Jiahai Zhou

发表

Reshaping an enzyme binding pocket for enhanced and inverted stereoselectivity: use of smallest amino acid alphabets in directed evolution.

Zhoutong Sun, Manfred T Reetz, Richard Lonsdale, 2015, Angewandte Chemie.

Substrate channel evolution of an esterase for the synthesis of cilastatin

Huilei Yu, Jian‐He Xu, Qi Chen, 2015 .

Photoinduced chemomimetic biocatalysis for enantioselective intermolecular radical conjugate addition

Huimin Zhao, Binju Wang, Jiahai Zhou, 2022, Nature Catalysis.

Molecular Basis of the General Base Catalysis of an α/β-Hydrolase Catalytic Triad*

Zhihong Guo, G. Zhu, Changdong Liu, 2014, The Journal of Biological Chemistry.

The 1.6Å resolution structure of activated D138L mutant of catabolite gene activator protein with two cAMP bound in each monomer.

Z. Huang, Zengqiang Gao, Yuhui Dong, 2011, International journal of biological macromolecules.

Surface initiated polymerization from substrates of low initiator density and its applications in biosensors.

Hongwei Ma, G. Jin, Jiahai Zhou, 2010, ACS applied materials & interfaces.

Enhancement of ε-poly-l-lysine production by overexpressing the ammonium transporter gene in Streptomyces albulus PD-1

Zhaoxian Xu, Sha Li, Hong Xu, 2018, Bioprocess and Biosystems Engineering.

Structural Basis of a Broadly Selective Acyltransferase from the Polyketide Synthase of Splenocin.

Z. Deng, Yuhui Sun, Hui Zhang, 2018, Angewandte Chemie.

Enhancement of Protein Crystallization Using Nano-Sized Metal–Organic Framework

Zhengtao Xu, Xiwen Xing, Jiahai Zhou, 2022, Crystals.

Chemoenzymatic synthesis of (R)- and (S)-propranolol using an engineered epoxide hydrolase with a high turnover number

Huilei Yu, Jian‐He Xu, X. Kong, 2015 .

The structural view of bacterial translocation‐specific chaperone SecB: implications for function

Zhaohui Xu, Jiahai Zhou, Jiahai Zhou, 2005, Molecular microbiology.

Structural Basis for Stereoselective Dehydration and Hydrogen-Bonding Catalysis by the SAM-Dependent Pericyclase LepI

K. Houk, M. Garcia‐Borràs, Y. Hai, 2018, bioRxiv.

Structural basis for stereoselective dehydration and hydrogen-bonding catalysis by the SAM-dependent pericyclase LepI.

K. Houk, M. Garcia‐Borràs, Y. Hai, 2019 .

Structure-guided engineering of a Thermobifida fusca cutinase for enhanced hydrolysis on natural polyester substrate

Shuguang Yuan, Jiahai Zhou, Lingqia Su, 2020, Bioresources and Bioprocessing.

Stereodivergent Protein Engineering of a Lipase To Access All Possible Stereoisomers of Chiral Esters with Two Stereocenters.

M. Reetz, Meilan Huang, Warispreet Singh, 2019, Journal of the American Chemical Society.

The Structural Basis of Erwinia rhapontici Isomaltulose Synthase

Renxiao Wang, Sha Li, Hong Xu, 2013, PloS one.

Structural insights into xylanase mutant 254RL1 for improved activity and lower pH optimum.

Jiahai Zhou, Guimin Zhang, Lian Wu, 2021, Enzyme and microbial technology.

Enhanced the catalytic efficiency and thermostability of maltooligosyltrehalose synthase from Arthrobacter ramosus by directed evolution

C. Chen, Jiahai Zhou, Lingqia Su, 2020, Biochemical Engineering Journal.

Switching a newly discovered lactonase into an efficient and thermostable phosphotriesterase by simple double mutations His250Ile/Ile263Trp

Jian‐He Xu, Qi Chen, X. Kong, 2014, Biotechnology and bioengineering.

Purification, crystallization and preliminary X-ray analysis of phycocyanin and phycoerythrin from Porphyra yezoensis Ueda.

Jiahai Zhou, P. He, Chuner Cai, 2011, Acta crystallographica. Section F, Structural biology and crystallization communications.

Expression, crystallization and preliminary X-ray analysis of an anomeric inverting agarase from Pseudoalteromonas sp. CY24.

Z. Xia, A. Ren, Jiahai Zhou, 2010, Acta crystallographica. Section F, Structural biology and crystallization communications.

Synthetic biology: A powerful booster for future agriculture

Lanteng Wang, Jiahai Zhou, X. Zang, 2022, Advanced Agrochem.

Photoinduced chemomimetic biocatalysis for enantioselective intermolecular radical conjugate addition

Huimin Zhao, Binju Wang, Jiahai Zhou, 2022, Nature Catalysis.

Biosynthesis of the fungal glyceraldehyde-3-phosphate dehydrogenase inhibitor heptelidic acid and mechanism of self-resistance†

K. Houk, Hsiao‐Ching Lin, Yi Tang, 2020, Chemical science.

l-Ribose isomerase and mannose-6-phosphate isomerase: properties and applications for l-ribose production

Sha Li, Hong Xu, Zheng Xu, 2016, Applied Microbiology and Biotechnology.

In Vitro Reconstitution of the Remaining Steps in Ovothiol A Biosynthesis: C-S Lyase and Methyltransferase Reactions.

Lixin Zhang, Heng Song, Pinghua Liu, 2018, Organic letters.

Synthesis, Curing Behaviors and Properties of a Bio-Based Trifunctional Epoxy Silicone Modified Epoxy Thermosets

Danlin Qian, Hong Fan, Jiahai Zhou, 2022, Polymers.

Regio‐ and Stereoselective Steroid Hydroxylation at C7 by Cytochrome P450 Monooxygenase Mutants

M. Reetz, Sílvia Osuna, M. Garcia‐Borràs, 2020, Angewandte Chemie.

Current Understanding toward Isonitrile Group Biosynthesis and Mechanism.

Wei‐chen Chang, Jiahai Zhou, Yijie Tang, 2020, Chinese journal of chemistry.

Deciphering the Reaction Pathway of Mononuclear Iron Enzyme-Catalyzed N≡C Triple Bond Formation in Isocyanide Lipopeptide and Polyketide Biosynthesis.

Hung‐wen Liu, Z. Zheng, Binju Wang, 2022, ACS catalysis.

Pathway from N-alkylglycine to alkylisonitrile catalyzed by iron(II) and 2-oxoglutarate dependent oxygenases.

Wei‐chen Chang, Jiahai Zhou, Yijie Tang, 2020, Angewandte Chemie.

Discovery and Development of Thiazolo[3,2‐a]pyrimidinone Derivatives as General Inhibitors of Bcl‐2 Family Proteins

Renxiao Wang, Biao Yu, Jiahai Zhou, 2011, ChemMedChem.

Reductive inactivation of the hemiaminal pharmacophore for resistance against tetrahydroisoquinoline antibiotics

Y. Zhang, Ting Shi, G. Tang, 2021, Nature Communications.

An enzymatic Alder-ene reaction

K. Houk, Yi Tang, D. Tan, 2020, Nature.

Engineering Streptomyces coelicolor Carbonyl Reductase for Efficient Atorvastatin Precursor Synthesis

Huilei Yu, Jian‐He Xu, Zhi‐Jun Zhang, 2017, Applied and Environmental Microbiology.

Enhanced enantioselectivity of a carboxyl esterase from Rhodobacter sphaeroides by directed evolution

Jiali Gu, Lingbo Jiang, J. Liu, 2013, Applied Microbiology and Biotechnology.

Resistance-Gene Directed Discovery of a Natural Product Herbicide with a New Mode of Action

S. Jacobsen, J. Gan, Shuguang Yuan, 2018, Nature.

Regioselectivity Engineering of Epoxide Hydrolase: Near-Perfect Enantioconvergence through a Single Site Mutation

Huilei Yu, Jian‐He Xu, Qin Xu, 2018, ACS Catalysis.

Enzymatic cis-Decalin Formation in Natural Product Biosynthesis.

Yi Tang, D. Tan, Jiahai Zhou, 2023, Journal of the American Chemical Society.

Single-step Replacement of an Unreactive C-H Bond by a C-S Bond Using Polysulfide as the Direct Sulfur Source in Anaerobic Ergothioneine Biosynthesis.

Z. Deng, Q. Cui, M. Grinstaff, 2020, ACS catalysis.

Marked enhancement of Acinetobacter sp. organophosphorus hydrolase activity by a single residue substitution Ile211Ala

Jiang Pan, Jian‐He Xu, Qi Chen, 2015, Bioresources and Bioprocessing.

Catalytic Asymmetric Reduction of Difficult-to-Reduce Ketones: Triple Code Saturation Mutagenesis of an Alcohol Dehydrogenase

Manfred T. Reetz, Zhoutong Sun, Guangyue Li, 2016 .

Engineering of an epoxide hydrolase for efficient bioresolution of bulky pharmaco substrates

Shuguang Yuan, She Chen, Lin Li, 2014, Proceedings of the National Academy of Sciences.

A smart library of epoxide hydrolase variants and the top hits for synthesis of (S)-β-blocker precursors.

Jian‐He Xu, X. Kong, Jiahai Zhou, 2014, Angewandte Chemie.

Active site binding and catalytic role of bicarbonate in 1,4-dihydroxy-2-naphthoyl coenzyme A synthases from vitamin K biosynthetic pathways.

Zhihong Guo, M. Jiang, Jiahai Zhou, 2012, Biochemistry.

Enhanced enantioselectivity of a carboxyl esterase from Rhodobacter sphaeroides by directed evolution

Jiali Gu, Jingbo Ma, Lian Wu, 2012, Applied Microbiology and Biotechnology.

Artificial cysteine-lipases with high activity and altered catalytic mechanism created by laboratory evolution

M. Reetz, Meilan Huang, Warispreet Singh, 2019, Nature Communications.

Structural and Computational Insight into the Catalytic Mechanism of Limonene Epoxide Hydrolase Mutants in Stereoselective Transformations.

M. Reetz, Shuguang Yuan, M. Bocola, 2018, Journal of the American Chemical Society.

Structure-Guided Triple-Code Saturation Mutagenesis: Efficient Tuning of the Stereoselectivity of an Epoxide Hydrolase

Manfred T. Reetz, Zhoutong Sun, Aitao Li, 2016 .

Structure-based design of agarase AgWH50C from Agarivorans gilvus WH0801 to enhance thermostability

C. Xue, Xiangzhao Mao, Jianan Sun, 2018, Applied Microbiology and Biotechnology.

Structure-based design of agarase AgWH50C from Agarivorans gilvus WH0801 to enhance thermostability

C. Xue, Xiangzhao Mao, Jianan Sun, 2018, Applied Microbiology and Biotechnology.

Thioesterase-Mediated Synthesis of Teixobactin Analogues: Mechanism and Substrate Specificity.

Wan-Qiu Liu, Jiahai Zhou, Wei Ding, 2018, The Journal of organic chemistry.

Radical S-Adenosyl Methionine Enzyme BlsE Catalyzes a Radical-Mediated 1,2-Diol Dehydration during the Biosynthesis of Blasticidin S.

Hung‐wen Liu, Jin-Ming Gao, Binju Wang, 2022, Journal of the American Chemical Society.

The Radical SAM Enzyme BlsE Catalyzes a Radical Mediated 1,2-Diol Dehydration during the Biosynthesis of Blasticidin S

Hung‐wen Liu, Binju Wang, Jiahai Zhou, 2022 .

Harzianic Acid from Trichoderma afroharzianum Is a Natural Product Inhibitor of Acetohydroxyacid Synthase.

Yi Tang, Jiahai Zhou, Linan Xie, 2021, Journal of the American Chemical Society.

Mechanistic insights into dideoxygenation in gentamicin biosynthesis

P. Leadlay, Z. Deng, Yuhui Sun, 2021, bioRxiv.

Structural basis of Vta1 function in the multi‐vesicular body sorting pathway

Zhaohui Xu, Junyu Xiao, Ishara F Azmi, 2008, Developmental cell.

Structural characterization of the ATPase reaction cycle of endosomal AAA protein Vps4.

Zhaohui Xu, Junyu Xiao, Jiahai Zhou, 2007, Journal of molecular biology.

Molecular basis of LMAN1 in coordinating LMAN1-MCFD2 cargo receptor formation and ER-to-Golgi transport of FV/FVIII.

Shuguang Yuan, Bin Zhang, Jiahai Zhou, 2010, Blood.

Lysine succinylation of Mycobacterium tuberculosis isocitrate lyase (ICL) fine-tunes the microbial resistance to antibiotics

Longxiang Xie, Jianping Xie, Mingliang Zhou, 2017, Journal of biomolecular structure & dynamics.

Crystal structures of Pseudomonas putida esterase reveal the functional role of residues 187 and 287 in substrate binding and chiral recognition.

Jian‐He Xu, Qi Chen, Jie Zhang, 2014, Biochemical and biophysical research communications.

Rational Crystal Polymorph Design of Olanzapine

Jinjin Li, Xiao He, Jiahai Zhou, 2019, Crystal Growth & Design.

The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response

Zhaohui Xu, D. Peisach, R. Kaufman, 2006, Proceedings of the National Academy of Sciences.

Crystal structure of Prp5p reveals interdomain interactions that impact spliceosome assembly.

J. Gu, Jiahai Zhou, Yong-Zhen Xu, 2013, Cell reports.

A Polyketide Cyclase That Forms Medium-Ring Lactones.

K. Houk, Gaoqiang Wang, Yi Tang, 2020, Journal of the American Chemical Society.

Molecular Basis of Prodrug Activation by Human Valacyclovirase, an α-Amino Acid Ester Hydrolase*

G. Amidon, Zhaohui Xu, Kyung-Dall Lee, 2008, Journal of Biological Chemistry.

receptor formation and ER-to-Golgi transport of FV/FVIII Molecular basis of LMAN1 in coordinating LMAN1-MCFD2 cargo

Shuguang Yuan, Bin Zhang, Jiahai Zhou, 2011 .

EF-hand domains of MCFD2 mediate interactions with both LMAN1 and coagulation factor V or VIII.

Bin Zhang, Jiahai Zhou, Hui-hui Liu, 2010, Blood.

Functional Implementation of the Posttranslational SecB-SecA Protein-Targeting Pathway in Bacillus subtilis

Zhaohui Xu, Sheng Yang, R. Freudl, 2011, Applied and Environmental Microbiology.

Crystal structure of tyrosine decarboxylase and identification of key residues involved in conformational swing and substrate binding

Y. Ni, Guochao Xu, Ruizhi Han, 2016, Scientific Reports.

The structural basis of an NADP+-independent dithiol oxidase in FK228 biosynthesis

J. Li, Yi-Qiang Cheng, Jiahai Zhou, 2014, Scientific Reports.

An unusual UMP C-5 methylase in nucleoside antibiotic polyoxin biosynthesis

Z. Deng, Renxiao Wang, Jiahai Zhou, 2016, Protein & Cell.

Structural basis of nonribosomal peptide macrocyclization in fungi.

Ralph A. Cacho, Yi Tang, Zhu Liu, 2016, Nature chemical biology.

Structural Basis of the Induced-Fit Mechanism of 1,4-Dihydroxy-2-Naphthoyl Coenzyme A Synthase from the Crotonase Fold Superfamily

Zhihong Guo, M. Jiang, Jiahai Zhou, 2013, PloS one.

Structural Insight into Enantioselective Inversion of an Alcohol Dehydrogenase Reveals a "Polar Gate" in Stereorecognition of Diaryl Ketones.

Y. Ni, U. Schwaneberg, Yi-Lei Zhao, 2018, Journal of the American Chemical Society.

Structural and mechanistic basis of the high catalytic activity of monooxygenase Tet(X4) on tigecycline

Rong Zhang, Jiahai Zhou, E. Chan, 2021, BMC Biology.

Solution structure of the Magnaporthe oryzae avirulence protein AvrPiz-t

Maili Liu, Xu Zhang, Hong-Yu Hu, 2013, Journal of Biomolecular NMR.

Structural determinants of SecB recognition by SecA in bacterial protein translocation

Zhaohui Xu, Jiahai Zhou, Jiahai Zhou, 2003, Nature Structural Biology.

Enzymatic hydrolysis of l-azetidine-2-carboxylate ring opening

Lanteng Wang, Xiwen Xing, Jiahai Zhou, 2023, Catalysis Science & Technology.

Enhanced Separation Performance of Hierarchically Porous Membranes Fabricated via the Combination of Crystallization Template and Foaming

D. Fan, Avner Ronen, Minggang Li, 2022, Polymers.

Dioxane Bridge Formation during the Biosynthesis of Spectinomycin Involves a Twitch Radical S-Adenosyl Methionine Dehydrogenase That May Have Evolved from an Epimerase.

Hung‐wen Liu, Jiahai Zhou, M. Ruszczycky, 2022, Journal of the American Chemical Society.

Tandem intermolecular [4 + 2] cycloadditions are catalysed by glycosylated enzymes for natural product biosynthesis

Jiahai Zhou, K. Houk, Jiawang Liu, 2023, Nature Chemistry.

X‐ray crystallographic and enzymatic analyses of shikimate dehydrogenase from Staphylococcus epidermidis

Hualiang Jiang, Xu Shen, Cong Han, 2009, The FEBS journal.

The engineering of decameric d-fructose-6-phosphate aldolase A by combinatorial modulation of inter- and intra-subunit interactions.

Hongwei Yu, Jiahai Zhou, Lidan Ye, 2020, Chemical communications.

An unusual UMP C-5 methylase in nucleoside antibiotic polyoxin biosynthesis

Z. Deng, Renxiao Wang, Jiahai Zhou, 2016, Protein & Cell.

Enzymatic catalysis favours eight-membered over five-membered ring closure in bicyclomycin biosynthesis

G. Tang, Jiahai Zhou, Hai-Xue Pan, 2023, Nature Catalysis.

Structural Insight into the Catalytic Mechanism of the Endoperoxide Synthase FtmOx1.

Binju Wang, Jiahai Zhou, Zhanfeng Wang, 2021, Angewandte Chemie.

Crystal Structures and Catalytic Mechanism of l-erythro-3,5-Diaminohexanoate Dehydrogenase and Rational Engineering for Asymmetric Synthesis of β-Amino Acids.

Qiaqing Wu, Dunming Zhu, Jiahai Zhou, 2021, Angewandte Chemie.

Crystal Structure of OvoB

Heng Song, Pinghua Liu, Jiahai Zhou, 2018 .

The crystal structure of an agarase, AgWH50C

C. Xue, Xiangzhao Mao, Jianan Sun, 2019 .

Structure-based design of agarase AgWH50C from Agarivorans gilvus WH0801 to enhance thermostability

C. Xue, Xiangzhao Mao, Jianan Sun, 2018, Applied Microbiology and Biotechnology.

Crystal structure of Prp5p reveals interdomain interactions that impact spliceosome assembly.

Jiahai Zhou, Yong-Zhen Xu, Qing Tang, 2013, Cell reports.

Preparation and Characterization of Metal–Organic Framework Coatings for Improving Protein Crystallization Screening

Xiwen Xing, Jiahai Zhou, Qin Yang, 2023, Nanomaterials.

Crystal structures of Pseudomonas putida esterase reveal the functional role of residues 187 and 287 in substrate binding and chiral recognition.

Jian‐He Xu, Qi Chen, Jie Zhang, 2014, Biochemical and Biophysical Research Communications - BBRC.

Solution structure of the Magnaporthe oryzae avirulence protein AvrPiz-t

Maili Liu, Xu Zhang, Hong-Yu Hu, 2013, Journal of Biomolecular NMR.

GyrI-like proteins catalyze cyclopropanoid hydrolysis to confer cellular protection

Shuguang Yuan, H. C. S. Chan, Y. Igarashi, 2017, Nature Communications.