J. Frazier

发表

The dynamics of metals in the American oyster, Crassostrea virginica . I. Seasonal effects

J. Frazier, 1975 .

Isolated fish hepatocytes — model systems for toxicology research☆

J. Frazier, S. M. Baksi, 1990 .

Cell culture systems andin vitro toxicity testing

D. Acosta, O. Flint, J. Resau, 1992, Cytotechnology.

Current status of knowledge of the biological effects of heavy metals in the Chesapeake Bay

J. Frazier, 1972 .

Workshop Overview: Scientific and Regulatory Challenges for the Reduction, Refinement, and Replacement of Animals in Toxicity Testing 1

I. Purchase, W. Stokes, O. Flint, 1998 .

The Three Rs: The Way Forward

W. Russell, R. L. Burch, M. Stephens, 1995 .

Cadmium uptake kinetics in rat hepatocytes: correction for albumin binding.

J. Gearhart, B. Foy, N. DelRaso, 2003, Toxicological sciences : an official journal of the Society of Toxicology.

Application of in vitro systems to the prediction of in vivo biokinetics.

J. Frazier, 1995, Toxicology in vitro : an international journal published in association with BIBRA.

Perturbation of a hippocampal zinc-binding pool after postnatal lead exposure in rats

A. Goldberg, J. Frazier, Sheryl M. Sato, 1984, Experimental Neurology.

Risk assessment of high-energy chemicals by in vitro toxicity screening and quantitative structure-activity relationships.

S. Hussain, R. Pachter, S. Trohalaki, 2002, Toxicological sciences : an official journal of the Society of Toxicology.

In vitro toxicity assessment of a new series of high energy compounds.

S. Hussain, J. Frazier, 2001, The Science of the total environment.

In vivo kinetics of trichloroacetate in male Fischer 344 rats.

H. Barton, J. Frazier, D. Mahle, 2000, Toxicological sciences : an official journal of the Society of Toxicology.

QSAR modeling of oxidative stress in vitro following hepatocyte exposures to halogenated methanes.

K. Geiss, J. Frazier, 2001, Toxicology in vitro : an international journal published in association with BIBRA.

Abnormal Hepatic Copper Storage in a Teleost Fish (Morone americana)

J. Frazier, S. M. Baksi, T. Bunton, 1987, Veterinary pathology.

Extrahepatic tissue copper concentrations in white perch with hepatic copper storage

J. Frazier, T. Bunton, 1994 .

Protective effect of metallothionein on cadmium toxicity in isolated rat hepatocytes.

J. Frazier, W. S. Din, 1985, The Biochemical journal.

Variability of DNA Microarray Gene Expression Profiles in Cultured Rat Primary Hepatocytes

Leming Shi, Charles Wang, Xutao Deng, 2007, Gene regulation and systems biology.

Bioaccumulation of cadmium in marine organisms.

J. Frazier, 1979, Environmental health perspectives.

A fish hepatocyte model for the investigation of the effects of environmental contaminants

J. Frazier, S. M. Baksi, 1988 .

Induction of metal binding proteins in striped bass, Morone saxatilis, following cadmium treatment.

J. Frazier, S. M. Baksi, N. Libbus, 1988, Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology.

Transition metal-binding proteins from three Chesapeake Bay fish species.

P. C. Huang, J. Frazier, R. Andersen, 1986, Environmental health perspectives.

Effects of cadmium exposure on metal-containing amoebocytes of the oyster Ostrea edulis

J. Frazier, S. George, B. Pirie, 1983 .

27 Cell-like Entities : Scientific Challenges and Future Applications

N. Kelley-Loughnane, J. Frazier, O. Paliy, 2009 .

A kinetic study of the in vivo incorporation of 65ZN into the rat hippocampus

A. Goldberg, J. Frazier, S. Sato, 1984, The Journal of neuroscience : the official journal of the Society for Neuroscience.

The distribution and binding of zinc in the hippocampus

A. Goldberg, J. Frazier, S. Sato, 1984, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Kinetics of trichloroacetic acid and dichloroacetic acid in the isolated perfused rat liver.

J. Frazier, C. Toxopeus, 1998, Toxicology and applied pharmacology.

The dynamics of metals in the American oyster, Crassostrea virginica . II. Environmental ef

J. Frazier, 1976 .

The role of metallothionein in the systemic distribution of cadmium.

J. Frazier, 1982, Developments in toxicology and environmental science.

Predicting Dose-Response Relationships of Acute Cadmium Hepatoxicity and Metallothionein Regulation in the Rat Via In Vitro to In Vivo Extrapolation

D. M. Todd, T. R. Sterner, J. Gearhart, 2006 .

The Use of Biokinetics and in Vitro Methods in Toxicological Risk Evaluation

Gunnar Johanson, John M. Frazier, Christoph A. Reinhardt, 1996 .

Potential use of human tissues for toxicity research and testing.

L. Ducat, G. Powis, C. Tyson, 1989, Toxicology and applied pharmacology.

Alternatives to and Reduction of Animal Use in Biomedical Research, Education and Testing

Alan M. Goldberg, John M. Frazier, A. Goldberg, 1990 .

Cadmium kinetics in oysters — a comparative study of Crassostrea gigas and Ostrea edulis

J. Frazier, S. George, 1983 .

Characterization of two molecular weight classes of cadmium binding proteins from the mussel, Mytilus edulis (L.).

T. L. Coombs, J. Frazier, J. Overnell, 1985, Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology.

Cell culture systems and in vitro toxicity testing. Technical report no. 4 of the Johns Hopkins Center for Alternatives to Animal Testing (CAAT): technical workshop of June 13-15, 1990.

Robert J. Hay, John Harbell, John M. Frazier, 1992, Cytotechnology.

The effect of sodium diethyldithiocarbamate treatment on copper and zinc concentrations in rat brain.

A. Goldberg, J. Frazier, S. Sato, 1982, Toxicology and applied pharmacology.

Involvement of apoptosis in hydrazine induced toxicity in rat primary hepatocytes.

John M Frazier, Saber M Hussain, S. Hussain, 2003, Toxicology in vitro : an international journal published in association with BIBRA.

Cellular toxicity of hydrazine in primary rat hepatocytes.

John M Frazier, Saber M Hussain, S. Hussain, 2002, Toxicological sciences : an official journal of the Society of Toxicology.

Cadmium and zinc kinetics in rat plasma following intravenous injection.

J. Frazier, 1980, Journal of toxicology and environmental health.

Dose dependence of cadmium kinetics in the rat liver following intravenous injection.

J. Frazier, J. Puglese, 1978, Toxicology and applied pharmacology.

Integrating time-course microarray gene expression profiles with cytotoxicity for identification of biomarkers in primary rat hepatocytes exposed to cadmium

Charles Wang, Jun Xu, Weida Tong, 2006, Bioinform..

Mathematical model for cadmium kinetics in the isolated perfused rat liver system.

J. Frazier, 1984, Toxicology and applied pharmacology.

Cadmium transport in isolated perfused rat liver: zinc-cadmium competition.

J. Frazier, B. Kingsley, 1979, The American journal of physiology.

Kinetics of cadmium transport in the isolated perfused rat liver.

J. Frazier, B. Kingsley, 1976, Toxicology and applied pharmacology.

Biotechnology - A Perspective

Kevin T. Geiss, John M. Frazier, K. Geiss, 2000, Inf. Knowl. Syst. Manag..

The three Rs: the way forward: the report and recommendations of ECVAM Workshop 11.

Michael Balls, Horst Spielmann, Alan M Goldberg, 1995, Alternatives to laboratory animals : ATLA.

Cell-like Entities: Scientific Challenges and Future Applications

Nancy Kelley-Loughnane, John M. Frazier, Oleg Paliy, 2008 .

Cell-Like Entities: On the Boundary Between Non-Living and Living

Nancy Kelley-Loughnane, Oleg Paliy, John M. Frazier, 2006 .

EFFECT OF CULTURE CONDITIONS PRIOR TO EXPOSURE ON CADMIUM CYTOTOXICITY IN PRIMARY RAT HEPATOCYTES

N. DelRaso, J. Frazier, N. J. Delraso, 1999 .

Lateralization of zinc in rat brain and its relationship to a spatial behavior

J. Valdés, J. Frazier, Sheryl M. Sato, 1982, Pharmacology Biochemistry and Behavior.

Alternatives to animals in toxicity testing.

J M Frazier, A M Goldberg, A. Goldberg, 1989, Scientific American.

In vitro toxicities of experimental jet fuel system ice-inhibiting agents.

K. Geiss, J. Frazier, 2001, The Science of the total environment.

Toxcity Screening of Halogenated Aliphatics Using a Novel In itro Volatile Chemical Exposure System | NIST

D. Dodd, K. Geiss, J. Frazier, 2001 .

Kinetic modeling of slow dissociation of bromosulphophthalein from albumin in perfused rat liver: toxicological implications.

B. Foy, J. Frazier, C. Toxopeus, 1999, Toxicological sciences : an official journal of the Society of Toxicology.

Workshop overview: scientific and regulatory challenges for the reduction, refinement, and replacement of animals in toxicity testing.

I. Purchase, I. Purchase, W. Stokes, 1998, Toxicological sciences : an official journal of the Society of Toxicology.

Simulation of trichloroacetic acid kinetics in the isolated perfused rat liver using a biologically based kinetic model.

J. Frazier, C. Toxopeus, 2002, Toxicological sciences : an official journal of the Society of Toxicology.

In vitro toxicity indicators

C. Tyson, J. Frazier, 1994 .

Report of the Validation and Technology Transfer Committee of the Johns Hopkins Center for Alternatives to Animal Testing. Framework for validation and implementation of in vitro toxicity tests.

J M Frazier, A M Goldberg, D Brusick, 1993, Xenobiotica; the fate of foreign compounds in biological systems.

Predictive toxicodynamics: Empirical/mechanistic approaches.

J. Frazier, 1997, Toxicology in vitro : an international journal published in association with BIBRA.

Effect of cadmium on bromosulfophthalein kinetics in the isolated perfused rat liver system.

B. Foy, J. Frazier, Armando Soto, 2002, Toxicological sciences : an official journal of the Society of Toxicology.

Biological Implications of Metals in the Environment

John M. Frazier, J. Frazier, 1978 .

The Isolated Perfused Rat Liver and its use in the Study of Chemical Kinetics: Quality and Performance Parameters

J. Frazier, C. Toxopeus, 1999 .

Gallium-67 uptake by the liver: studies using isolated rat hepatocytes and perfused livers.

H. Wagner, M. Tsan, U. Scheffel, 1984, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Cadmium-binding proteins in the mussel, Mytilus edulis.

J. Frazier, 1986, Environmental health perspectives.

Stochastic simulation and analysis of biomolecular reaction networks

Brent D. Foy, John M. Frazier, Yaroslav Chushak, 2009, BMC Systems Biology.

Stochastic Simulation of Biomolecular Reaction Networks Using the Biomolecular Network Simulator Software

Brent D. Foy, John M. Frazier, Yaroslav Chusak, 2008 .

Stochastic Simulations of Cellular Biological Processes

Y. Chushak, B. Foy, J. Frazier, 2007, 2007 DoD High Performance Computing Modernization Program Users Group Conference.

Biomolecular Network Simulator: software for stochastic simulation of cellular biological processes

Brent D. Foy, John M. Frazier, Yaroslav Chushak, 2007, SpringSim '07.

BIOLOGICALLY BASED KINETIC MODEL FOR CHEMICAL KINETICS IN THE ISOLATED PERFUSED RAT LIVER SYSTEM: BASIC RECIRCULATION MODEL FOR WATER-SOLUBLE/LIPID-INSOLUBLE CHEMICALS

J. Frazier, 1998 .

Incorporation of Protein-Binding Kinetics and Carrier-Mediated Membrane Transport into a Model of Chemical Kinetics in the Isolated Perfused Rat Liver

B. Foy, J. Frazier, 2003, Toxicology mechanisms and methods.

Tailored gene array databases: applications in mechanistic toxicology

Brent D. Foy, John M. Frazier, Tatiana V. Karpinets, 2004, Bioinform..

The Report and Recommendations of ECVAM Workshop 11

R. L. Burch, M. Stephens, J. Yager, 1995 .

In vitro toxicity testing : applications to safety evaluation

John M. Frazier, J. Frazier, 1992 .