R. Charubala

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Nucleotides: Part LXXVI : Synthesis and Properties of New Isoalloxazine (=Benzo[g]pteridine‐2,4(1H,3H)‐dione) Derivatives as Labels for Oligonucleotides

W. Pfleiderer, Evgeny Kvassiouk, R. Charubala, 2010 .

Specific interaction of the diastereomers 7(R)‐ and 7(S)‐tetrahydrobiopterin with phenylalanine hydroxylase: implications for understanding primapterinuria and vitiligo

Aurora Martínez, K. Teigen, J. Wood, 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

(2'-5')Oligoadenylate and intracellular immunity against retrovirus infection.

H. Schröder, W. Müller, W. Pfleiderer, 1992, The International journal of biochemistry.

Inhibition of Epstein-Barr virus-associated nuclear antigen (EBNA) induction by (2',5')oligoadenylate and the cordycepin analog: mechanism of action for inhibition of EBV-induced transformation.

P. Doetsch, W. Pfleiderer, R. Charubala, 1982, Virology.

Biochemical Dysregulation of the 2-5A Synthetase/RNase L Antiviral Defense Pathway in Chronic Fatigue Syndrome

W. Pfleiderer, R. Charubala, P. Cheney, 1999 .

Biochemical evidence for a novel low molecular weight 2-5A-dependent RNase L in chronic fatigue syndrome.

M. Adelson, N. Kon, W. Pfleiderer, 1997, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Inhibition of morphine-potentiated HIV-1 replication in peripheral blood mononuclear cells with the nuclease-resistant 2-5A agonist analog, 2-5AN6B

T. Rogers, W. Pfleiderer, R. Charubala, 2002 .

Inhibition of HIV-1 replication in CD4 + and CD14 + cells purified from HIV-1-infected individuals by the 2-5A agonist immunomodulator, 2-5A N6B

Robert, J. Gaughan, B. Suh, 2007 .

Cordycepin analogues of 2',5'-oligoadenylate inhibit human immunodeficiency virus infection via inhibition of reverse transcriptase.

L. Leserman, W. Müller, R. Sobol, 1991, Biochemistry.

2',5'-Oligoadenylate trimer core and the cordycepin analog augment the tumoricidal activity of human natural killer cells.

W. Pfleiderer, R. Charubala, E. Henderson, 1984, Journal of immunology.

Synthesis of O6-p-nitrophenylethyl guanosine and 2′-deoxyguanosine derivatives

W. Pfleiderer, R. Charubala, T. Trichtinger, 1983 .

The p-nitrophenylethyl (NPE) group: A versatile new blocking group for phosphate and aglycone protection in nucleosides and nucleotides

F. Himmelsbach, W. Pfleiderer, R. Charubala, 1984 .

Nucleotide. XV. Synthese und Eigenschaften von 2′-O-t-Butyldimethylsilyl-5′-O-monomethoxytritylribonucleosid-3′-phosphotriestern, Ausgangssubstanzen für Oligonucleotid-Synthesen†

R. S. Varma, W. Pfleiderer, R. Charubala, 1981 .

2′-OH Protection by the p-Nitrophenylethylsulfonyl (NPES) Group in Oligoribonucleotide Synthesis

W. Pfleiderer, R. Charubala, 1987 .

Synthesis and properties of 3′-deoxyadenylate trimer dA2′p5′A2′p5′A

W. Pfleiderer, R. Charubala, 1981 .

New Photolabile Protecting Groups in Nucleoside and Nucleotide Chemistry—Synthesis, Cleavage Mechanisms and Applications

W. Pfleiderer, R. Charubala, E. Kvasyuk, 1998 .

Phosphorothioate and cordycepin analogues of 2',5'-oligoadenylate: inhibition of human immunodeficiency virus type 1 reverse transcriptase and infection in vitro.

D. Montefiori, W. Robinson, R. Sobol, 1989, Proceedings of the National Academy of Sciences of the United States of America.

The p-Nitrophenylethyl Group - An Universal Blocking Group in Nucleoside and Nucleotide Chemistry

A. Beiter, F. Himmelsbach, W. Pfleiderer, 1985 .

A new solid phase approach for rapid syntheses of oligonucleotides bearing a 3′-terminal phosphate group

E. Felder, R. Schwyzer, W. Pfleiderer, 1985 .

Nucleotides Part LXX

T. Rogers, W. Pfleiderer, R. Charubala, 2002 .

Pteridine Nucleosides—New Versatile Building Blocks in Oligonucleotide Synthesis

W. Pfleiderer, R. Charubala, M. Hawkins, 1997 .

Nucleotides, Part LXIII, New 2-(4-Nitrophenyl)ethyl(Npe)- and 2-(4-Nitrophenyl)ethoxycarbonyl(Npeoc)-Protected 2′-Deoxyribonucleosides and Their 3′-Phosphoramidites – Versatile Building Blocks for Oligonucleotide Synthesis

F. Himmelsbach, M. Schwarz, W. Pfleiderer, 1999 .

Inhibition of HIV-1 Replication and Activation of RNase L by Phosphorothioate/Phosphodiester 2′,5′-Oligoadenylate Derivatives (*)

E. Mordechai, N. Kon, R. Sobol, 1995, The Journal of Biological Chemistry.

HIV-1 reverse transcriptase: inhibition by 2',5'-oligoadenylates.

Samuel H. Wilson, A. Kumar, W. Beard, 1993, Biochemistry.

Only one 3'-hydroxyl group of ppp5' A2'p5'A2'p5' A (2-5A) is required for activation of the 2-5A-dependent endonuclease.

W. Pfleiderer, R. Charubala, P. Torrence, 1988, The Journal of biological chemistry.

Nucleotides. Part 63. New 2‐(4‐Nitrophenyl)ethyl(Npe)‐ and 2‐(4‐Nitrophenyl)ethoxycarbonyl(Npeoc)‐Protected 2′‐Deoxyribonucleosides and Their 3′‐Phosphoramidites — Versatile Building Blocks for Oligonucleotide Synthesis.

F. Himmelsbach, M. Schwarz, W. Pfleiderer, 2000 .

Model Studies Towards the Automated Synthesis of tRNAs

K. Stengele, W. Pfleiderer, R. Charubala, 1991 .

Nucleotides. Part XXVIII. Chemical syntheses of the 2′‐5′‐cordycepin‐trimer core

F. Himmelsbach, W. Pfleiderer, R. Charubala, 1987 .

Recent progress in oligonucleotide synthesis.

R. S. Varma, W. Pfleiderer, R. Charubala, 1980, Nucleic Acids Symposium Series.

Inhibition of HIV type 1 replication in CD4+ and CD14+ cells purified from HIV type 1-infected individuals by the 2-5A agonist immunomodulator, 2-5A(N6B).

J. Gaughan, B. Suh, Xiaowei Yang, 2007, AIDS research and human retroviruses.

Structural and functional features of the 37-kDa 2-5A-dependent RNase L in chronic fatigue syndrome.

B. Lebleu, W. Pfleiderer, R. Charubala, 2002, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Nucleotides. Part XLV. Synthesis of new (2′–5′)adenylate trimers, containing 5′‐amino‐5′‐deoxyadenosine residues at the 5′‐end of the oligoadenylate chain, and of its analogues, carrying a 9‐[(2‐hydroxyethoxy)methyl]adenine residue at the 2′‐terminus

W. Pfleiderer, R. Charubala, T. I. Kulak, 1995 .

Inhibition of DNA topoisomerase I activity by 2',5'-oligoadenylates and mismatched double-stranded RNA in uninfected and HIV-1-infected H9 cells.

W. Müller, M. Kelve, W. Pfleiderer, 1994, Chemico-biological interactions.

Nucleotides. Part XXXVIII.†. Syntheses and characterization of phosphorothioate analogues of (2′–5′) adenylate dimer and trimer and their 5′-O-monophosphates‡

W. Pfleiderer, R. Charubala, 1992 .

Chemical Synthesis and Biological Activity of 2′-5′-Phosphorothioate Tetramer Cores

R. Sobol, W. Pfleiderer, R. Charubala, 1991 .

Phosphorothioate analogues of (2'-5')(A)4: agonist and antagonist activities in intact cells.

C. Bisbal, M. Silhol, B. Lebleu, 1990, Biochemistry.

Nucleotides part XXX Chemical synthesis of adenylyl-(2′ 5′)-adenylyl-(2′ 5′)-8-azidoadenosine, and activation and photoaffinity labelling of RNase L by [32P]p5′A2′p5′A2′p5′N38A†

R. Sobol, W. Pfleiderer, R. Charubala, 1989 .

Phosphorothioate analogues of 2',5'-oligoadenylate. Activation of 2',5'-oligoadenylate-dependent endoribonuclease by 2',5'-phosphorothioate cores and 5'-monophosphates.

K. Karikó, R. Sobol, W. Pfleiderer, 1987, Biochemistry.

Phosphorothioate analogues of 2',5'-oligoadenylate. Enzymatically synthesized 2',5'-phosphorothioate dimer and trimer: unequivocal structural assignment and activation of 2',5'-oligoadenylate-dependent endoribonuclease.

K. Karikó, R. Sobol, W. Pfleiderer, 1987, Biochemistry.

Synthesis of new modified 2′,5′-adenylate trimers carrying 3′-amino-3′-deoxyadenosine at the 2′-terminus

F. Himmelsbach, W. Pfleiderer, R. Charubala, 1994 .

Chemical synthesis of 2',5'-oligoadenylate analogues.

W. Pfleiderer, R. Charubala, 1994, Progress in molecular and subcellular biology.

Nucleotides. Part XXXI. Modified Oligomeric 2′–5′ A Analogues: Synthesis of 2′–5′ oligonucleotides with 9‐(3′‐azido‐3′‐deoxy‐β‐D‐xylofuranosyl)adenine and 9‐(3′‐amino‐3′‐deoxy‐β‐D‐xylofuranosyl)adenine as modified nucleosides

P. Herdewijn, W. Pfleiderer, R. Charubala, 1989 .

Synthesis and Biological Activity of a Bis-Substituted 3′-Deoxyadenosine Analog of 2–5A

W. Pfleiderer, R. Charubala, P. Torrence, 1989 .

NUCLEOTIDES. XII. SYNTHESIS AND PROPERTIES OF TRINUCLEOSIDE DIPHOSPHATES WITH H THYMIDINE, 2′-DEOXYADENOSINE, AND 1-(2′-DEOXY-α- AND 1-(2′-DEOXY-β-D-RIBOFURANOSYL)LUMAZINES AS BUILDING BLOCKS

W. Bannwarth, W. Pfleiderer, R. Charubala, 1980 .

A route to 2′,5′‐oligoadenylates with increased stability towards phosphodiesterases

G. Yakovlev, M. Karpeisky, S. Mikhailov, 1988, FEBS letters.

5'-dephosphorylated 2',5'-adenylate trimer and its analogs. Inhibition of tobacco mosaic virus replication in tobacco mosaic virus-infected leaf discs, protoplasts, and intact tobacco plants.

M. Reichman, W. Pfleiderer, R. Charubala, 1984, The Journal of biological chemistry.

Nucleotides. Part XXV. Chemical synthesis of the hexaribonucleotide C‐A‐A‐C‐C‐A

R. S. Varma, W. Pfleiderer, R. Charubala, 1986 .

Nucleotides. Part XXVII Bis[2-(p-nitrophenyl)ethyl] Phosphorochloridate, a New Versatile Phosphorylating Agent in Nucleotide Chemistry†

F. Himmelsbach, W. Pfleiderer, R. Charubala, 1987 .

Nucleotides. Part XXXV. Synthesis of 3′‐deoxyadenylyl‐(2′–5′)‐3′‐deoxyadenyIyl‐(2′–ω)‐9‐(ω‐hydroxyalkyl)adenines

S. Mikhailov, W. Pfleiderer, R. Charubala, 1991 .

Nucleotides. Part 28. Chemical Syntheses of the 2′-5′-Cordycepin-Trimer Core (I).

F. Himmelsbach, W. Pfleiderer, R. Charubala, 1988 .

Synthesis of 3′-Deoxyadenylate Trimer

F. Himmelsbach, W. Pfleiderer, R. Charubala, 1985 .

Conformational analysis of the trinucleoside diphosphate 3'd(A2'-5'A2'- 5'A). An NMR and CD study

Cornelis Altona, Johannes Doornbos, Ramamurthy Charubala, 1983, Nucleic Acids Res..

Core (2'-5')oligoadenylate and the cordycepin analog: inhibitors of Epstein--Barr virus-induced transformation of human lymphocytes in the absence of interferon.

J. Mosca, P. Doetsch, W. Pfleiderer, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Recent Progress in Oligoribonucleotide Synthesis

W. Pfleiderer, R. Charubala, M. Pfister, 1988 .

Synthesis and characterization of deoxy- and ribo H-phosphonate dimers.

W. Pfleiderer, R. Charubala, A. Jäger, 1987, Nucleic acids symposium series.

Synthesis of P-Thioadenylyl (2′-5′) Adenosine and P-Thioadenylyl (2′-5′)-P-Thioadenylyl-(2′-5′)-Adenosine

W. Pfleiderer, R. Charubala, 1987 .

Synthesis of inosinate trimer I2′p5′I2′pt′I and tetramer I2′p5′I2′p5′I2′p5′I

W. Pfleiderer, R. Charubala, 1982 .

2′,5′-Adenylate and Cordycepin Trimer Cores: Metabolic Stability and Evidence for Antimitogenesis without 5′-Rephosphorylation

P. Doetsch, W. Pfleiderer, R. Charubala, 1983 .

Synthesis and properties of adenylate trimers A2′p5′A2′p5′A, A2′p5′A3′p5′A and A3′p5′A2′p5′A

W. Pfleiderer, R. Charubala, 1980 .

Synthesis of a modified 2′, 5′-Adenylate trimer with a 2′,3′-Di-O-(2-Carboxyethyl)-ethylidene terminal group

W. Pfleiderer, R. Charubala, T. I. Kulak, 1984 .

2′,5′-phosphodiesterase activity depends upon the presence of a 3′-hydroxyl moiety in the penultimate position of the oligonucleotide substrate

Y. Kitade, W. Pfleiderer, R. Charubala, 1986 .

Synthesis and Biological Activity of 3′-Modified 2′-5′ Adenylate Trimers

R. Pauwels, P. Herdewijn, E. Clercq, 1987 .

2′–5′-Oligoadenylates (2–5A) As Mediators of Interferon Action. Synthesis and Biological Activity of New 2–5A Analogues

R. Pauwels, P. Herdewijn, E. Clercq, 1987 .

Phosphorothioate Analogs of 2–5A: Elucidation of the Stereochemical Course of the Enzymes of the 2–5A Synthetase/RNase L System

K. Karikó, R. Sobol, W. Pfleiderer, 1987 .

Cordycepin Analogs of 2–5 a as Activators of RNase L: Study of the Structural Requirements for RNase L Activation

K. Karikó, W. Pfleiderer, R. Charubala, 1987 .

Chemical synthesis and biological characterization of phosphorothioate analogs of 2', 5'-3'-deoxyadenylate trimer.

R. Sobol, W. Pfleiderer, R. Charubala, 1993, Nucleic acids research.

Nucleotides. Part 45. Synthesis of New (2′5′)Adenylate Trimers, Containing 5′-Amino-5′-deoxyadenosine Residues at the 5′-End of the Oligoadenylate Chain, and of Its Analogues, Carrying a 9-((2- Hydroxyethoxy)methyl)adenine Residue at the 2′-Terminus.

W. Pfleiderer, R. Charubala, T. I. Kulak, 1996 .

The Chemical Syntheses of (2′-5′)-P-Thioadenylate Dimers, Trimers and Tetramers

W. Pfleiderer, R. Charubala, 1988 .

Phosphorothioate Analogs OF 2-5A: Activation / Inhibition of Rnase L and Inhibition of HIV-1 Reverse Transcriftase

D. Montefiori, B. Lebleu, K. Karikó, 1989 .

Nucleotides. Part 38. Syntheses and Characterization of Phosphorothioate Analogues of (2′‐5′)Adenylate Dimer and Trimer and Their 5′‐O‐Monophosphates.

W. Pfleiderer, R. Charubala, 1992 .

Nucleotides. Part 30. Chemical Synthesis of Adenylyl‐(2′ → 5′)‐adenylyl‐(2′ → 5′)‐8‐azidoadenosine, and Activation and Photoaffinity Labeling of RNase L by (32P)p5′A2′p5′A2′p5′N3 8A.

R. Sobol, W. Pfleiderer, R. Charubala, 1989 .

Nucleotides. Part 36. Syntheses and Biological Characterization of Phosphorothioate Analogues of (3′‐5′)Adenylate Trimer.

N. Kon, R. Sobol, W. Pfleiderer, 1991 .

Only One 3′-Hydroxyl Group Of ppp 5′A 2′p 5′A 2′p 5′A(2–5A) is Required for Activation of the Mouse 2–5A-Dependent Endonuclease

W. Pfleiderer, R. Charubala, P. Torrence, 1987 .

Nucleotides. Part. XXXII. Synthesis of 2′–5′ Connected oligonucleotides. Prodrugs for antiviral and antitumoral nucleosides†

P. Herdewijn, E. Clercq, W. Pfleiderer, 1989 .

Nucleotides. Part 31. Modified Oligomeric 2′-5′ A Analogues: Synthesis of 2′-5′ Oligonucleotides with 9-(3′-Azido-3′-deoxy-β-D-xylofuranosyl)adenine and 9-(3′-Amino-3′-deoxy-β-D-xylofuranosyl)adenine as Modified Nucleosides.

P. Herdewijn, W. Pfleiderer, R. Charubala, 1990 .

Nucleotides XXIV;1 Preparative Synthesis of Trimeric (2′-5′) Oligoadenylic Acid

W. Pfleiderer, R. Charubala, T. I. Kulak, 1987 .

Chemical Synthesis of 2′,5′-Oligoadenylate Analogues

W. Pfleiderer, R. Charubala, 1995 .

Specificities of rabbit anti-(2',5')oligoadenylate antibodies towards phosphorothioate and seco analogs of oligoadenylates.

S. Mikhailov, W. Pfleiderer, R. Charubala, 1991, Nucleic acids symposium series.

Chemical synthesis, characterization, and biological properties of four possible trimeric 3'-deoxyadenosine (cordycepin) phosphorothioates and their 3'→5'-adenylate analogues

W. Pfleiderer, R. Charubala, 1990 .

Nucleotides. XXXIII, Synthesis and properties of inosinate trimer 12'p5'12'p5'I and inosinate tetramer 12'p5'12'p5'12'p5'I

W. Pfleiderer, R. Charubala, 1990 .

The p-Nitrophenylethyl Group - a Universal Blocking Group in Nucleoside and Nucleotide Chemistry

A. Beiter, F. Himmelsbach, W. Pfleiderer, 1986 .

Nucleosides. LXII. Synthesis of 6-Methyl-8-(2-deoxy-β-D-ribofuranosyl)-isoxanthopterin and Derivatives

W. Pfleiderer, R. Charubala, M. Melguizo, 1998 .

Inhibition of growth of estrogen receptor positive and estrogen receptor negative breast cancer cells in culture by AA-etherA, a stable 2-5A derivative.

M. Adelson, E. Mordechai, K. Latham, 1996, Oncogene.

Inhibition of morphine-potentiated HIV-1 replication in peripheral blood mononuclear cells with the nuclease-resistant 2-5A agonist analog, 2-5A(N6B).

T. Rogers, W. Pfleiderer, R. Charubala, 2002, Journal of acquired immune deficiency syndromes.

Synthesis and Activity of Oligonucleotides Containing a Biologically Active Nucleoside at the 2′End

R. Pauwels, P. Herdewijn, E. Clercq, 1987 .