G. Manfroni

发表

Inhibition of subgenomic hepatitis C virus RNA replication by acridone derivatives: identification of an NS3 helicase inhibitor.

Barbara Gatto, Jan Paeshuyse, Giuseppe Manfroni, 2009, Journal of medicinal chemistry.

Evolution of HCV NS4B Inhibitors

G. Manfroni, R. Cannalire, 2019, Topics in Medicinal Chemistry.

A Comprehensive Structural Overview of p38α Mitogen‐Activated Protein Kinase in Complex with ATP‐Site and Non‐ATP‐Site Binders

G. Manfroni, V. Cecchetti, M. Barreca, 2018, ChemMedChem.

Synthesis and characterization of 1,2,4-triazolo[1,5-a]pyrimidine-2-carboxamide-based compounds targeting the PA-PB1 interface of influenza A virus polymerase

M. Loza, J. Brea, L. Goracci, 2020, European Journal of Medicinal Chemistry.

Synthesis and anti-BVDV activity of acridones as new potential antiviral agents.

E. De Clercq, J. Rozenski, J. Neyts, 2006, Journal of medicinal chemistry.

Discovery of the 2-phenyl-4,5,6,7-Tetrahydro-1H-indole as a novel anti-hepatitis C virus targeting scaffold.

Noreena L. Sweeney, Neerja Kaushik-Basu, D. Frick, 2015, European journal of medicinal chemistry.

Natural isoflavone biochanin A as a template for the design of new and potent 3-phenylquinolone efflux inhibitors against Mycobacterium avium.

M. Viveiros, I. Couto, S. Sabatini, 2017, European journal of medicinal chemistry.

Modifications on C6 and C7 Positions of 3-Phenylquinolone Efflux Pump Inhibitors Led to Potent and Safe Antimycobacterial Treatment Adjuvants.

M. Viveiros, S. Sabatini, G. Manfroni, 2019, ACS infectious diseases.

Mode of action of the 2-phenylquinoline efflux inhibitor PQQ4R against Escherichia coli

M. Viveiros, I. Couto, S. Sabatini, 2017, PeerJ.

Exploiting the anti-HIV 6-desfluoroquinolones to design multiple ligands.

C. Pannecouque, A. Marcello, D. Daelemans, 2014, Bioorganic & medicinal chemistry.

Re-evolution of the 2-phenylquinolines: ligand-based design, synthesis, and biological evaluation of a potent new class of Staphylococcus aureus NorA efflux pump inhibitors to combat antimicrobial resistance.

G. Kaatz, S. Sabatini, G. Manfroni, 2013, Journal of medicinal chemistry.

Pyrazolo[4,3-c][1,2]benzothiazines 5,5-dioxide: a promising new class of Staphylococcus aureus NorA efflux pump inhibitors.

E. Carosati, G. Kaatz, M. Villarini, 2012, Journal of medicinal chemistry.

Evolution from a natural flavones nucleus to obtain 2-(4-Propoxyphenyl)quinoline derivatives as potent inhibitors of the S. aureus NorA efflux pump.

G. Kaatz, S. Sabatini, D. Patel, 2011, Journal of medicinal chemistry.

Lipid nanoparticles for brain targeting III. Long-term stability and in vivo toxicity.

M. Ricci, G. Manfroni, A. Schoubben, 2013, International journal of pharmaceutics.

New Pyrazolobenzothiazine Derivatives as Hepatitis C Virus NS5B Polymerase Palm Site I Inhibitors

C. Zamperini, E. Dreassi, Neerja Kaushik-Basu, 2014, Journal of medicinal chemistry.

Advantageous Use of Ionic Liquids for the Synthesis of Pharmaceutically Relevant Quinolones

Matteo Tiecco, G. Manfroni, V. Cecchetti, 2018, European Journal of Organic Chemistry.

Discovery of 2-Phenylquinolines with Broad-Spectrum Anti-coronavirus Activity

J. Neyts, D. Schols, E. Tramontano, 2022, ACS medicinal chemistry letters.

C-2 phenyl replacements to obtain potent quinoline-based Staphylococcus aureus NorA inhibitors

D. Pietrella, S. Sabatini, G. Manfroni, 2020, Journal of enzyme inhibition and medicinal chemistry.

1,4-Benzothiazine ATP-sensitive potassium channel openers: modifications at the C-2 and C-6 positions.

V. Calderone, M. Novelli, P. Masiello, 2013, Journal of medicinal chemistry.

Pharmacophore-Based Repositioning of Approved Drugs as Novel Staphylococcus aureus NorA Efflux Pump Inhibitors.

G. Kaatz, D. Pietrella, S. Sabatini, 2017, Journal of medicinal chemistry.

Exploring the cycloheptathiophene-3-carboxamide scaffold to disrupt the interactions of the influenza polymerase subunits and obtain potent anti-influenza activity.

L. Goracci, G. Palù, A. Loregian, 2017, European journal of medicinal chemistry.

A Broad Anti-influenza Hybrid Small Molecule That Potently Disrupts the Interaction of Polymerase Acidic Protein-Basic Protein 1 (PA-PB1) Subunits.

L. Goracci, G. Cruciani, G. Palù, 2015, Journal of medicinal chemistry.

Co-crystal structure determination and cellular evaluation of 1,4-dihydropyrazolo[4,3-c] [1,2] benzothiazine 5,5-dioxide p38α MAPK inhibitors.

D. Rauh, G. Manfroni, V. Cecchetti, 2019, Biochemical and biophysical research communications.

Pyridobenzothiazolones as anti-flavivirus agents: Impact on Zika virus

G. Manfroni, Maria Sole Burali, 2021, Zika Virus Impact, Diagnosis, Control, and Models.

Virucidal Activity of the Pyridobenzothiazolone Derivative HeE1-17Y against Enveloped RNA Viruses

M. Bolognesi, M. Zoppè, A. Marcello, 2022, Viruses.

From Quinoline to Quinazoline‐Based S. aureus NorA Efflux Pump Inhibitors by Coupling a Focused Scaffold Hopping Approach and a Pharmacophore Search

S. Sabatini, G. Manfroni, Serena Massari, 2021, ChemMedChem.

Structural Modifications of the Quinolin-4-yloxy Core to Obtain New Staphylococcus aureus NorA Inhibitors

S. Sabatini, G. Manfroni, Serena Massari, 2020, International journal of molecular sciences.

Novel 1,4-benzothiazine derivatives as large conductance Ca2+-activated potassium channel openers.

Roberto Spogli, V. Calderone, S. Sabatini, 2008, Journal of medicinal chemistry.

New Insights On KCA3.1 Channel Modulation.

R. Iannitti, G. Manfroni, V. Cecchetti, 2020, Current pharmaceutical design.

Targeting flavivirus RNA dependent RNA polymerase through a pyridobenzothiazole inhibitor.

M. Bolognesi, G. Quérat, G. Manfroni, 2016, Antiviral research.

Tumour cell population growth inhibition and cell death induction of functionalized 6‐aminoquinolone derivatives

L. Altucci, G. Manfroni, O. Tabarrini, 2015, Cell proliferation.

Sustainable, three-component, one-pot procedure to obtain active anti-flavivirus agents.

S. Vasudevan, S. Alonso, S. Sabatini, 2020, European journal of medicinal chemistry.

Discovery of novel inhibitors of the NorA multidrug transporter of Staphylococcus aureus.

Stefano Sabatini, Gabriele Cruciani, Emanuele Carosati, 2011, Journal of medicinal chemistry.

Structural Investigation of the Naphthyridone Scaffold: Identification of a 1,6‐Naphthyridone Derivative with Potent and Selective Anti‐HIV Activity

C. Pannecouque, D. Daelemans, S. Sabatini, 2011, ChemMedChem.

Structure modifications of 6-aminoquinolones with potent anti-HIV activity.

E. De Clercq, C. Pannecouque, M. Palumbo, 2004, Journal of medicinal chemistry.

The versatile nature of the 6-aminoquinolone scaffold: identification of submicromolar hepatitis C virus NS5B inhibitors.

Neerja Kaushik-Basu, J. Neyts, P. Leyssen, 2014, Journal of medicinal chemistry.

Pyridobenzothiazole derivatives as new chemotype targeting the HCV NS5B polymerase.

G. Maga, J. Neyts, P. Leyssen, 2012, Bioorganic & medicinal chemistry.

Computer‐Aided Design, Synthesis and Validation of 2‐Phenylquinazolinone Fragments as CDK9 Inhibitors with Anti‐HIV‐1 Tat‐Mediated Transcription Activity

C. Pannecouque, A. Marcello, S. Sabatini, 2013, ChemMedChem.

Structure-activity relationship study on anti-HIV 6-desfluoroquinolones.

C. Pannecouque, J. Balzarini, D. Daelemans, 2008, Journal of medicinal chemistry.

Searching for Novel Inhibitors of the S. aureus NorA Efflux Pump: Synthesis and Biological Evaluation of the 3‐Phenyl‐1,4‐benzothiazine Analogues

G. Kaatz, B. Schindler, S. Sabatini, 2017, ChemMedChem.

1,2,4-Triazolo[1,5-a]pyrimidines as a Novel Class of Inhibitors of the HIV-1 Reverse Transcriptase-Associated Ribonuclease H Activity

C. Pannecouque, E. Tramontano, S. Sabatini, 2020, Molecules.

Broad spectrum anti-flavivirus pyridobenzothiazolones leading to less infective virions.

A. Marcello, G. Quérat, S. Sabatini, 2019, Antiviral research.

Synthesis of 2‐(Arylamino)ethanethiols via Lewis Acid Catalyzed Aminolysis of 2,2‐Dimethylthiirane as Precursors of the 1,4‐Benzothiazine Nucleus.

Roberto Spogli, S. Sabatini, G. Manfroni, 2009 .

The Pyrazolobenzothiazine Core as a New Chemotype of p38 Alpha Mitogen‐Activated Protein Kinase Inhibitors

M. Loza, J. Brea, S. Laufer, 2015, Chemical biology & drug design.

Synthesis and biological evaluation of 2-phenylquinolones targeted at Tat/TAR recognition.

B. Gatto, M. Palumbo, C. Del Vecchio, 2009, Bioorganic & medicinal chemistry letters.

Antitubercular polyhalogenated phenothiazines and phenoselenazine with reduced binding to CNS receptors.

J. Handzlik, A. Bojarski, G. Satała, 2020, European journal of medicinal chemistry.

Studies on anti-HIV quinolones: new insights on the C-6 position.

C. Pannecouque, D. Daelemans, S. Sabatini, 2009, Bioorganic & medicinal chemistry.

From cycloheptathiophene-3-carboxamide to oxazinone-based derivatives as allosteric HIV-1 ribonuclease H inhibitors

C. Pannecouque, E. Tramontano, S. Sabatini, 2018, Journal of enzyme inhibition and medicinal chemistry.

Studies on Cycloheptathiophene‐3‐carboxamide Derivatives as Allosteric HIV‐1 Ribonuclease H Inhibitors

C. Pannecouque, E. Tramontano, S. Sabatini, 2016, ChemMedChem.

Structural investigation of cycloheptathiophene-3-carboxamide derivatives targeting influenza virus polymerase assembly.

L. Goracci, G. Cruciani, G. Palù, 2013, Journal of medicinal chemistry.

Investigation on the effect of known potent S. aureus NorA efflux pump inhibitors on the staphylococcal biofilm formation

M. Nocchetti, D. Pietrella, R. Pagiotti, 2017 .

Pyridobenzothiazolones Exert Potent Anti-Dengue Activity by Hampering Multiple Functions of NS5 Polymerase.

S. Vasudevan, S. Sabatini, G. Manfroni, 2020, ACS medicinal chemistry letters.

Accounting for Target Flexibility and Water Molecules by Docking to Ensembles of Target Structures: The HCV NS5B Palm Site I Inhibitors Case Study

Stefano Sabatini, M. Letizia Barreca, Nunzio Iraci, 2014, J. Chem. Inf. Model..

Allosteric inhibition of the hepatitis C virus NS5B polymerase: in silico strategies for drug discovery and development.

Nunzio Iraci, Giuseppe Manfroni, Violetta Cecchetti, 2011, Future medicinal chemistry.

Modulating microRNA Processing: Enoxacin, the Progenitor of a New Class of Drugs

G. Manfroni, V. Cecchetti, T. Felicetti, 2020, Journal of medicinal chemistry.

A Comprehensive Structural Overview of p38α MAPK in Complex with Type I Inhibitors

G. Manfroni, V. Cecchetti, M. Barreca, 2015, ChemMedChem.

Comprehensive response to Usutu virus following first isolation in blood donors in the Friuli Venezia Giulia region of Italy: Development of recombinant NS1-based serology and sensitivity to antiviral drugs

A. Marcello, T. Avšič-Županc, G. Manfroni, 2020, PLoS neglected tropical diseases.

Bicyclic octahydrocyclohepta[b]pyrrol-4(1H)one derivatives as novel selective anti-hepatitis C virus agents.

O. Cevik, Neerja Kaushik-Basu, D. Frick, 2016, European journal of medicinal chemistry.

A Journey around the Medicinal Chemistry of Hepatitis C Virus Inhibitors Targeting NS4B: From Target to Preclinical Drug Candidates.

G. Manfroni, V. Cecchetti, M. Barreca, 2016, Journal of medicinal chemistry.

Design and Synthesis of WM5 Analogues as HIV-1 TAR RNA Binders

C. Pannecouque, B. Gatto, G. Manfroni, 2019, The Open Medicinal Chemistry Journal.

Studies on 2-phenylquinoline Staphylococcus aureus NorA efflux pump inhibitors: New insights on the C-6 position.

G. Kaatz, B. Schindler, S. Sabatini, 2018, European journal of medicinal chemistry.

Discovery of potent p38α MAPK inhibitors through a funnel like workflow combining in silico screening and in vitro validation.

M. Loza, J. Brea, S. Laufer, 2019, European journal of medicinal chemistry.

Ethyl 1,8-naphthyridone-3-carboxylates downregulate human papillomavirus-16 E6 and E7 oncogene expression.

A. Loregian, R. Cavalli, D. Lembo, 2014, Journal of medicinal chemistry.

Broad‐Spectrum Flavivirus Inhibitors: a Medicinal Chemistry Point of View

G. Manfroni, V. Cecchetti, R. Cannalire, 2020, ChemMedChem.

Functionalized sulfonyl anthranilic acid derivatives inhibit replication of all the four dengue serotypes.

S. Vasudevan, S. Alonso, S. Sabatini, 2023, European journal of medicinal chemistry.

2-Phenylquinoline S. aureus NorA Efflux Pump Inhibitors: Evaluation of the Importance of Methoxy Group Introduction.

K. Kieć‐Kononowicz, G. Kaatz, D. Pietrella, 2018, Journal of medicinal chemistry.

Functionalized 2,1-benzothiazine 2,2-dioxides as new inhibitors of Dengue NS5 RNA-dependent RNA polymerase.

G. Quérat, S. Sabatini, G. Manfroni, 2018, European journal of medicinal chemistry.

Studies of Anti‐HIV Transcription Inhibitor Quinolones: Identification of Potent N1‐Vinyl Derivatives

C. Pannecouque, B. Gatto, M. Palumbo, 2010, ChemMedChem.

A cellular screening platform, stably expressing DENV2 NS5, defines a novel anti-DENV mechanism of action of Apigenin based on STAT2 activation.

Mohamed Mysara, M. Elhefnawi, S. Vasudevan, 2023, Virology.

Enantioresolution, stereochemical characterization and biological activity of a chiral large-conductance calcium-activated potassium channel opener.

C. Bertucci, B. Natalini, G. Manfroni, 2014, Journal of chromatography. A.

New C-6 functionalized quinoline NorA inhibitors strongly synergize with ciprofloxacin against planktonic and biofilm growing resistant Staphylococcus aureus strains.

S. Sabatini, G. Manfroni, Serena Massari, 2022, European journal of medicinal chemistry.

Structure-based discovery of pyrazolobenzothiazine derivatives as inhibitors of hepatitis C virus replication.

Neerja Kaushik-Basu, Stefano Sabatini, Jan Paeshuyse, 2013, Journal of medicinal chemistry.

Truth and lies about the use of old drugs against COVID-19: have we learned the lesson?

G. Manfroni, Carmine Iorio, 2023, Future medicinal chemistry.