V. Slepak

发表

Microbial life in the Lake Medee, the largest deep-sea salt-saturated formation

M. Borghini, M. Ferrer, P. Golyshin, 2013, Scientific Reports.

Analysis of protein-protein interactions in phototransduction cascade using surface plasmon resonance.

V. Slepak, D. Satpaev, 2000, Methods in enzymology.

Human Beta Cells Produce and Release Serotonin to Inhibit Glucagon Secretion from Alpha Cells.

P. Berggren, Joana Almaça, A. Pronin, 2016, Cell reports.

Teaching an Old Drug New Tricks: Agonism, Antagonism, and Biased Signaling of Pilocarpine through M3 Muscarinic Acetylcholine Receptor

Q. Wang, A. Pronin, V. Slepak, 2017, Molecular Pharmacology.

Evidence for Multiple Phototransduction Pathways in a Reef-Building Coral

Q. Wang, P. Gibbs, M. Schmale, 2012, PloS one.

Signal-Dependent Translocation of Transducin, RGS9-1-Gβ5L Complex, and Arrestin to Detergent-Resistant Membrane Rafts in Photoreceptors

V. Slepak, N. Balasubramanian, K. Nair, 2002, Current Biology.

Pannexin 1 sustains the electrophysiological responsiveness of retinal ganglion cells

V. Porciatti, B. Sagdullaev, A. Pronin, 2018, Scientific Reports.

Phosphorylation of the regulator of G protein signaling RGS9-1 by protein kinase A is a potential mechanism of light- and Ca2+-mediated regulation of G protein function in photoreceptors.

V. Slepak, E. Faurobert, N. Balasubramanian, 2001, Biochemistry.

Gβ5 prevents the RGS7-Gαo interaction through binding to a distinct Gγ-like domain found in RGS7 and other RGS proteins

V. Slepak, D. Satpaev, K. Levay, 1999 .

Characterization of tescalcin, a novel EF-hand protein with a single Ca2+-binding site: metal-binding properties, localization in tissues and cells, and effect on calcineurin.

A. Gomes, J. Benovic, You-Me Kim, 2003, Biochemistry.

Targeted deletion of one or two copies of the G protein β subunit Gβ5 gene has distinct effects on body weight and behavior in mice

O. Gavrilova, Q. Wang, E. Gurevich, 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Interaction of retinal guanylate cyclase with the alpha subunit of transducin: potential role in transducin localization.

A. Dizhoor, D. Rosenzweig, J. Crabb, 2009, The Biochemical journal.

Gbeta5 prevents the RGS7-Galphao interaction through binding to a distinct Ggamma-like domain found in RGS7 and other RGS proteins.

V. Slepak, D. Satpaev, K. Levay, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Time resolved kinetics of direct G beta 1 gamma 2 interactions with the carboxyl terminus of Kir3.4 inward rectifier K+ channel subunits.

N. Davidson, C. Dessauer, A. Gilman, 1996, Neuropharmacology.

Postnatal induction and localization of R7BP, a membrane- anchoring protein for RGS7 family-Gβ5 complexes in brain

Y. Smith, K. Kaltenbronn, M. Jayaraman, 2008 .

G alpha 16, a G protein alpha subunit specifically expressed in hematopoietic cells.

M. Simon, Melvin I. Simon, V. Slepak, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Localization of the sites for Ca2+-binding proteins on G protein-coupled receptor kinases.

J. Benovic, A. Pronin, V. Slepak, 1998, Biochemistry.

Characterization of a Goα Mutant That Binds Xanthine Nucleotides*

M. Simon, V. Slepak, Bo Yu, 1997, The Journal of Biological Chemistry.

Arrestin mobilizes signaling proteins to the cytoskeleton and redirects their activity.

V. Gurevich, W. Cleghorn, C. Klug, 2007, Journal of molecular biology.

Differential Effects of the Gβ5-RGS7 Complex on Muscarinic M3 Receptor–Induced Ca2+ Influx and Release

S. Brothers, C. Volmar, V. Slepak, 2014, Molecular Pharmacology.

Differential Effects of the G b 5-RGS 7 Complex on Muscarinic M 3 Receptor – Induced Ca 2 1 Influx and Release

S. Brothers, C. Volmar, V. Slepak, 2014 .

Gβ5·RGS7 Inhibits Gαq-mediated Signaling via a Direct Protein-Protein Interaction*

D. Witherow, S. Tovey, V. Slepak, 2003, Journal of Biological Chemistry.

Gal6, a G protein a subunit specifically expressed in hematopoietic cells

Simon, V. Slepak, D. A. Steele, 2022 .

Mechanism of light‐induced translocation of arrestin and transducin in photoreceptors: Interaction‐restricted diffusion

J. Hurley, V. Slepak, 2007, IUBMB life.

An Effector Site That Stimulates G-protein GTPase in Photoreceptors (*)

H. Hamm, V. Arshavsky, J. Sondek, 1995, The Journal of Biological Chemistry.

Direct Binding of Visual Arrestin to Microtubules Determines the Differential Subcellular Localization of Its Splice Variants in Rod Photoreceptors*

J. Hurley, V. Gurevich, M. Kennedy, 2004, Journal of Biological Chemistry.

Light-Mediated Activation of Rac-1 in Photoreceptor Outer Segments

V. Slepak, N. Balasubramanian, Nagaraj Balasubramanian, 2003, Current Biology.

Complexes of the G protein subunit gbeta 5 with the regulators of G protein signaling RGS7 and RGS9. Characterization in native tissues and in transfected cells.

J. Chen, D. Witherow, V. Slepak, 2000, The Journal of biological chemistry.

Genetic Ablation of Pannexin1 Protects Retinal Neurons from Ischemic Injury

R. Wen, A. Grinberg, V. Shestopalov, 2012, PloS one.

PhLPs and PhLOPs in the phosducin family of G beta gamma binding proteins.

J. Xu, C. Craft, V. Slepak, 1998, Biochemistry.

PhLPs and PhLOPs in the phosducin family of Gβγ binding proteins

Jun Xu, C. Craft, V. Slepak, 1997 .

Functional Analysis of a Dominant Negative Mutant of Gαi2(*)

M. Simon, A. Katz, V. Slepak, 1995, The Journal of Biological Chemistry.

Random mutagenesis of G protein alpha subunit G(o)alpha. Mutations altering nucleotide binding.

N. Davidson, M. Quick, M. Simon, 1993, The Journal of biological chemistry.

The N terminus of phosducin is involved in binding of beta gamma subunits of G protein.

M. Simon, V. Slepak, J. Xu, 1995, Proceedings of the National Academy of Sciences of the United States of America.

The N terminus of phosducin is involved in binding of fry subunits of G protein

Jun Xu, V. Slepak, WU Dianqing, 2005 .

Subunit Dissociation and Diffusion Determine the Subcellular Localization of Rod and Cone Transducins

A. Swaroop, J. Hurley, D. Rosenzweig, 2007, The Journal of Neuroscience.

Expression of Olfactory Signaling Genes in the Eye

M. Faghihi, A. Pronin, Dmitry Velmeshev, 2014, PloS one.

Regulation of Cop9 signalosome activity by the EF-hand Ca2+-binding protein tescalcin

V. Slepak, K. Levay, 2014, Journal of Cell Science.

Primary structure of bovine cerebellum GTP‐binding protein G39 and its effect on the adenylate cyclase system

Y. Ovchinnikov, A. Pronin, V. Slepak, 1987, FEBS letters.

Diversity of bacteria at healthy human conjunctiva.

D. Antonopoulos, Jennifer M. Brulc, Xiang Gao, 2011, Investigative ophthalmology & visual science.

The regulatory G protein signaling complex, Gβ5–R7, promotes glucose- and extracellular signal–stimulated insulin secretion

E. Bernal-Mizrachi, A. Pronin, J. Crabb, 2020, The Journal of Biological Chemistry.

From Mechanosensitivity to Inflammatory Responses: New Players in the Pathology of Glaucoma

N. Tian, G. Tezel, C. Mitchell, 2014, Current eye research.

Light-Dependent Redistribution of Arrestin in Vertebrate Rods Is an Energy-Independent Process Governed by Protein-Protein Interactions

J. Hurley, Jeannie Chen, V. Gurevich, 2005, Neuron.

A Novel Form of the G Protein β Subunit Gβ5 Is Specifically Expressed in the Vertebrate Retina*

M. Simon, A. Watson, V. Slepak, 1996, The Journal of Biological Chemistry.

Involvement of endoplasmic reticulum stress in a novel Classic Galactosemia model.

V. Slepak, M. Tang, K. Lai, 2007, Molecular genetics and metabolism.

Regulation of G Protein-coupled Receptor Kinases by Calmodulin and Localization of the Calmodulin Binding Domain*

J. Benovic, A. Pronin, V. Slepak, 1997, The Journal of Biological Chemistry.

Correction: Emerging roles of the single EF-hand Ca2+ sensor tescalcin in the regulation of gene expression, cell growth and differentiation

A. Rizvanov, V. Slepak, K. Levay, 2017, Journal of Cell Science.

The Gbeta5-RGS7 complex selectively inhibits muscarinic M3 receptor signaling via the interaction between the third intracellular loop of the receptor and the DEP domain of RGS7.

V. Slepak, S. Sandiford, 2009, Biochemistry.

Structure, function, and localization of Gβ5-RGS complexes.

V. Slepak, 2009, Progress in molecular biology and translational science.

A Novel Kind of G Protein Heterodimer: The Gβ5-RGS Complex

D. Witherow, V. Slepak, 2003 .

Inflammasome Activation Induces Pyroptosis in the Retina Exposed to Ocular Hypertension Injury

A. Pronin, V. Shestopalov, Galina Dvoriantchikova, 2019, Front. Mol. Neurosci..

Tescalcin is an essential factor in megakaryocytic differentiation associated with Ets family gene expression.

V. Slepak, K. Levay, 2007, The Journal of clinical investigation.

Elemental sulfur and acetate can support life of a novel strictly anaerobic haloarchaeon

M. Ferrer, P. Golyshin, P. Roman, 2015, The ISME Journal.

Application of surface plasmon resonance for analysis of protein–protein interactions in the G protein‐mediated signal transduction pathway

V. Slepak, V Z Slepak, 2000, Journal of molecular recognition : JMR.

Ectopically expressed olfactory receptors OR51E1 and OR51E2 suppress proliferation and promote cell death in a prostate cancer cell line

A. Pronin, V. Slepak, 2021, The Journal of biological chemistry.

Structure and function of the α-subunit of the GTP-binding protein Go from bovine cerebellum

E. Frolova, A. Pronin, V. Slepak, 1989, Journal of protein chemistry.

Biochemical purification and functional analysis of complexes between the G-protein subunit Gbeta5 and RGS proteins.

D. Witherow, V. Slepak, 2004, Methods in enzymology.

Structural Basis for Calcium-induced Inhibition of Rhodopsin Kinase by Recoverin*

V. Slepak, J. Ames, K. Levay, 2006, Journal of Biological Chemistry.

Time Resolved Kinetics of Direct Gβ1γ2 Interactions with the Carboxyl Terminus of Kir3.4 Inward Rectifier K+ Channel Subunits

H. Lester, N. Davidson, C. Dessauer, 1996, Neuropharmacology.

Partaking of Archaea to biogeochemical cycling in oxygen-deficient zones of meromictic saline Lake Faro (Messina, Italy).

M. Yakimov, S. Mazzola, F. Smedile, 2013, Environmental microbiology.

Identification of the Gβ5-RGS7 Protein Complex in the Retina☆

V. Slepak, D. Satpaev, J. L. Cabrera, 1998 .

Multiple opsins in a reef-building coral, Acropora millepora

A. Terakita, M. Koyanagi, Y. Sakai, 2023, Scientific Reports.

Up- or downregulation of tescalcin in HL-60 cells is associated with their differentiation to either granulocytic or macrophage-like lineage.

V. Slepak, K. Levay, 2010, Experimental cell research.

Molecular pathways of pannexin1-mediated neurotoxicity

V. Shestopalov, V. Slepak, 2014, Front. Physiol..

Regulator of G‐protein signaling Gβ5‐R7 is a crucial activator of muscarinic M3 receptor‐stimulated insulin secretion

Joana Almaça, A. Fornoni, A. Pronin, 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Regulator of G Protein Signaling 7 (RGS7) Can Exist in a Homo-oligomeric Form That Is Regulated by Gαo and R7-binding Protein*

C. Orlandi, A. Pronin, K. Martemyanov, 2016, The Journal of Biological Chemistry.

Subcellular localization of regulator of G protein signaling RGS7 complex in neurons and transfected cells

G. Gaidosh, E. Liapis, D. Motti, 2012, Journal of neurochemistry.

Targeted deletion of one or two copies of the G protein (cid:1) subunit G (cid:1) 5 gene has distinct effects on body weight and behavior in mice

O. Gavrilova, E. Gurevich, A. Pileggi, 2011 .

Identification of the Gbeta5-RGS7 protein complex in the retina.

F. de Freitas, V. Slepak, D. Satpaev, 1998, Biochemical and biophysical research communications.

Intramolecular interaction between the DEP domain of RGS7 and the Gbeta5 subunit.

V. Slepak, S. Sandiford, T. Keren-Raifman, 2007, Biochemistry.

G beta 5.RGS7 inhibits G alpha q-mediated signaling via a direct protein-protein interaction.

D. Witherow, S. Tovey, V. Slepak, 2003, Journal of Biological Chemistry.

A novel kind of G protein heterodimer: the G beta5-RGS complex.

D. Witherow, V. Slepak, 2003, Receptors and Channels.

A novel form of the G protein beta subunit Gbeta5 is specifically expressed in the vertebrate retina.

M. Simon, A. Watson, V. Slepak, 1996, The Journal of biological chemistry.

Helix 8 and the i3 Loop of the Muscarinic M3 Receptor Are Crucial Sites for Its Regulation by the Gβ5-RGS7 Complex

V. Bhat, A. Farooq, C. Volmar, 2014, Biochemistry.

Pannexin 1 sustains the electrophysiological responsiveness of retinal ganglion cells

V. Porciatti, B. Sagdullaev, A. Pronin, 2018, Scientific Reports.

Emerging roles of the single EF-hand Ca2+ sensor tescalcin in the regulation of gene expression, cell growth and differentiation

A. Rizvanov, V. Slepak, K. Levay, 2016, Journal of Cell Science.

Expression levels of RGS7 and RGS4 proteins determine the mode of regulation of the G protein‐activated K+ channel and control regulation of RGS7 by Gβ5

N. Dascal, D. Witherow, A. Bera, 2001, FEBS letters.

Mutational analysis of G protein α subunit Goα expressed in Escherichia coli

M. Simon, T. Wilkie, V. Slepak, 1993 .

Regulation of g protein-coupled receptor kinases by calmodulin and localization of the calmodulin binding domain

J. Benovic, A. Pronin, V. Slepak, 1997 .

Molecular organization of the complex between the muscarinic M3 receptor and the regulator of G protein signaling, Gbeta(5)-RGS7.

P. Buchwald, V. Slepak, S. Sandiford, 2010, Biochemistry.

Characterization of G-protein alpha subunits in the Gq class: expression in murine tissues and in stromal and hematopoietic cell lines.

M. Simon, Melvin I. Simon, M. Strathmann, 1991, Proceedings of the National Academy of Sciences of the United States of America.

The presence of a Leu-Gly-Asn repeat-enriched protein (LGN), a putative binding partner of transducin, in ROD photoreceptors.

D. Rosenzweig, V. Slepak, A. Méndez, 2005, Investigative ophthalmology & visual science.

Partaking of Archaea to biogeochemical cycling in oxygen-deficient zones of meromictic saline Lake Faro (Messina, Italy).

M. Yakimov, S. Mazzola, F. Smedile, 2013, Environmental microbiology.

Na+ Promotes the Dissociation between GαGDP and Gβγ, Activating G Protein-gated K+ Channels*

Tal Keren-Raifman, Carmen W. Dessauer, Nathan Dascal, 2003, The Journal of Biological Chemistry.

[High molecular weight forms of GTP-binding regulatory proteins from the bovine cerebellum].

A. Pronin, V. Slepak, V. Voeikov, 1987, Biokhimiia.

Vysokomolekuliarnye formy GTP-sviazyvaiushchikh reguliatornykh belkov iz mozzhechka byka.

A. Pronin, V. Slepak, V. Voeikov, 1987 .

Teaching an Old Drug New Tricks: Agonism, Antagonism, and Biased Signaling of Pilocarpine through M3 Muscarinic Acetylcholine Receptor

A. Pronin, V. Slepak, Qiang Wang, 2017, Molecular Pharmacology.

Functional analysis of a dominant negative mutant of G alpha i2.

M. Simon, A. Katz, V. Slepak, 1995, The Journal of biological chemistry.

Autophosphorylation and ADP regulate the Ca2+-dependent interaction of recoverin with rhodopsin kinase.

J. Hurley, M. Simon, V. Slepak, 1998, Biochemistry.