J. Melling

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In vitro assays for botulinum toxin and antitoxins.

C. Shone, N. Appleton, P. Wilton-Smith, 1986, Developments in biological standardization.

In vivo evidence that bacteria in urinary tract infection grow under iron-restricted conditions

G. Shand, M. R. Brown, J. Melling, 1985, Infection and immunity.

P. Rutter, J. Lynch, J. Melling, 1980 .

Radioiodination of botulinum neurotoxin type A with retention of biological activity and its binding to brain synaptosomes.

R. S. Williams, J. Dolly, P. Hambleton, 1983, European journal of biochemistry.

Inactivation of Clostridium botulinum type A neurotoxin by trypsin and purification of two tryptic fragments. Proteolytic action near the COOH-terminus of the heavy subunit destroys toxin-binding activity.

C. Shone, P. Hambleton, J. Melling, 1985, European journal of biochemistry.

Botulinum neurotoxin type B. Its purification, radioiodination and interaction with rat-brain synaptosomal membranes.

R. S. Williams, J. Dolly, C. Shone, 1986, European journal of biochemistry.

A 50-kDa fragment from the NH2-terminus of the heavy subunit of Clostridium botulinum type A neurotoxin forms channels in lipid vesicles.

C. Shone, P. Hambleton, J. Melling, 1987, European journal of biochemistry.

Botulinum type F neurotoxin. Large-scale purification and characterization of its binding to rat cerebrocortical synaptosomes.

J. Dolly, C. Shone, P. Hambleton, 1990, The Biochemical journal.

Preparation and Characterisation of Homogeneous Neurotoxin Type A from Clostridium botulinum

J. Dolly, P. Hambleton, J. Melling, 2005 .

Evaluation of a monoclonal antibody-based immunoassay for detecting type A Clostridium botulinum toxin produced in pure culture and an inoculated model cured meat system.

T. A. Roberts, C. Shone, P. Hambleton, 1987, The Journal of applied bacteriology.

Botulinum neurotoxin B inhibits insulin-stimulated glucose uptake into 3T3-L1 adipocytes and cleaves cellubrevin unlike type A toxin which failed to proteolyze the SNAP-23 present.

J. Dolly, C. Shone, J. Melling, 1997, Biochemistry.

Microbial transformations of non-steroid cyclic compounds: edited by Klaus Kieslich, published by Georg Thieme Verlag, Stuttgart, 1976, DM196. (xxii+ 1212 pages)

J. Melling, 1977 .

Characteristics of Bacillus cereus emetic toxin

J. Melling, B. Capel, 1978 .

Inhibition of calcium-dependent release of noradrenaline from PC12 cells by botulinum type-A neurotoxin. Long-term effects of the neurotoxin on intact cells.

C. Shone, J. Melling, Jack Melling, 1992, European journal of biochemistry.

Monoclonal antibody-based immunoassay for type A Clostridium botulinum toxin is comparable to the mouse bioassay

C. Shone, N. Appleton, P. Wilton-Smith, 1985, Applied and environmental microbiology.

Protection conferred by microbially-supplemented UK and purified PA vaccines

R. Hewson, J. Melling, 1990 .

Properties and production characteristics of vomiting, diarrheal, and necrotizing toxins of Bacillus cereus.

R. J. Gilbert, J. Kramer, J. Melling, 1979, The American journal of clinical nutrition.

Identification of a novel enterotoxigenic activity associated with Bacillus cereus.

R. J. Gilbert, J. Melling, P. Turnbull, 1976, Journal of clinical pathology.

Expression of recombinant protein A from the lac promoter in Escherichia coli JM83 is not subject to catabolite repression when grown under specific conditions of continuous culture

J. Stephenson, A. Fooks, A. Warnes, 1991, Biotechnology and bioengineering.

Loss of sensitivity to EDTA by Pseudomonas aeruginosa grown under conditions of Mg limitation.

M. R. Brown, J. Melling, 1968, Journal of general microbiology.

Localization of sites for 125I-labelled botulinum neurotoxin at murine neuromuscular junction and its binding to rat brain synaptosomes.

R. S. Williams, J. Black, J. Dolly, 1982, Toxicon : official journal of the International Society on Toxinology.

Evaluation of a monoclonal antibody-based immunoassay for detecting type B Clostridium botulinum toxin produced in pure culture and an inoculated model cured meat system.

T. A. Roberts, P. Hambleton, N. Modi, 1988, The Journal of applied bacteriology.

Role of divalent cations in the action of polymyxin B and EDTA on Pseudomonas aeruginosa.

M. R. Brown, J. Melling, 1969, Journal of general microbiology.

PRODUCTION, PURIFICATION AND TOXOIDING OF CLOSTRIDIUM BOTULINUM TYPE A TOXIN

J. Dolly, P. Hambleton, J. Melling, 1981 .

Involvement of the constituent chains of botulinum neurotoxins A and B in the blockade of neurotransmitter release.

L. Tauc, J. Dolly, B. Poulain, 1988, European journal of biochemistry.

Inhibition of transmitter release by botulinum neurotoxin A. Contribution of various fragments to the intoxication process.

L. Tauc, J. Dolly, B. Poulain, 1989, European journal of biochemistry.

A comparison of the effects of various stimulatory agents on t‐PA secretion by normal and malignant cell lines

T. Atkinson, J. Melling, J. Clarke, 1989, Cell biochemistry and function.

The complete amino acid sequence of the Clostridium botulinum type A neurotoxin, deduced by nucleotide sequence analysis of the encoding gene.

T. Atkinson, N. Minton, J. D. Oultram, 1990, European journal of biochemistry.

Multiple domains of botulinum neurotoxin contribute to its inhibition of transmitter release in Aplysia neurons.

L. Tauc, J. Dolly, B. Poulain, 1989, The Journal of biological chemistry.

Identification of Bacillus anthracis by API tests.

J. Melling, N. A. Logan, J. A. Carman, 1985, Journal of medical microbiology.

Large-scale purification of staphylococcal enterotoxins A, B, and C2 by dye ligand affinity chromatography

P. Hambleton, J. Melling, R. Brehm, 1990, Applied and environmental microbiology.

BOTULISM AND SUDDEN INFANT DEATH

R. J. Gilbert, N. Grist, J. Melling, 1976, The Lancet.

Separation, purification and properties of β-lactamase I and β-lactamase II from Bacillus cereus 569/H/9

J. Melling, E. Abraham, R. B. Davies, 1974 .

Survival of R-factor carrying Escherichia coli in mixed cultures in the chemostat

D. Ellwood, J. Melling, A. Robinson, 1977 .

Herpes simplex virus genital infection of the female guinea pig as a model for the evaluation of an experimental vaccine.

P. Hambleton, J. Melling, A. Baskerville, 1984, Vaccine.

Adhesion of microorganisms to surfaces

D. C. Ellwood, P. Rutter, D. Ellwood, 1979 .

Export of extracellular levansucrase by Bacillus subtilis: inhibition by cerulenin and quinacrine

M. Caulfield, J. Melling, R. Berkeley, 1979, Journal of bacteriology.

Antibody reactivity with Skinner HSV vaccine

J. Durham, J. Melling, C. Wiblin, 1987, Medical Microbiology and Immunology.

Follow-up report on 50 subjects vaccinated against herpes genitalis with Skinner vaccine

C. Fink, J. Durham, J. Melling, 1987, Medical Microbiology and Immunology.

Report of twelve years experience in open study of Skinner herpes simplex vaccine towards prevention of herpes genitalis

C. Fink, J. Melling, C. Wiblin, 1992, Medical Microbiology and Immunology.

Anthrax: the disease in relation to vaccines.

P. Hambleton, J. Melling, J. A. Carman, 1984, Vaccine.

Early experience with "antigenoid" vaccine Ac NFU1(S-) MRC towards prevention or modification of herpes genitalis.

C. Woodman, J. Melling, C. Wiblin, 1982, Developments in biological standardization.

Animal cell culture collections and the supply of authenticated cultures and services for industry and research.

J. Melling, C. B. Morris, A. Doyle, 1989, Biotechnology & genetic engineering reviews.

Adjuvant effect of human growth hormone with an inactivated flavivirus vaccine.

J. Stephenson, J. Melling, J. M. Lee, 1991, The Journal of infectious diseases.

Control of herpes simplex virus infections of the genital tract by vaccination.

J. Melling, C. Wiblin, A. Buchan, 1985, Vaccine.

TREATMENT OF ANISMUS IN INTRACTABLE CONSTIPATION WITH BOTULINUM A TOXIN

N. Williams, J. Morrison, J. Melling, 1988, The Lancet.

Development of antibodies to protective antigen and lethal factor components of anthrax toxin in humans and guinea pigs and their relevance to protective immunity

J. Melling, J. A. Carman, M. Broster, 1986, Infection and immunity.

Nuclease treatment of broken bacterial suspensions for removal of highly polymerised nucleic acids

J. Melling, A. Atkinson, 1972 .

Antitoxins and botulinum toxin treatment.

H E Cohen, P Hambleton, H. E. Cohen, 1992, BMJ.

Assay of the heat-labile enterotoxin of Escherichia coli in infant rabbits.

J. Melling, C. Cowley, N. Mullan, 1979, Journal of Medical Microbiology.

Preparation of gram quantities of a purified R-factor-mediated penicillinase from Escherichia coli strain W3310.

G. K. Scott, J. Melling, G. Scott, 1972, The Biochemical journal.

Actions of beta-bungarotoxin on spontaneous release of transmitter at muscle end-plates treated with botulinum toxin.

J. Dolly, J. Melling, C. Tse, 1986, Toxicon : official journal of the International Society on Toxinology.

IDENTIFICATION OF BACILLUS A NTHRACIS BY API TESTS

J. Melling, N. A. Logan, J. A. Carman, 1985 .

Bacillus anthracis on Gruinard Island

J. Melling, A. J. Stagg, J. Melling, 1981, Nature.

Distinction between emetic and other strains of Bacillus Cereus using the API system and numerical methods

J. Melling, N. A. Logan, R. Berkeley, 1979 .

Decontamination of Bacillus anthracis on Gruinard Island?

J. Melling, M. Broster, R. Manchee, 1983, Nature.

Acceptors for botulinum neurotoxin reside on motor nerve terminals and mediate its internalization

J. Black, J. Dolly, Richard S. Williams, 1984, Nature.

Continuous culture 6. Applications and new fields.

A. C. R. Dean, D. C. Ellwood, C. G. T. Evans, 1976 .

Containment of unit processes

P. Hambleton, P. Hambleton, J. Melling, 1994 .

Chapter 1 – Inhibition and Destruction of Microorganisms by Heat

J. Melling, Michael R. W. Brown, 1971 .

Clostridium botulinum toxins: nature and preparation for clinical use

C. Shone, P. Hambleton, J. Melling, 1988, Eye.

Bacillus anthracis but not always anthrax.

C. J. Duggleby, M. N. Jones, C. Quinn, 1992, The Journal of applied bacteriology.

Purification of anthrax-toxin components by high-performance anion-exchange, gel-filtration and hydrophobic-interaction chromatography.

C. Quinn, C. Shone, J. Melling, 1988, The Biochemical journal.

Bacillus cereus infections

J. Melling, R. Gilbert, 1980, Journal of Clinical Pathology.

Clostridium botulinum and Associated Neurotoxins

J. Melling, J. Chaddock, 2002 .

The inhibition of Staphylococcus aureus enterotoxin a production by cerulenin and quinacrine; presumptive evidence for a lipid intermediate/protease release mechanism

M. Caulfield, J. Melling, R. Berkeley, 1978 .

The influence of ph value and ionic strength on the ultrafiltration characteristics of a penicillinase produced by Escherichia coli Strain W3310

J. Melling, D. Westmacott, 2007 .

Preparation and characterisation of homogeneous neurotoxin type A from Clostridium botulinum. Its inhibitory action on neuronal release of acetylcholine in the absence and presence of beta-bungarotoxin.

J. Dolly, P. Hambleton, J. Melling, 1982, European journal of biochemistry.

A test for the relative potency of herpes simplex virus vaccines based upon the female guinea-pig model of HSV 2 genital infection.

M. Welch, J. Melling, R. Phillpotts, 1988, Journal of biological standardization.

Clues to the multi-phasic inhibitory action of botulinum neurotoxins on release of transmitters.

L. Tauc, J. Dolly, B. Poulain, 1990, Journal de physiologie.

Persistence of pBR322-related plasmids in Escherichia coli grown in chemostat cultures

J. Melling, S. A. Jones, 1984 .

A high containment polymodal pilot-plant fermenter--design concepts.

P Hambleton, J. B. Griffiths, J B Griffiths, 2007, Journal of chemical technology and biotechnology.

Loss of sensitivity to EDTA by Pseudomonas aeruginosa grown under conditions of Mg-limitation.

M. R. Brown, J. Melling, 1968, Journal of General Microbiology.

Production and characterization of monoclonal antibodies to outer membrane proteins of Pseudomonas aeruginosa grown in iron-depleted media.

O. Alpar, M. R. Brown, J. Melling, 1991, Journal of general microbiology.

The membrane binding C-terminus of protein A fromStaphylococcus aureus affects its cellular localization and causes structural deformation when expressed inEscherichia coli

J. Stephenson, A. Fooks, A. Warnes, 1993, Current Microbiology.

Release of dipicolinic acid and calcium and activation of Bacillus stearothermophilus spores as a function of time, temperature and pH

J. Melling, M. Brown, 1973, The Journal of pharmacy and pharmacology.