G. Hughes

发表

Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture

Paul N. Devine, Gjalt W. Huisman, E. Mundorff, 2010, Science.

Design of an in vitro biocatalytic cascade for the manufacture of islatravir

Shane T. Grosser, Deeptak Verma, Edward C. Sherer, 2019, Science.

Industrial Hydrolases and Related Enzymes

Roger M. Howard, Gary Francis GlaxoSmithKline Breen, Rebecca E. Meadows, 2012 .

Convergent, Fit-For-Purpose, Kilogram-Scale Synthesis of a 5-Lipoxygenase Inhibitor

I. Davies, G. Hughes, Louis-Charles Campeau, 2012 .

Development of a Practical Synthesis of Stearoyl-CoA Desaturase (SCD1) Inhibitor MK-8245

Paul Fernandez, G. Hughes, M. Girardin, 2011 .

Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of tertiary alcohol-bearing piperidines.

J. Falgueyret, M. Percival, Yongxin Han, 2011, Bioorganic & medicinal chemistry letters.

Site-selective redox isomerizations of furanosides using a combined arylboronic acid/photoredox catalyst system†

Mark S. Taylor, G. Hughes, Victoria Dimakos, 2020, Chemical science.

Practical synthesis of a potent bradykinin B(1) antagonist via enantioselective hydrogenation of a pyridyl N-acyl enamide.

F. Gosselin, G. Hughes, D. Gauvreau, 2009, The Journal of organic chemistry.

Palladium-catalyzed cross-coupling reactions of pyridylboronic acids with heteroaryl halides bearing a primary amine group: synthesis of highly substituted bipyridines and pyrazinopyridines.

A. Batsanov, G. Hughes, M. Bryce, 2005, The Journal of organic chemistry.

A practical enantioselective synthesis of odanacatib, a potent Cathepsin K inhibitor, via triflate displacement of an alpha-trifluoromethylbenzyl triflate.

F. Gosselin, G. Hughes, R. Volante, 2009, The Journal of organic chemistry.

Ligand-dependent site-selective Suzuki cross-coupling of 3,5-dichloropyridazines.

A. Palani, R. Nargund, G. Hughes, 2013, The Journal of organic chemistry.

Electron-transporting materials for organic electroluminescent and electrophosphorescent devices

G. Hughes, M. Bryce, 2005 .

Cyanoketenes. Cycloadditions of chlorocyanoketene to α,β-unsaturated imines

G. Hughes, H. W. Moore, 1983 .

A practical synthesis of 5-lipoxygenase inhibitor MK-0633.

I. Davies, F. Gosselin, M. Palucki, 2010, The Journal of organic chemistry.

Catalytic enantioselective conjugate reduction of lactones and lactams.

S. Buchwald, G. Hughes, M. Kimura, 2003, Journal of the American Chemical Society.

New pyrimidine- and fluorene-containing oligo(arylene)s: synthesis, crystal structures, optoelectronic properties and a theoretical study.

A. Monkman, I. F. Perepichka, A. Batsanov, 2003, Organic & biomolecular chemistry.

HETEROAROMATIC DITHIOACETALS PART I : THE PREPARATION OF UNSYMMETRICAL DITHIOACETALS FROM HETEROAROMATIC THIOLS

R. Young, J. Gauthier, R. Zamboni, 1998 .

Cycloadditions of cyanoketenes to cinnamylidenamines and benzylidenamines. Synthetic scope, stereochemistry, and mechanism

G. Hughes, K. Srinivasachar, H. W. Moore, 1985 .

Practical synthesis of a renin inhibitor via a diastereoselective Dieckmann cyclization.

Bing Yu, I. Davies, G. Hughes, 2010, Organic letters.

Scalable synthesis of a prostaglandin EP4 receptor antagonist.

I. Davies, G. Hughes, D. Gauvreau, 2010, The Journal of organic chemistry.

2,3-Diarylcyclopentenones as orally active, highly selective cyclooxygenase-2 inhibitors.

R Gordon, D. Riendeau, P. Prasit, 1999, Journal of medicinal chemistry.

Use of γ-Carboxy-α,β-unsaturated Aldehydes as Synthetic Equivalents of β,γ-Unsaturated Aldehydes in a Novel Stereoselective Approach to Diketides

M. Lautens, G. Hughes, C. K. Wen, 2000 .

Diastereoselective Ring Closing Metathesis Reactions: Synthesis of Bicyclic Diallylic Alcohols and Ethers

M. Lautens, G. Hughes, 1999 .

Diastereoselective Reductive Amination of Aryl Trifluoromethyl Ketones and α‐Amino Esters

Paul N. Devine, J. R. Naber, G. Hughes, 2007 .

Convergent Kilogram-Scale Synthesis of Dual Orexin Receptor Antagonist

Paul N. Devine, Louis-Charles Campeau, Paul D. O’Shea, 2013 .

2. Reductive Amination

G. Huisman, A. Chadha, Jeffrey C. Moore, 2012 .

Development of an Immobilized Transaminase Capable of Operating in Organic Solvent

Gregory Hughes, Matthew D. Truppo, M. Truppo, 2012 .

Phenylene-2,5-dimethylpyrazine co-oligomers: synthesis by Suzuki couplings, X-ray structures of neutral and diprotonated teraryl species and efficient blue emission

A. Batsanov, G. Hughes, M. Bryce, 2003 .

Nucleophilic displacements of non-racemic α-trifluoromethyl benzylic triflates

G. Hughes, D. Gauvreau, P. O'shea, 2009 .

Ethynyl π-extended 2,5-diphenyl-1,3,4-oxadiazoles and 2-phenyl 5-(2-thienyl)-1,3,4-oxadiazoles: synthesis, X-ray crystal structures and optical properties

A. Batsanov, G. Hughes, M. Bryce, 2004 .

Development of an Improved Immobilized CAL-B for the Enzymatic Resolution of a Key Intermediate to Odanacatib

Gregory Hughes, Matthew D. Truppo, M. Truppo, 2011 .

New 2,5-diaryl-1,3,4-oxadiazole–fluorene hybrids as electron transporting materials for blended-layer organic light emitting diodes

C. Pearson, M. Petty, I. F. Perepichka, 2005 .

Development of an Efficient Route to 2-Ethynylglycerol for the Synthesis of Islatravir

Shaoguang Zhang, Gregory Hughes, Brian M. Wyvratt, 2021 .

Magnesiation of electron-rich aryl bromides and their use in nickel-catalyzed cross-coupling reactions.

I. Davies, G. Hughes, P. O'shea, 2007, Organic letters.

Diastereoselective double ring closing metathesis reactions as an approach to symmetrical bicyclodienes

M. Lautens, G. Hughes, V. Zunic, 2000 .

3,4-Diaryl-5-hydroxyfuranones: highly selective inhibitors of cyclooxygenase-2 with aqueous solubility.

D. Riendeau, P. Prasit, C. Brideau, 2003, Bioorganic & medicinal chemistry letters.

Diastereoselective Double Ring Closing Metathesis Reactions as an Approach to Symmetrical Bicyclodienes.

M. Lautens, G. Hughes, V. Zunic, 2000 .

Asymmetric, biocatalytic labeled compound synthesis using transaminases

S. Pollack, I. Davies, M. Truppo, 2012 .

Remote electronic control in the regioselective reduction of succinimides: a practical, scalable synthesis of Ep4 antagonist MF-310.

Yongxin Han, C. Raab, M. Palucki, 2009, The Journal of organic chemistry.

Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture

Paul N. Devine, E. Mundorff, Sarena Tam, 2010, Science.