P. Mäntsälä

发表

Identification of Late‐Stage Glycosylation Steps in the Biosynthetic Pathway of the Anthracycline Nogalamycin

G. Schneider, M. Metsä-Ketelä, V. Siitonen, 2012, Chembiochem : a European journal of chemical biology.

The potential of VCD to resolve the epimer vs. inverse epimer quandary

M. Metsä-Ketelä, K. Klika, P. Mäntsälä, 2012 .

Oxidation of crocein orange G by lignin peroxidase isoenzymes

P. Mäntsälä, P. Ollikka, Tiina Harjunpää, 1998, Applied biochemistry and biotechnology.

Glutamine amidotransferase function. Replacement of the active-site cysteine in glutamine phosphoribosylpyrophosphate amidotransferase by site-directed mutagenesis.

H. Zalkin, P. Mäntsälä, 1984, The Journal of biological chemistry.

Extracellular and membrane-bound proteases from Bacillus subtilis

H. Zalkin, P. Mäntsälä, 1980, Journal of bacteriology.

Active Subunits of Escherichia coli Glutamate Synthase

H. Zalkin, P. Mäntsälä, 1976, Journal of bacteriology.

Site-directed mutagenesis of a thermostable alpha-amylase from Bacillus stearothermophilus: putative role of three conserved residues.

L. Holm, M. Vihinen, J. Knowles, 1990, Journal of biochemistry.

Opioid peptides derived from in-vitro proteolysis of bovine whey proteins

M. Mattila, A. Pihlanto-Leppälä, I. Paakkari, 1991 .

Nucleotide sequences and expression of genes from Streptomyces purpurascens that cause the production of new anthracyclines in Streptomyces galilaeus

P. Mäntsälä, J. Niemi, 1995, Journal of bacteriology.

Production of hybrid anthracycline antibiotics by heterologous expression of Streptomyces nogalater nogalamycin biosynthesis genes.

P. Mäntsälä, J. Hakala, K. Ylihonko, 1996, Microbiology.

Discovery of a two-component monooxygenase SnoaW/SnoaL2 involved in nogalamycin biosynthesis.

P. Kallio, M. Metsä-Ketelä, V. Siitonen, 2012, Chemistry & biology.

Flavoprotein hydroxylase PgaE catalyzes two consecutive oxygen-dependent tailoring reactions in angucycline biosynthesis.

P. Kallio, M. Metsä-Ketelä, Pekka Patrikainen, 2011, Biochemistry.

Alnumycins A2 and A3: new inverse-epimeric pairs stereoisomeric to alnumycin A1

M. Metsä-Ketelä, K. Klika, P. Mäntsälä, 2012 .

Characterization of lignin peroxidase-encoding genes from lignin-degrading basidiomycetes.

K. Huoponen, J. Reiser, I. Walther, 1990, Gene.

Thermostable Alpha Amylase of Bacillus Stearothermophilus : Cloning, Expression, and Secretion by Escherichia Coli

J. Knowles, M. Karp, P. Mäntsälä, 1987 .

Extracellular production of cloned α-amylase by Escherichia coli

T. Glumoff, M. Karp, P. Mäntsälä, 1987 .

Expression in E. coli and purification of intracellular proteins by fusion to cyclomaltodextrin glucanotransferase.

S. Paavilainen, J. Hellman, P. Mäntsälä, 1992, Journal of biotechnology.

Characterization of Streptomyces nogalater genes encoding enzymes involved in glycosylation steps in nogalamycin biosynthesis

M. Skurnik, P. Mäntsälä, J. Hakala, 1997, Molecular and General Genetics MGG.

Hybrid anthracycline antibiotics: production of new anthracyclines by cloned genes from Streptomyces purpurascens in Streptomyces galilaeus.

P. Mäntsälä, J. Niemi, J. Hakala, 1994, Microbiology.

Amino acid sequence similarities of the mitochondrial short chain delta 3, delta 2-enoyl-CoA isomerase and peroxisomal multifunctional delta 3, delta 2-enoyl-CoA isomerase, 2-enoyl-CoA hydratase, 3-hydroxyacyl-CoA dehydrogenase enzyme in rat liver. The proposed occurrence of isomerization and hydrat

J. Hiltunen, M. Vihinen, T. Pihlajaniemi, 1991, The Journal of biological chemistry.

Expression of luciferase genes from different origins in Bacillus subtilis

M. Karp, M. Wahlsten, P. Mäntsälä, 1992, Molecular and General Genetics MGG.

An efficient approach for screening minimal PKS genes from Streptomyces.

M. Metsä-Ketelä, P. Mäntsälä, V. Saló, 1999, FEMS microbiology letters.

Structural basis for C-ribosylation in the alnumycin A biosynthetic pathway

G. Schneider, M. Metsä-Ketelä, K. Klika, 2013, Proceedings of the National Academy of Sciences.

Crystallization and preliminary X-ray diffraction studies of aclacinomycin-10-methyl esterase and aclacinomycin-10-hydroxylase from Streptomyces purpurascens.

G. Schneider, A. Jansson, P. Mäntsälä, 2003, Acta crystallographica. Section D, Biological crystallography.

Biosynthetic pathway toward carbohydrate-like moieties of alnumycins contains unusual steps for C-C bond formation and cleavage

M. Metsä-Ketelä, K. Klika, J. Sinkkonen, 2012, Proceedings of the National Academy of Sciences.

Biosynthetic Anthracycline Variants

G. Schneider, M. Metsä-Ketelä, P. Mäntsälä, 2008 .

Characterization of mutations in aclacinomycin A-non-producing Streptomyces galilaeus strains with altered glycosylation patterns.

P. Mäntsälä, J. Hakala, K. Ylihonko, 2002, Microbiology.

A gene cluster from Streptomyces galilaeus involved in glycosylation of aclarubicin

P. Mäntsälä, J. Hakala, K. Ylihonko, 2000, Molecular and General Genetics MGG.

Phage lambda pL promoter controlled α-amylase expression inEscherichia coli during fermentation

M. Karp, P. Reinikainen, P. Mäntsälä, 1988, Biotechnology Letters.

Purification of pantoate and dimethylmalate dehydrogenase from Pseudomonas fluorescens UK-1.

P. Mäntsälä, 1978, Biochimica et biophysica acta.

Evidence for the importance of cysteine and arginine residues in Pseudomonas fluorescens UK-1 pantoate dehydrogenase.

P. Mäntsälä, T. Myöhänen, 1980, Biochimica et biophysica acta.

Characterization of the Two-Component Monooxygenase System AlnT/AlnH Reveals Early Timing of Quinone Formation in Alnumycin Biosynthesis

M. Metsä-Ketelä, P. Mäntsälä, J. Niemi, 2012, Journal of bacteriology.

The entire nogalamycin biosynthetic gene cluster of Streptomyces nogalater: characterization of a 20-kb DNA region and generation of hybrid structures

P. Mäntsälä, K. Palmu, J. Hakala, 2001, Molecular Genetics and Genomics.

Secretion of β-lactamase by Escherichia coli in vivo and in vitro: effect of cerulenin

P. Mäntsälä, Hannu Lehtinen, 2004, Antonie van Leeuwenhoek.

Inhibition of protein secretion by cerulenin in Bacillus subtilis.

P. Mäntsälä, 1982, Journal of general microbiology.

Comparison of levansucrase from Bacillus subtilis and from Bacillus amyloliquefaciens

P. Mäntsälä, Mailis Puntala, 1982 .

Coproduction of several exoenzymes in Bacillus subtilis

P. Mäntsälä, Maija Sippola, 1981 .

A gene cluster involved in nogalamycin biosynthesis fromStreptomyces nogalater: sequence analysis and complementation of early-block mutations in the anthracycline pathway

L. Cong, P. Mäntsälä, K. Ylihonko, 1996, Molecular and General Genetics MGG.

Identification of a Cyclase Gene Dictating the C-9 Stereochemistry of Anthracyclines from Streptomyces nogalater

P. Mäntsälä, K. Palmu, J. Hakala, 2000, Antimicrobial Agents and Chemotherapy.

Crystal structure of the cofactor-independent monooxygenase SnoaB from Streptomyces nogalater: implications for the reaction mechanism.

G. Schneider, Y. Lindqvist, P. Mäntsälä, 2010, Biochemistry.

Sequential action of two flavoenzymes, PgaE and PgaM, in angucycline biosynthesis: chemoenzymatic synthesis of gaudimycin C.

P. Kallio, Zhanliang Liu, M. Metsä-Ketelä, 2008, Chemistry & biology.

Construction of an Escherichia coli export-affinity vector for expression and purification of foreign proteins by fusion to cyclomaltodextrin glucanotransferase.

J. Hellman, P. Mäntsälä, 1992, Journal of biotechnology.

Properties of apoglutamate synthase and comparison with glutamate dehydrogenase.

H. Zalkin, P. Mäntsälä, 1976, The Journal of biological chemistry.

Characterization of the alnumycin gene cluster reveals unusual gene products for pyran ring formation and dioxan biosynthesis.

O. Leppäranta, M. Metsä-Ketelä, P. Mäntsälä, 2008, Chemistry & biology.

Crystallization and preliminary crystallographic data of SnoaL, a polyketide cyclase in nogalamycin biosynthesis.

G. Schneider, P. Kallio, A. Jansson, 2004, Acta crystallographica. Section D, Biological crystallography.

Engineering Anthracycline Biosynthesis toward Angucyclines

M. Metsä-Ketelä, P. Mäntsälä, K. Palmu, 2003, Antimicrobial Agents and Chemotherapy.

Elucidation of anthracyclinone biosynthesis by stepwise cloning of genes for anthracyclines from three different Streptomyces spp.

P. Mäntsälä, J. Hakala, K. Ylihonko, 2000, Microbiology.

Hybrid compounds derived from the combination of anthracycline and actinorhodin biosynthetic pathways

K. Klika, P. Mäntsälä, J. Hakala, 1999 .

Microbial amylolytic enzymes.

M. Vihinen, P. Mäntsälä, 1989, Critical reviews in biochemistry and molecular biology.

Crystal structure of Bacillus subtilis YabJ, a purine regulatory protein and member of the highly conserved YjgF family.

J. L. Smith, H. Zalkin, P. Mäntsälä, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Aclacinomycin 10-Hydroxylase Is a Novel Substrate-assisted Hydroxylase Requiring S-Adenosyl-l-methionine as Cofactor*

G. Schneider, A. Jansson, P. Mäntsälä, 2005, Journal of Biological Chemistry.

Structure of the polyketide cyclase SnoaL reveals a novel mechanism for enzymatic aldol condensation

Gunter Schneider, G. Schneider, P. Kallio, 2004, The EMBO journal.

Crystal Structure of a Ternary Complex of DnrK, a Methyltransferase in Daunorubicin Biosynthesis, with Bound Products*

Gunter Schneider, G. Schneider, A. Jansson, 2004, Journal of Biological Chemistry.

Crystal structure of aclacinomycin-10-hydroxylase, a S-adenosyl-L-methionine-dependent methyltransferase homolog involved in anthracycline biosynthesis in Streptomyces purpurascens.

G. Schneider, Y. Lindqvist, A. Jansson, 2003, Journal of molecular biology.

Opioid peptides produced by in-vitro proteolysis of bovine caseins

A. Pihlanto-Leppälä, J. Hellman, P. Mäntsälä, 1994 .

AMINO-ACID-SEQUENCE SIMILARITIES OF THE MITOCHONDRIAL SHORT CHAIN DELTA-3,DELTA-2-ENOYL-COA ISOMERASE AND PEROXISOMAL MULTIFUNCTIONAL DELTA-3,DELTA-2-ENOYL-COA ISOMERASE, 2-ENOYL-COA HYDRATASE, 3-HYDROXYACYL-COA DEHYDROGENASE ENZYME IN RAT-LIVER - THE PROPOSED OCCURRENCE OF ISOMERIZATION AND HYDRATI

J. Hiltunen, M. Vihinen, T. Pihlajaniemi, 1991 .

Hybrid compounds generated by the introduction of a nogalamycin-producing plasmid into Streptomyces argillaceus

C. Méndez, J. Salas, K. Klika, 2002 .

Artificial Reconstruction of Two Cryptic Angucycline Antibiotic Biosynthetic Pathways

K. Ishida, C. Hertweck, M. Metsä-Ketelä, 2007, Chembiochem : a European journal of chemical biology.

Aclacinomycin oxidoreductase (AknOx) from the biosynthetic pathway of the antibiotic aclacinomycin is an unusual flavoenzyme with a dual active site

G. Schneider, P. Mäntsälä, J. Niemi, 2007, Proceedings of the National Academy of Sciences.

Glutamate synthase. Properties of the glutamine-dependent activity.

H. Zalkin, P. Mäntsälä, 1976, The Journal of biological chemistry.

Translocation of proteins across membranes.

P. Mäntsälä, I. Suominen, 1983, The International journal of biochemistry.

Anthracycline Biosynthesis: Genes, Enzymes and Mechanisms

G. Schneider, P. Mäntsälä, J. Niemi, 2007 .

Suppression of growth defects of α-amylase secreting Escherichia coli by signal sequence fusion

V. Glumoff, J. Käpylä, C. Tilgmann, 1988 .

Effects of signal peptide mutations on processing of Bacillus stearothermophilus alpha-amylase in Escherichia coli.

T. Glumoff, V. Glumoff, J. Käpylä, 1995, Microbiology.

Time-resolved europium fluorescence in enzyme activity measurements: a sensitive protease assay.

M. Karp, P. Mäntsälä, I. Hemmilä, 1983, Journal of applied biochemistry.

A Role for a Highly Conserved Protein of Unknown Function in Regulation of Bacillus subtilis purA by the Purine Repressor

H. Zalkin, P. Mäntsälä, P. Rappu, 1999, Journal of bacteriology.

Molecular Evolution of Aromatic Polyketides and Comparative Sequence Analysis of Polyketide Ketosynthase and 16S Ribosomal DNA Genes from Various Streptomyces Species

P. Mäntsälä, E. Munukka, J. Hakala, 2002, Applied and Environmental Microbiology.

Tracing the evolution of angucyclinone monooxygenases: structural determinants for C-12b hydroxylation and substrate inhibition in PgaE.

P. Kallio, G. Belogurov, Keqian Yang, 2013, Biochemistry.

Structural basis for substrate recognition and specificity in aklavinone-11-hydroxylase from rhodomycin biosynthesis.

G. Schneider, Y. Lindqvist, R. Schnell, 2009, Journal of molecular biology.

Observations on methionine transport in Pseudomonas fluorescens UK1.

P. Mäntsälä, V. Nurmikko, S. Laakso, 1974, Journal of general microbiology.

Crystal structures of two aromatic hydroxylases involved in the early tailoring steps of angucycline biosynthesis.

Gunter Schneider, G. Schneider, P. Kallio, 2007, Journal of molecular biology.

Membrane-bound and soluble extracellular alpha-amylase from Bacillus subtilis.

H. Zalkin, P. Mäntsälä, 1979, The Journal of biological chemistry.

C-terminal truncations of a thermostable Bacillus stearothermophilus alpha-amylase.

M. Vihinen, P. Mäntsälä, I. Suominen, 1994, Protein engineering.

Stable-light-emitting Escherichia coli as a biosensor.

M. Karp, E. Lilius, P. Mäntsälä, 1989, Journal of bioluminescence and chemiluminescence.

Isolation and characterization of a pur C(or f)QLF operon from Lactobacillus lactis MG1614

P. Mäntsälä, T. Peltonen, 1999, Molecular and General Genetics MGG.

Cloning and sequence of Bacillus subtilis purA and guaA, involved in the conversion of IMP to AMP and GMP

H. Zalkin, P. Mäntsälä, H Zalkin, 1992, Journal of Bacteriology.

Crystal structures of SnoaL2 and AclR: two putative hydroxylases in the biosynthesis of aromatic polyketide antibiotics.

Gunter Schneider, Bernhard Lohkamp, G. Schneider, 2006, Journal of molecular biology.

Tailoring enzymes involved in the biosynthesis of angucyclines contain latent context-dependent catalytic activities.

K. Fan, J. Rohr, P. Kallio, 2012, Chemistry & biology.

Comparison of d-malate and β,β-dimethylmalate dehydrogenases from Pseudomonas fluorescens UK-1

P. Mäntsälä, M. Lähdesmäki, 1980 .

In vitro refolding of cyclomaltodextrin glucanotransferase from cytoplasmic inclusion bodies formed upon expression in Escherichia coli.

J. Hellman, P. Mäntsälä, P. Lassila, 1995, Protein expression and purification.

Cloning, sequencing, expression and characterization of three anti-estradiol-17beta Fab fragments.

M. Karp, K. Pettersson, P. Saviranta, 1997, Biochimica et Biophysica Acta.

Cloning and characterization of Streptomyces galilaeus aclacinomycins polyketide synthase (PKS) cluster.

P. Mäntsälä, Pekka Mäntsälä, Kristiina Ylihonko, 2002, Gene.

Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.

C. Méndez, J. Salas, G. Blanco, 1997, Chemistry and Biology.

Isolation and characterization of aclacinomycin A-non-producing Streptomyces galilaeus (ATCC 31615) mutants.

P. Mäntsälä, J. Niemi, J. Hakala, 1994, Microbiology.

Structural and functional analysis of angucycline C-6 ketoreductase LanV involved in landomycin biosynthesis.

P. Kallio, Pekka Patrikainen, P. Mäntsälä, 2013, Biochemistry.

Glutamine nucleotide sequence of Saccharomyces cerevisiae ADE4 encoding phosphoribosylpyrophosphate amidotransferase.

H. Zalkin, P. Mäntsälä, 1984, The Journal of biological chemistry.

Thermophilic NAD-dependent glutamate dehydrogenase from Bacillus stearothermophilus.

P. Mäntsälä, 1985, Biochemistry international.

Purification and properties of glutamate synthase and glutamate dehydrogenase from Bacillus megaterium.

P. Mäntsälä, I. Hemmilä, 1978, The Biochemical journal.

Crystal structure of the polyketide cyclase AknH with bound substrate and product analogue: implications for catalytic mechanism and product stereoselectivity.

G. Schneider, P. Kallio, P. Mäntsälä, 2006, Journal of molecular biology.

Structure-based engineering of angucyclinone 6-ketoreductases.

Pekka Patrikainen, P. Mäntsälä, P. Tähtinen, 2014, Chemistry & biology.

Epimers vs. inverse epimers: the C-1 configuration in alnumycin A1

K. Klika, P. Mäntsälä, P. Tähtinen, 2012 .

Incorrectly folded aromatic polyketides from polyketide reductase deficient mutants.

K. Klika, P. Mäntsälä, J. Hakala, 1999, Bioorganic & medicinal chemistry letters.

A gene cluster involved in nogalamycin biosynthesis from

L. Cong, P. Mäntsälä, K. Ylihonko, 1996 .

Modification of aklavinone and aclacinomycins in vitro and in vivo by rhodomycin biosynthesis gene products.

Yulong Wang, P. Mäntsälä, J. Niemi, 2002, FEMS microbiology letters.

Characterization of aklavinone-11-hydroxylase from Streptomyces purpurascens.

P. Mäntsälä, J. Niemi, J. Hakala, 1999, Biochimica et biophysica acta.

In Vivo Effect of Mutations at the PRPP Binding Site of the Bacillus subtilis Purine Repressor

P. Mäntsälä, P. Rappu, Terhi Pullinen, 2003, Journal of bacteriology.

Mutational Analysis of the Bacillus subtilis purA Operator Site

P. Mäntsälä, P. Rappu, Mari Leppihalme, 2005, Current Microbiology.

Crystal Structure of Aclacinomycin Methylesterase with Bound Product Analogues

Gunter Schneider, G. Schneider, A. Jansson, 2003, Journal of Biological Chemistry.

A nested gene in Streptomyces bacteria encodes a protein involved in quaternary complex formation.

P. Kallio, Zhanliang Liu, P. Mäntsälä, 2008, Journal of molecular biology.

Crystal structure of the polyketide cyclase AknH with bound substrate and product analogue: implications for catalytic mechanism and product stereoselectivity.

G. Schneider, P. Kallio, P. Mäntsälä, 2006, Journal of molecular biology.

Tracing the evolution of angucyclinone monooxygenases: structural determinants for C-12b hydroxylation and substrate inhibition in PgaE.

P. Kallio, G. Belogurov, Keqian Yang, 2013, Biochemistry.

Partial activation of a silent angucycline-type gene cluster from a rubromycin beta producing Streptomyces sp. PGA64.

P. Mäntsälä, K. Ylihonko, M. Metsä‐Ketelä, 2004, The Journal of antibiotics.