A. Cochrane

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Interaction of the human immunodeficiency virus type 1 Rev protein with a structured region in env mRNA is dependent on multimer formation mediated through a basic stretch of amino acids.

H. Olsen, C. Rosen, A. Cochrane, 1990, Genes & development.

Interaction of Human Immunodeficiency Virus Type 1 Integrase with Cellular Nuclear Import Receptor Importin 7 and Its Impact on Viral Replication*

Xiaojian Yao, A. Cochrane, Zhujun Ao, 2007, Journal of Biological Chemistry.

Identification of positive and negative splicing regulatory elements within the terminal tat-rev exon of human immunodeficiency virus type 1

A. Staffa, A. Cochrane, 1995, Molecular and cellular biology.

Use of modified U1 snRNAs to inhibit HIV-1 replication

C. Upton, A. Cochrane, D. Branch, 2006, Nucleic acids research.

The retrovirus RNA trafficking granule: from birth to maturity

A. Mouland, A. Cochrane, M. McNally, 2006, Retrovirology.

The HIV-1 Rev protein: a model system for coupled RNA transport and translation.

J. Lawrence, C. Rosen, C. Johnson, 1991, The New biologist.

Targeting ABL1 or ARG Tyrosine Kinases to Restrict HIV-1 Infection in Primary CD4+ T-Cells or in Humanized NSG Mice.

M. Ostrowski, B. Binnington, A. Cochrane, 2019, Journal of acquired immune deficiency syndromes.

Medroxyprogesterone Acetate Regulates HIV-1 Uptake and Transcytosis but Not Replication in Primary Genital Epithelial Cells, Resulting in Enhanced T-Cell Infection.

M. Tremblay, V. Ferreira, Aisha Nazli, 2015, The Journal of infectious diseases.

Functional significance of phosphorylation to the human immunodeficiency virus Rev protein

S. Ruben, D. Volsky, C. Rosen, 1989, Journal of virology.

NC-mediated nucleolar localization of retroviral gag proteins.

Darrin V Bann, A. Cochrane, Andrea R. Beyer, 2013, Virus research.

Long-term effects of estrogen on avian liver: estrogen-inducible switch in expression of nuclear, hormone-binding proteins

R. Haché, R. Deeley, M. Nesheim, 1987, Molecular and cellular biology.

Screening for small molecule inhibitors of HIV-1 Gag expression.

A. Cochrane, Ahalya Balachandran, 2017, Methods.

Detection of SARS-CoV-2 Viral Particles Using Direct, Reagent-Free Electrochemical Sensing

S. Kelley, E. Sargent, J. Rini, 2020, Journal of the American Chemical Society.

Opposing roles of CLK SR kinases in controlling HIV-1 gene expression and latency

L. Shkreta, B. Chabot, K. Clayton, 2022, Retrovirology.

Viral fitness implications of variation within an immunodominant CD8+ T-cell epitope of HIV-1.

M. Ostrowski, M. Luscher, K. MacDonald, 2009, Virology.

Suppression of Adenovirus Replication by Cardiotonic Steroids

P. Stoilov, C. Lingwood, Martha J. Brown, 2016, Journal of Virology.

The human immunodeficiency virus rev protein is a nuclear phosphoprotein.

S. Ruben, C. Rosen, A. Cochrane, 1989, Virology.

Identification ofSequences Important intheNucleolar Localization ofHumanImmunodeficiency VirusRev:Relevance ofNucleolar Localization toFunction

A. Cochrane, A. Perkins, 1990 .

Ex‐vivo analysis of human Natural Killer T cells demonstrates heterogeneity between tissues and within established CD4+ and CD4− subsets

L. Harrison, D. Godfrey, S. Berzins, 2013, Clinical and experimental immunology.

Immune characterization of an individual with an exceptionally high natural killer T cell frequency and her immediate family

L. Harrison, D. Godfrey, S. Berzins, 2009, Clinical and experimental immunology.

Induction of HIV-1 long terminal repeat-mediated transcription by Neisseria gonorrhoeae

S. Gray-Owen, A. Cochrane, I. Boulton, 2003 .

Identification andCharacterization ofIntragenic Sequences Which Repress HumanImmunodeficiency VirusStructural GeneExpression

A. Skalka, A. Cochrane, S. Beidas, 1991 .

Structural and functional characterization of the human immunodeficiency virus rev protein.

S. Ruben, C. Rosen, A. Cochrane, 1989, Journal of acquired immune deficiency syndromes.

Liquid-liquid phase separation of nucleocapsid proteins during SARS-CoV-2 and HIV-1 replication

A. Mouland, A. Cochrane, L. Parent, 2022, Cell Reports.

HIV-1 Rev is capable of shuttling between the nucleus and cytoplasm.

N. Richard, A. Cochrane, S. Iacampo, 1994, Virology.

Differential effect of CLK SR Kinases on HIV-1 gene expression: potential novel targets for therapy

S. Gray-Owen, A. Cochrane, Raymond W. Wong, 2011, Retrovirology.

Specific binding of [3H]oxytocin in the female rat brain.

A. Cochrane, S. McClorry, B. Ferrier, 1983, Canadian journal of physiology and pharmacology.

Cardiac glycoside/aglycones inhibit HIV-1 gene expression by a mechanism requiring MEK1/2-ERK1/2 signaling

M. Ostrowski, C. Lingwood, A. Cochrane, 2018, Scientific Reports.

Thriving under Stress: Selective Translation of HIV-1 Structural Protein mRNA during Vpr-Mediated Impairment of eIF4E Translation Activity

Alper Yilmaz, K. Boris-Lawrie, A. Cochrane, 2012, PLoS pathogens.

Cytosolic detection of the bacterial metabolite HBP activates TIFA-dependent innate immunity

Jianjun Li, J. Moffat, A. Cox, 2015, Science.

Characterization of novel inhibitors of HIV-1 replication that function via alteration of viral RNA processing and rev function

P. Stoilov, A. Cochrane, Raymond W. Wong, 2013, Nucleic acids research.

The Thiazole-5-Carboxamide GPS491 Inhibits HIV-1, Adenovirus, and Coronavirus Replication by Altering RNA Processing/Accumulation

M. Babu, W. Houry, L. Shkreta, 2021, Viruses.

2-Trifluoromethylthiazole-5-carboxamides: Analogues of a Stilbene-Based Anti-HIV Agent that Impact HIV mRNA Processing.

B. Chabot, Z. Brumme, D. Grierson, 2021, ACS medicinal chemistry letters.

An activator of G protein-coupled receptor and MEK1/2-ERK1/2 signaling inhibits HIV-1 replication by altering viral RNA processing

B. Blencowe, Q. Pan, P. Stoilov, 2020, PLoS pathogens.

Identification of small molecule modulators of HIV-1 Tat and Rev protein accumulation

B. Blencowe, P. Stoilov, P. Harrigan, 2017, Retrovirology.

Modulation of the splicing regulatory function of SRSF10 by a novel compound that impairs HIV-1 replication

M. Blanchette, L. Shkreta, Johanne Toutant, 2016, Nucleic acids research.

Differential effects of hnRNP D/AUF1 isoforms on HIV-1 gene expression

B. Chabot, S. Abou Elela, Miroslav P. Milev, 2011, Nucleic acids research.

Modulating HIV-1 RNA processing and utilization.

A. Cochrane, K. Marsh, Meredith Mclaren, 2008, Frontiers in bioscience : a journal and virtual library.

Identification of sequences important in the nucleolar localization of human immunodeficiency virus Rev: relevance of nucleolar localization to function

C. Rosen, A. Cochrane, A. Perkins, 1990, Journal of virology.

Regulated expression vectors demonstrate cell-type-specific sensitivity to human immunodeficiency virus type 1 Nef-induced cytostasis.

J. McKeating, D. Mann, A. Cochrane, 1997, The Journal of general virology.

Novel Exonic Elements That Modulate Splicing of the Human Fibronectin EDA Exon*

A. Staffa, A. Cochrane, N. Acheson, 1997, The Journal of Biological Chemistry.

Identification of positive and negative splicing regulatory elements within the terminal tat-rev exon of human immunodeficiency virus type 1

A. Staffa, A. Cochrane, Alfredo Staffa, 1995, Molecular and cellular biology.

Regulated expression of HIV-1 Rev function in mammalian cell lines.

A. Cochrane, P. Harakidas, L. Swenarchuk, 1999, Canadian journal of microbiology.

Control of HIV-1 env RNA splicing and transport: investigating the role of hnRNP A1 in exon splicing silencer (ESS3a) function.

C. Platt, A. Cochrane, K. Asai, 2003, Virology.

Positive and Negative Modulation of Human Immunodeficiency Virus Type 1 Rev Function by cis and trans Regulators of Viral RNA Splicing

A. Cochrane, K. Asai, J. Pongoski, 2002, Journal of Virology.

HIV-1 Gag Forms Ribonucleoprotein Complexes with Unspliced Viral RNA at Transcription Sites

A. Cochrane, L. Parent, Jordan Chang, 2020, Viruses.

Sik (BRK) Phosphorylates Sam68 in the Nucleus and Negatively Regulates Its RNA Binding Ability

S. Richard, V. Vasioukhin, A. Tyner, 2000, Molecular and Cellular Biology.

A Late Role for the Association of hnRNP A2 with the HIV-1 hnRNP A2 Response Elements in Genomic RNA, Gag, and Vpr Localization*[boxs]

B. Chabot, É. Cohen, A. Mouland, 2004, Journal of Biological Chemistry.

Identification and characterization of intragenic sequences which repress human immunodeficiency virus structural gene expression

A. Skalka, C. Rosen, K. Jones, 1991, Journal of virology.

The tat/rev intron of human immunodeficiency virus type 1 is inefficiently spliced because of suboptimal signals in the 3' splice site

A. Staffa, A. Cochrane, A Staffa, 1994, Journal of virology.

Interaction of cellular factors with intragenic cis-acting repressive sequences within the HIV genome.

H. Olsen, C. Rosen, A. Cochrane, 1992, Virology.

Control of Human Immunodeficiency Virus Type 1 RNA Metabolism: Role of Splice Sites and Intron Sequences in Unspliced Viral RNA Subcellular Distribution

A. Staffa, A. Cochrane, B. Séguin, 1998, Journal of Virology.

Estrogen-dependent activation of the avian very low density apolipoprotein II and vitellogenin genes. Transient alterations in mRNA polyadenylation and stability early during induction.

R. Deeley, A. Cochrane, 1988, Journal of molecular biology.

Selective translational repression of HIV-1 RNA by Sam68DeltaC occurs by altering PABP1 binding to unspliced viral RNA

A. Cochrane, V. Soros, K. Marsh, 2008, Retrovirology.

Mapping of determinants required for the function of the HIV-1 env nuclear retention sequence.

A. Emili, B. Ozdamar, A. Staffa, 2003, Virology.

Structural Insights into Immune Recognition of the Severe Acute Respiratory Syndrome Coronavirus S Protein Receptor Binding Domain

F. Plummer, J. Seetharaman, J. Rini, 2009, Journal of Molecular Biology.

Influence of HIV-1 genomic RNA on the formation of Gag biomolecular condensates

A. Mouland, J. Flanagan, A. Cochrane, 2023, bioRxiv.

Immunogenicity of a receptor-binding domain of SARS coronavirus spike protein in mice: Implications for a subunit vaccine

Chetna Sharon, Robert C. Brunham, Lorne A. Babiuk, 2006, Vaccine.

A novel function for Sam68: enhancement of HIV-1 RNA 3' end processing.

A. Cochrane, K. Asai, Meredith Mclaren, 2004, RNA.

Purification of biologically active human immunodeficiency virus rev protein from Escherichia coli.

C. H. Chen, C. Rosen, A. Cochrane, 1989, Virology.

Digoxin Suppresses HIV-1 Replication by Altering Viral RNA Processing

M. Ostrowski, A. Cochrane, Raymond W. Wong, 2013, PLoS pathogens.

Detection and characterization of degradative intermediates of avian apo very low density lipoprotein II mRNA present in estrogen-treated birds and following destabilization by hormone withdrawal.

R. Deeley, A. Cochrane, 1989, The Journal of biological chemistry.

hnRNP E1 and E2 have distinct roles in modulating HIV-1 gene expression

A. Emili, A. Cochrane, K. Asai, 2007, Retrovirology.

Flavonoid-based inhibition of cyclin-dependent kinase 9 without concomitant inhibition of histone deacetylases durably reinforces HIV latency.

L. Montaner, K. Mounzer, I. Tietjen, 2021, Biochemical pharmacology.

Secondary structure is the major determinant for interaction of HIV rev protein with RNA.

H. Olsen, C. Rosen, A. Cochrane, 1990, Science.

How does the journey affect the message(RNA)?

A. Cochrane, 2009, RNA biology.

Stable complex formation between HIV Rev and the nucleosome assembly protein, NAP1, affects Rev function.

C. Burks, D. Richards, Veronica Canadien, 2009, Virology.

Human immunodeficiency virus type 1 Rev function requires continued synthesis of its target mRNA

A. Cochrane, S. Iacampo, Sandra Iacampo, 1996, Journal of virology.

HIV-1 Rev function and RNA nuclear-cytoplasmic export.

A. Cochrane, 2014, Methods in molecular biology.

Mapping of determinants involved in the stimulation of HIV-1 expression by Sam68.

A. Cochrane, Meredith Mclaren, 2009, Virology.

Inhibition of Human Immunodeficiency Virus Type 1 Rev Function by a Dominant-Negative Mutant of Sam68 through Sequestration of Unspliced RNA at Perinuclear Bundles

S. Richard, A. Cochrane, V. Soros, 2001, Journal of Virology.

Controlling HIV-1 Rev function.

A. Cochrane, 2004, Current drug targets. Immune, endocrine and metabolic disorders.

Induction of HIV-1 long terminal repeat-mediated transcription by Neisseria gonorrhoeae.

S. Gray-Owen, A. Cochrane, I. Boulton, 2003, AIDS.

Analysis of HIV‐1 RNA Splicing

S. Duffy, A. Cochrane, 2012 .

Differential effects of Tra2β isoforms on HIV-1 RNA processing and expression

C. Platt, A. Cochrane, Jodi L Bubenik, 2013, Retrovirology.

Differential Effects of Tra2ß Isoforms on HIV-1 RNA Processing and Expression

C. Platt, A. Cochrane, Jodi L Bubenik, 2013, Retrovirology.

Differential Response of Primary and Immortalized CD4+ T Cells to Neisseria gonorrhoeae-Induced Cytokines Determines the Effect on HIV-1 Replication

M. Ostrowski, S. Gray-Owen, W. Dobson-Belaire, 2011, PloS one.

Opposing roles of CLK SR kinases in controlling HIV-1 gene expression and latency

L. Shkreta, B. Chabot, K. Clayton, 2022, Retrovirology.

A Yeast System for Discovering Optogenetic Inhibitors of Eukaryotic Translation Initiation.

M. Altmann, Mostafizur Mazumder, A. Cochrane, 2019, ACS synthetic biology.

Identification of small molecule modulators of HIV-1 Tat and Rev protein accumulation

B. Blencowe, P. Stoilov, P. Cheung, 2017, Retrovirology.

Specific interaction of the human immunodeficiency virus Rev protein with a structured region in the env mRNA.

C. H. Chen, C. Rosen, A. Cochrane, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Influence of HIV-1 genomic RNA on the formation of Gag biomolecular condensates.

A. Mouland, J. Flanagan, A. Cochrane, 2023, Journal of molecular biology.

HIV-1 RNA processing as therapeutic target: characterization of small molecule modulators of HIV-1 RNA processing and transport

P. Stoilov, A. Cochrane, Raymond W. Wong, 2013, Retrovirology.

Inhibition of HIV-1 gene expression by Sam68ΔC: multiple targets but a common mechanism?

A. Cochrane, 2009, Retrovirology.

Alterations in HIV-1 Rev transport in response to cell stress.

A. Cochrane, V. Soros, 2001, Virology.

On a path toward a broad-spectrum anti-viral: inhibition of HIV-1 and coronavirus replication by SR kinase inhibitor harmine

W. Houry, Ramy H. Malty, A. Cochrane, 2023, Journal of virology.

Use of modified U1 snRNAs to inhibit HIV-1 replication

C. Upton, A. Cochrane, D. Sakac, 2006, Nucleic acids research.

On a path toward a broad-spectrum anti-viral: inhibition of HIV-1 and coronavirus replication by SR kinase inhibitor harmine

W. Houry, Ramy H. Malty, A. Cochrane, 2023, Journal of virology.

RNA — Protein Interactions Required for Rev Mediated Regulation of HIV Gene Expression

H. Olsen, C. Rosen, A. Cochrane, 1991 .

Estrogen-dependent modification of ribosomal proteins. Effects of estrogen withdrawal on the distribution of constitutive and hormonally regulated mRNAs.

R. Deeley, A. Cochrane, 1984, The Journal of biological chemistry.

Estrogen-dependent Modification of Ribosomal Proteins

R. Deeley, A. Cochrane, Hormonally Regulated mRNAs, 1984 .

hnRNP E1 and E2 have distinct roles in modulating HIV-1 gene expression

A. Emili, A. Cochrane, K. Asai, 2007, Retrovirology.