonium salts and their cytotoxicity against human lymphoma U937 cells

Etsuko Tokunaga, H. Akiyama, N. Shibata, 2018, Beilstein journal of organic chemistry.

SF5-Pyridylaryl-λ3-iodonium salts and their utility as electrophilic reagents to access SF5-pyridine derivatives in the late-stage of synthesis.

N. Shibata, Kohei Matsuzaki, Masahiro Takada, 2017, Chemical communications.

Electrophilic Triflyl-arylation and Triflyl-pyridylation by Unsymmetrical Aryl/Pyridyl-λ3-iodonium Salts: Synthesis of Aryl and Pyridyl Triflones.

N. Shibata, Pulakesh Das, 2017, The Journal of organic chemistry.

Silver-induced self-immolative Cl-F exchange fluorination of arylsulfur chlorotetrafluorides: synthesis of arylsulfur pentafluorides.

Etsuko Tokunaga, N. Shibata, Benqiang Cui, 2017, Chemical communications.

Importance of a Fluorine Substituent for the Preparation of meta- and para-Pentafluoro-λ(6) -sulfanyl-Substituted Pyridines.

Etsuko Tokunaga, N. Shibata, Kohei Matsuzaki, 2016, Angewandte Chemie.

2‐Diazo‐1‐phenyl‐2‐((trifluoromethyl)sulfonyl)ethan‐1‐one: Another Utility for Electrophilic Trifluoromethylthiolation Reactions

Chen Wang, Etsuko Tokunaga, N. Shibata, 2016, ChemistryOpen.

Organocatalyzed Trifluoromethylation of Ketones and Sulfonyl Fluorides by Fluoroform under a Superbase System

Etsuko Tokunaga, N. Shibata, Satoshi Okusu, 2015, ChemistryOpen.

Synthesis of Phthalocyanines with a Pentafluorosulfanyl Substituent at Peripheral Positions

Kenta Tanaka, Etsuko Tokunaga, N. Shibata, 2015, ChemistryOpen.

Pentafluorosulfanyl (SF5) in dyes: C3-Regioselective synthesis of α-mono-substituted subphthalocyanine with SF5-phenyl group

Etsuko Tokunaga, N. Shibata, Norihito Iida, 2015 .

Catalytic trifluoromethylation of aryl- and vinylboronic acids by 2-cyclopropyl-1-(trifluoromethyl)benzo[b]thiophenium triflate.

N. Shibata, S. Arimori, 2015, Organic letters.

Asymmetric synthesis of agrochemically attractive trifluoromethylated dihydroazoles and related compounds under organocatalysis.

N. Shibata, Hiroyuki Kawai, 2014, Chemical record.

Enantioselective synthesis of epoxides having a tetrasubstituted trifluoromethylated carbon center: methylhydrazine-induced aerobic epoxidation of β,β-disubstituted enones.

A. Yamano, Etsuko Tokunaga, N. Shibata, 2013, Angewandte Chemie.

Highly enantioselective monofluoromethylation of C2-arylindoles using FBSM under chiral phase-transfer catalysis.

Takashi Matsumoto, Etsuko Tokunaga, N. Shibata, 2013, Organic letters.

Decarboxylative allylation of trifluoroethyl sulfones and approach to difluoromethyl compounds.

Etsuko Tokunaga, N. Shibata, D. Cahard, 2012, Organic letters.

Poly[(3-hexylthiophene)-block-(3-semifluoroalkylthiophene)] for Polymer Solar Cells

Y. Hayashi, T. Soga, N. Shibata, 2010, International journal of molecular sciences.

Asymmetric Desymmetrization via Metal-Free C-F Bond Activation: Synthesis of 3,5-Diaryl-5-fluoromethyloxazolidin-2-ones with Quaternary Carbon Centers.

G. Haufe, Etsuko Tokunaga, N. Shibata, 2016, Angewandte Chemie.

Design and synthesis of N-nonpolar nucleobase dipeptides: application of the Ugi reaction for the preparation of dipeptides having fluoroarylalkyl groups appended to the nitrogen atom

B. Das, Y. Takéuchi, N. Shibata, 2002 .

Regioselective Synthesis of Pyridine-SF4-Methyl Ketones via Hydration of Pyridine-SF4-Alkynes.

N. Shibata, Yuji Sumii, Kentaro Iwaki, 2022, Organic letters.

Contribution of Organofluorine Compounds to Pharmaceuticals

N. Shibata, Yuji Sumii, M. Inoue, 2020, ACS omega.

Synthesis of Both Enantiomers of Nine‐Membered CF 3 ‐Substituted Heterocycles Using a Single Chiral Ligand: Palladium‐Catalyzed Decarboxylative Ring Expansion with Kinetic Resolution

Etsuko Tokunaga, N. Shibata, M. Shiro, 2020 .

Synthesis of Both Mirror Images of 9-Membered CF3-Heterocycles using a Single Antipode of Chiral Ligand under Pd-catalyzed Decarboxylative Ring-expansion with Kinetic Resolution.

Etsuko Tokunaga, N. Shibata, M. Shiro, 2020, Angewandte Chemie.

Aryl gem-Difluorovinyl Pinacolboronates: Synthesis and Utility for Suzuki-Miyaura Coupling Reaction

B. Jiang, N. Shibata, Ming-juan Guo, 2020 .

Sterically Demanding Unsymmetrical Diaryl-λ3-iodanes for Electrophilic Pentafluorophenylation and an Approach to α-Pentafluorophenyl Carbonyl Compounds with an All-Carbon Stereocenter

Etsuko Tokunaga, N. Shibata, M. Shiro, 2014, ChemistryOpen.

Silylboronate-Mediated Defluorosilylation of Aryl Fluorides with or without Ni-Catalyst

N. Shibata, Jun Zhou, Zhengyu Zhao, 2021, Frontiers in Chemistry.

Pyridine tetrafluoro-λ6-sulfanyl chlorides: spontaneous addition to alkynes and alkenes in the presence or absence of photo-irradiation

N. Shibata, Yuji Sumii, Norimichi Saito, 2020 .

Synthesis of aryl and heteroaryl tetrafluoro-λ6-sulfanyl chlorides from diaryl disulfides using trichloroisocyanuric acid and potassium fluoride

N. Shibata, Yumeng Liang, Norimichi Saito, 2019, Organic Chemistry Frontiers.

Nucleophilic fluoroalkylation/cyclization route to fluorinated phthalides

Y. Nishina, H. Amii, N. Shibata, 2018, Beilstein journal of organic chemistry.

Fluorobis(phenylsulfonyl)methane: a fluoromethide equivalent and palladium-catalyzed enantioselective allylic monofluoromethylation.

N. Shibata, Shuichi Nakamura, T. Toru, 2006, Angewandte Chemie.

Etherification of Fluoroarenes with Alkoxyboronic Acid Pinacol Esters via C-F Bond Cleavage.

B. Jiang, N. Shibata, Jun Zhou, 2022, Organic letters.

Defluorosilylation of fluoroarenes and fluoroalkanes

Etsuko Tokunaga, N. Shibata, Benqiang Cui, 2018, Nature Communications.

Synthesis of fluorinated donepezil by palladium-catalyzed decarboxylative allylation of α-fluoro-β-keto ester with tri-substituted heterocyclic alkene and the self-disproportionation of its enantiomers

Etsuko Tokunaga, N. Shibata, Mayaka Maeno, 2016 .

Chiral N‐Fluorodibenzenesulfonimide Analogues for Enantioselective Electrophilic Fluorination and Oxidative Fluorination

N. Shibata, Jun‐An Ma, Mayaka Maeno, 2013 .

Efficient direct ester condensation between equimolar amounts of carboxylic acids and alcohols catalyzed by trifluoromethanesulfonic acid (TfOH) in Solkane365mfc

Etsuko Tokunaga, N. Shibata, Xiuhua Xu, 2013 .

Modern Approaches for Asymmetric Construction of Carbon-Fluorine Quaternary Stereogenic Centers: Synthetic Challenges and Pharmaceutical Needs.

M. Sodeoka, F. Toste, Jianlin Han, 2018, Chemical reviews.

A dynamic kinetic asymmetric transformation in the alpha-hydroxylation of racemic malonates and its application to biologically active molecules.

N. Shibata, Shuichi Nakamura, J. Nagai, 2009, Angewandte Chemie.

Enantioselective Aldol Reaction using Recyclable Montmorillonite‐Entrapped N‐(2‐Thiophenesulfonyl)prolinamide

N. Shibata, Shuichi Nakamura, T. Toru, 2010 .

Cytotoxic effect of amide derivatives of trifluoromethionine against the enteric protozoan parasite Entamoeba histolytica.

M. Suematsu, T. Soga, T. Nozaki, 2010, International journal of antimicrobial agents.

Studies on the C/O-regioselectivity in Electrophilic Fluoromethylations of β-Ketoesters based on Thermodynamics by Ab initio Calculations

S. Tsuzuki, Etsuko Tokunaga, N. Shibata, 2014 .

Cation versus Radical: Studies on the C/O Regioselectivity in Electrophilic Tri-, Di- and Monofluoromethylations of β-Ketoesters

S. Tsuzuki, Etsuko Tokunaga, N. Shibata, 2012, ChemistryOpen.

New utility of electrophilic trifluoromethylthiolation reagents for the synthesis of a variety of triflones

Chen Wang, Etsuko Tokunaga, N. Shibata, 2017 .

Stereoselective Synthesis of β-Lactam-triflones under Catalyst-Free Conditions.

Chen Wang, Etsuko Tokunaga, N. Shibata, 2015, Organic letters.

Synthesis of Morita–Baylis–Hillman-fluorides using 1,1,2,2-tetrafluoroethyl-N,N-dimethylamine

H. Mimura, N. Shibata, Yuji Sumii, 2021, Tetrahedron.

Ar-SF4Cl Deoxofluorination

N. Shibata, Benqiang Cui, 2020, Fluorination.

Ar-SF 4 Cl Deoxofluorination

N. Shibata, Benqiang Cui, 2018 .

Perfluoroalkyl Analogues of Diethylaminosulfur Trifluoride: Reagents for Perfluoroalkylthiolation of Active Methylene Compounds under Mild Conditions.

Shugo Suzuki, Etsuko Tokunaga, N. Shibata, 2016, Organic letters.

Successive C–C bond cleavage, fluorination, trifluoromethylthio- and pentafluorophenylthiolation under metal-free conditions to provide compounds with dual fluoro-functionalization† †Electronic supplementary information (ESI) available. CCDC 1415530 and 1415531. For ESI and crystallographic data in

Shugo Suzuki, Etsuko Tokunaga, N. Shibata, 2015, Chemical science.

Construction of Fluorinated Benzoxathiin Skeleton by Successive Perfluorophenylthiolation/Cyclization of Activated α-Methylene Ketones by Perfluorophenyl Diethylaminosulfur Difluoride.

Shugo Suzuki, Etsuko Tokunaga, N. Shibata, 2017, Organic letters.

Direct Fluoro‐aminosulfenylation of Active Methylenes by Dialkylaminosulfur Trifluorides under Catalyst‐Free Conditions

Etsuko Tokunaga, N. Shibata, Ming-juan Guo, 2016 .

Remote anionic Fries rearrangement of sulfonates: regioselective synthesis of indole triflones.

Etsuko Tokunaga, N. Shibata, Xiuhua Xu, 2013, Organic letters.

Transition-metal-free oxidative trifluoromethylation of unsymmetrical biaryls with trifluoromethanesulfinate.

Etsuko Tokunaga, N. Shibata, Yudong Yang, 2013, Chemical communications.

Dephospho-Coenzyme A Kinase Is an Exploitable Drug Target against Plasmodium falciparum: Identification of Selective Inhibitors by High-Throughput Screening of a Large Chemical Compound Library

Kazuki Z. Yamamoto, M. Sekijima, T. Nozaki, 2022, Antimicrobial agents and chemotherapy.

Stille cross-coupling of secondary and tertiary α-(trifluoromethyl)-benzyl chlorides with allylstannanes.

N. Shibata, Nagender Punna, Kyosuke Harada, 2018, Chemical communications.

Catalytic asymmetric synthesis of enantioenriched heterocycles bearing a C-CF3 stereogenic center.

F. Verpoort, Yiyong Huang, N. Shibata, 2015, Chemistry.

Direct Nucleophilic Difluoromethylation of Aromatic Isoxazoles Activated by Electron-Withdrawing Groups Using (Difluoromethyl)trimethylsilane

Norio Shibata, N. Shibata, 2014 .

Diastereoselective Additive Trifluoromethylation/Halogenation of Isoxazole Triflones: Synthesis of All-Carbon-Functionalized Trifluoromethyl Isoxazoline Triflones

Hiroyasu Sato, Etsuko Tokunaga, N. Shibata, 2014, ChemistryOpen.

Enantioselective synthesis of trifluoromethyl-substituted 2-isoxazolines: asymmetric hydroxylamine/enone cascade reaction.

Etsuko Tokunaga, N. Shibata, M. Shiro, 2010, Angewandte Chemie.

Synthesis of nonpolar peptide nucleic acid monomers containing fluoroaromatics

B. Das, Y. Takéuchi, N. Shibata, 2001 .

Application of the Ugi four-component condensation reaction for the synthesis of α,α- and α,β-dipeptides substituted with fluoroarylalkyl pendent groups

B. Das, Y. Takéuchi, N. Shibata, 2000 .

N‐fluoro‐N‐(phenylsulfonyl)benzenesulfonamide

N. Shibata, D. Cahard, E. Differding, 2013 .

Synthetic methods for compounds having CF3-S units on carbon by trifluoromethylation, trifluoromethylthiolation, triflylation, and related reactions.

N. Shibata, Kohei Matsuzaki, Xiuhua Xu, 2015, Chemical Reviews.

Organocatalytic asymmetric synthesis of trifluoromethyl-substituted diarylpyrrolines: enantioselective conjugate cyanation of β-aryl-β-trifluoromethyl-disubstituted enones.

Hiroyasu Sato, Etsuko Tokunaga, N. Shibata, 2012, Angewandte Chemie.

Catalytic enantioselective synthesis of β-trifluoromethyl pyrrolines.

Takashi Matsumoto, Hiroyasu Sato, Etsuko Tokunaga, 2012, Chemical communications.

Partially saturated fluorinated heterocycles: diastereo- and enantioselective synthesis of β-trifluoromethyl-pyrroline carboxylates.

Hiroyasu Sato, Etsuko Tokunaga, N. Shibata, 2012, Chemical communications.

Direct Trifluoromethylthiolation Toward C ( sp 3 )– SCF 3 Compounds

N. Shibata, D. Cahard, Yumeng Liang, 2020 .

Trifluoromethylthiolation of allylsilanes and silyl enol ethers with trifluoromethanesulfonyl hypervalent iodonium ylide under copper catalysis.

N. Shibata, Masahiro Takada, S. Arimori, 2015, Organic letters.

Stereoselective synthesis of vinyl triflones and heteroaryl triflones through anionic O→C(vinyl) and N→C(vinyl) trifluoromethanesulfonyl migration reactions.

H. Masuda, T. Ozawa, Etsuko Tokunaga, 2013, Angewandte Chemie.

Trifluoromethanesulfonyl hypervalent iodonium ylide for copper-catalyzed trifluoromethylthiolation of enamines, indoles, and β-keto esters.

Etsuko Tokunaga, N. Shibata, M. Shiro, 2013, Journal of the American Chemical Society.

Cu-mediated chemoselective trifluoromethylation of benzyl bromides using shelf-stable electrophilic trifluoromethylating reagents.

Etsuko Tokunaga, N. Shibata, T. Furukawa, 2011, Organic letters.

A sterically demanding organo-superbase avoids decomposition of a naked trifluoromethyl carbanion directly generated from fluoroform.

Etsuko Tokunaga, N. Shibata, Hiroyuki Kawai, 2013, Organic & biomolecular chemistry.

Organocatalyzed regio- and enantioselective allylic trifluoromethylation of Morita-Baylis-Hillman adducts using Ruppert-Prakash reagent.

Etsuko Tokunaga, N. Shibata, M. Shiro, 2011, Organic letters.

Stereodivergent trifluoromethylation of N-sulfinylimines by fluoroform with either organic-superbase or organometallic-base.

Etsuko Tokunaga, N. Shibata, Yuji Sumii, 2018, Chemical communications.

Trifluoromethylation of aromatic isoxazoles: regio- and diastereoselective route to 5-trifluoromethyl-2-isoxazolines.

Etsuko Tokunaga, N. Shibata, M. Shiro, 2011, Angewandte Chemie.

Recent advances in enantioselective trifluoromethylation reactions

N. Shibata, S. Mizuta, Hiroyuki Kawai, 2008 .

Regioselective synthesis of heteroaryl triflones by LDA (lithium diisopropylamide)-mediated anionic thia-Fries rearrangement.

Etsuko Tokunaga, N. Shibata, Xin Wang, 2012, Organic letters.

Enantioselective fluorination mediated by cinchona alkaloids/selectfluor combinations: A catalytic approach

N. Shibata, Shuichi Nakamura, T. Toru, 2006 .

Highly enantioselective catalytic fluorination and chlorination reactions of carbonyl compounds capable of two-point binding.

N. Shibata, Shuichi Nakamura, J. Kohno, 2005, Angewandte Chemie.

20-Deoxy-20-fluorocamptothecin: Design and Synthesis of Camptothecin Isostere

N. Shibata, T. Toru, Takehisa Ishimaru, 2004 .

First Enantio-Flexible Fluorination Reaction Using Metal-Bis(oxazoline) Complexes

N. Shibata, J. Kohno, T. Toru, 2004 .

Enantioselective fluorination mediated by N-fluoroammonium salts of cinchona alkaloids: first enantioselective synthesis of BMS-204352 (MaxiPost).

K. Kirk, N. Shibata, Takehisa Ishimaru, 2003, The Journal of organic chemistry.

Enantioselective fluorination mediated by cinchona alkaloid derivatives/Selectfluor combinations: reaction scope and structural information for N-fluorocinchona alkaloids.

T. Asahi, N. Shibata, M. Shiro, 2001, Journal of the American Chemical Society.

Novel enantioselective fluorinating agents, (R)- and (S)-N-fluoro-3-tert-butyl-7-nitro-3,4-dihydro-2H-benzo[e][1,2]thiazine 1,1-dioxides.

Y. Takéuchi, N. Shibata, Z. Liu, 2000, Chemical & pharmaceutical bulletin.

Novel methods for the facile construction of 3,3-disubstituted and 3, 3-spiro-2H,4H-benzo[e]1,2-thiazine-1,1-diones: synthesis of (11S,12R, 14R)-2-fluoro-14-methyl-11-(methylethyl)spiro[4H-benzo[e]- 1, 2-thiazine-3,2'-cyclohexane]-1,1-dione, an agent for the electrophilic asymmetric fluorination of

Y. Takéuchi, N. Shibata, Z. Liu, 2000, The Journal of organic chemistry.

A Fundamentally New Approach to Enantioselective Fluorination Based on Cinchona Alkaloid Derivatives/Selectfluor Combination

Y. Takéuchi, N. Shibata, and Emiko Suzuki, 2000 .

A novel and efficient synthesis of 3-fluorooxindoles from indoles mediated by Selectfluor.

Y. Takéuchi, N. Shibata, Y. Takeuchi, 2000, Organic letters.

Expeditious Synthesis of 3, 4-Dihydro-2H-1λ6-benzo[e][1, 2]thiazine 1, 1-Dioxides

Y. Takéuchi, N. Shibata, A. Satoh, 1999 .

Regioselective electrophilic fluorination of indoles: syntheses of 4-fluoroserotonin and 4-fluoromelatonin

Y. Takéuchi, K. Kirk, N. Shibata, 1999 .

N-Fluoro-3-ethyl-3-methyl-1,1-dioxo-2,3-dihydro-1H-1λ6-benzo[e]1,2-thiazin-4-one, a new and efficient agent for electrophilic fluorination of carbanions

Y. Takéuchi, K. Kirk, N. Shibata, 1999 .

N-Fluoro-3-cyclohexyl-3-methyl-2,3- dihydrobenzo[1,2-d]isothiazole 1,1-Dioxide: An Efficient Agent for Electrophilic Asymmetric Fluorination of Enolates.

Y. Takéuchi, N. Shibata, Takanori Suzuki, 1999, The Journal of organic chemistry.

New approaches to enantioselective fluorination: Cinchona alkaloids combinations and chiral ligands/metal complexes

N. Shibata, Shuichi Nakamura, T. Toru, 2007 .

Synthesis of Chiral Nonracemic α-Difluoromethylthio Compounds with Tetrasubstituted Stereogenic Centers via a Palladium-Catalyzed Decarboxylative Asymmetric Allylic Alkylation.

N. Shibata, M. Shiro, K. Sasaki, 2018, Organic letters.

Methyl NFSI: atom-economical alternative to NFSI shows higher fluorination reactivity under Lewis acid-catalysis and non-catalysis

Etsuko Tokunaga, N. Shibata, Yuji Sumii, 2016 .

Iodoarene-catalyzed fluorination and aminofluorination by an Ar-I/HF·pyridine/mCPBA system

T. Dohi, Y. Kita, Etsuko Tokunaga, 2014 .

Development of Shelf-Stable Reagents for Fluoro-Functionalization Reactions

Norio Shibata, N. Shibata, 2016 .

Enantioselective synthesis of imidazolines with quaternary stereocenters by organocatalytic reaction of N-(heteroarenesulfonyl)imines with isocyanoacetates.

Y. Funahashi, N. Shibata, Shuichi Nakamura, 2012, Organic letters.

Cinchona alkaloids/TMAF combination-catalyzed nucleophilic enantioselective trifluoromethylation of aryl ketones.

N. Shibata, Shuichi Nakamura, S. Mizuta, 2007, Organic letters.

Construction of poly-N-heterocyclic scaffolds via the controlled reactivity of Cu-allenylidene intermediates

S. Tsuzuki, N. Shibata, T. Imai, 2021, Communications Chemistry.

One-step Synthesis of 2-Hydroxy-2-(trifluoromethyl)malonates by Trifluoromethylation of 2-Oxomalonates with Ruppert-Prakash Reagent

N. Shibata, Yuji Sumii, Takumi Kagawa, 2020 .

Diastereoselective synthesis of fluoroisosteric analogues of antiparasitic pyrrolobenzoxazine alkaloids from tryptophan by successive fluorination–cyclization and a Meisenheimer-type rearrangement

B. Das, Etsuko Tokunaga, N. Shibata, 2017 .

Alkynyl Cinchona Catalysts affect Enantioselective Trifluoromethylation for Efavirenz under Metal-Free Conditions.

Etsuko Tokunaga, N. Shibata, H. Fukaya, 2016, Organic letters.

An aza-Michael addition protocol to fluoroalkylated β-amino acid derivatives and enantiopure trifluoromethylated N-heterocycles

Yiyong Huang, N. Shibata, Xing Yang, 2014 .

Efficient access to trifluoromethyl diarylpyrrolines and their N-oxides through enantioselective conjugate addition of nitromethane to β,β-disubstituted enones.

Etsuko Tokunaga, N. Shibata, T. Kitayama, 2013, Angewandte Chemie.

C-F bond activation of unactivated aliphatic fluorides: synthesis of fluoromethyl-3,5-diaryl-2-oxazolidinones by desymmetrization of 2-aryl-1,3-difluoropropan-2-ols.

G. Haufe, N. Shibata, M. Shiro, 2012, Angewandte Chemie.

Regioselective synthesis of pyrazole triflones based on triflyl alkyne cycloadditions.

Etsuko Tokunaga, N. Shibata, Hiroyuki Kawai, 2012, Organic letters.

Enantioselective Synthesis of Trifluoromethyl‐Substituted 2‐Isoxazolines: Asymmetric Hydroxylamine/Enone Cascade Reaction.

Etsuko Tokunaga, N. Shibata, M. Shiro, 2010 .

Catalytic enantioselective trifluoromethylation of azomethine imines with trimethyl(trifluoromethyl)silane.

N. Shibata, M. Shiro, Shuichi Nakamura, 2009, Angewandte Chemie.

Development of Enantioselective Fluorination Reaction and Its Application to the Synthesis of Biologically Active Compounds

N. Shibata, 2006 .

Pd-Catalyzed Decarboxylative Cyclization of Trifluoromethyl Vinyl Benzoxazinanones with Sulfur Ylides: Access to Trifluoromethyl Dihydroquinolines.

N. Shibata, Jun Zhou, Nagender Punna, 2019, Organic letters.

Highly Diastereoselective Synthesis of Trifluoromethyl Indolines by Interceptive Benzylic Decarboxylative Cycloaddition of Nonvinyl, Trifluoromethyl Benzoxazinanones with Sulfur Ylides under Palladium Catalysis.

N. Shibata, V. Gouverneur, Nagender Punna, 2018, Organic letters.

Efficient access to extended Yagupolskii-Umemoto-type reagents: triflic acid catalyzed intramolecular cyclization of ortho-ethynylaryltrifluoromethylsulfanes.

Etsuko Tokunaga, N. Shibata, Shuichi Nakamura, 2010, Angewandte Chemie.

Anionic Triflyldiazomethane: Generation and Its Application for Synthesis of Pyrazole-3-triflones via [3 + 2] Cycloaddition Reaction.

Etsuko Tokunaga, N. Shibata, Yuji Sumii, 2018, Organic letters.

Synthesis of Isoxazole Triflones

Etsuko Tokunaga, N. Shibata, Yutaka Sugita, 2012 .

Ortho-lithiation reaction of aryl triflones

Etsuko Tokunaga, N. Shibata, Yuji Sumii, 2018, Tetrahedron.

Diastereoselective Additive Trifluoromethylation/Halogenation of Isoxazole Triflones: Synthesis of All‐Carbon‐Functionalized Trifluoromethyl Isoxazoline Triflones.

Hiroyasu Sato, Etsuko Tokunaga, N. Shibata, 2014 .

Kinetic resolution of allyl fluorides by enantioselective allylic trifluoromethylation based on silicon-assisted C-F bond cleavage.

A. Yamano, Etsuko Tokunaga, N. Shibata, 2014, Angewandte Chemie.

New Approaches to the Regioselective Synthesis of Heteroaryl Triflones

N. Shibata, Xiuhua Xu, 2013 .

Regioselective 1,4-trifluoromethylation of α,β-unsaturated ketones via a S-(trifluoromethyl)diphenylsulfonium salts/copper system

Etsuko Tokunaga, N. Shibata, Yutaka Sugita, 2013, Beilstein journal of organic chemistry.

Enantioselective Synthesis of 5-Trifluoromethyl-2-isoxazolines and Their N-Oxides by [Hydroxy(tosyloxy)iodo]benzene-Mediated Oxidative N–O Coupling

Etsuko Tokunaga, N. Shibata, Hiroyuki Kawai, 2013 .

Synthesis of indole and biindolyl triflones: trifluoromethanesulfonylation of indoles with Tf2O/TTBP (2,4,6-tri-tert-butylpyridine) system.

Etsuko Tokunaga, N. Shibata, Xiuhua Xu, 2011, Organic letters.

Asymmetric synthesis of α-fluoro-α-sulfenyl-β-ketoesters using DBFOX–Ph/Ni(II) complex

Etsuko Tokunaga, N. Shibata, Shuichi Nakamura, 2009 .

DBFOX-Ph/metal complexes: Evaluation as catalysts for enantioselective fluorination of 3-(2-arylacetyl)-2-thiazolidinones

N. Shibata, Shuichi Nakamura, T. Toru, 2008, Beilstein journal of organic chemistry.

Cinchona alkaloid/TMAF combination: Enantioselective trifluoromethylation of aryl aldehydes

Etsuko Tokunaga, N. Shibata, S. Mizuta, 2013 .

Ammonium bromides/KF catalyzed trifluoromethylation of carbonyl compounds with (trifluoromethyl)trimethylsilane and its application in the enantioselective trifluoromethylation reaction

N. Shibata, Shuichi Nakamura, S. Mizuta, 2007 .

Synthesis of Nonpolar Peptide Nucleic Acid Monomers Containing Fluoroaromatics.

B. Das, Y. Takéuchi, N. Shibata, 2001 .

Application of the Ugi Four-Component Condensation Reaction for the Synthesis of α,α- and α,β-Dipeptides Substituted with Fluoroarylalkyl Pendent Groups.

B. Das, Y. Takéuchi, N. Shibata, 2001 .

Synthesis of γ-fluoro-α-methyl-α-amino acids. A new alkylation procedure for ester imines

G. Haufe, Y. Takéuchi, K. Laue, 1998 .

Highly Enantioselective Reactions of α‐Sulfonyl Carbanions of Trifluoromethyl Sulfones

D. Nakane, N. Shibata, Shuichi Nakamura, 2007 .

Synthesis of Fluorogypsetin and Fluorobrevianamide E by a Novel Fluorination-Cyclization ofcyclo-L-Trp-L-AAs

K. Kirk, N. Shibata, Y. Doi, 2001 .

A DBFOX-Ph-based combinatorial catalyst for enantioselective fluorination of aryl acetyl and 3-butenoyl thiazolidinones.

N. Shibata, M. Shiro, Shuichi Nakamura, 2009, Chemistry, an Asian journal.

Cinchona alkaloid catalyzed enantioselective fluorination of allyl silanes, silyl enol ethers, and oxindoles.

N. Shibata, M. Shiro, Shuichi Nakamura, 2008, Angewandte Chemie.

Desymmetrization-like catalytic enantioselective fluorination of malonates and its application to pharmaceutically attractive molecules.

N. Shibata, Shuichi Nakamura, J. Nagai, 2008, Angewandte Chemie.

Asymmetric synthesis of α-trifluoromethoxy ketones with a tetrasubstituted α-stereogenic centre via the palladium-catalyzed decarboxylative allylic alkylation of allyl enol carbonates.

N. Shibata, Mayaka Maeno, Kazuki Hirano, 2018, Chemical communications.

Facile synthesis of disubstituted and spiro five-membered benzosultams mediated by TMSCl–NaI–MeCN reagent

Y. Takéuchi, N. Shibata, Zhaopeng Liu, 2002 .

N-Fluoro-(3,5-di-tert-butyl-4-methoxy)benzenesulfonimide (NFBSI): A sterically demanding electrophilic fluorinating reagent for enantioselective fluorination

Etsuko Tokunaga, N. Shibata, M. Shiro, 2011 .

Difluoromethanesulfonyl hypervalent iodonium ylides for electrophilic difluoromethylthiolation reactions under copper catalysis

N. Shibata, M. Shiro, Masahiro Takada, 2016, Royal Society Open Science.

Trifluoromethyl sulfoxides from allylic alcohols and electrophilic SCF3 donor by [2,3]-sigmatropic rearrangement.

N. Shibata, Mayaka Maeno, D. Cahard, 2015, Organic letters.

Efficient synthesis of unsymmetrical S-(bromodifluoromethyl)diarylsulfonium salts for electrophilic bromodifluoromethylating reagents

Etsuko Tokunaga, N. Shibata, Satoru Mori, 2012 .

Synthesis of fluorinated allenes via palladium-catalyzed monofluoromethylation using FBSM.

H. Murakami, Tamotsu Takahashi, M. Ogasawara, 2009, Chemical communications.

Difluoromethylthiolation of Phenols and Related Compounds with a HF2CSO2Na/Ph2PCl/Me3SiCl System.

Etsuko Tokunaga, N. Shibata, Zhong Huang, 2017, Organic letters.

Robust synthesis of trifluoromethionine and its derivatives by reductive trifluoromethylation of amino acid disulfides by CF3I/Na/Liq.NH3 system

Etsuko Tokunaga, N. Shibata, Takeshi Yamamoto, 2011 .

Synthesis of Chiral gem-Difluoromethylene Compounds by Enantioselective Ethoxycarbonyldifluoromethylation of MBH Fluorides via Silicon-Assisted C-F Bond Activation.

N. Shibata, Yuji Sumii, Jiandong Wang, 2020, The Journal of organic chemistry.

Mechanistic studies of a Pummerer-type reaction in acyclic and rigid cyclic sulfoxides induced by ketene tert-butyldimethylsilyl methyl acetal

Y. Kita, N. Shibata, N. Yoshikawa, 1995 .

Synthesis of Highly Functionalized 12-Membered Trifluoromethyl Heterocycles via a Nondecarboxylative Pd-Catalyzed [6 + 6] Annulation

N. Shibata, T. Imai, Hiroto Uno, 2020 .

Intramolecular Aminotrifluoromethanesulfinyloxylation of ω-Aminoalkenes by CF3SO2Na/Pd(OAc)2/PhI(OAc)2/tBuOCl/PivOH System

Etsuko Tokunaga, N. Shibata, Yuji Sumii, 2017 .

Enantioselective fluorination mediated by cinchona alkaloid derivatives/Selectfluor combinations: reaction scope and structural information for N-fluorocinchona alkaloids.

T. Asahi, N. Shibata, M. Shiro, 2001, Journal of the American Chemical Society.

Chemistry of O-silylated ketene acetals: an efficient synthesis of carbapenem and 1β-methylcarbapenem intermediates

Y. Kita, N. Shibata, N. Yoshida, 1992 .

Structure of isopenicillinN synthase complexed with substrate and the mechanism ofpenicillin formation

J. Hajdu, P. Roach, C. Schofield, 1997, Nature.

An Efficient Synthesis of 4-Heterofunction-Substituted 3-(1-Hydroxy)ethylazetidin-2-ones from 3-(1-Hydroxy)ethyl-4-phenylsulfinylazatidin-2-one by Reaction with Silylated Heteronucleophiles

Y. Kita, N. Shibata, N. Yoshida, 1992 .

Chemistry of O-silylated ketene acetals: a stereoselective synthesis of chiral thienamycin intermediate

Y. Kita, N. Shibata, O. Tamura, 1990 .

Enantioselective Reaction of Imines and Benzyl Nitriles Using Palladium Pincer Complexes with C2‐Symmetric Chiral Bis(imidazoline)s

Y. Funahashi, N. Shibata, Shuichi Nakamura, 2011 .

Direct nucleophilic trifluoromethylation of carbonyl compounds by potent greenhouse gas, fluoroform: Improving the reactivity of anionoid trifluoromethyl species in glymes

S. Tsuzuki, Etsuko Tokunaga, N. Shibata, 2018, Scientific Reports.

KHMDS/Triglyme Cryptate as an Alternative to Phosphazene Base in Stereodivergent Pentafluoroethylation of N-Sulfinylimines Using HFC-125.

N. Shibata, Yuji Sumii, D. Cahard, 2022, The Journal of organic chemistry.

Gas/Liquid‐Phase Micro‐Flow Trifluoromethylation using Fluoroform: Trifluoromethylation of Aldehydes, Ketones, Chalcones, and N‐Sulfinylimines

Etsuko Tokunaga, N. Shibata, Nagender Punna, 2019, ChemistryOpen.

Gas/Liquid‐Phase Micro‐Flow Trifluoromethylation using Fluoroform: Trifluoromethylation of Aldehydes, Ketones, Chalcones, and N‐Sulfinylimines

Etsuko Tokunaga, N. Shibata, Nagender Punna, 2019, ChemistryOpen.

Flow trifluoromethylation of carbonyl compounds by Ruppert–Prakash reagent and its application for pharmaceuticals, efavirenz and HSD-016

Etsuko Tokunaga, N. Shibata, Satoshi Okusu, 2016 .

Catalyst-free carbosilylation of alkenes using silyl boronates and organic fluorides via selective C-F bond activation

B. Jiang, N. Shibata, Jun Zhou, 2021, Nature Communications.

Enantioselective aza-Morita-Baylis-Hillman reactions of acrylonitrile catalyzed by palladium(II) pincer complexes having C2-symmetric chiral bis(imidazoline) ligands.

N. Shibata, Shuichi Nakamura, Kengo Hyodo, 2012, Angewandte Chemie.

Enantioselective desymmetrization of meso-N-(heteroarenesulfonyl)aziridines with TMSN3 catalyzed by chiral Lewis acids

N. Shibata, Shuichi Nakamura, M. Hayashi, 2010 .

First enantioselective synthesis of (R)-convolutamydine B and E with N-(heteroarenesulfonyl)prolinamides.

N. Shibata, Shuichi Nakamura, T. Toru, 2009, Chemistry.

Enantioselective synthesis of (R)-convolutamydine A with new N-heteroarylsulfonylprolinamides.

N. Shibata, Shuichi Nakamura, T. Toru, 2008, Chemistry.

Novel Enantiocomplementary C2‐Symmetric Chiral Bis(imidazoline) Ligands: Highly Enantioselective Friedel–Crafts Alkylation of Indoles with Ethyl 3,3,3‐Trifluoropyruvate

N. Shibata, Shuichi Nakamura, T. Toru, 2008 .

Enantioselective C--C bond formation to sulfonylimines through use of the 2-pyridinesulfonyl group as a novel stereocontroller.

H. Sano, N. Shibata, Shuichi Nakamura, 2008, Chemistry.

Enantioselective Mannich-type reaction of sulfonylimines having 2-pyridylsulfonyl group as a novel stereocontroller

H. Sano, N. Shibata, Shuichi Nakamura, 2007 .

Enantioselective Strecker-type reaction to sulfonylimines having a 2-pyridylsulfonyl group as a novel stereocontroller

N. Shibata, Shuichi Nakamura, H. Sugimoto, 2006 .

Organic reaction in Solkane® 365 mfc: homocoupling reaction of terminal alkynes

Etsuko Tokunaga, N. Shibata, Xin Wang, 2011 .

Copper-catalyzed enantioselective three-component synthesis of optically active propargylamines from aldehydes, amines, and aliphatic alkynes.

N. Shibata, Shuichi Nakamura, T. Toru, 2010, Chemistry.

NH-type of chiral Ni(II) complexes of glycine Schiff base: design, structural evaluation, reactivity and synthetic applications.

C. Roussel, Jianlin Han, V. Soloshonok, 2014, Organic & biomolecular chemistry.

Lewis acid-catalyzed tri- and difluoromethylation reactions of aldehydes.

N. Shibata, Shuichi Nakamura, S. Mizuta, 2006, Chemical communications.

5.9 Oxidation: C–X Bond Formation (X=Halogen, S, Se)

N. Shibata, D. Cahard, X. Xu, 2012 .

Lewis acid-catalyzed enantioselective hydroxylation reactions of oxindoles and beta-keto esters using DBFOX ligand.

N. Shibata, Shuichi Nakamura, J. Nagai, 2006, Journal of the American Chemical Society.

Cinchona-alkaloid-catalyzed enantioselective direct aldol-type reaction of oxindoles with ethyl trifluoropyruvate.

N. Shibata, M. Shiro, Shuichi Nakamura, 2007, Angewandte Chemie.

Catalytic Asymmetric 1,3-Dipolar Cycloaddition of β-Fluoroalkylated α,β-Unsaturated 2-Pyridylsulfones with Nitrones for Chiral Fluoroalkylated Isoxazolidines and γ-Amino Alcohols.

Yiyong Huang, N. Shibata, Feng Cheng, 2017, Angewandte Chemie.

Two Catalytic Annulation Modes via Cu-Allenylidenes with Sulfur Ylides that Are Dominated by the Presence or Absence of Trifluoromethyl Substituents

B. Jiang, N. Shibata, Jun Zhou, 2020, iScience.

Enantioselective electrophilic trifluoromethylation of beta-keto esters with Umemoto reagents induced by chiral nonracemic guanidines.

Yiyong Huang, N. Shibata, Shuichi Nakamura, 2009, Organic & biomolecular chemistry.

Asymmetric allylic monofluoromethylation and methylation of Morita-Baylis-Hillman carbonates with FBSM and BSM by cooperative cinchona alkaloid/FeCl2 catalysis.

Takashi Matsumoto, Wei Zhang, Etsuko Tokunaga, 2011, Angewandte Chemie.

Enantioselective nucleophilic addition to N-(2-pyridylsulfonyl)imines by use of dynamically induced chirality

N. Shibata, Shuichi Nakamura, H. Sugimoto, 2005 .

Catalyst-free and catalytic Friedel–Crafts alkylations of indoles in Solkane® 365mfc, an environmentally benign alternative solvent

Etsuko Tokunaga, N. Shibata, Akihiro Kusuda, 2011 .

Highly C-selective difluoromethylation of β-ketoesters by using TMSCF2Br/lithium hydroxide/N,N,N-trimethylhexadecan-1-ammonium bromide.

Etsuko Tokunaga, N. Shibata, Jiandong Wang, 2018, Chemical communications.

Perfluoroisopropyl Zinc Phthalocyanines Conjugated with Deoxyribonucleosides: Synthesis, Photophysical Properties and In Vitro Photodynamic Activities

Takuma Sasaki, Etsuko Tokunaga, N. Shibata, 2010 .

Catalytic enantioselective Michael addition of 1-fluorobis(phenylsulfonyl)methane to alpha,beta-unsaturated ketones catalyzed by cinchona alkaloids.

N. Shibata, M. Shiro, Shuichi Nakamura, 2008, Angewandte Chemie.

Fluorinated Johnson Reagent for Transfer-Trifluoromethylation to Carbon Nucleophiles

N. Shibata, M. Shiro, Shuichi Nakamura, 2008 .

Organocatalytic EnantioselectiveAza-Friedel-Crafts Alkylation of Pyrroles with N-(Heteroarenesulfonyl)imines

N. Shibata, Shuichi Nakamura, T. Toru, 2009 .

Highly enantioselective reactions of configurationally labile epimeric diamine complexes of lithiated S-benzyl thiocarbamates.

Heiko Lange, N. Shibata, Shuichi Nakamura, 2008, Chemistry, an Asian journal.

Asymmetric lithiation of 2-alkynyl aryl sulfides : Enantio-and diastereoselective formation of allenyl aryl sulfides and their application in nickel-catalyzed cross-coupling reactions

B. Wibbeling, N. Shibata, Shuichi Nakamura, 2007 .

Design and Synthesis of a Chiral Halogen-Bond Donor with a Sp3-Hybridized Carbon–Iodine Moiety in a Chiral Fluorobissulfonyl Scaffold

N. Shibata, M. Shiro, Kohei Matsuzaki, 2020, Molecules.

Asymmetric pummerer rearrangement and related reactions

Y. Kita, N. Shibata, M. Matsugi, 2000 .

Chemistry of O-Silylated Ketene Acetals: An Efficient Synthesis of Carbapenem and 1β-Methylcarbapenem Intermediates.

Y. Kita, N. Shibata, N. Yoshida, 1992 .

Chemistry of O-Silylated Ketene Acetals : A Stereoselective Synthesis of Optically Active Carbapenem Antibiotics, (+)-Thienamycin and (+)-PS-5

Y. Kita, N. Shibata, O. Tamura, 1992 .

Chemistry of O-silylated ketene acetals : a mild and convenient synthesis of β-lactam antibiotics

Y. Kita, N. Shibata, O. Tamura, 1991 .

Chemistry of O-silylated ketene acetals: a synthesis of β-lactam antibiotics

Y. Kita, N. Shibata, O. Tamura, 1989 .

Operationally Convenient and Scalable Asymmetric Synthesis of (2S)‐ and (2R)‐α‐(Methyl)cysteine Derivatives through Alkylation of Chiral Alanine Schiff Base NiII Complexes

H. Moriwaki, V. Soloshonok, N. Shibata, 2017 .

Organocatalytic Enantioselective Decarboxylative Addition of Malonic Acids Half Thioesters to Isatins.

Y. Funahashi, N. Shibata, Shuichi Nakamura, 2011 .

Research on the correlation between the Pummerer reaction and penicillin biosynthesis (review)

Y. Kita, N. Shibata, 1998 .

Practical synthesis of (2s,3s)-3-amino-2-hydroxy-4-phenylbutyric acid, a key component of HIV protease inhibitors.

S. Terashima, N. Shibata, E. Itoh, 1998, Chemical & pharmaceutical bulletin.

An Unprecedented Cleavage of the .beta.-Lactam Ring: Stereoselective Synthesis of Chiral .beta.-Amido Cyanides

Y. Kita, N. Shibata, N. Yoshida, 1994 .

A novel method for the alkoxylation of azetidin-2-ones at the 4-position

N. Shibata, N. Yoshida, Takashi Tohjo, 1992 .

Synthesis of Thalidomide

N. Shibata, T. Toru, Takeshi Yamamoto, 2007 .

(R)- and (S)-3-Fluorothalidomides: Isosteric Analogues of Thalidomide

Y. Takéuchi, N. Shibata, K. Kimura, 1999 .

Recent advancements in the synthesis of pentafluorosulfanyl (SF 5 )-containing heteroaromatic compounds

Etsuko Tokunaga, N. Shibata, Pulakesh Das, 2017 .

Enantioselective 5-endo-dig carbocyclization of β-ketoesters with internal alkynes employing a four-component catalyst system.

Takashi Matsumoto, Etsuko Tokunaga, N. Shibata, 2012, Angewandte Chemie.

Asymmetric synthesis of chiral trifluoromethylated heliotridane via highly catalytic asymmetric Friedel–Crafts alkylation with β-trifluoromethylated acrylates and pyrroles

Yiyong Huang, Etsuko Tokunaga, N. Shibata, 2011 .

Construction of Trifluoromethyl‐Bearing Quaternary Carbon Centers by Intramolecular Decarboxylative Allylation of α‐Trifluoromethyl β‐Keto Esters

Etsuko Tokunaga, N. Shibata, D. Cahard, 2011 .

Highly asymmetric Pummerer-type reaction induced by ethoxy vinyl esters

Y. Kita, N. Shibata, M. Matsugi, 1997 .

Asymmetric Synthesis of Efavirenz via Organocatalyzed Enantioselective Trifluoromethylation

Etsuko Tokunaga, N. Shibata, T. Kitayama, 2014 .

A New Synthetic Approach to Efavirenz through Enantioselective Trifluoromethylation by Using the Ruppert–Prakash Reagent

Etsuko Tokunaga, N. Shibata, T. Kitayama, 2011 .

Cinchona alkaloid-catalyzed asymmetric trifluoromethylation of alkynyl ketones with trimethylsilyl trifluoromethane.

Etsuko Tokunaga, N. Shibata, M. Shiro, 2010, Organic letters.

Remote asymmetric trifluoromethylation induced by chiral sulfinyl group: synthesis of enantiomerically pure 1-(2-naphthyl)-2,2,2-trifluoroethanol

N. Shibata, Shuichi Nakamura, H. Sugimoto, 2006 .

Enantioselective synthesis of chiral sulfinates using chiral diamines.

M. Nakagawa, N. Shibata, Shuichi Nakamura, 2005, Chirality.

A novel diastereoselective synthesis of chiral, non-racemic unsymmetrical thioacetals using silicon-induced Pummerer-type reaction

Y. Kita, Kouzou Matsumoto, N. Shibata, 1995 .

Asymmetric Synthesis of Axially Chiral cis-Arylmethylenebicyclo[3.3.0]octanes Using α-Thio- and α-Selenoorganolithium Compounds

N. Shibata, Shuichi Nakamura, T. Toru, 2005 .

A development of Pictet-Spengler reaction in aprotic media using chloroformates. A short synthesis of borrerine

N. Shibata, S. Sakai, E. Yamanaka, 1984 .

Synthesis of Tetra‐Substituted Trifluoromethyl‐3,1‐Benzoxazines by Transition‐Metal‐Catalyzed Decarboxylative Cyclization of N‐Benzoyl Benzoxazinones

N. Shibata, D. Fujimoto, C. Tanaka, 2021, ChemistryOpen.

Enantioselective Reaction of Imines and Benzyl Nitriles Using Palladium Pincer Complexes with C2-Symmetric Chiral Bis(imidazoline)s.

Y. Funahashi, N. Shibata, Shuichi Nakamura, 2012 .

An unprecedented cleavage of the β-lactam ring: a novel synthesis of acyclic N,O- and N,S-acetals

Y. Kita, Kouzou Matsumoto, N. Shibata, 1996 .

Pd-catalyzed fluoro-carbonylation of aryl, vinyl, and heteroaryl iodides using 2-(difluoromethoxy)-5-nitropyridine

Zhengyu Zhao, N. Shibata, Yumeng Liang, 2020, Communications Chemistry.

Activation of Saturated Fluorocarbons to Synthesize Spirobiindanes, Monofluoroalkenes, and Indane Derivatives

N. Shibata, Jiandong Wang, Y. Ogawa, 2019, iScience.

B(C 6F>sub>5) 3-Catalyzed C(Sp 3)-F Bond Activation With/Without the Cooperation of HFIP: Synthesis of Spirobiindanes, Monofluoroalkenes, and Indane Derivatives

N. Shibata, Jiandong Wang, Y. Ogawa, 2019, SSRN Electronic Journal.

Enantioselective Trichloromethylation of MBH-Fluorides with Chloroform Based on Silicon-assisted C-F Activation and Carbanion Exchange Induced by a Ruppert-Prakash Reagent.

Etsuko Tokunaga, N. Shibata, M. Shiro, 2016, Angewandte Chemie.

Electrophilic sulfenylation in a stereocontrolled synthesis of protected (2R,3R)-3-mercaptoaspartic acid from L-aspartic acid

M. Wood, N. Shibata, J. Baldwin, 1996 .

3,5-Bis(pentafluorosulfanyl)phenylboronic acid: A new organocatalyst for Conia-ene carbocyclization of 1,3-dicarbonyl compounds having terminal alkynes

Etsuko Tokunaga, N. Shibata, Yudong Yang, 2012 .

Understanding the Thalidomide Chirality in Biological Processes by the Self-disproportionation of Enantiomers

Etsuko Tokunaga, N. Shibata, E. Ito, 2018, Scientific Reports.

A phthalocyanine-subphthalocyanine heterodinuclear dimer: comparison of spectroscopic properties with those of homodinuclear dimers of constituting units.

Hiroyasu Sato, Etsuko Tokunaga, N. Shibata, 2014, Chemical communications.

Studies of Halogen Bonding Induced by Pentafluorosulfanyl Aryl Iodides: A Potential Group of Halogen Bond Donors in a Rational Drug Design

S. Tsuzuki, N. Shibata, K. Sasaki, 2019, Molecules.

Synthesis of novel C2-symmetric chiral crown ethers and their application to enantioselective trifluoromethylation of aldehydes and ketones

H. Masuda, Y. Funahashi, N. Shibata, 2009 .

Selective synthesis of spirobiindanes, alkenyl chlorides, and monofluoroalkenes from unactivated gem-difluoroalkanes controlled by aluminum-based Lewis acids

N. Shibata, Jiandong Wang, Y. Ogawa, 2019, Scientific Reports.

Cinchona alkaloid-catalyzed enantioselective monofluoromethylation reaction based on fluorobis(phenylsulfonyl)methane chemistry combined with a Mannich-type reaction.

N. Shibata, Shuichi Nakamura, S. Mizuta, 2007, Journal of the American Chemical Society.

Pentafluoroethylation of Carbonyl Compounds by HFC-125 via the Encapsulation of the K Cation with Glymes.

H. Mimura, N. Shibata, S. Fustero, 2021, The Journal of organic chemistry.

Design and synthesis of galactose-conjugated fluorinated and non-fluorinated proline oligomers: towards antifreeze molecules.

N. Shibata, Yuji Sumii, H. Kawahara, 2018, Chemical communications.

Unusual Photoisomerization Pathway in a Near-Infrared Light Absorbing Enzymerhodopsin.

S. Tsunoda, L. Brown, M. Sugiura, 2022, The journal of physical chemistry letters.

Enantioselective Friedel-Crafts reaction of beta-trifluoromethylated acrylates with pyrroles and its application to the synthesis of trifluorinated heliotridane.

Yiyong Huang, Etsuko Tokunaga, N. Shibata, 2010, Organic letters.

Vibrational analysis of acetylcholine binding to the M2 receptor

S. Iwata, Tomoya Nakagita, Takuya Kobayashi, 2021, RSC advances.

The first highly asymmetric pummerer-type reaction in chiral acyclic sulfoxides: Chemistry of O-silylated ketene acetals

Y. Kita, N. Shibata, N. Yoshida, 1993 .

Studies toward the total synthesis of antibiotic roseophilin: A novel synthesis of the macrotricyclic part

T. Katoh, S. Terashima, N. Shibata, 1998 .

An expeditious synthesis of (2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol, a key building block of HIV protease inhibitors

T. Katoh, S. Terashima, N. Shibata, 1997 .

S-((phenylsulfonyl)difluoromethyl)thiophenium salts: carbon-selective electrophilic difluoromethylation of β-ketoesters, β-diketones, and dicyanoalkylidenes.

Etsuko Tokunaga, N. Shibata, Xin Wang, 2014, Angewandte Chemie.

Selective O-difluoromethylation of 1,3-diones by bromodifluoromethylating reagents.

S. Tsuzuki, Etsuko Tokunaga, N. Shibata, 2013, Organic letters.

Efficient Difluoromethylation of sp3 Carbon Nucleophiles by Bromodifluoromethylation Reagents with Organic Bases

Etsuko Tokunaga, N. Shibata, Xin Wang, 2012, ChemistryOpen.

Asymmetric synthesis of both mirror images of 3'-fluorothalidomide by enantiodivergent fluorination using a single, cinchona alkaloid.

Etsuko Tokunaga, N. Shibata, E. Ito, 2011, Organic letters.

Catalytic Desymmetrization of 1,3‐Difluoropropan‐2‐ols via C−F Bond Activation Using a Phosphazene Base Affords Monofluoromethyl‐Substituted Epoxides

Etsuko Tokunaga, N. Shibata, Jiandong Wang, 2019, Asian Journal of Organic Chemistry.

A highly asymmetric Pummerer-type cyclization of chiral, non-racemic β-amidosulfoxides induced by O-silylated ketene acetals

Y. Kita, N. Shibata, Keita Matsumoto, 1995 .

Highly asymmetric Pummerer-type cyclization of chiral, non-racemic β-amido sulfoxides

Y. Kita, N. Shibata, Keita Matsumoto, 1995 .

Enantioselective pummerer-type rearrangement by reaction of O-silylated ketene acetal with enantiopure α-substituted sulfoxides

Y. Kita, N. Shibata, M. Bando, 1994 .

A novel asymmetric pummerer reaction induced by ethoxy vinyl ester

Y. Kita, N. Shibata, S. Fukui, 1994 .

Mechanistic studies of pummerer reaction in acyclic sulfoxides induced by O-silylated ketene acetals

Y. Kita, N. Shibata, N. Yoshida, 1994 .

First highly asymmetric Pummerer-type reaction in chiral, non-racemic acyclic sulfoxides induced by O-silylated ketene acetal

Y. Kita, N. Shibata, N. Yoshida, 1994 .

The First Highly Asymmetric Pummerer Type Reaction in Chiral Acyclic Sulfoxides: Chemistry of O‐Silylated Ketene Acetals.

Y. Kita, N. Shibata, N. Yoshida, 1993 .

Chemistry of O-silylated ketene acetals: A novel intramolecular Pummerer-type reaction of .OMEGA.-carbamoylsulfoxides leading to .ALPHA.-thiolactams.

Y. Kita, N. Shibata, O. Tamura, 1990 .

Chemistry of O-silylated ketene acetals: Biomimetic synthesis of cis-β-lactams

Y. Kita, N. Shibata, O. Tamura, 1989 .

Trifluoroethoxy‐Coated Subphthalocyanine affects Trifluoromethylation of Alkenes and Alkynes even under Low‐Energy Red‐Light Irradiation

Etsuko Tokunaga, N. Shibata, Kohei Matsuzaki, 2017, ChemistryOpen.

Structural basis of thalidomide enantiomer binding to cereblon

H. Handa, T. Hakoshima, Y. Yamaguchi, 2018, Scientific Reports.

Synthesis and configurational stability of (S)- and (R)-deuteriothalidomides.

Etsuko Tokunaga, N. Shibata, Shuichi Nakamura, 2010, Chemical & pharmaceutical bulletin.

Design and Synthesis of Thalidomide–Deoxyribonucleoside Chimeras

Takuma Sasaki, Etsuko Tokunaga, N. Shibata, 2009 .

Synthesis, configurational stability and stereochemical biological evaluations of (S)- and (R)-5-hydroxythalidomides.

H. Hara, Takuma Sasaki, M. Takashima, 2009, Bioorganic & medicinal chemistry letters.

Enzymatic resolution and evaluation of enantiomers of cis-5'-hydroxythalidomide.

H. Hara, M. Takashima, N. Shibata, 2008, Organic & biomolecular chemistry.

Asymmetric Pummerer-Type Reactions Induced by O-Silylated Ketene Acetals

Y. Kita, N. Shibata, 1994 .

New diarylmethanofullerene derivatives and their properties for organic thin-film solar cells

Rakesh A. Afre, Y. Hayashi, T. Soga, 2009, Beilstein journal of organic chemistry.

Synthesis, Characterization, and Study of Catalytic Activity of Chiral Cu(II) and Ni(II) Salen Complexes in the α-Amino Acid C-α Alkylation Reaction

G. Roviello, V. I. Maleev, N. Shibata, 2023, Molecules.

Acyl Fluorides from Carboxylic Acids, Aldehydes, or Alcohols under Oxidative Fluorination.

Zhengyu Zhao, N. Shibata, Yumeng Liang, 2021, Organic letters.

Organic base-catalyzed stereodivergent synthesis of (R)- and (S)-3-amino-4,4,4-trifluorobutanoic acids.

V. Soloshonok, Etsuko Tokunaga, N. Shibata, 2012, Chemical communications.

Structure of isopenicillin N synthase complexed with substrate and the mechanism of penicillin formation.

J. Hajdu, P. Roach, C. Schofield, 1997, Nature.

DNA-Mediated Enantioselective Carbon-Fluorine Bond Formation

N. Shibata, Shuichi Nakamura, T. Toru, 2007 .

Carbene-Induced Intra- vs Intermolecular Transfer-Fluoromethylation of Aryl Fluoromethylthio Compounds under Rhodium Catalysis

Etsuko Tokunaga, N. Shibata, I. Saidalimu, 2015 .

Structural bases of IMiD selectivity that emerges by 5-hydroxythalidomide

M. Tanokura, T. Sawasaki, N. Shibata, 2020, Nature Communications.

PLZF is a new substrate of CRBN with thalidomide and 5-hydroxythalidomide

D. Saito, Hirotaka Takahashi, T. Sawasaki, 2020, bioRxiv.

Human cytochrome P450 oxidation of 5-hydroxythalidomide and pomalidomide, an amino analogue of thalidomide.

H. Yamazaki, F. Guengerich, G. Chowdhury, 2014, Chemical research in toxicology.

In vivo formation of dihydroxylated and glutathione conjugate metabolites derived from thalidomide and 5-Hydroxythalidomide in humanized TK-NOG mice.

M. Shimizu, H. Yamazaki, H. Suemizu, 2012, Chemical research in toxicology.

In vivo formation of a glutathione conjugate derived from thalidomide in humanized uPA-NOG mice.

M. Shimizu, H. Yamazaki, H. Suemizu, 2011, Chemical research in toxicology.

Thalidomide and its metabolite 5‐hydroxythalidomide induce teratogenicity via the cereblon neosubstrate PLZF

D. Saito, Hirotaka Takahashi, T. Sawasaki, 2021, The EMBO journal.

Inherent oxygen preference in enolate monofluoromethylation and a synthetic entry to monofluoromethyl ethers.

Etsuko Tokunaga, N. Shibata, Y. Nomura, 2011, Angewandte Chemie.

Thalidomide increases human hepatic cytochrome P450 3A enzymes by direct activation of the pregnane X receptor.

M. Shimizu, H. Yamazaki, R. Houtman, 2014, Chemical research in toxicology.

Defluorosilylation of fluoroarenes and fluoroalkanes

Etsuko Tokunaga, N. Shibata, Benqiang Cui, 2018, Nature Communications.

In vivo drug interactions of the teratogen thalidomide with midazolam: heterotropic cooperativity of human cytochrome P450 in humanized TK-NOG mice.

H. Yamazaki, H. Suemizu, Masato Nakamura, 2013, Chemical Research in Toxicology.

Metabolic profiles of pomalidomide in human plasma simulated with pharmacokinetic data in control and humanized-liver mice

M. Shimizu, H. Yamazaki, H. Suemizu, 2017, Xenobiotica; the fate of foreign compounds in biological systems.

Simulation of Human Plasma Concentrations of Thalidomide and Primary 5-Hydroxylated Metabolites Explored with Pharmacokinetic Data in Humanized TK-NOG Mice.

H. Yamazaki, H. Suemizu, F. Guengerich, 2015, Chemical research in toxicology.

Efficient Synthesis of Bicyclic a-Hydroxy-a-trifluoromethyl-?-lactams

N. Shibata, Shuichi Nakamura, S. Mizuta, 2006 .

Synthetic methods for compounds having CF3-S units on carbon by trifluoromethylation, trifluoromethylthiolation, triflylation, and related reactions.

N. Shibata, Kohei Matsuzaki, Xiuhua Xu, 2015, Chemical reviews.

Anaerobic crystallisation of an isopenicillin N synthase.Fe(II).substrate complex demonstrated by X-ray studies.

J. Hajdu, R. Strange, P. Roach, 1996, European journal of biochemistry.

Resin-bound peptide libraries showing specific metal ion binding

M. Wood, N. Shibata, J. Baldwin, 1997 .

Adipoyl-6-aminopenicillanic acid is a substrate for deacetoxycephalosporin C synthase (DAOCS)

M. D. Lloyd, C. Schofield, N. Shibata, 1996 .

Modular Synthesis of Medium-Sized Fluorinated and Nonfluorinated Heterocyclic Lactones by Sequential CN-Bond-Cleaving Ring Expansion under Pd Catalysis

N. Shibata, M. Shiro, Hiroto Uno, 2020 .

Organic Base‐Catalyzed Stereodivergent Synthesis of (R)‐ and (S)‐3‐Amino‐4,4,4‐trifluorobutanoic Acids.

V. Soloshonok, Etsuko Tokunaga, N. Shibata, 2012 .

Fluorobissulfonylmethyl Iodides: An Efficient Scaffold for Halogen Bonding Catalysts with an sp3-Hybridized Carbon–Iodine Moiety

Etsuko Tokunaga, N. Shibata, Kohei Matsuzaki, 2018, ACS Catalysis.

Enantioselective monofluoromethylation of aldehydes with 2-fluoro-1,3-benzodithiole-1,1,3,3-tetraoxide catalyzed by a bifunctional cinchona alkaloid-derived thiourea-titanium complex.

H. Masuda, T. Ozawa, D. Nakane, 2013, Chemical communications.

Synthesis of Benzene-centered Trinuclear Phthalocyanines by Triple-click Chemistry

Etsuko Tokunaga, N. Shibata, Banibrata Das, 2010 .

Synthesis of an Eccentric Electron-Deficient Fluorinated Motif, Tetrafluoro-λ6-sulfanyl gem-Difluorocyclopropenes.

N. Shibata, O. Nagata, Kiyoteru Niina, 2022, Organic letters.

Assessment of Protein Binding of 5-Hydroxythalidomide Bioactivated in Humanized Mice with Human P450 3A-Chromosome or Hepatocytes by Two-Dimensional Electrophoresis/Accelerator Mass Spectrometry.

M. Shimizu, H. Yamazaki, H. Suemizu, 2016, Chemical research in toxicology.

Direct nucleophilic trifluoromethylation of carbonyl compounds by potent greenhouse gas, fluoroform: Improving the reactivity of anionoid trifluoromethyl species in glymes

S. Tsuzuki, Etsuko Tokunaga, N. Shibata, 2018, Scientific Reports.

Novel Use of CF3SO2Cl for the Metal-Free Electrophilic Trifluoromethylthiolation.

N. Shibata, Mayaka Maeno, D. Cahard, 2016, Organic letters.

C—F Bond Activation of Unactivated Aliphatic Fluorides: Synthesis of Fluoromethyl‐3,5‐diaryl‐2‐oxazolidinones by Desymmetrization of 2‐Aryl‐1,3‐difluoropropan‐2‐ols.

N. Shibata, M. Shiro, T. Kitayama, 2013 .

Enantioselective Benzylation and Allylation of α-Trifluoromethoxy Indanones under Phase-Transfer Catalysis

Zhengyu Zhao, N. Shibata, Mayaka Maeno, 2019, Molecules.

Elemental Sulfur-Mediated Transformation of Carboxylic Acids to Acyl Fluorides by Electrophilic Fluorinating Reagent, Selectfluor.

N. Shibata, Yuji Sumii, Elsayed M. Mahmoud, 2023, Organic letters.

Deoxyfluorination of acyl fluorides to trifluoromethyl compounds by FLUOLEAD®/Olah’s reagent under solvent-free conditions

N. Shibata, Yumeng Liang, Norimichi Saito, 2020, Beilstein journal of organic chemistry.

Continuous-Flow Synthesis of Perfluoroalkyl Ketones via Perfluoroalkylation of Esters Using HFC-23 and HFC-125 under a KHMDS–Triglyme System

N. Shibata, Yuji Sumii, Hiroaki Adachi, 2022, Bulletin of the Chemical Society of Japan.

Synthesis of trifluoromethyl ketones by nucleophilic trifluoromethylation of esters under a fluoroform/KHMDS/triglyme system

N. Shibata, Yumeng Liang, M. Ono, 2021, Beilstein journal of organic chemistry.

Diastereoselective Synthesis of Enantioenriched Trifluoromethylated Ethylenediamines and Isoindolines Containing Two Stereogenic Carbon Centers by Nucleophilic Trifluoromethylation Using HFC-23.

N. Shibata, S. Fustero, Takuya Saito, 2020, The Journal of organic chemistry.

Title A small-molecule inhibitor of SOD 1-Derlin-1 interactionameliorates pathology in an ALS mouse model

H. Ichijo, M. Shibuya, H. Inoue, 2019 .

Copper-catalyzed regioselective trifluoromethylthiolation of pyrroles by trifluoromethanesulfonyl hypervalent iodonium ylide.

Etsuko Tokunaga, N. Shibata, Zhong Huang, 2015, Organic letters.

CHEMISTRY OF α-FLUORO-α-AMINO ACIDS : THE FIRST SYNTHESIS OF α-FLUOROGLYCINE-CONTAINING DIPEPTIDES

G. Haufe, Y. Takéuchi, K. Laue, 1998 .

Transition-metal-free silylboronate-mediated cross-couplings of organic fluorides with amines

N. Shibata, Jun Zhou, Zhengyu Zhao, 2023, Nature Communications.

Evaluation of stability difference between asymmetric homochiral dimer in (S)-thalidomide crystal and symmetric heterochiral dimer in (RS)-thalidomide crystal

T. Osaka, T. Asahi, Masahito Tanaka, 2010 .

Synthesis and optical properties of subphthalocyanine homo- and heterodimers axially connected via a hydroquinone linker.

Etsuko Tokunaga, N. Shibata, Satoru Mori, 2015, Dalton transactions.

Development of Shelf-Stable Reagents for Electrophilic Trifluoromethylthiolation Reaction

N. Shibata, Zhong Huang, 2017 .

A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model

H. Ichijo, M. Shibuya, H. Inoue, 2018, Nature Communications.

Organocatalytic Enantioselective Aza-Friedel-Crafts Alkylation of Pyrroles with N-(Heteroarenesulfonyl)imines.

N. Shibata, Shuichi Nakamura, T. Toru, 2009 .

Synthesis of chiral (tetrazolyl)methyl-containing acrylates via silicon-induced organocatalytic kinetic resolution of Morita-Baylis-Hillman fluorides.

V. Soloshonok, Etsuko Tokunaga, H. Akiyama, 2017, Chemical communications.

Synthesis and properties of trifluoroethoxy-coated binuclear phthalocyanine.

N. Shibata, Shuichi Nakamura, T. Toru, 2008, Chemical communications.

Super-Sensitive Protonation Behavior of Trifluoroethoxy-Substituted Phthalocyanines and Their Application to Solvent Discrimination

Etsuko Tokunaga, N. Shibata, Satoru Mori, 2018, ACS omega.

Design and Photonic Properties of Novel Fluorinated Copolymers Bearing Phthalocyanine Side Groups

D. Fortin, P. Harvey, B. Améduri, 2012 .

Photodynamic Therapy Using Novel Zinc Phthalocyanine Derivatives and a Diode Laser for Superficial Tumors in Experimental Animals

Etsuko Tokunaga, N. Shibata, Yuka Suzuki, 2015 .

Synthesis And Spectroscopic Investigations of Trifluoroethoxy Semi-Coated Zinc(li) Phthalocyanine

N. Shibata, Shuichi Nakamura, H. Yoshiyama,, 2009 .

Cinchona alkaloid/sulfinyl chloride combinations: enantioselective sulfinylating agents of alcohols.

M. Nakagawa, N. Shibata, Shuichi Nakamura, 2005, Journal of the American Chemical Society.

Ammonium Bromides/KF Catalyzed Trifluoromethylation of Carbonyl Compounds with (Trifluoromethyl)trimethylsilane and Its Application in the Enantioselective Trifluoromethylation Reaction.

N. Shibata, Shuichi Nakamura, S. Mizuta, 2007 .

Synthesis of Billard–Langlois Reagents and their Derivatives by Copper‐Catalyzed N‐Trifluoromethylthiolation of Arylamines with a Trifluoromethanesulfonyl Hypervalent Iodonium Ylide

Etsuko Tokunaga, N. Shibata, Zhong Huang, 2015 .

Difluoromethylation of Terminal Alkynes by Fluoroform.

Etsuko Tokunaga, N. Shibata, Satoshi Okusu, 2015, Organic letters.

An aza-Michael addition protocol to fluoroalkylated β-amino acid derivatives and enantiopure trifluoromethylated N-heterocycles

Yiyong Huang, N. Shibata, Xing Yang, 2014 .

Asymmetric Electrophilic Difluoromethylthiolation of Indanone-Based β-Keto Esters Using Difluoromethanesulfonyl Hypervalent Iodonium Ylides

N. Shibata, Yuji Sumii, D. Cahard, 2019, Molecules.

Diastereodivergent Synthesis of Chiral 4-Fluoropyrrolidines (exo and exo') Based on the Cu(II)-Catalyzed Asymmetric 1,3-Dipolar Cycloaddition.

Yiyong Huang, Q. Fan, N. Shibata, 2021, Journal of Organic Chemistry.

Treatment of idiopathic cervical internal carotid artery vasospasms with carotid artery stenting: a report of 2 cases

N. Shibata, H. Itokawa, Noriyoshi Okamoto, 2013 .

Induction of human cytochrome P450 3A enzymes in cultured placental cells by thalidomide and relevance to bioactivation and toxicity.

D. Satoh, H. Yamazaki, F. Guengerich, 2017, The Journal of toxicological sciences.

Current State of Microflow Trifluoromethylation Reactions

N. Shibata, Yuji Sumii, 2023, Chemical record.

Catalytic asymmetric synthesis of enantioenriched heterocycles bearing a C-CF3 stereogenic center.

F. Verpoort, Yiyong Huang, N. Shibata, 2015, Chemistry.

Cinchona alkaloid-catalyzed enantioselective monofluoromethylation reaction based on fluorobis(phenylsulfonyl)methane chemistry combined with a Mannich-type reaction.

N. Shibata, Shuichi Nakamura, S. Mizuta, 2007, Journal of the American Chemical Society.

N-Fluoro Ammonium salts of Cinchona Alkaloids in Enantioselective Electrophilic Fluorination.

N. Shibata, D. Cahard, 2023, Chemical record.

N-2-Iodobenzylcinchoninium bromide is effective for catalytic enantioselective trifluoromethylation of azomethine imines in Solkane® 365mfc

Etsuko Tokunaga, N. Shibata, Hiroyuki Kawai, 2012 .

Corrigendum to “Cytotoxic effect of amide derivatives of trifluoromethionine against the enteric protozoan parasite Entamoeba histolytica” [Int. J. Antimicrob. Agents 31 (2010) 56–61]

M. Suematsu, T. Soga, T. Nozaki, 2010 .

Influence of new fullerene derivatives with fluorocarbon substituent on performance of polymer solar cells

Y. Hayashi, M. Pandey, N. Shibata, 2011 .

A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model

H. Ichijo, M. Shibuya, H. Inoue, 2018, Nature Communications.

Silver-induced self-immolative Cl-F exchange fluorination of arylsulfur chlorotetrafluorides: synthesis of arylsulfur pentafluorides.

Etsuko Tokunaga, N. Shibata, Benqiang Cui, 2017, Chemical communications.

Difluoromethylthiolation of Phenols and Related Compounds with a HF2CSO2Na/Ph2PCl/Me3SiCl System.

Etsuko Tokunaga, N. Shibata, Zhong Huang, 2017, Organic letters.

Modern Approaches for Asymmetric Construction of Carbon-Fluorine Quaternary Stereogenic Centers: Synthetic Challenges and Pharmaceutical Needs.

M. Sodeoka, F. Toste, Jianlin Han, 2018, Chemical reviews.

NH-type of chiral Ni(II) complexes of glycine Schiff base: design, structural evaluation, reactivity and synthetic applications.

C. Roussel, Jianlin Han, V. Soloshonok, 2014, Organic & biomolecular chemistry.

Stereoselective synthesis of vinyl triflones and heteroaryl triflones through anionic O→C(vinyl) and N→C(vinyl) trifluoromethanesulfonyl migration reactions.

H. Masuda, T. Ozawa, Etsuko Tokunaga, 2013, Angewandte Chemie.

Copper-catalyzed regioselective trifluoromethylthiolation of pyrroles by trifluoromethanesulfonyl hypervalent iodonium ylide.

Etsuko Tokunaga, N. Shibata, Zhong Huang, 2015, Organic letters.

Cinchona-alkaloid-catalyzed enantioselective direct aldol-type reaction of oxindoles with ethyl trifluoropyruvate.

N. Shibata, M. Shiro, Shuichi Nakamura, 2007, Angewandte Chemie.

Asymmetric allylic monofluoromethylation and methylation of Morita-Baylis-Hillman carbonates with FBSM and BSM by cooperative cinchona alkaloid/FeCl2 catalysis.

Takashi Matsumoto, Wei Zhang, Etsuko Tokunaga, 2011, Angewandte Chemie.

Efficient access to extended Yagupolskii-Umemoto-type reagents: triflic acid catalyzed intramolecular cyclization of ortho-ethynylaryltrifluoromethylsulfanes.

Etsuko Tokunaga, N. Shibata, Shuichi Nakamura, 2010, Angewandte Chemie.

Synthesis of Sulfur Perfluorophenyl Compounds Using a Pentafluorobenzenesulfonyl Hypervalent Iodonium Ylide.

Etsuko Tokunaga, N. Shibata, Yuji Sumii, 2017, The Journal of organic chemistry.

Synthesis of pyridine trans-tetrafluoro-λ6-sulfane derivatives via radical addition

Etsuko Tokunaga, N. Shibata, Masahiro Takada, 2018 .

Benzene, 1,1′‐[(Fluoromethylene)bis(sulfonyl)]bis‐

N. Shibata, T. Furukawa, 2010 .

Catalytic Enantioselective Michael Addition of 1-Fluoro-bis(phenylsulfonyl)methane to α,β-Unsaturated Ketones Catalyzed by Cinchona Alkaloids.

N. Shibata, M. Shiro, Shuichi Nakamura, 2009 .

Suzuki–Miyaura Cross‐Coupling Reactions in a Solkane365/227/Ethanol Blend at Ambient Temperature

Etsuko Tokunaga, N. Shibata, Akihiro Kusuda, 2012 .

Organocatalytic Enantioselective Nucleophilic Alkynylation of Allyl Fluorides Affording Chiral Skipped Ene-ynes.

V. Soloshonok, Etsuko Tokunaga, N. Shibata, 2016, Angewandte Chemie.

Enantioselective Trichloromethylation of MBH-Fluorides with Chloroform Based on Silicon-assisted C-F Activation and Carbanion Exchange Induced by a Ruppert-Prakash Reagent.

Etsuko Tokunaga, N. Shibata, M. Shiro, 2016, Angewandte Chemie.

Kinetic Resolution of Allyl Fluorides by Enantioselective Allylic Trifluoromethylation Based on Silicon‐Assisted C—F Bond Cleavage.

A. Yamano, Etsuko Tokunaga, N. Shibata, 2014 .

Regio- and Z-Selective Alkyne Hydroamination and Hydrophenoxylation using Tetrafluoro-λ6-Sulfanyl Alkynes under Superbasic, Naked Anion Conditions.

Y. Murata, N. Shibata, J. Escorihuela, 2023, Angewandte Chemie.

Stille cross-coupling of secondary and tertiary α-(trifluoromethyl)-benzyl chlorides with allylstannanes.

N. Shibata, Nagender Punna, Kyosuke Harada, 2018, Chemical communications.

Ethynyl-SF4-Pyridines: Reagents for SF4-Alkynylation to Carbonyl Compounds.

N. Shibata, O. Nagata, Kentaro Iwaki, 2022, The Journal of organic chemistry.

Structural basis of thalidomide enantiomer binding to cereblon

H. Handa, T. Hakoshima, Y. Yamaguchi, 2018, Scientific Reports.

Enantioselective 5-endo-dig carbocyclization of β-ketoesters with internal alkynes employing a four-component catalyst system.

Takashi Matsumoto, Etsuko Tokunaga, N. Shibata, 2012, Angewandte Chemie.

Catalytic enantioselective hydrophosphonylation of ketimines using cinchona alkaloids.

Y. Funahashi, N. Shibata, Shuichi Nakamura, 2009, Journal of the American Chemical Society.

A dynamic kinetic asymmetric transformation in the alpha-hydroxylation of racemic malonates and its application to biologically active molecules.

N. Shibata, Shuichi Nakamura, J. Nagai, 2009, Angewandte Chemie.

Synthesis of Chiral Nonracemic α-Difluoromethylthio Compounds with Tetrasubstituted Stereogenic Centers via a Palladium-Catalyzed Decarboxylative Asymmetric Allylic Alkylation.

N. Shibata, M. Shiro, K. Sasaki, 2018, Organic letters.

Enantiomerization of Allylic Trifluoromethyl Sulfoxides Studied by HPLC Analysis and DFT Calculations.

O. Trapp, N. Shibata, I. Chataigner, 2016, Chirality.

Successive C–C bond cleavage, fluorination, trifluoromethylthio- and pentafluorophenylthiolation under metal-free conditions to provide compounds with dual fluoro-functionalization

Shugo Suzuki, Etsuko Tokunaga, N. Shibata, 2015, Chemical science.

The Dihydroxy Metabolite of the Teratogen Thalidomide Causes Oxidative DNA Damage.

H. Yamazaki, G. Chowdhury, N. Shibata, 2017, Chemical research in toxicology.