D. Kwan

发表

Toward Efficient Enzymes for the Generation of Universal Blood through Structure-Guided Directed Evolution.

S. Withers, E. Samain, A. Boraston, 2015, Journal of the American Chemical Society.

Prediction and manipulation of the stereochemistry of enoylreduction in modular polyketide synthases.

Frank Schulz, Hui Hong, P. Leadlay, 2008, Chemistry & biology.

Resources and Methods for Engineering “Designer” Glycan-Binding Proteins

D. Kwan, Ruben Warkentin, 2021, Molecules.

Enhancement of Biological Reactions on Cell Surfaces via Macromolecular Crowding

S. Withers, N. Rossi, J. Kizhakkedathu, 2014, Nature Communications.

A High-Throughput Glycosyltransferase Inhibition Assay for Identifying Molecules Targeting Fucosylation in Cancer Cell-Surface Modification.

F. Chen, D. Kwan, P. Forgione, 2019, ACS chemical biology.

The Stereochemistry of Complex Polyketide Biosynthesis by Modular Polyketide Synthases

D. Kwan, F. Schulz, 2011, Molecules.

Insights into the stereospecificity of ketoreduction in a modular polyketide synthase.

P. Leadlay, D. Kwan, F. Schulz, 2011, Organic & biomolecular chemistry.

Enzymatic Synthesis of a Fluorogenic Reporter Substrate and a High-Throughput Assay for Fucosyltransferase VIII Provide a Toolkit to Probe and Inhibit Core Fucosylation

D. Kwan, Maxim Soroko, 2019 .

Controlling Glycosyltransferase Activity: Inhibition and Enzyme Engineering

D. Kwan, F. Mohideen, T. Ghosh, 2021 .

A fucosyltransferase inhibition assay using image-analysis and digital microfluidics.

Steve C. C. Shih, D. Kwan, Guy Soffer, 2019, Biomicrofluidics.

Periplasmic de-acylase helps bacteria don their biofilm coat

S. Withers, D. Kwan, 2014, Proceedings of the National Academy of Sciences.

Enzymatic synthesis of a fluorogenic reporter substrate and development of a high-throughput assay for fucosyltransferase VIII provide a toolkit to probe and inhibit core fucosylation.

D. Kwan, Maxim Soroko, 2020, Biochemistry.

A glyco-gold nanoparticle based assay for α-2,8-polysialyltransferase from Neisseria meningitidis.

S. Withers, W. Wakarchuk, Chun‐Cheng Lin, 2013, Chemical communications.

Structure of human ST8SiaIII sialyltransferase provides insight into cell-surface polysialylation

Nichollas E. Scott, S. Withers, L. Foster, 2015, Nature Structural &Molecular Biology.

A plate-based high-throughput activity assay for polysialyltransferase from Neisseria meningitidis.

S. Withers, W. Wakarchuk, Chun‐Cheng Lin, 2014, Analytical biochemistry.

Toward Efficient Enzymatic Glycan Synthesis: Directed Evolution and Enzyme Engineering

S. Withers, D. Kwan, 2011 .

Divergent directed evolution of a TetR-type repressor towards aromatic molecules

V. Martin, Mohamed A. Nasr, D. Kwan, 2022, bioRxiv.

Facile Formation of β‐thioGlcNAc Linkages to Thiol‐Containing Sugars, Peptides, and Proteins using a Mutant GH20 Hexosaminidase

S. Withers, D. Kwan, Hongming Chen, 2019, Angewandte Chemie.

Mutagenesis of a modular polyketide synthase enoylreductase domain reveals insights into catalysis and stereospecificity.

P. Leadlay, D. Kwan, Peter F Leadlay, 2010, ACS chemical biology.

Scytalone (3,6,8-Trihydroxytetralone), a Metabolite from a Scytalidium Species

J. Findlay, D. Kwan, 1973 .

Chemoenzymatic synthesis of 6‐phospho‐cyclophellitol as a novel probe of 6‐phospho‐β‐glucosidases

S. Withers, G. Davies, J. Jiang, 2016, FEBS letters.

Structure-Guided Directed Evolution of Glycosidases: A Case Study in Engineering a Blood Group Antigen-Cleaving Enzyme.

D. Kwan, 2017, Methods in enzymology.

Chemoenzymatic Synthesis of a Type 2 Blood Group A Tetrasaccharide and Development of High-throughput Assays Enables a Platform for Screening Blood Group Antigen-cleaving Enzymes.

S. Withers, D. Kwan, Miriam P. Kötzler, 2015, Glycobiology.

Self-immobilizing fluorogenic imaging agents of enzyme activity.

S. Withers, S. Hancock, A. Samuels, 2011, Angewandte Chemie.

Corrigendum: Facile Formation of β-thioGlcNAc Linkages to Thiol-Containing Sugars, Peptides, and Proteins using a Mutant GH20 Hexosaminidase.

S. Withers, D. Kwan, Hongming Chen, 2019, Angewandte Chemie.

A “biphasic glycosyltransferase high-throughput screen” identifies novel anthraquinone glycosides in the diversification of phenolic natural products

D. Kwan, F. Mohideen, 2023, The Journal of biological chemistry.

In Vitro Reconstitution of the dTDP-l-Daunosamine Biosynthetic Pathway Provides Insights into Anthracycline Glycosylation.

D. Kwan, J. D. Richard, F. Mohideen, 2021, ACS chemical biology.

A Versatile Transcription Factor Biosensor System Responsive to Multiple Aromatic and Indole Inducers

V. Martin, Mohamed A. Nasr, D. Kwan, 2022, ACS synthetic biology.

Engineering the Enzyme Toolbox to Tailor Glycosylation in Small Molecule Natural Products and Protein Biologics.

D. Kwan, F. Mohideen, Sara Ouadhi, 2022, Protein engineering, design & selection : PEDS.

Functional and Structural Characterization of an IclR Family Transcription Factor for the Development of Dicarboxylic Acid Biosensors

V. Martin, R. Mahadevan, P. Stogios, 2023, bioRxiv.