U. Hommel

发表

Correct folding of circularly permuted variants of a beta alpha barrel enzyme in vivo.

K. Luger, J. Hofsteenge, K. Kirschner, 1989, Science.

Design and NMR-based screening of LEF, a library of chemical fragments with different local environment of fluorine.

Anna Vulpetti, Richard Lewis, Gregory Landrum, 2009, Journal of the American Chemical Society.

A lead discovery strategy driven by a comprehensive analysis of proteases in the peptide substrate space

Rajiv Chopra, Meir Glick, Florian Nigsch, 2010, Protein science : a publication of the Protein Society.

Solution structure of a cysteine rich domain of rat protein kinase C

Ulrich Hommel, M. Zurini, U. Hommel, 1994, Nature Structural Biology.

New pulsed field gradient NMR experiments for the detection of bound water in proteins

C. Dalvit, U. Hommel, 1995, Journal of biomolecular NMR.

Half-filter experiments for assignment, structure determination and hydration analysis of unlabelled ligands bound to 13C/15N labelled proteins

C. Dalvit, P. Ramage, U. Hommel, 1999, Journal of biomolecular NMR.

Structure and allosteric regulation of the αXβ2 integrin I domain

Timothy A. Springer, Motomu Shimaoka, Thomas Vorup-Jensen, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Direct methods and residue type specific isotope labeling in NMR structure determination and model-driven sequential assignment

R. Konrat, A. Schedlbauer, R. Auer, 2008, Journal of biomolecular NMR.

Structure-Based Library Design and Fragment Screening for the Identification of Reversible Complement Factor D Protease Inhibitors.

N. Ostermann, A. Vulpetti, B. Gerhartz, 2017, Journal of medicinal chemistry.

Structure and allosteric regulation of the alpha X beta 2 integrin I domain.

M. Shimaoka, T. Springer, C. Ostermeier, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site

Joerg Kallen, Volker Brinkmann, Christian Bruns, 2001, Nature Medicine.

Backbone 1H, 13C, and 15N resonance assignments for the 26-kD human de-ubiquitinating enzyme UCH-L3

P. Driscoll, M. Renatus, U. Eidhoff, 2007, Biomolecular NMR assignments.

Letter to the Editor: Assignment of 1H, 13C and 15N resonances of the I-domain of human leukocyte function associated antigen-1

H. Dyson, P. Wright, R. Kriwacki, 2000, Journal of biomolecular NMR.

Structure-function relationships in human epidermal growth factor studied by site-directed mutagenesis and 1H NMR.

I. Campbell, T. Dudgeon, U. Hommel, 1991, Biochemistry.

Phosphoribosyl anthranilate isomerase catalyzes a reversible amadori reaction.

K. Kirschner, U. Hommel, M. Eberhard, 1995, Biochemistry.

Probing the Helical Secondary Structure of Short‐Chain β‐Peptides

B. Jaun, D. Seebach, Dario Rigo, 1996 .

β‐Peptides: Synthesis by Arndt‐Eistert homologation with concomitant peptide coupling. Structure determination by NMR and CD spectroscopy and by X‐ray crystallography. Helical secondary structure of a β‐hexapeptide in solution and its stability towards pepsin

Ulrich Hommel, D. Seebach, U. Hommel, 1996 .

Human epidermal growth factor

I. Campbell, T. Harvey, P. Driscoll, 1992 .

The 3D‐structure of a natural inhibitor of cell adhesion molecule expression

C. A. Foster, H. Weber, U. Hommel, 1996, FEBS letters.

β2‐ and β3‐Peptides with Proteinaceous Side Chains: Synthesis and solution structures of constitutional isomers, a novel helical secondary structure and the influence of solvation and hydrophobic interactions on folding

B. Jaun, D. Seebach, K. Gademann, 1998 .

1,4-Diazepane-2-ones as novel inhibitors of LFA-1.

Claus Ehrhardt, Michael Sabio, Didier Roche, 2003, Bioorganic & medicinal chemistry letters.

Small-molecule factor D inhibitors targeting the alternative complement pathway.

N. Ostermann, C. Durand, A. Vulpetti, 2016, Nature chemical biology.

"Mixed" β-peptides. A unique helical secondary structure in solution. Preliminary communication

B. Jaun, D. Seebach, K. Gademann, 1997 .

β‐Peptides: Synthesis by Arndt‐Eistert Homologation with Concomitant Peptide Coupling. Structure Determination by NMR and CD Spectroscopy and by X‐Ray Crystallography. Helical Secondary Structure of a β‐Hexapeptide in Solution and Its Stability Towards Pepsin.

D. Seebach, U. Hommel, M. Overhand, 1996 .

Protease‐Directed Drug Discovery

J. Eder, R. Sedrani, U. Hommel, 2008 .

Small Molecule Inhibitors Induce Conformational Changes in the I Domain and the I-like Domain of Lymphocyte Function-associated Antigen-1

Ulrich Hommel, U. Hommel, Karl Welzenbach, 2002, The Journal of Biological Chemistry.

Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus

Zheng Yin, Ulrich Hommel, A. D'arcy, 2006, Nature Structural &Molecular Biology.

Aspartic proteases in drug discovery.

Bruno Martoglio, Jörg Eder, Ulrich Hommel, 2007, Current pharmaceutical design.

Influence of cross-correlation between dipolar and chemical shift anisotropy relaxation mechanisms upon the transverse relaxation rates of 15N in macromolecules

V. Krishnan, J. Boyd, U. Hommel, 1991 .

Influence of cross-correlation between dipolar and anisotropic chemical shift relaxation mechanisms upon longitudinal relaxation rates of 15N in macromolecules

I. Campbell, J. Boyd, U. Hommel, 1990 .

Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain.

R. Kriwacki, P. Ramage, J. Kallen, 1999, Journal of molecular biology.

Heteronuclear X-filter 1H PFG double-quantum experiments for the proton resonance assignment of a ligand bound to a protein.

C. Dalvit, P. Ramage, U. Hommel, 1998, Journal of magnetic resonance.

The discovery of steroids and other novel FKBP inhibitors using a molecular docking program.

P Burkhard, M. Sanner, P. Burkhard, 1999, Journal of molecular biology.

Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo.

Karen Anderson, Anna Vulpetti, Ulrich Hommel, 2017, Journal of medicinal chemistry.

Crystal structure of human BACE2 in complex with a hydroxyethylamine transition-state inhibitor.

N. Ostermann, U. Hassiepen, U. Eidhoff, 2006, Journal of molecular biology.

Purification and characterization of yeast anthranilate phosphoribosyltransferase.

A. Lustig, K. Kirschner, U. Hommel, 1989, European journal of biochemistry.

NMR solution structure of the inserted domain of human leukocyte function associated antigen-1.

P E Wright, D. Case, H. Dyson, 2000, Journal of molecular biology.

Discovery of Potent Small-Molecule Inhibitors of WDR5-MYC Interaction.

Stephen M. Canham, John A. Tallarico, P. Atadja, 2023, ACS chemical biology.

Discovery of Potent, Selective, and Structurally Novel Dot1L Inhibitors by a Fragment Linking Approach.

Philipp Holzer, R. Tiedt, G. Caravatti, 2017, ACS medicinal chemistry letters.

Comprehensive and High‐Throughput Exploration of Chemical Space Using Broadband 19 F NMR‐Based Screening

A. Vulpetti, B. Luy, Andreas Lingel, 2020, Angewandte Chemie.

Comprehensive and High-Throughput Exploration of Chemical Space Using Broadband 19F NMR-Based Screening.

Anna Vulpetti, Andreas Lingel, Tony Reinsperger, 2020, Angewandte Chemie.

1,4-Diazepane-2,5-diones as novel inhibitors of LFA-1.

M. Sabio, C. Ehrhardt, U. Hommel, 2005, Bioorganic & medicinal chemistry letters.

Crystal structure of the SH2 domain from the adaptor protein SHC: a model for peptide binding based on X-ray and NMR data.

M. Zurini, V. Mikol, U. Hommel, 1995, Journal of molecular biology.

Sensitivity-Improved Detection of Protein Hydration and Its Extension to the Assignment of Fast-Exchanging Resonances

C. Dalvit, U. Hommel, 1995 .

Probing the Helical Secondary Structure of Short-Chain β-Peptides.

B. Jaun, D. Seebach, Dario Rigo, 1997 .

Indoleglycerol phosphate synthase-phosphoribosyl anthranilate isomerase: comparison of the bifunctional enzyme from Escherichia coli with engineered monofunctional domains.

K. Kirschner, U. Hommel, K. Bolewska, 1995, Biochemistry.

"Virtual fragment linking": an approach to identify potent binders from low affinity fragment hits.

Andreas Bender, Meir Glick, Mariusz Milik, 2008, Journal of medicinal chemistry.

Direct methods and residue type specific isotope labeling in NMR structure determination and model-driven sequential assignment

R. Konrat, A. Schedlbauer, K. Kloiber, 2008, Journal of biomolecular NMR.