Claudia H. Ruiz

发表

Evaluation of Platensimycin and Platensimycin-Inspired Thioether Analogues against Methicillin-Resistant Staphylococcus aureus in Topical and Systemic Infection Mouse Models.

B. Shen, Lin Qiu, M. Cameron, 2019, Molecular pharmaceutics.

Synthesis and SAR of 4-(pyrazol-3-yl)-pyridines as novel c-jun N-terminal kinase inhibitors.

P. Lograsso, M. Cameron, Y. Ling, 2011, Bioorganic & medicinal chemistry letters.

Synthesis and SAR of 2-phenoxypyridines as novel c-Jun N-terminal kinase inhibitors.

M. Cameron, T. Kamenecka, Claudia H. Ruiz, 2011, Bioorganic & medicinal chemistry letters.

In vivo instability of platensimycin and platencin: Synthesis and biological evaluation of urea- and carbamate-platensimycin.

B. Shen, M. Cameron, Claudia H. Ruiz, 2017, Bioorganic & medicinal chemistry.

Synthesis, biological evaluation, X-ray structure, and pharmacokinetics of aminopyrimidine c-jun-N-terminal kinase (JNK) inhibitors.

P. Lograsso, J. Habel, M. Cameron, 2010, Journal of medicinal chemistry.

Structure-Activity Relationship and Biological Investigation of SR18292 (16), a Suppressor of Glucagon-Induced Glucose Production.

P. Puigserver, P. Griffin, K. Sharabi, 2021, Journal of medicinal chemistry.

Tetrahydroisoquinoline derivatives as highly selective and potent Rho kinase inhibitors.

P. Lograsso, S. Schürer, J. Pocas, 2010, Journal of medicinal chemistry.

Discovery and optimization of indoles and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-I).

P. Lograsso, S. Schürer, J. Pocas, 2011, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of 4-quinazolinones as Rho kinase inhibitors.

P. Lograsso, J. Pocas, Yan Yin, 2011, Bioorganic & medicinal chemistry letters.

The development of benzimidazoles as selective rho kinase inhibitors.

P. Lograsso, J. Pocas, Yan Yin, 2010, Bioorganic & Medicinal Chemistry Letters.

Benzimidazole- and benzoxazole-based inhibitors of Rho kinase.

P. Lograsso, S. Schürer, J. Pocas, 2008, Bioorganic & medicinal chemistry letters.

Chroman-3-amides as potent Rho kinase inhibitors.

P. Lograsso, S. Schürer, M. Cameron, 2008, Bioorganic & medicinal chemistry letters.

Identification of an aminothiazole series of RORβ modulators.

Ruben D. Garcia-Ordonez, P. Griffin, M. Cameron, 2018, Bioorganic & medicinal chemistry letters.

Synthesis and SAR of 2,4-diaminopyrimidines as potent c-jun N-terminal kinase inhibitors

M. Cameron, Y. Ling, T. Kamenecka, 2012 .

Design, Synthesis, and Biological Evaluation of Indole Biphenylcarboxylic Acids as PPARγ Antagonists.

Scott A. Busby, Ruben D. Garcia-Ordonez, P. Griffin, 2015, ACS medicinal chemistry letters.

Synthesis and biological evaluation of urea derivatives as highly potent and selective rho kinase inhibitors.

P. Lograsso, J. Pocas, Yan Yin, 2013, Journal of medicinal chemistry.

Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors.

P. Lograsso, S. Schürer, J. Pocas, 2009, Bioorganic & medicinal chemistry letters.

Morphing Natural Product Platensimycin via Heck, Sonogashira, and One-Pot Sonogashira/Cycloaddition Reactions to Produce Antibiotics with In Vivo Activity

M. Cameron, Youchao Deng, Claudia H. Ruiz, 2022, Antibiotics.

Development of a putative Zn2+-chelating but highly selective MMP-13 inhibitor.

Mark S. Sundrud, G. Fields, M. Cameron, 2022, Bioorganic & medicinal chemistry letters.

Discovery of Hydrolysis-Resistant Isoindoline N-Acyl Amino Acid Analogues that Stimulate Mitochondrial Respiration.

B. Spiegelman, P. Griffin, D. Nomura, 2018, Journal of medicinal chemistry.

Synthesis and SAR of tetrahydroisoquinolines as Rev-erbα agonists.

D. Kojetin, Subhashish Banerjee, M. Cameron, 2012, Bioorganic & Medicinal Chemistry Letters.

Rational development of 4-aminopyridyl-based inhibitors targeting Trypanosoma cruzi CYP51 as anti-chagas agents.

J. McKerrow, M. Cameron, W. Roush, 2013, Journal of medicinal chemistry.

Characterization of Dasatinib and Its Structural Analogs as CYP3A4 Mechanism-Based Inactivators and the Proposed Bioactivation Pathways

M. Cameron, Xiaohai Li, Yuanjun He, 2009, Drug Metabolism and Disposition.

Structure-activity relationships, and drug metabolism and pharmacokinetic properties for indazole piperazine and indazole piperidine inhibitors of ROCK-II.

P. Lograsso, M. Cameron, Claudia H. Ruiz, 2007, Bioorganic & medicinal chemistry letters.

Development of matrix metalloproteinase-13 inhibitors - A structure-activity/structure-property relationship study.

G. Fields, M. Cameron, W. Roush, 2018, Bioorganic & medicinal chemistry.

Small Molecule c-jun-N-terminal Kinase (JNK) Inhibitors Protect Dopaminergic Neurons in a Model of Parkinson's Disease.

Li Lin, P. Lograsso, M. Cameron, 2011, ACS chemical neuroscience.

Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors.

P. Lograsso, S. Schürer, Yan Yin, 2008, Journal of medicinal chemistry.

Probing the Complex Binding Modes of the PPARγ Partial Agonist 2-Chloro-N-(3-chloro-4-((5-chlorobenzo[d]thiazol-2-yl)thio)phenyl)-4-(trifluoromethyl)benzenesulfonamide (T2384) to Orthosteric and Allosteric Sites with NMR Spectroscopy.

Ian Mitchelle S. de Vera, T. Hughes, D. Kojetin, 2016, Journal of medicinal chemistry.

Structure-based design of bitopic ligands for the µ-opioid receptor

Samuel T. Slocum, B. Roth, V. Katritch, 2022, Nature.

Development of dual casein kinase 1δ/1ε (CK1δ/ε) inhibitors for treatment of breast cancer.

M. Cameron, W. Roush, Claudia H. Ruiz, 2017, Bioorganic & medicinal chemistry.

Small molecule amides as potent ROR-γ selective modulators.

Ruben D. Garcia-Ordonez, P. Griffin, Naresh Kumar, 2013, Bioorganic & medicinal chemistry letters.

Synthesis and SAR of novel isoxazoles as potent c-jun N-terminal kinase (JNK) inhibitors.

P. Lograsso, M. Cameron, Y. Ling, 2014, Bioorganic & medicinal chemistry letters.

Amino acid derived quinazolines as Rock/PKA inhibitors.

P. Lograsso, J. Pocas, M. Cameron, 2013, Bioorganic & medicinal chemistry letters.