M. Gait

发表

In situ hybridization histochemistry: localisation of vasopressin mRNA in rat brain using a biotinylated oligonucleotide probe.

P. Emson, S. Agrawal, H. Arai, 1988, Brain research.

Simultaneous Visualization of Vasopressin and Oxytocin mRNA‐ Containing Neurons in the Hypothalamus Using Non‐Radioactive in situ Hybridization Histochemistry

P. Emson, C. Christodoulou, M. Gait, 1989, Journal of neuroendocrinology.

A New Multiple Labelling Method for Synthetic Oligonucleotides and Increased Sensitivity in DNA Detection

M. Gait, I. Durrant, K. Misiura, 1991 .

Oligonucleotide synthesis : a practical approach

M. Gait, M. J. Gait, 1984 .

Cell-penetrating-peptide-based delivery of oligonucleotides: an overview.

P. Iversen, H. Moulton, B. Lebleu, 2007, Biochemical Society transactions.

Cell-penetrating Peptides

Eric Vives, Birgit Verbeure, E. Vivés, 2003, The Journal of Biological Chemistry.

Synthesis and Splice-Redirecting Activity of Branched, Arginine-Rich Peptide Dendrimer Conjugates of Peptide Nucleic Acid Oligonucleotides

B. Lebleu, A. F. Saleh, M. Gait, 2010, Bioconjugate chemistry.

Improved cell-penetrating peptide–PNA conjugates for splicing redirection in HeLa cells and exon skipping in mdx mouse muscle

B. Lebleu, M. Wood, H. Yin, 2008, Nucleic acids research.

Pip6-PMO, A New Generation of Peptide-oligonucleotide Conjugates With Improved Cardiac Exon Skipping Activity for DMD Treatment

S. Hammond, M. Wood, A. F. Saleh, 2012, Molecular therapy. Nucleic acids.

Peptide-mediated cellular delivery of antisense oligonucleotides and their analogues

M. Gait, 2003, Cellular and Molecular Life Sciences CMLS.

Efficient splicing correction by PNA conjugation to an R6-Penetratin delivery peptide

B. Lebleu, M. Gait, A. Arzumanov, 2007, Nucleic acids research.

Lung delivery studies using siRNA conjugated to TAT(48-60) and penetratin reveal peptide induced reduction in gene expression and induction of innate immunity.

Simon W. Jones, M. Lindsay, B. Sproat, 2007, Bioconjugate chemistry.

Peptide Nanoparticle Delivery of Charge-Neutral Splice-Switching Morpholino Oligonucleotides

S. Hammond, M. Wood, M. Hällbrink, 2015, Nucleic acid therapeutics.

Cell penetrating peptides: overview and applications to the delivery of oligonucleotides

B. Lebleu, A. F. Saleh, M. Gait, 2010, Cellular and Molecular Life Sciences.

RNA targeting with peptide conjugates of oligonucleotides, siRNA and PNA.

Simon W. Jones, M. Gait, A. Arzumanov, 2007, Blood cells, molecules & diseases.

Peptide Conjugates of Oligonucleotides As Enhanced Antisense Agents

V. Korshun, M. Gait, A. Arzumanov, 2000, Molecular Biology.

Studies Towards the Synthesis of Peptide-Oligonucleotide Conjugates

M. Gait, F. Burlina, S. Peyrottes, 1999 .

Systemic antibody-oligonucleotide delivery to the central nervous system ameliorates mouse models of spinal muscular atrophy

S. Hammond, M. Wood, M. Gait, 2021, bioRxiv.

Phosphoramidites and solid supports based on N-substituted 2,4-dihydroxybutyramides: universal reagents for synthesis of modified oligonucleotides

D. Stetsenko, V. Korshun, M. Gait, 2006 .

Solid-phase synthesis of oligoribonucleotides using 9-fluorenylmethoxycarbonyl (Fmoc) for 5'-hydroxyl protection.

C. Christodoulou, M. Gait, C. Lehmann, 1989, Nucleic acids research.

Increased RNAi is related to intracellular release of siRNA via a covalently attached signal peptide.

G. Sczakiel, A. Detzer, M. Overhoff, 2009, RNA.

Combination Antisense Treatment for Destructive Exon Skipping of Myostatin and Open Reading Frame Rescue of Dystrophin in Neonatal mdx Mice.

L. Popplewell, G. Dickson, A. F. Saleh, 2015, Molecular therapy : the journal of the American Society of Gene Therapy.

Steric Block High Affinity Oligonucleotide Analogues: A New Tool for Mapping RNA-Protein Binding Sites

A. Lever, M. Gait, J. Greatorex, 2008, Nucleosides, nucleotides & nucleic acids.

Inhibition of HIV-1 Replication by Oligonucleotide Analogues Directed to the Packaging Signal and Trans-Activating Response Region

A. Lever, M. Gait, A. Arzumanov, 2006, Antiviral chemistry & chemotherapy.

Efficient conjugation of peptides to oligonucleotides by "native ligation".

M. Gait, D. Stetsenko, 2000, The Journal of organic chemistry.

How much dystrophin is enough: the physiological consequences of different levels of dystrophin in the mdx mouse.

S. Hammond, M. Wood, S. El Andaloussi, 2015, Human molecular genetics.

Diaphragm rescue alone prevents heart dysfunction in dystrophic mice.

K. Davies, K. Clarke, H. Moulton, 2011, Human molecular genetics.

Peptide-based in vivo delivery agents for oligonucleotides and siRNA.

P. Järver, M. Gait, T. Coursindel, 2012, Nucleic acid therapeutics.

Identification of novel, therapy-responsive protein biomarkers in a mouse model of Duchenne muscular dystrophy by aptamer-based serum proteomics

H. Lochmüller, R. Manzano, M. Wood, 2015, Scientific Reports.

Cell-penetrating Peptides A REEVALUATION OF THE MECHANISM OF CELLULAR UPTAKE*

E. Vivés, B. Lebleu, L. Chernomordik, 2002 .

A bi-functional siRNA construct induces RNA interference and also primes PCR amplification for its own quantification

J. Milner, M. Jiang, M. Gait, 2005, Nucleic acids research.

MALDI-TOF mass spectral analysis of siRNA degradation in serum confirms an RNAse A-like activity.

Simon W. Jones, M. Lindsay, M. Gait, 2007, Molecular bioSystems.

Rapid synthesis of oligodeoxyribonucleotides. VII. Solid phase synthesis of oligodeoxyribonucleotides by a continuous flow phosphotriester method on a kieselguhr-polyamide support.

B. Sproat, R. Titmas, M. Gait, 1982, Nucleic acids research.

Overview of alternative oligonucleotide chemistries for exon skipping.

A. F. Saleh, M. Gait, A. Arzumanov, 2012, Methods in molecular biology.

Synthesis of site-specifically modified oligoribonucleotides for studies of the recognition of TAR RNA by HIV-1 tat protein and studies of hammerhead ribozymes.

M. Gait, U. Asseline, E. Biała, 1991, Nucleic acids symposium series.

The bacteriophage T4 gene for the small subunit of ribonucleotide reductase contains an intron.

Catherine, B. Sjöberg, C. Mathews, 1986, The EMBO journal.

Identification of a Peptide for Systemic Brain Delivery of a Morpholino Oligonucleotide in Mouse Models of Spinal Muscular Atrophy

S. Hammond, M. Wood, M. Gait, 2017, Nucleic acid therapeutics.

Development of a general methodology for labelling peptide–morpholino oligonucleotide conjugates using alkyne–azide click chemistry† †Electronic supplementary information (ESI) available: Experimental section and supplementary figures. See DOI: 10.1039/c3cc46067c Click here for additional data file.

M. Gait, F. Shabanpoor, 2013, Chemical communications.

Enhanced splice correction by 3′, 5′-serinol and 2′-(ω-O-methylserinol) guarded OMe-RNA/DNA mixmers in cells

M. Gait, A. Arzumanov, Vaijayanti A. Kumar, 2013, Artificial DNA, PNA & XNA.

Systemic peptide-mediated oligonucleotide therapy improves long-term survival in spinal muscular atrophy

M. Bowerman, F. Muntoni, Haiyan Zhou, 2016, Proceedings of the National Academy of Sciences.

Peptide-conjugated phosphodiamidate oligomer-mediated exon skipping has benefits for cardiac function in mdx and Cmah-/-mdx mouse models of Duchenne muscular dystrophy

G. MacGowan, R. Manzano, M. Wood, 2018, PloS one.

Uridine 2′‐Carbamates: Facile Tools for Oligonucleotide 2′‐Functionalization

D. Stetsenko, V. Korshun, M. Gait, 2003, Current protocols in nucleic acid chemistry.

Cmah-dystrophin deficient mdx mice display an accelerated cardiac phenotype that is improved following peptide-PMO exon skipping treatment

R. Manzano, D. Tyler, S. Hammond, 2018, Human molecular genetics.

Pip5 transduction peptides direct high efficiency oligonucleotide-mediated dystrophin exon skipping in heart and phenotypic correction in mdx mice.

P. Camelliti, S. Hammond, M. Wood, 2011, Molecular therapy : the journal of the American Society of Gene Therapy.

Location of the adenylylation site in T4 RNA ligase.

H. Morris, M. Gait, H. Thøgersen, 1985, European journal of biochemistry.

T4 RNA ligase: New structural studies on an unusual but useful enzyme

M. Gait, H. Thøgersen, K. Rand, 1985, Journal of Biosciences.

Nucleotide and deduced amino acid sequence of stp: the bacteriophage T4 anticodon nuclease gene.

G. Kaufmann, M. Gait, D. Chapman, 1988, Journal of molecular biology.

Oligonucleotides containing 2'-O-[2-(2,3-dihydroxypropyl)amino-2-oxoethyl]uridine as suitable precursors of 2'-aldehyde oligonucleotides for chemoselective ligation.

T. Oretskaya, D. Stetsenko, T. Zatsepin, 2005, Bioorganic & medicinal chemistry.

Chemical methods for peptide-oligonucleotide conjugate synthesis.

D. Stetsenko, M. Gait, 2005, Methods in molecular biology.

OLIGONUCLEOTIDE ANALOGUE INTERFERENCE WITH THE HIV-1 TAT PROTEIN-TAR RNA INTERACTION

J. Wengel, V. Rajwanshi, M. Gait, 2001, Nucleosides, nucleotides & nucleic acids.

A NEW “NATIVE LIGATION” PROCEDURE FOR PEPTIDE-OLIGONUCLEOTIDE CONJUGATION

M. Gait, D. Stetsenko, 2001, Nucleosides, nucleotides & nucleic acids.

Implications for Cardiac Function Following Rescue of the Dystrophic Diaphragm in a Mouse Model of Duchenne Muscular Dystrophy

K. Clarke, S. Hammond, M. Wood, 2015, Scientific Reports.

Solid-Phase Synthesis of Difficult Purine-Rich PNAs through Selective Hmb Incorporation: Application to the Total Synthesis of Cell Penetrating Peptide-PNAs

J. Wade, Y. Aoki, J. Tailhades, 2017, Front. Chem..

2'-O-methyl-RNA hairpins generate loop-loop complexes and selectively inhibit HIV-1 Tat-mediated transcription.

C. Di Primo, J. Toulmé, F. Darfeuille, 2002, Biochemistry.

A peptide-based dendrimer that enhances the splice-redirecting activity of PNA conjugates in cells.

J. Gariépy, E. Bolewska-Pedyczak, B. Lebleu, 2009, Bioconjugate chemistry.

Optimization of peptide nucleic acid antisense oligonucleotides for local and systemic dystrophin splice correction in the mdx mouse.

M. Wood, H. Yin, A. F. Saleh, 2010, Molecular therapy : the journal of the American Society of Gene Therapy.

In vitro evaluation of novel antisense oligonucleotides is predictive of in vivo exon skipping activity for Duchenne muscular dystrophy

P. Camelliti, H. Moulton, M. Wood, 2010, The journal of gene medicine.

Development and Application of an Ultrasensitive Hybridization-Based ELISA Method for the Determination of Peptide-Conjugated Phosphorodiamidate Morpholino Oligonucleotides.

S. Laval, V. Straub, M. Gait, 2015, Nucleic acid therapeutics.

The use of synthetic oligodeoxynucleotide primers in cloning and sequencing segment of 8 influenza virus (A/PR/8/34).

S. Fields, G. Winter, G. Brownlee, 1981, Nucleic acids research.

Anti‐HIV Activity of Steric Block Oligonucleotides

A. Lever, J. Toulmé, S. Reigadas, 2006, Annals of the New York Academy of Sciences.

Synthesis of DNA conjugates by solid-phase fragment condensation via aldehyde–nucleophile coupling

T. Oretskaya, D. Stetsenko, T. Zatsepin, 2005 .

Efficient conjugation and preferential DNA binding of oligonucleotides containing 2'-O-(2-oxoethyl)arabinouridine

T. Oretskaya, D. Stetsenko, T. Zatsepin, 2004 .

Oligonucleotide inhibition of the interaction of HIV-1 Tat protein with the trans-activation responsive region (TAR) of HIV RNA.

M. Gait, S. Litvak, A. Arzumanov, 1999, Biochimica et biophysica acta.

The synthesis of peptide-oligonucleotide conjugates by a fragment coupling approach

M. Gait, F. Burlina, S. Peyrottes, 1998 .

Cell-Penetrating Peptide Conjugates of Steric Blocking Oligonucleotides as Therapeutics for Neuromuscular Diseases from a Historical Perspective to Current Prospects of Treatment

S. Hammond, M. Wood, Corinne A Betts, 2019, Nucleic acid therapeutics.

Splice redirection as a convenient assay to monitor CPP-ON efficiency and mechanism.

B. Lebleu, A. F. Saleh, M. Gait, 2011, Methods in molecular biology.

Peptide-based delivery of steric-block PNA oligonucleotides.

B. Lebleu, M. Gait, R. Abes, 2009, Methods in molecular biology.

Efficient splicing correction by PNA conjugation to an R6-Penetratin delivery peptide

B. Lebleu, M. Gait, A. Arzumanov, 2007, Nucleic acids research.

Lipoplex and peptide-based strategies for the delivery of steric-block oligonucleotides.

B. Lebleu, S. Resina, P. Prévot, 2007, International journal of pharmaceutics.

Efficient splicing correction by PNA conjugation to an R6-Penetratin delivery peptide

B. Lebleu, M. Gait, A. Arzumanov, 2007, Nucleic acids research.

Disulfide Conjugation of Peptides to Oligonucleotides and Their Analogs

M. Gait, D. Owen, J. Turner, 2006, Current protocols in nucleic acid chemistry.

Antibody-oligonucleotide conjugate achieves CNS delivery in animal models for spinal muscular atrophy

S. Hammond, M. Wood, M. Gait, 2022, JCI insight.

Evaluation of Cell-Penetrating Peptide Delivery of Antisense Oligonucleotides for Therapeutic Efficacy in Spinal Muscular Atrophy.

S. Hammond, M. Wood, M. Gait, 2019, Methods in molecular biology.

Interactions of INS (CRS) elements and the splicing machinery regulate the production of Rev-responsive mRNAs.

J. Karn, M. Krieg, M. Gait, 1996, Journal of molecular biology.

Dual Myostatin and Dystrophin Exon Skipping by Morpholino Nucleic Acid Oligomers Conjugated to a Cell-penetrating Peptide Is a Promising Therapeutic Strategy for the Treatment of Duchenne Muscular Dystrophy

L. Popplewell, G. Dickson, M. Wood, 2012, Molecular therapy. Nucleic acids.

A structure-activity study of the inhibition of HIV-1 Tat-dependent trans-activation by mixmer 2'-O-methyl oligoribonucleotides containing locked nucleic acid (LNA), alpha-L-LNA, or 2'-thio-LNA residues.

J. Wengel, D. Stetsenko, B. R. Babu, 2003, Oligonucleotides.

New Phosphoramidite Reagents for the Synthesis of Oligonucleotides Containing a Cysteine Residue Useful in Peptide Conjugation

D. Stetsenko, M. Gait, D. Stetsenko, 2000, Nucleosides, nucleotides & nucleic acids.

Total stepwise solid-phase synthesis of oligonucleotide-(3'-->N)-peptide conjugates.

D. Stetsenko, M. Gait, A. Malakhov, 2002, Organic letters.

A convenient solid-phase method for synthesis of 3'-conjugates of oligonucleotides.

D. Stetsenko, M. Gait, D. Stetsenko, 2001, Bioconjugate chemistry.

Conjugates of oligonucleotides and analogues with cell penetrating peptides as gene silencing agents.

T. Zatsepin, M. Gait, J. Turner, 2005, Current pharmaceutical design.

2'‐Functionalized Nucleic Acids as Structural Tools in Molecular Biology

T. Oretskaya, T. Zatsepin, M. Gait, 2004, IUBMB life.

A Base‐Labile Protecting Group (Fluorenylmethoxycarbonyl) for the 5′‐Hydroxy Function of Nucleosides

M. Gait, C. Lehmann, 2000, Current protocols in nucleic acid chemistry.

Novel uridin-2′-yl carbamates: synthesis, incorporation into oligodeoxyribonucleotides, and remarkable fluorescence properties of 2′-pyren-1-ylmethylcarbamate

D. Stetsenko, V. Korshun, M. Gait, 2002 .

Rapid synthesis of oligodeoxyribonucleotides. II. Machine-aided solid-phase syntheses of two nonanucleotides and an octanucleotide.

R. Sheppard, M. Gait, 1977, Nucleic acids research.

Pyrenemethyl ara‐Uridine‐2′‐carbamate: A Strong Interstrand Excimer in the Major Groove of a DNA Duplex

R. Efremov, P. Volynsky, D. Stetsenko, 2003, Chembiochem : a European journal of chemical biology.

The polyamide method of solid phase peptide and oligonucleotide synthesis

R. Sheppard, M. Gait, B. Williams, 1979 .

Rapid synthesis of oligodeoxyribonucleotides. IV. Improved solid phase synthesis of oligodeoxyribonucleotides through phosphotriester intermediates.

A. Markham, R. Sheppard, M. Gait, 1980, Nucleic acids research.

Easily prepared polar support for solid phase peptide and oligonucleotide synthesis. Preparation of substance P and a nonadeoxyribonucleotide

R. Arshady, R. Sheppard, M. Gait, 1979 .

High affinity binding of TAR RNA by the human immunodeficiency virus type-1 tat protein requires base-pairs in the RNA stem and amino acid residues flanking the basic region.

J. Karn, P. Butler, C. Dingwall, 1993, Journal of molecular biology.

HIV‐1 tat protein stimulates transcription by binding to a U‐rich bulge in the stem of the TAR RNA structure.

M. Singh, J. Karn, I. Ernberg, 1990, The EMBO journal.

Efficient methods for attaching non-radioactive labels to the 5' ends of synthetic oligodeoxyribonucleotides.

S. Agrawal, C. Christodoulou, M. Gait, 1986, Nucleic acids research.

STUDIES ON POLYNUCLEOTIDES. CXLIII. A RAPID AND CONVENIENT METHOD FOR THE SYNTHESIS OF DEOXYRIBOOLIGONUCLEOTIDES CARRYING 5′-PHOSPHATE END GROUPS USING A NEW PROTECTING GROUP

H. Khorana, H. Fritz, D. Kleid, 1976 .

Use of carbonyl group addition--elimination reactions for synthesis of nucleic acid conjugates.

T. Oretskaya, D. Stetsenko, T. Zatsepin, 2005, Bioconjugate chemistry.

Biotinyl and phosphotyrosinyl phosphoramidite derivatives useful in the incorporation of multiple reporter groups on synthetic oligonucleotides.

M. Gait, I. Durrant, K. Misiura, 1990, Nucleic acids research.

Exploiting cell surface thiols to enhance cellular uptake.

A. Torres, M. Gait, A. G. Torres, 2012, Trends in biotechnology.

Modified oligoribonucleotides as site‐specific probes of RNA structure and function

M. Gait, D. Earnshaw, 1998 .

Synthetic RNA Modification and Cross-linking Approaches towards the Structure of the Hairpin Ribozyme and the HIV-1 Tat Protein Interaction with TAR RNA

N. Naryshkin, M. Gait, M. Farrow, 1998 .

Applications of synthetic oligoribonucleotide analogues in studies of RNA structure and function

J. Grasby, M. Gait, C. Pritchard, 1994, Proceedings / Indian Academy of Sciences.

Synthetic oligoribonucleotides carrying site-specific modifications for RNA structure-function analysis.

J. Grasby, M. Gait, 1994, Biochimie.

Synthesis and Properties of Modified Oligodeoxyribonucleotides Containing 2"-O-(2,3-Dihydroxypropyl)uridine and 2"-O-(2-Oxoethyl)uridine

T. Oretskaya, D. Stetsenko, T. Zatsepin, 2004, Russian journal of bioorganic chemistry.

Hairpin ribozyme cleavage catalyzed by aminoglycoside antibiotics and the polyamine spermine in the absence of metal ions.

M. Gait, D. Earnshaw, Michael J. Gait, 1998, Nucleic acids research.

Inter-domain cross-linking and molecular modelling of the hairpin ribozyme.

E. Westhof, B. Masquida, S. Sigurdsson, 1997, Journal of molecular biology.

Purine functional groups in essential residues of the hairpin ribozyme required for catalytic cleavage of RNA.

J. Grasby, M. Gait, M. Singh, 1995, Biochemistry.

The antitumor drug cis-dichlorodiammineplatinum forms an intrastrand d(GpG) crosslink upon reaction with [d(ApGpGpCpCpT)]2

S. Lippard, M. Gait, J. Caradonna, 1982 .

Syntheses and Oligonucleotide Incorporation of Nucleoside Analogues Containing Pendant Imidazolyl or Amino Functionalities – The Search for Sequence‐Specific Artificial Ribonucleases

M. Gait, S. C. Holmes, 2005 .

Synthesis and properties of oligodeoxyribonucleotides containing 2’-O-(2,3-dihydroxypropyl)- and 2’-O-(2-oxoethyl)arabinouridine residues

D. Stetsenko, T. Zatsepin, M. Gait, 2005 .

Oligonucleotides with 2'-O-carboxymethyl group: synthesis and 2'-conjugation via amide bond formation on solid phase.

T. Oretskaya, D. Stetsenko, M. Gait, 2004, Organic & biomolecular chemistry.

Synthesis of oligo-2′-O-methylribonucleotides containing α-amino acid residues in 2′-position

T. Oretskaya, M. Gait, D. Stetsenko, 2007 .

Preparation Of 2′-Hydrazino Oligonucleotides And Their Reaction With Aldehydes And 1,3-Diketones

T. Oretskaya, D. Stetsenko, T. Zatsepin, 2007, Nucleosides, nucleotides & nucleic acids.

Synthesis of 2′-hydrazine oligonucleotides and their efficient conjugation with aldehydes and 1,3-diketones

T. Oretskaya, D. Stetsenko, T. Zatsepin, 2006 .

Synthesis of oligonucleotide 2'-conjugates via amide bond formation in solution.

T. Oretskaya, D. Stetsenko, M. Gait, 2004, Bioorganic & medicinal chemistry letters.

Synthesis of 2′-Modified Oligonucleotides Containing Aldehyde or Ethylenediamine Groups

T. Oretskaya, D. Stetsenko, T. Zatsepin, 2003, Nucleosides, nucleotides & nucleic acids.

1,2-Diol and Hydrazide Phosphoramidites for Solid-Phase Synthesis and Chemoselective Ligation of 2′-Modified Oligonucleotides

T. Oretskaya, D. Stetsenko, M. Gait, 2003, Nucleosides, nucleotides & nucleic acids.

Synthesis of Modified Nucleotide Building Blocks Containing Electrophilic Groups in the 2′‐Position.

T. Oretskaya, D. Stetsenko, T. Zatsepin, 2002 .

The synthesis of oligoribonucleotides containing O6-methylguanosine: the role of conserved guanosine residues in hammerhead ribozyme cleavage.

J. Grasby, M. Gait, G. Butler, 1993, Nucleic acids research.

Novel spermine-amino acid conjugates and basic tripeptides enhance cleavage of the hairpin ribozyme at low magnesium ion concentration.

M. Gait, D. Stetsenko, M. Singh, 2001, Bioorganic & medicinal chemistry letters.

Progress toward the structure and therapeutic use of the hairpin ribozyme.

M. Gait, D. Earnshaw, Michael J. Gait, 1997, Antisense & nucleic acid drug development.

Configurationally defined phosphorothioate-containing oligoribonucleotides in the study of the mechanism of cleavage of hammerhead ribozymes.

M. Gait, G. Slim, Michael J. Gait, 1991, Nucleic acids research.

Incorporation of Modified Nucleotides into RNA for Studies on RNA Structure, Function and Intermolecular Interactions

M. Moore, M. Gait, R. Zimmermann, 1998 .

Synthetic-analogues of polynucleotides XII. Synthesis of thymidine derivatives containing an oxyacetamido- or an oxyformamido-linkage instead of a phosphodiester group.

R. T. Walker, M. Gait, A. S. Jones, 1974, Journal of the Chemical Society. Perkin transactions 1.

Multi-level omics analysis in a murine model of dystrophin loss and therapeutic restoration

C. I. Smith, M. Wood, J. Lehtiö, 2015, Human molecular genetics.

A chemical view of oligonucleotides for exon skipping and related drug applications.

Michael J Gait, P. Järver, M. Gait, 2014, Nucleic acid therapeutics.

Incompatibility of acid-labile 2′ and 5′ protecting groups for solid-phase synthesis of oligoribonucleotides

S. Agrawal, C. Christodoulou, M. Gait, 1986 .

Chemical modifications to improve the cellular uptake of oligonucleotides.

H. Moulton, B. Lebleu, Gaëlle Deglane, 2007, Current topics in medicinal chemistry.

(R)-2,4-Dihydroxybutyramide seco-pseudonucleosides: new versatile homochiral synthons for synthesis of modified oligonucleotides.

D. Stetsenko, V. Korshun, M. Gait, 2002, Organic letters.

Solid Phase Synthesis and Chromatographic Characteristics of Nucleophilic Agents Conjugated with Oligonucleotides Containing 5'-Terminal Carboxyl Group

T. Oretskaya, D. Stetsenko, E. Romanova, 2003, Russian journal of bioorganic chemistry.

Rapid synthesis of oligodeoxyribonucleotides: a new solid-phase method.

R. Sheppard, M. Gait, 1977, Nucleic acids research.

Studies on polynucleotides. CXLIII. A rapid and convenient method for the synthesis of deoxyribooligonucleotides carrying 5'-phosphate end groups using a new protecting group.

H. Khorana, H. Fritz, D. Kleid, 1976, Journal of the American Chemical Society.

Comparison of rates of phosphotriester formation and sulphonation by coupling agents in oligodeoxyribonucleotide synthesis by the phosphotriester method

S. G. Popov, M. Gait, 1980 .

Chemical cross-linking of the human immunodeficiency virus type 1 Tat protein to synthetic models of the RNA recognition sequence TAR containing site-specific trisubstituted pyrophosphate analogues.

N. Naryshkin, M. Gait, Z. Shabarova, 1997, Biochemistry.

Use of Carbonyl Group Addition—Elimination Reactions for Synthesis of Nucleic Acid Conjugates

T. Oretskaya, D. Stetsenko, T. Zatsepin, 2005 .

Comparison of controlled pore glass and Kieselguhr-polydimethylacrylamide composite as supports for solid-phase synthesis of 23-residue oligodeoxyribonucleotides in milligram amounts.

K. N. Ganesh, B. Sproat, C. Minganti, 1985, Analytical biochemistry.

Rapid synthesis of oligodeoxyribonucleotides VI. Efficient, mechanised synthesis of heptadecadeoxyribonucleotides by an improved solid phase phosphotriester route.

G. Hong, R. Titmas, M. Gait, 1981, Nucleic acids research.

Steric inhibition of human immunodeficiency virus type-1 Tat-dependent trans-activation in vitro and in cells by oligonucleotides containing 2'-O-methyl G-clamp ribonucleoside analogues.

M. Gait, A. Arzumanov, S. C. Holmes, 2003, Nucleic acids research.

Immortalized Canine Dystrophic Myoblast Cell Lines for Development of Peptide-Conjugated Splice-Switching Oligonucleotides

K. Mamchaoui, V. Mouly, M. Wood, 2021, Nucleic acid therapeutics.

Comparative Studies of Tricyclo-DNA- and LNA-Containing Oligonucleotides as Inhibitors of HIV-1 Gene Expression

J. Toulmé, D. Ittig, C. Leumann, 2007, Nucleosides, nucleotides & nucleic acids.

Tricyclo-DNA containing oligonucleotides as steric block inhibitors of human immunodeficiency virus type 1 tat-dependent trans-activation and HIV-1 infectivity.

J. Toulmé, D. Ittig, C. Leumann, 2007, Oligonucleotides.

Methylphosphonate mapping of phosphate contacts critical for RNA recognition by the human immunodeficiency virus tat and rev proteins

Michael J. Gait, Mohinder Singh, Clare E. Pritchard, 1994, Nucleic Acids Res..

Targeting the A site RNA of the Escherichia coli ribosomal 30 S subunit by 2'-O-methyl oligoribonucleotides: a quantitative equilibrium dialysis binding assay and differential effects of aminoglycoside antibiotics.

G. Lentzen, M. Gait, F. Aboul-ela, 2004, The Biochemical journal.

Synthesis, cellular uptake and HIV-1 Tat-dependent trans-activation inhibition activity of oligonucleotide analogues disulphide-conjugated to cell-penetrating peptides

M. Gait, A. Arzumanov, J. Turner, 2005, Nucleic acids research.

Synthetic analogues of polynucleotides. Part 15. The synthesis and properties of poly(5′-amino-3′-O-carboxymethyl-2′,5′-dideoxy-erythro-pentonucleosides) containing 3′(O)→ 5′(C) acetamidate linkages

R. T. Walker, M. Gait, M. J. Shepherd, 1979 .

Continuous-flow phosphotriester method for solid-phase synthesis of oligodeoxyribonucleotides.

B. Sproat, R. Titmas, M. Gait, 1983, Cold Spring Harbor symposia on quantitative biology.

Nucleotide sequence of tobacco mosaic virus RNA.

J. Karn, M. Akam, P. Butler, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Synthesis of peptide-oligonucleotide conjugates with single and multiple peptides attached to 2'-aldehydes through thiazolidine, oxime, and hydrazine linkages

T. Oretskaya, D. Stetsenko, T. Zatsepin, 2002 .

A New 5′-Protecting Group for Use in Solid-Phase Synthesis of Oligoribonucleotides

S. Agrawal, C. Christodoulou, M. Gait, 1987 .

Rapid chemical synthesis and circular dichroism properties of some 2'-5'-linked oligoriboadenylates.

I. Kerr, A. Markham, R. Sheppard, 1979, Nucleic acids research.

ARP, A Peptide Derived from the Stress-Associated Acetylcholinesterase Variant, Has Hematopoietic Growth Promoting Activities

M. Shapira, D. Kaufer, H. Soreq, 2001, Molecular medicine.

Cell-penetrating peptides do not cross mitochondrial membranes even when conjugated to a lipophilic cation: evidence against direct passage through phospholipid bilayers.

Robin A. J. Smith, M. Murphy, A. Filipovska, 2004, The Biochemical journal.

Complete sequence of constant and 3′ noncoding regions of an immunoglobulin mRNA using the dideoxynucleotide method of RNA sequencing

C. Milstein, G. Brownlee, M. Gait, 1978, Cell.

Expression Analysis in Multiple Muscle Groups and Serum Reveals Complexity in the MicroRNA Transcriptome of the mdx Mouse with Implications for Therapy

M. Wood, T. Roberts, K. Blomberg, 2012, Molecular therapy. Nucleic acids.

Synthesis and biological activity of phosphonoacetate- and thiophosphonoacetate-modified 2'-O-methyl oligoribonucleotides.

M. Caruthers, A. Krivenko, A. Torres, 2012, Organic & biomolecular chemistry.

miR-122 targeting with LNA/2'-O-methyl oligonucleotide mixmers, peptide nucleic acids (PNA), and PNA-peptide conjugates.

M. Gait, M. Fabani, 2007, RNA.

RNA-targeted splice-correction therapy for neuromuscular disease.

M. Wood, H. Yin, M. Gait, 2010, Brain : a journal of neurology.

Chemical structure requirements and cellular targeting of microRNA-122 by peptide nucleic acids anti-miRs

O. Seitz, E. Vigorito, A. Torres, 2011, Nucleic acids research.

Delivery of therapeutic oligonucleotides with cell penetrating peptides☆

P. Boisguérin, B. Lebleu, M. Wood, 2015, Advanced Drug Delivery Reviews.

Peptide-mediated Cell and In Vivo Delivery of Antisense Oligonucleotides and siRNA

M. Wood, P. Järver, M. Gait, 2012, Molecular Therapy - Nucleic Acids.

Potent and sustained cellular inhibition of miR-122 by lysine-derivatized peptide nucleic acids (PNA) and phosphorothioate locked nucleic acid (LNA)/2'-O-methyl (OMe) mixmer anti-miRs in the absence of transfection agents

A. Torres, M. Gait, Richard Threlfall, 2011, Artificial DNA, PNA & XNA.

Human immunodeficiency virus type 1 regulator of virion expression, rev, forms nucleoprotein filaments after binding to a purine-rich "bubble" located within the rev-responsive region of viral mRNAs.

J. Karn, J. Finch, S. Heaphy, 1991, Proceedings of the National Academy of Sciences of the United States of America.

PepFect 14, a novel cell-penetrating peptide for oligonucleotide delivery in solution and as solid formulation

C. I. Smith, S. Hammond, M. Wood, 2011, Nucleic acids research.

Endosome trapping limits the efficiency of splicing correction by PNA-oligolysine conjugates.

Alain Thierry, Michael J Gait, B. Lebleu, 2006, Journal of controlled release : official journal of the Controlled Release Society.

Cell-penetrating peptide conjugates of peptide nucleic acids (PNA) as inhibitors of HIV-1 Tat-dependent trans-activation in cells

B. Lebleu, B. Verbeure, M. Gait, 2005, Nucleic acids research.

Self-Assembly into Nanoparticles Is Essential for Receptor Mediated Uptake of Therapeutic Antisense Oligonucleotides.

S. Gordon, M. Behlke, C. Leumann, 2015, Nano letters.

Cellular trafficking determines the exon skipping activity of Pip6a-PMO in mdx skeletal and cardiac muscle cells

P. Boisguérin, B. Lebleu, M. Wood, 2013, Nucleic acids research.

Loop–loop interaction of HIV-1 TAR RNA with N3′ → P5′ deoxyphosphoramidate aptamers inhibits in vitro Tat-mediated transcription

C. Di Primo, J. Toulmé, F. Darfeuille, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Human immunodeficiency virus type-1 Tat is an integral component of the activated transcription-elongation complex.

J. Karn, N. Keen, M. Gait, 1996, Proceedings of the National Academy of Sciences of the United States of America.

RNA recognition by the human immunodeficiency virus Tat and Rev proteins.

J. Karn, M. Gait, Michael J. Gait, 1993, Trends in biochemical sciences.

A molecular rheostat: Co-operative rev binding to stem I of the rev-response element modulates human immunodeficiency virus type-1 late gene expression

J. Karn, P. Butler, D. Mann, 1994 .

Inhibition of HIV-1 Tat-dependent trans activation by steric block chimeric 2'-O-methyl/LNA oligoribonucleotides.

J. Wengel, R. Kumar, V. Rajwanshi, 2001, Biochemistry.

Cell penetrating peptide conjugates of steric block oligonucleotides☆

D. A. Stein, P. Iversen, H. Moulton, 2007, Advanced Drug Delivery Reviews.

RNA recognition and regulation of HIV-1 gene expression by viral factor Tat.

N. Naryshkin, M. Gait, M. Ivanovskaya, 1998, Biochemistry. Biokhimiia.

Dystrophin regulates peripheral circadian SRF signalling

A. Bhomra, M. Bowerman, M. Falzarano, 2021, bioRxiv.

A new selective phage cloning vector, λ2001, with sites for XbaI, BamHI, HindIII, EcoRI, SstI and XhoI

S. Brenner, J. Karn, M. Gait, 1984 .

Assessing the Delivery of Molecules to the Mitochondrial Matrix Using Click Chemistry

R. Lightowlers, Robin A. J. Smith, M. Murphy, 2016, Chembiochem : a European journal of chemical biology.

A short primer for sequencing DNA cloned in the single-stranded phage vector M13mp2.

I. G. Young, L. Mayol, M. Gait, 1980, Nucleic acids research.

Human immunodeficiency virus type 1 transactivator protein, tat, stimulates transcriptional read-through of distal terminator sequences in vitro.

J. Karn, M. Gait, M. Churcher, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Regulation of hiv 1 gene expression by the rna binding proteins tat and rev

J. Karn, C. Dingwall, M. Skinner, 1991 .

Complete sequence of an immunoglobulin mRNA using specific priming and the dideoxynucleotide method of RNA sequencing.

C. Milstein, M. Gait, P. Hamlyn, 1981, Nucleic acids research.

Human immunodeficiency virus 1 tat protein binds trans-activation-responsive region (TAR) RNA in vitro.

J. Karn, I. Ernberg, C. Dingwall, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Hydrogen-bonding contacts in the major groove are required for human immunodeficiency virus type-1 tat protein recognition of TAR RNA.

J Grasby, J. Karn, J. Grasby, 1993, Journal of molecular biology.

Recognition of the high affinity binding site in rev-response element RNA by the human immunodeficiency virus type-1 rev protein.

J. Karn, S. Iwai, D. Mann, 1992, Nucleic acids research.

MicroRNA fate upon targeting with anti-miRNA oligonucleotides as revealed by an improved Northern-blot-based method for miRNA detection.

E. Vigorito, A. Torres, M. Gait, 2011, RNA.

Nucleotide sequence of tobacco mosaic virus RNA ( oligonucleotide primers / cDNA library / RNA polymorphism / eukaryotic ribosome binding / leaky amber termination )

J. Karn, P. Butler, G. Lomonossoff, 2022 .

Rapid crystallization of chemically synthesized hammerhead RNAs using a double screening procedure.

A Klug, J T Finch, A. Klug, 1995, Journal of molecular biology.

Progress in anti-HIV structure-based drug design.

J. Karn, M. Gait, 1995, Trends in biotechnology.

Effect of single amino acid changes in the region of the adenylylation site of T4 RNA ligase.

S. Heaphy, M. Gait, M. Singh, 1987, Biochemistry.

Targeting the HIV-1 RNA leader sequence with synthetic oligonucleotides and siRNA: chemistry and cell delivery.

M. Gait, A. Arzumanov, G. Ivanova, 2006, Biochimica et biophysica acta.

A new selective phage cloning vector, lambda 2001, with sites for XbaI, BamHI, HindIII, EcoRI, SstI and XhoI.

S. Brenner, J. Karn, M. Gait, 1984, Gene.

Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia model.

R. Månsson, M. Behlke, K. E. Lundin, 2014, The Journal of clinical investigation.

Peptide-conjugated oligonucleotides evoke long-lasting myotonic dystrophy correction in patient-derived cells and mice

G. Bassez, J. Puymirat, M. Wood, 2019, The Journal of clinical investigation.

3′/5′-Regioselectivity of Introduction of the 9-Fluorenyl-Methoxycarbonyl Group to 2′-O- Tetrahydropyran-2-Yl- and 2′-O-(4- methoxytetrahydropyran-4-Yl-)-nucleosides Useful Intermediates for Solid-Phase-RNA-Synthesis

C. Christodoulou, M. Gait, Yaozhong Xu, 1991 .

Sequence and cloning of bacteriophage T4 gene 63 encoding RNA ligase and tail fibre attachment activities.

M. Gait, M J Gait, K N Rand, 1984, The EMBO journal.

Total synthesis of a tyrosine suppressor transfer RNA gene. XVI. Enzymatic joinings to form the total 207-base pair-long DNA.

R. Contreras, H. Khorana, E. Brown, 1979, The Journal of biological chemistry.

Efficient inhibition of miR-155 function in vivo by peptide nucleic acids

Anton J. Enright, Kenneth G. C. Smith, A. Enright, 2010, Nucleic acids research.

Chemical synthesis of a gene for somatomedin C.

B. Sproat, M. Gait, 1985, Nucleic acids research.

Expression Analysis in Multiple Muscle Groups and Serum Reveals Complexity in the MicroRNA Transcriptome of the mdx Mouse with Implications for Therapy.

M. Wood, T. Roberts, K. Blomberg, 2012, Molecular Therapy: Nucleic Acids.

Parallel synthesis of cell-penetrating peptide conjugates of PMO toward exon skipping enhancement in Duchenne muscular dystrophy.

P. Deuss, I. Okamoto, M. Gait, 2015, Nucleic acid therapeutics.

Bi-specific splice-switching PMO oligonucleotides conjugated via a single peptide active in a mouse model of Duchenne muscular dystrophy

M. Wood, P. Järver, A. F. Saleh, 2014, Nucleic acids research.

Parallel synthesis and splicing redirection activity of cell-penetrating peptide conjugate libraries of a PNA cargo

P. Deuss, M. Gait, A. Arzumanov, 2013, Organic & biomolecular chemistry.

RNA targeting in cells by peptide conjugates of peptide nucleic acids (PNA)

B. Lebleu, M. Gait, R. Abes, 2008 .

Rapid Synthesis of Oligodeoxyribonucleotides VIII.1 An Improved Procedure for Solid-Phase Oligodeoxyribonucleotide Synthesis Using a Controlled Pore Glass Support and Phosphotriester Chemistry

B. Sproat, C. Minganti, M. Gait, 1985 .

The Synthesis of 2′-O-Methyl G-Clamp Containing Oligonucleotides and Their Inhibition of the HIV-1 Tat-TAR Interaction

M. Gait, S. C. Holmes, 2003, Nucleosides, nucleotides & nucleic acids.

Novel Uridin‐2′‐yl Carbamates: Synthesis, Incorporation into Oligodeoxyribonucleotides, and Remarkable Fluorescence Properties of 2′‐Pyren‐1‐ylmethylcarbamate.

D. Stetsenko, V. Korshun, M. Gait, 2002 .

TOTAL SYNTHESIS OF A BACTERIAL GENE II: THE TOTAL DNA INCLUDING THE PROMOTER AND ITS TRANSCRIPTION

R. Contreras, H. Khorana, E. Brown, 1978 .

PNA-peptide conjugates as intracellular gene control agents.

B. Lebleu, M. Wood, H. Yin, 2008, Nucleic acids symposium series.

The human immunodeficiency virus long terminal repeat includes a specialised initiator element which is required for Tat-responsive transcription.

J. Karn, K. Rittner, M. Gait, 1995, Journal of molecular biology.

Total synthesis of a tyrosine suppressor transfer RNA gene. XIII. Synthesis of deoxyribopolynucleotide segments corresponding to the nucleotide sequence -1 to -29 in the promoter region.

H. Khorana, E. Brown, M. Gait, 1979, The Journal of biological chemistry.

7-Deazaadenosine: Oligoribonucleotide building block synthesis and autocatalytic hydrolysis of base-modified hammerhead ribozymes

J. Grasby, F. Seela, M. Gait, 1993 .

The role of the exocyclic amino groups of conserved purines in hammerhead ribozyme cleavage.

M. Gait, G. Slim, 1992, Biochemical and biophysical research communications.

Hexitol nucleic acid-containing aptamers are efficient ligands of HIV-1 TAR RNA.

J. Toulmé, P. Herdewijn, A. Van Aerschot, 2005, Biochemistry.

8 – Nonradioactive Methods of in Situ Hybridization: Visualization of Neuroendocrine mRNA

P. Emson, S. Agrawal, H. Arai, 1989 .

Nonradioactive methods of in situ hybridization: visualization of neuroendocrine mRNA.

P. Emson, S. Agrawal, H. Arai, 1989, Methods in enzymology.

Peptide-based delivery of nucleic acids: design, mechanism of uptake and applications to splice-correcting oligonucleotides.

P. Iversen, H. Moulton, B. Lebleu, 2007, Biochemical Society transactions.

RNA binding by the tat and rev proteins of HIV-1.

J T Finch, J. Karn, J. Finch, 1991, Biochimie.

Trans-Activation Requires the Binding of the HIV-1 Tat Protein to Tar RNA

J. Karn, I. Ernberg, C. Dingwall, 1991 .

Cell-penetrating-peptide-based delivery of oligonucleotides: an overview.

P. Iversen, H. Moulton, B. Lebleu, 2007, Biochemical Society transactions.

ClickIn: a flexible protocol for quantifying mitochondrial uptake of nucleobase derivatives

R. Lightowlers, Robin A. J. Smith, M. Murphy, 2017, Interface Focus.

Total synthesis of a tyrosine suppressor tRNA gene. XV. Synthesis of the promoter region.

H. Khorana, E. Brown, T. Sekiya, 1979, The Journal of biological chemistry.

Synthesis of oligodeoxyribonucleotides by a continuous-flow, solid-phase method using phosphotriester intermediates

R. Titmas, M. Gait, H. Matthes, 1982 .

LNA and α-L-LNA: Towards Therapeutic Applications

S. Douthwaite, J. Wengel, B. Vester, 2003 .

LNA and alpha-L-LNA: towards therapeutic applications.

S. Douthwaite, J. Wengel, B. Vester, 2003, Nucleosides, nucleotides & nucleic acids.

Synthesis of peptide-oligonucleotide conjugates with single and multiple peptides attached to 2'-aldehydes through thiazolidine, oxime, and hydrazine linkages.

T. Oretskaya, D. Stetsenko, T. Zatsepin, 2002, Bioconjugate chemistry.

Synthetic donor and acceptor splice sites function in an RNA polymerase B (II) transcription unit.

M. Gait, R. Breathnach, H. Matthes, 1984, The EMBO journal.

Prevention of exercised induced cardiomyopathy following Pip-PMO treatment in dystrophic mdx mice

K. Clarke, S. Hammond, M. Wood, 2015, Scientific Reports.

RNA-targeted splice-correction therapy for neuromuscular disease.

M. Wood, H. Yin, M. Gait, 2010, Brain : a journal of neurology.

In Vitro Assays to Assess Exon Skipping in Duchenne Muscular Dystrophy.

P. Boisguérin, B. Lebleu, M. Gait, 2015, Methods in molecular biology.

Enhanced splice correction by 3′, 5′-serinol and 2′-(ω-O-methylserinol) guarded OMe-RNA/DNA mixmers in cells

M. Gait, A. Arzumanov, Vaijayanti A. Kumar, 2013, Artificial DNA, PNA & XNA.

Human immunodeficiency virus 1 tat protein binds transactivation-responsive region ( TAR ) RNA in vitro ( transactivation / RNA-binding proteins / gene synthesis / andsense RNA )

J. Karn, I. Ernberg, C. Dingwall, 2022 .

Rapid synthesis of oligodeoxyribonucleotides. III. Effect of added carboxylate ion on the efficiency of internucleotide bond formation. Solid-phase synthesis of the dodecanucleotide, d(pT-A-A-C-T-G-C-T-C-A-C-T).

R. Sheppard, M. Gait, 1979, Nucleic acids research.

Steric Block High Affinity Oligonucleotide Analogues: A New Tool for Mapping RNA-Protein Binding Sites

A. Lever, M. Gait, J. Greatorex, 2008, Nucleosides, nucleotides & nucleic acids.

OLIGONUCLEOTIDE ANALOGUE INTERFERENCE WITH THE HIV-1 TAT PROTEIN-TAR RNA INTERACTION

Xiaohai Liu, J. Wengel, V. Rajwanshi, 2001, Nucleosides, nucleotides & nucleic acids.

Cloning and expression in E. coli of a synthetic gene for the bacteriocidal protein caltrin/seminalplasmin.

S. Heaphy, M. Gait, M. Singh, 1987, Protein engineering.

Sequential NMR assignments of labile protons in DNA using two-dimensional nuclear-Overhauser-enhancement spectroscopy with three jump-and-return pulse sequences.

K. Wüthrich, B. Sproat, G. Otting, 1987, European journal of biochemistry.

Arginine‐rich cell penetrating peptides: Design, structure–activity, and applications to alter pre‐mRNA splicing by steric‐block oligonucleotides

P. Iversen, H. Moulton, B. Lebleu, 2008, Journal of peptide science : an official publication of the European Peptide Society.