J. Cummings

发表

Toxin-antitoxin systems and regulatory mechanisms in Mycobacterium tuberculosis.

R. Slayden, Clinton C. Dawson, J. Cummings, 2018, Pathogens and disease.

during Infection to Bacterial Viability and Is Expressed Essential Carrier Protein Reductase Gene Is The Francisella tularensis FabI Enoyl-Acyl

P. Tonge, K. Brookman, C. Kingry, 2014 .

Rational Design of Broad Spectrum Antibacterial Activity Based on a Clinically Relevant Enoyl-Acyl Carrier Protein (ACP) Reductase Inhibitor*

C. Sotriffer, P. Tonge, C. Kisker, 2014, The Journal of Biological Chemistry.

Modulating the Spectrum of FabI Inhibition by Pyridones 1 Rational Design of Broad-Spectrum Antibacterial Activity based on a Clinically Relevant Enoyl-ACP Reductase Inhibitor *

C. Sotriffer, P. Tonge, C. Kisker, 2014 .

The Francisella tularensis FabI Enoyl-Acyl Carrier Protein Reductase Gene Is Essential to Bacterial Viability and Is Expressed during Infection

P. Tonge, K. Brookman, R. Slayden, 2012, Journal of bacteriology.

Efficacy Target of a Novel Chemotherapeutic with Growth and Is the In Vivo Essential for Carrier Protein Reductase FabI 1 Is The Burkholderia pseudomallei Enoyl-Acyl

Herbert, P. Tonge, R. Slayden, 2014 .

The Burkholderia pseudomallei Enoyl-Acyl Carrier Protein Reductase FabI1 Is Essential for In Vivo Growth and Is the Target of a Novel Chemotherapeutic with Efficacy

P. Tonge, H. Schweizer, R. Slayden, 2013, Antimicrobial Agents and Chemotherapy.

Rationalizing the Binding Kinetics for the Inhibition of the Burkholderia pseudomallei FabI1 Enoyl-ACP Reductase.

P. Tonge, C. Kisker, R. Slayden, 2017, Biochemistry.

Thiolactomycin-Based Inhibitors of Bacterial β-Ketoacyl-ACP Synthases with in Vivo Activity.

P. Tonge, R. Slayden, Susan E. Knudson, 2016, Journal of medicinal chemistry.

Rational Optimization of Diphenyl Ether Binding Kinetics to the Enoyl-ACP Reductase FabI1 from Burkholderia pseudomallei

P. Tonge, C. Kisker, R. Slayden, 2017 .

Quantitative interactions between cryptdin-4 amino terminal variants and membranes

M. Selsted, A. Ouellette, T. Vanderlick, 2003, Peptides.

Matrix Metalloproteinase-7 Activation of Mouse Paneth Cell Pro-α-defensins

A. Ouellette, S. Crampton, T. Vanderlick, 2006, Journal of Biological Chemistry.

Kinetics of cryptdin-4 translocation coupled with peptide-induced vesicle leakage.

T. Vanderlick, J. Cummings, 2007, Biochemistry.

Substituted Diphenyl Ethers as a Novel Chemotherapeutic Platform against Burkholderia pseudomallei

P. Tonge, H. Schweizer, R. Slayden, 2013, Antimicrobial Agents and Chemotherapy.

Discovery of a novel type IIb RelBE toxin‐antitoxin system in Mycobacterium tuberculosis defined by co‐regulation with an antisense RNA

R. Slayden, Clinton C. Dawson, J. Cummings, 2022, Molecular microbiology.

Rational design of a new antibiotic class for drug-resistant infections

S. McLeod, A. Ferguson, G. Drusano, 2021, Nature.

Benzimidazole-based antibacterial agents against Francisella tularensis.

Kunal Kumar, R. Slayden, Susan E. Knudson, 2013, Bioorganic & medicinal chemistry.

Binding orientation and activity determinants of the antimicrobial peptide cryptdin-4 revealed by potency of mutants.

T. Vanderlick, J. Cummings, 2007, Colloids and surfaces. B, Biointerfaces.

New Investigations with Lupane Type A-Ring Azepane Triterpenoids for Antimycobacterial Drug Candidate Design

G. Robertson, R. Slayden, O. Kazakova, 2021, International journal of molecular sciences.

Transient In Vivo Resistance Mechanisms of Burkholderia pseudomallei to Ceftazidime and Molecular Markers for Monitoring Treatment Response

R. Slayden, J. Cummings, 2017, PLoS neglected tropical diseases.

Optimization of TopoIV Potency, ADMET Properties, and hERG Inhibition of 5-Amino-1,3-dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Identification of a Lead with In Vivo Efficacy against MRSA.

Mark J. Mitton-Fry, S. Lindert, C. McElroy, 2021, Journal of medicinal chemistry.

Manganese exposure in juvenile C57BL/6 mice increases glial inflammatory responses in the substantia nigra following infection with H1N1 influenza virus

Richard J Smeyne, R. Slayden, J. Cummings, 2021, PloS one.

TPR1, a novel rifampicin derivative, demonstrates efficacy alone and in combination with doxycycline against the NIAID Category A priority pathogen Francisella tularensis

R. Slayden, J. Cummings, Keaton W. Slayden, 2021, JAC-antimicrobial resistance.

TPR1, a novel rifampin derivative demonstrates efficacy alone and in combination with doxycycline against the NIAID Category A Priority Pathogen F. tularensis

R. Slayden, J. Cummings, Keaton W. Slayden, 2021, bioRxiv.

A Novel Glucocorticoid and Androgen Receptor Modulator Reduces Viral Entry and Innate Immune Inflammatory Responses in the Syrian Hamster Model of SARS-CoV-2 Infection

R. Slayden, N. Theise, T. Schountz, 2022, Frontiers in Immunology.

Structure-activity determinants in paneth cell alpha-defensins: loss-of-function in mouse cryptdin-4 by charge-reversal at arginine residue positions.

M. Selsted, A. Ouellette, T. Vanderlick, 2004, The Journal of biological chemistry.

Aggregation and hemi-fusion of anionic vesicles induced by the antimicrobial peptide cryptdin-4.

T. Vanderlick, J. Cummings, 2007, Biochimica et biophysica acta.

Mechanism and inhibition of the FabI enoyl-ACP reductase from Burkholderia pseudomallei.

P. Tonge, R. Slayden, K. England, 2011, The Journal of antimicrobial chemotherapy.

Formulation studies of InhA inhibitors and combination therapy to improve efficacy against Mycobacterium tuberculosis.

P. Tonge, R. Slayden, Susan E. Knudson, 2016, Tuberculosis.

Immune Modulation as an Effective Adjunct Post-exposure Therapeutic for B. pseudomallei

W. Hanneman, R. Slayden, J. Cummings, 2016, PLoS neglected tropical diseases.

A novel glucocorticoid and androgen receptor modulator reduces viral entry and innate immune inflammatory responses in the Syrian Hamster model of SARS-CoV-2

R. Slayden, N. Theise, T. Schountz, 2021, bioRxiv.

Rapid in vitro activity of telavancin against Bacillus anthracis and in vivo protection against inhalation anthrax infection in the rabbit model

D. Beasley, W. Baze, E. Whorton, 2023, bioRxiv.

Improved non-redundant species screening panels for benchmarking the performance of new investigational antibacterial candidates against Category A and B priority pathogens

Z. Abdo, R. Slayden, J. Cummings, 2022, JAC-antimicrobial resistance.

Structure-Activity Determinants in Paneth Cell α-Defensins

M. Selsted, A. Ouellette, T. Vanderlick, 2004, Journal of Biological Chemistry.

Rational Design of Broad-Spectrum Antibacterial Activity based on a Clinically Relevant Enoyl-ACP Reductase Inhibitor*

P. Tonge, C. Kisker, R. Slayden, 2014 .

Mechanism and inhibition of the FabI enoyl-ACP reductase from Burkholderia pseudomallei.

P. Tonge, R. Slayden, K. England, 2011, The Journal of antimicrobial chemotherapy.