J. Wiebe

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Inhibition of cell proliferation by glycerol.

J. Wiebe, C. Dinsdale, J P Wiebe, 1991, Life sciences.

Rat sertoli cells: a rapid method for obtaining viable cells.

M. Welsh, J. Wiebe, 1975, Endocrinology.

The role of progesterone metabolites in breast cancer: Potential for new diagnostics and therapeutics

J. Wiebe, M. J. Lewis, V. Cialacu, 2005, The Journal of Steroid Biochemistry and Molecular Biology.

Progesterone-induced stimulation of mammary tumorigenesis is due to the progesterone metabolite, 5α-dihydroprogesterone (5αP) and can be suppressed by the 5α-reductase inhibitor, finasteride

J. Wiebe, M. Mercogliano, M. Rivas, 2015, The Journal of Steroid Biochemistry and Molecular Biology.

Progesterone metabolites regulate induction, growth, and suppression of estrogen- and progesterone receptor-negative human breast cell tumors

Guihua Zhang, I. Welch, J. Wiebe, 2013, Breast Cancer Research.

Effect of prenatal and neonatal exposure to lead on the affinity and number of estradiol receptors in the uterus.

J. Wiebe, K. Barr, 1988, Journal of toxicology and environmental health.

Triple-Negative Breast Cancer (TNBC) Cell Metastasis is Controlled by the Opposing Actions of 5alpha-dihydroprogesterone (5alphap) and 3alpha-dihydroprogesterone (3alphahp) on Expression of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases

J. Wiebe, J. Jarvis, A. Kwok, 2020 .

FSH receptors in isolated Sertoli cells: changes in concentration of binding sites at the onset of sexual maturation.

J. Wiebe, A. Salhanick, 1980, Life sciences.

The effects of temperature and daylength on the reproductive physiology of the viviparous seaperch, Cymatogaster aggregata Gibbons

J. Wiebe, 1968 .

Supplemental Figure : Manuscript title : Decreased Cytochrome C Oxidase IV ( COX IV ) Expression Reduces Steroidogenesis

C. Gairola, H. Bose, R. Whittal, 2011 .

The 4-pregnene and 5alpha-pregnane progesterone metabolites formed in nontumorous and tumorous breast tissue have opposite effects on breast cell proliferation and adhesion.

J. Wiebe, D. Szwajcer, D. Muzia, 2000, Cancer research.

Glycerol alters cytoskeleton and cell adhesion while inhibiting cell proliferation.

J. Wiebe, C. Dinsdale, F. Mirza, 1992, Cell biology international reports.

Sertoli cell capacity to metabolize C19 steroids: variation with age and the effect of follicle-stimulating hormone.

M. Welsh, J. Wiebe, 1978, Endocrinology.

Plasma membrane receptors for the cancer-regulating progesterone metabolites, 5alpha-pregnane-3,20-dione and 3alpha-hydroxy-4-pregnen-20-one in MCF-7 breast cancer cells.

J. Wiebe, P. J. Weiler, Peter J. Weiler, 2000, Biochemical and biophysical research communications.

Microsomal 5-ane-3 beta-hydroxysteroid oxidoreductase from pubertal rat Leydig cells: partial purification and characterization.

J. Larner, J. Wiebe, 1983, Journal of steroid biochemistry.

Endocrine controls of spermatogenesis and oogenesis in the viviparous seaperch Cymatogaster aggregata Gibbons.

J. Wiebe, 1969, General and comparative endocrinology.

Role of progesterone metabolites in mammary cancer

J. Wiebe, 2005, Journal of Dairy Research.

Glycerol disrupts tight junction-associated actin microfilaments, occludin, and microtubules in Sertoli cells.

J. Wiebe, B. Clubb, R. Gallardi, 2000, Journal of andrology.

Suppression of follicle-stimulating hormone by the gonadal- and neurosteroid 3 alpha-hydroxy-4-pregnen-20-one involves actions at the level of the gonadotrope membrane/calcium channel.

J. Wiebe, S. Dhanvantari, 1994, Endocrinology.

Inhibition of the pituitary gonadotropic activity of fishes by a dithiocarbamoylhydrazine derivative (I.C.I. 33,828)

J. Wiebe, W. Hoar, E. Wai, 1967 .

Stimulation of spermatocyte development in prepubertal rats by the Sertoli cell steroid, 3 alpha-hydroxy-4-pregnen-20-one.

J. Wiebe, S. M. Campbell, 1989, Biology of reproduction.

Opposite Effects on Breast Cell Proliferation and Adhesion Formed in Nontumorous and Tumorous Breast Tissue Have-Pregnane Progesterone Metabolites α The 4-Pregnene and 5 Updated Version

J. Wiebe, D. Szwajcer, D. Muzia, 2000 .

Identification of a unique sertoli cell steroid as 3α-hydroxy-4-pregnen-20-one (3α-dihyroprogesterone: 3α-DHP)

J. Wiebe, 1982, Steroids.

Antinociceptive effects of the neuroactive steroid, 3α-hydroxy-5α-pregnan-20-one and progesterone in the land snail, Cepaea nemoralis

M. Kavaliers, J. Wiebe, T. Perrot-Sinal, 1999, Neuroscience.

Sertoli cells from immature rats : in vitro stimulation of steroid metabolism by FSH.

M. Welsh, J. Wiebe, 1976, Biochemical and biophysical research communications.

Steroid dehydrogenases and steroids in gonads of the seaperch Cymatogaster aggregata Gibbons.

J. Wiebe, 1969, General and comparative endocrinology.

Selective suppression of follicle-stimulating hormone secretion in anterior pituitary cells by the gonadal steroid 3 alpha-hydroxy-4-pregnen-20-one.

J. Wiebe, P. Wood, 1989, Endocrinology.

Selective suppression of follicle-stimulating hormone by 3 alpha-hydroxy-4-pregnen-20-one, a steroid found in Sertoli cells.

J. Wiebe, P. Wood, 1987, Endocrinology.

Steroidogenesis in rat leydig cells: changes in activity of 5-ane and 5-ene 3beta-hydroxysteroid dehydrogenases during sexual maturation.

J. Wiebe, 1976, Endocrinology.

A simple procedure for solubilizing 3β-hydroxysteroid dehydrogenase from microsomes of rat adrenals and testis interstitial cells

J. Larner, J. Wiebe, 1977, Steroids.

Progesterone metabolites in breast cancer.

J. Wiebe, 2006, Endocrine-related cancer.

On the mechanism and subcellular site of action of gonadotropins with respect to steroidogenic enzyme activity in testes of lower vertebrates

J. Wiebe, 1972 .

Transformed by Kirsten Murine Sarcoma Virus Modification of Steroidogenesis in Rat Adrenocortical Cells

N. Auersperg, J. Wiebe, K. I. Myers, 2013 .

Modification of steroidogenesis in rat adrenocortical cells transformed by Kirsten murine sarcoma virus.

N. Auersperg, J. Wiebe, K. I. Myers, 1987, Cancer research.

Suppression of spermatogenesis by low-level glycerol treatment.

J. Wiebe, Suleiman A. Igdoura, 1994, Journal of andrology.

Steroidogenesis in rat Leydig cells: effect of gonadotropins on the activity of 5-ane and 5-ene 3alpha- and 3beta-hydroxysteroid dehydrogenases during sexual maturation.

J. Wiebe, 1978, Endocrinology.

Sustained azoospermia in squirrel monkey, Saimiri sciureus, resulting from a single intratesticular glycerol injection.

J. Wiebe, K. Barr, K. Buckingham, 1989, Contraception.

Analgesic effects of the progesterone metabolite, 3α-hydroxy-5α-pregnan-20-one, and possible modes of action in mice

M. Kavaliers, J. Wiebe, 1987, Brain Research.

Analgesic effects of the putative FSH-suppressing gonadal steroid, 3α-hydroxy-4-pregnen-20-one: possible modes of action

M. Kavaliers, J. Wiebe, 1988, Brain Research.

Expression of progesterone metabolizing enzyme genes (AKR1C1, AKR1C2, AKR1C3, SRD5A1, SRD5A2) is altered in human breast carcinoma

J. Wiebe, Michael J Lewis, John P Wiebe, 2004, BMC Cancer.

Analysis of steroid metabolites produced by theca cells from the adult domestic hen.

B. Marrone, J. Wiebe, F. Hertelendy, 1985, Journal of steroid biochemistry.

Activity and expression of progesterone metabolizing 5α-reductase, 20α-hydroxysteroid oxidoreductase and 3α(β)-hydroxysteroid oxidoreductases in tumorigenic (MCF-7, MDA-MB-231, T-47D) and nontumorigenic (MCF-10A) human breast cancer cells

J. Wiebe, M. J. Lewis, John P Wiebe, 2003, BMC Cancer.

Lead administration during pregnancy and lactation affects steroidogenesis and hormone receptors in testes of offspring.

J. Wiebe, K. Barr, K. Buckingham, 1982, Journal of toxicology and environmental health.

Biochemical, histochemical, and ultrastructural analyses of presumed steroid-producing tissues in the sexually mature sea lamprey, Petromyzon marinus L.

J. Wiebe, J. Youson, M. Weisbart, 1978, General and comparative endocrinology.

Effect of prenatal and neonatal exposure to lead on gonadotropin receptors and steroidogenesis in rat ovaries.

J. Wiebe, K. Barr, K. Buckingham, 1988, Journal of toxicology and environmental health.

On the mechanism of action of lead in the testis: in vitro suppression of FSH receptors, cyclic AMP and steroidogenesis.

J. Wiebe, A. Salhanick, K. I. Myers, 1983, Life sciences.

An analysis of the metabolites of progesterone produced by isolated sertoli cells at the onset of gametogenesis

K. Tilbe, J. Wiebe, K. Buckingham, 1980, Steroids.

De novo synthesis of steroids (from acetate) by isolated rat Sertoli cells.

K. Tilbe, J. Wiebe, 1979, Biochemical and biophysical research communications.

Antinociceptive effects of the neuroactive steroid, 3alpha-hydroxy-5alpha-pregnan-20-one and progesterone in the land snail, Cepaea nemoralis.

M. Kavaliers, J. Wiebe, T. Perrot-Sinal, 2000, Neuroscience.

Inhibition of pituitary gonadotrophic activity in the viviparous seaperch Cymatogaster aggregata Gibbons by a dithiocarbamoylhydrazine derivative (I.C.I. 33 828).

J. Wiebe, 1968, Canadian journal of zoology.

The reproductive cycle of the viviparous seaperch, Cymatogaster aggregata Gibbons

J. Wiebe, 1968 .

The mechanism of action of gonadotrophic hormones in amphibians: the stimulation of delta5-3beta-hydroxysteroid dehydrogenase activity in testes of Xenopus laevis Daudin.

J. Wiebe, 1970, The Journal of endocrinology.

Isolated Sertoli cells from immature rats produce 20α-hydroxy-pregn-4-en-3-one from progesterone and 3β,20α-dihydroxy-5α-pregnane from pregnenolone

J. Wiebe, 1978 .

Male preference for the odors of estrous female mice is enhanced by the neurosteroid 3α-hydroxy-4-pregnen-20-one (3αHP)

M. Kavaliers, L. Galea, J. Wiebe, 1994, Brain Research.

Reduction of predator odor-induced anxiety in mice by the neurosteroid 3α-hydroxy-4-pregnen-20-one (3αHP)

M. Kavaliers, L. Galea, J. Wiebe, 1994, Brain Research.

Progesterone metabolism by guinea pig intrauterine tissues

M. Glasier, J. Wiebe, R. Hobkirk, 1994, The Journal of Steroid Biochemistry and Molecular Biology.

A technique for gonadectomy in the seaperch Cymatogaster aggregata.

J. Wiebe, 1968, Canadian journal of zoology.

Mechanism of Gonadotropin Action in Amphibia: Involvement of Mitochondria

J. Wiebe, 1972, Science.

The endogenous progesterone metabolite, 5α-pregnane-3,20-dione, decreases cell-substrate attachment, adhesion plaques, vinculin expression, and polymerized F-actin in MCF-7 breast cancer cells

J. Wiebe, D. Muzia, David Muzia, 2001, Endocrine.

Reproductive physiology of the viviparous sea perch, Cymatogaster aggregata Gibbons

J. Wiebe, 1967 .

Suppression of spermatogenesis without inhibition of steroidogenesis by a 1,2,3-trihydroxypropane solution.

J. Wiebe, K. Barr, J. P. Wiebe, 1984, Life sciences.

Progesterone metabolites regulate induction, growth, and suppression of estrogen- and progesterone receptor-negative human breast cell tumors

Guihua Zhang, I. Welch, J. Wiebe, 2013, Breast Cancer Research.

Acute, nongenomic actions of the neuroactive gonadal steroid, 3α-hydroxy-4-pregnen-20-one (3αHP), on FSH release in perifused rat anterior pituitary cells

J. Wiebe, L. D. Murphy, M. Wolfe, 1997, Endocrine.

Regulation of estrogen receptor (ER) levels in MCF-7 cells by progesterone metabolites

J. Wiebe, K. Pawlak, J. P. Wiebe, 2007, The Journal of Steroid Biochemistry and Molecular Biology.

Effect of brief exposure to a potential predator on cortisol concentrations in female Columbian ground squirrels (Spermophilus columbianus)

J. Millar, J. Wiebe, A. Hubbs, 2000 .

Dutasteride affects progesterone metabolizing enzyme activity/expression in human breast cell lines resulting in suppression of cell proliferation and detachment

J. Wiebe, L. Souter, G. Zhang, 2006, The Journal of Steroid Biochemistry and Molecular Biology.

Mechanism of action of the breast cancer-promoter hormone, 5α-dihydroprogesterone (5αP), involves plasma membrane-associated receptors and MAPK activation

J. Wiebe, K. Pawlak, A. Kwok, 2016, The Journal of Steroid Biochemistry and Molecular Biology.

Opposing actions of the progesterone metabolites, 5α-dihydroprogesterone (5αP) and 3α-dihydroprogesterone (3αHP) on mitosis, apoptosis, and expression of Bcl-2, Bax and p21 in human breast cell lines

Guihua Zhang, J. Wiebe, Michel S Beausoleil, 2010, The Journal of Steroid Biochemistry and Molecular Biology.

Membrane 5α-pregnane-3,20-dione (5αP) receptors in MCF-7 and MCF-10A breast cancer cells are up-regulated by estradiol and 5αP and down-regulated by the progesterone metabolites, 3α-dihydroprogesterone and 20α-dihydroprogesterone, with associated changes in cell proliferation and detachment

J. Wiebe, K. Pawlak, G. Zhang, 2005, The Journal of Steroid Biochemistry and Molecular Biology.

Synthesis, metabolism and levels of the neuroactive steroid, 3α-hydroxy-4-pregnen-20-one (3αHP), in rat pituitaries

J. Wiebe, M. Wolfe, D. Boushy, 1997, Brain Research.

Synthesis of the allylic gonadal steroids, 3α-hydroxy-4-pregnen-20-one and 3α-hydroxy-4-androsten-17-one, and of 3α-hydroxy-5α-pregnan-20-one

J. Wiebe, J. B. Stothers, V. Dave, 1985, Steroids.

Synthesis and characteristics of allylic 4-pregnene-3,20-diols found in gonadal and breast tissues

J. Wiebe, J. B. Stothers, V. Dave, 1986, Steroids.

Analgesic effects of the progesterone metabolite, 3 alpha-hydroxy-5 alpha-pregnan-20-one, and possible modes of action in mice.

M. Kavaliers, J. Wiebe, 1987, Brain research.

Suppression in gonadotropes of gonadotropin-releasing hormone-stimulated follicle-stimulating hormone release by the gonadal- and neurosteroid 3 alpha-hydroxy-4-pregnen-20-one involves cytosolic calcium.

J. Wiebe, S. Dhanvantari, P. Watson, 1994, Endocrinology.

Long-term alterations in the permeability of the blood-testis barrier following a single intratesticular injection of dilute aqueous glycerol.

J. Wiebe, F. Eng, L. Alima, 1994, Journal of Andrology.

Sertoli cell capacity to metabolize progesterone: variation with age and the effect of follicle-stimulating hormone.

K. Tilbe, J. Wiebe, 1981, Endocrinology.

The control of male fertility by 1,2,3-trihydroxypropane (THP;glycerol): rapid arrest of spermatogenesis without altering libido, accessory organs, gonadal steroidogenesis, and serum testosterone, LH and FSH.

J. Wiebe, K. Barr, 1984, Contraception.

Prospects of a male contraceptive based on the selective antispermatogenic action of 123-trihydroxypropane (THP glycerol).

J. Wiebe, K. Barr, K. Buckingham, 1986 .

Membrane 5alpha-pregnane-3,20-dione (5alphaP) receptors in MCF-7 and MCF-10A breast cancer cells are up-regulated by estradiol and 5alphaP and down-regulated by the progesterone metabolites, 3alpha-dihydroprogesterone and 20alpha-dihydroprogesterone, with associated changes in cell proliferation and

J. Wiebe, K. Pawlak, G. Zhang, 2005, Journal of Steroid Biochemistry and Molecular Biology.

Brief exposure of mice to 60 Hz magnetic fields reduces the analgesic effects of the neuroactive steroid, 3α-hydroxy-4-pregnen-20-one

M. Kavaliers, K. Ossenkopp, J. Wiebe, 1998, Neuroscience Letters.

Synthesis of the allylic regulatory steroid, 3 alpha-hydroxy-4-pregnen-20-one, by rat granulosa cells and its regulation by gonadotropins.

J. Wiebe, M. Dallaire, G. D. De Gannes, 1994, Biology of reproduction.