I. Owens

发表

The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence.

D W Nebert, A Bairoch, J Magdalou, 1997, Pharmacogenetics.

Glucuronidation of 7-ethyl-10-hydroxycamptothecin (SN-38) by the human UDP-glucuronosyltransferases encoded at the UGT1 locus.

M. Ciotti, M. Brangi, I. Owens, 1999, Biochemical and biophysical research communications.

Human UDP-glucuronosyltransferases show atypical metabolism of mycophenolic acid and inhibition by curcumin.

I. Owens, L. Kole, N. Basu, 2004, Drug metabolism and disposition: the biological fate of chemicals.

Genetic regulation of UDP-glucuronosyltransferase induction by polycyclic aromatic compounds in mice. Co-segregation with aryl hydrocarbon (benzo(alpha)pyrene) hydroxylase induction.

I. Owens, 1977, The Journal of biological chemistry.

Expression of UDP-glucuronosyltransferase cDNA in Saccharomyces cerevisiae as a membrane-bound and as a cytosolic form.

T. Kimura, I. Owens, F. Toghrol, 1990, Biochemistry.

Aryl hydrocarbon hydroxylase induction in mammalian liver-derived cell cultures. Effects of various metabolic inhibitors on the enzyme activity in hepatoma cells.

D. Nebert, I. Owens, 1976, Biochemical pharmacology.

Effect of different detergent systems on the molecular size of UDP glucuronosyltransferase and other microsomal drug-metabolizing enzymes.

P. Mackenzie, M. Lang, I. Owens, 1984, Membrane biochemistry.

Differences in UDP-glucuronosyltransferase activities in congenic inbred rats homozygous and heterozygous for the jaundice locus.

P. Mackenzie, I. Owens, 1983, Biochemical pharmacology.

Mouse pulmonary cytochrome P-450 naphthalene hydroxylase: cDNA cloning, sequence, and expression in Saccharomyces cerevisiae.

M. Negishi, J. Ritter, I. Owens, 1991, Biochemistry.

Regulatory gene product of the Ah locus. Characterization of receptor mutants among mouse hepatoma clones.

O. Hankinson, D. Nebert, H. Eisen, 1982, The Journal of biological chemistry.

Aryl hydrocarbon hydroxylase induction in mammalian liver-derived cell cultures. Stimulation of "cytochrome P1-450-associated" enzyme activity by many inducing compounds.

D. Nebert, I. Owens, 1975, Molecular pharmacology.

Aryl hydrocarbon hydroxylase induction in mammalian liver cell culture. IV. Stimulation of the enzyme activity in established cell lines derived from rat or mouse hepatoma and from normal rat liver.

W. Benedict, J. Gielen, I. Owens, 1973, Biochemical pharmacology.

The novel bilirubin/phenol UDP-glucuronosyltransferase UGT1 gene locus: implications for multiple nonhemolytic familial hyperbilirubinemia phenotypes.

J. Ritter, I. Owens, 1992, Pharmacogenetics.

The Major Chemical-detoxifying System of UDP-glucuronosyltransferases Requires Regulated Phosphorylation Supported by Protein Kinase C*

P. Mitra, I. Owens, L. Kole, 2008, Journal of Biological Chemistry.

Targeted inhibition of glucuronidation markedly improves drug efficacy in mice - a model.

I. Owens, A. Mcdonagh, L. Kole, 2007, Biochemical and biophysical research communications.

2,3,7,8-tetrachlorodibenzo-p-dioxin as cocarcinogen causing 3-methylcholanthrene-initiated subcutaneous tumors in mice genetically "nonresponsive" at Ah locus.

D. Jerina, R. E. Kouri, D. Nebert, 1978, Cancer research.

Expression of human liver 3, 4-catechol estrogens UDP-Glucuronosyltransferase cDNA in COS 1 cells

I. Owens, Y. Sheen, M. Ahn, 1997, Archives of pharmacal research.

Cloning and expression of human liver UDP-glucuronosyltransferase cDNA, UDPGTh2

I. Owens, Y. Sheen, Misook Dong, 1997, Archives of pharmacal research.

Mouse UDP glucuronosyltransferase. cDNA and complete amino acid sequence and regulation.

T. Kimura, I. Owens, 1987, European journal of biochemistry.

Src supports UDP-glucuronosyltransferase-2B7 detoxification of catechol estrogens associated with breast cancer.

P. Mitra, I. Owens, N. Basu, 2009, Biochemical and biophysical research communications.

Genetic expression of aryl hydrocarbon hydroxylase induction. VI. Control of other aromatic hydrocarbon-inducible mono-oxygenase activities at or near the same genetic locus.

D. Nebert, I. Owens, N. Considine, 1973, Archives of biochemistry and biophysics.

Hemopexin and aryl hydrocarbon hydroxylase induction in the mouse and in cell culture.

D. Nebert, U. Müller‐Eberhard, I. Owens, 1978, Biochemical pharmacology.

UDP-glucuronosyltransferases: gene structures of UGT1 and UGT2 families.

R. Banerjee, I. Owens, N. Basu, 2005, Methods in enzymology.

Concerning the necessary coupling of development to proliferation of mouse mammary epithelial cells.

Y. J. Topper, B. Vonderhaar, I. Owens, 1973, The Journal of biological chemistry.

An early effect of prolactin on the formation of -lactalbumin by mouse mammary epithelial cells.

Y. J. Topper, B. Vonderhaar, I. Owens, 1973, The Journal of biological chemistry.

Differential and Special Properties of the Major Human UGT1-encoded Gastrointestinal UDP-glucuronosyltransferases Enhance Potential to Control Chemical Uptake*

P. Mitra, M. Ciotti, I. Owens, 2004, Journal of Biological Chemistry.

Phosphorylation of a UDP-glucuronosyltransferase regulates substrate specificity.

P. Mitra, J. Rivera, R. Banerjee, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Some aspects of mouse mammary gland development from maturity to early pregnancy

Y. J. Topper, T. Oka, B. Vonderhaar, 1972, In Vitro.

Purification of a form of mouse liver UDP glucuronosyltransferase which glucuronidates androgens.

P. Mackenzie, I. Owens, 1983, Journal of steroid biochemistry.

Separation of different UDP glucuronosyltransferase activities according to charge heterogeneity by chromatofocusing using mouse liver microsomes. Three major types of aglycones.

P. Mackenzie, I. Owens, P. J. Munson, 1985, Biochemical pharmacology.

Cell-free translation of mouse liver mRNA coding for two forms of UDP glucuronosyltransferase.

P. Mackenzie, F. Gonzalez, I. Owens, 1984, Archives of biochemistry and biophysics.

The phenobarbital response enhancer module in the human bilirubin UDP‐glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR

J. Sugatani, T. Sueyoshi, M. Negishi, 2001, Hepatology.

Delayed response to phenobarbital treatment of a Crigler-Najjar type II patient with partially inactivating missense mutations in the bilirubin UDP-glucuronosyltransferase gene.

M. Ciotti, S. Werlin, I. Owens, 1999, Journal of pediatric gastroenterology and nutrition.

2-Fluoro-L-histidine, an inhibitor of enzyme induction.

D. Klein, J. Weller, K. Kirk, 1976, Molecular pharmacology.

A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini.

J. Ritter, S. Kimura, I. Owens, 1992, The Journal of biological chemistry.

Gene structure at the human UGT1 locus creates diversity in isozyme structure, substrate specificity, and regulation.

J. Ritter, I. Owens, Ida S. Owens, 1995, Progress in nucleic acid research and molecular biology.

Deoxyribonucleic acid binding of 3-hydroxy- and 9-hydroxybenzo[a]pyrene following further metabolism by mouse liver microsomal cytochrome P1-450.

O. Pelkonen, C. Legraverend, I. Owens, 1979, Biochemical pharmacology.

Regulated Phosphorylation of a Major UDP-glucuronosyltransferase Isozyme by Tyrosine Kinases Dictates Endogenous Substrate Selection for Detoxification*

P. Mitra, I. Owens, T. Saha, 2010, The Journal of Biological Chemistry.

Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily.

C. Guillemette, J. Miners, D. Nebert, 2005, Pharmacogenetics and genomics.

Genetic polymorphism in the human UGT1A6 (planar phenol) UDP-glucuronosyltransferase: pharmacological implications.

M. Ciotti, I. Owens, A. Marrone, 1997, Pharmacogenetics.

Characterization of a cloned human dihydrotestosterone/androstanediol UDP-glucuronosyltransferase and its comparison to other steroid isoforms.

O. Mcbride, M. Wang, R. Lubet, 1993, Biochemistry.

Purification and immunochemical characterization of a low-pI form of UDP glucuronosyltransferase from mouse liver.

P. Mackenzie, I. Owens, L. Hjelmeland, 1984, Archives of biochemistry and biophysics.

Protein Kinase Cα and Src Kinase Support Human Prostate-distributed Dihydrotestosterone-metabolizing UDP-glucuronosyltransferase 2B15 Activity*

S. Jana, A. Raychoudhuri, I. Owens, 2012, The Journal of Biological Chemistry.

The glucuronidation of exogenous and endogenous compounds by stably expressed rat and human UDP-glucuronosyltransferase 1.1.

M. Green, T. Tephly, C. King, 1996, Archives of biochemistry and biophysics.

Cloning and expression of human liver UDP-glucuronosyltransferase in COS-1 cells. 3,4-catechol estrogens and estriol as primary substrates.

J. Ritter, I. Owens, Y. Sheen, 1990, The Journal of biological chemistry.

DEVELOPMENT OF THE LACTOSE SYNTHETASE SYSTEM

Y. J. Topper, I. Owens, 1972 .

Cloning of two human liver bilirubin UDP-glucuronosyltransferase cDNAs with expression in COS-1 cells.

J. Crawford, J. Ritter, I. Owens, 1991, The Journal of biological chemistry.

Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus.

Matthew W. Pennington, S. Carvalho, Q. Gong, 2001, Pharmacogenetics.

The novelUGT1 gene complex links bilirubin, xenobiotics, and therapeutic drug metabolism by encoding UDP-glucuronosyltransferase isozymes with a common carboxyl terminus

J. Ritter, I. Owens, Fan Chen, 1996, Journal of Pharmacokinetics and Biopharmaceutics.

Identification of a genetic alteration in the code for bilirubin UDP-glucuronosyltransferase in the UGT1 gene complex of a Crigler-Najjar type I patient.

J. Ritter, I. Owens, P. Ferreira, 1992, The Journal of clinical investigation.

Coding defect and a TATA box mutation at the bilirubin UDP-glucuronosyltransferase gene cause Crigler-Najjar type I disease.

M. Ciotti, I. Owens, F. Chen, 1998, Biochimica et biophysica acta.

Glucuronidation of benzidine and its metabolites by cDNA-expressed human UDP-glucuronosyltransferases and pH stability of glucuronides.

M. Ciotti, V. Lakshmi, I. Owens, 1999, Carcinogenesis.

Evidence for overlapping active sites for 17 alpha-ethynlestradiol and bilirubin in the human major bilirubin UDPglucuronosyltransferase.

M. Ciotti, I. Owens, 1996, Biochemistry.

Two human liver cDNAs encode UDP-glucuronosyltransferases with 2 log differences in activity toward parallel substrates including hyodeoxycholic acid and certain estrogen derivatives.

R. Lubet, J. Ritter, I. Owens, 1992, Biochemistry.

A novel action of insulin on phosphoprotein formation by mammary gland explants.

Y. J. Topper, I. Owens, A. Voytovich, 1969, Proceedings of the National Academy of Sciences of the United States of America.

Genetic defects at the UGT1 locus associated with Crigler-Najjar type I disease, including a prenatal diagnosis.

M. Ciotti, I. Owens, M. G. Martin, 1997, American journal of medical genetics.

Identification of two single base substitutions in the UGT1 gene locus which abolish bilirubin uridine diphosphate glucuronosyltransferase activity in vitro.

N. Martin, J. Ritter, I. Owens, 1994, The Journal of clinical investigation.

A phenylalanine codon deletion at the UGT1 gene complex locus of a Crigler-Najjar type I patient generates a pH-sensitive bilirubin UDP-glucuronosyltransferase.

J. Ritter, B. Gridelli, I. Owens, 1993, The Journal of biological chemistry.

Comparison of glucuronidating activity of two human cDNAs, UDPGTh1 and UDPGTh2

I. Owens, Y. Sheen, Soon-Sun Kim, 1997, Archives of pharmacal research.

Altered Coding for a Strictly Conserved Di-glycine in the Major Bilirubin UDP-glucuronosyltransferase of a Crigler-Najjar Type I Patient *

R. Sokol, M. Ciotti, I. Owens, 1995, The Journal of Biological Chemistry.

Cleavage of nascent UDP glucuronosyltransferase from rat liver by dog pancreatic microsomes.

P. Mackenzie, I. Owens, 1984, Biochemical and biophysical research communications.

Mutagenesis of certain benzo(a)pyrene phenols in vitro following further metabolism by mouse liver.

C. Legraverend, I. Owens, G. M. Koteen, 1979, Biochemical pharmacology.

UDP-glucuronosyltransferase activities. Guidelines for consistent interim terminology and assay conditions.

G. Siest, G. Mulder, B. Burchell, 1983, Biochemical pharmacology.

Aryl Hydrocarbon Hydroxylase. Evidence of Receptors for Induction Process in Cell Culture

D. Nebert, I. Owens, T. Guenthner, 1979 .

Gastrointestinally Distributed UDP-glucuronosyltransferase 1A10, Which Metabolizes Estrogens and Nonsteroidal Anti-inflammatory Drugs, Depends upon Phosphorylation*

M. Meselhy, M. Ciotti, I. Owens, 2004, Journal of Biological Chemistry.

Evidence for phosphorylation requirement for human bilirubin UDP-glucuronosyltransferase (UGT1A1) activity.

I. Owens, L. Kole, N. Basu, 2003, Biochemical and biophysical research communications.

Required buried alpha-helical structure in the bilirubin UDP-glucuronosyltransferase, UGT1A1, contains a nonreplaceable phenylalanine.

M. Ciotti, I. Owens, J. Cho, 1998, Biochemistry.

Genetic regulation of bilirubin-UDP-glucuronosyltransferase induction by polycyclic aromatic compounds and phenobarbital in mice. Association with aryl hydrocarbon (benzo[a]pyrene) hydroxylase induction.

I. Owens, N. Malik, 1981, The Journal of biological chemistry.

Cloning and characterization of DNA complementary to rat liver UDP-glucuronosyltransferase mRNA.

P. Mackenzie, F. Gonzalez, I. Owens, 1984, The Journal of biological chemistry.

Gene expression, ontogeny and transplacental induction of hepatic UDP-glucuronosyl transferase activity in mice.

L. Anderson, I. Owens, D. Chauhan, 1991, Developmental pharmacology and therapeutics.

Induction of abnormal cell division in Euglena gracilis by glutamic diethyl ester.

J. Blum, I. Owens, 1969, The Journal of protozoology.

Amino acid esters as inhibitors of growth and of aminoacyl transfer ribonucleic acid synthetases in Euglena and Astasia.

J. Blum, I. Owens, 1967, The Journal of biological chemistry.

Human liver glucuronidation of benzidine.

S. R. Babu, V. Lakshmi, I. Owens, 1994, Carcinogenesis.

Some aspects of mouse mammary gland development from maturity to early pregnancy

Y. J. Topper, T. Oka, B. Vonderhaar, 1972, In Vitro.