L. Snyder

发表

Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect

Min Gao, Nicholas A. Meanwell, Lawrence G. Hamann, 2010, Nature.

Molecular genetics of bacteria

L. Snyder, W. Champness, Lawrence B. Snyder, 1997 .

Characterizations of HCV NS5A replication complex inhibitors.

N. Meanwell, D. Langley, J. Lemm, 2013, Virology.

HCV NS5A replication complex inhibitors. Part 5: discovery of potent and pan-genotypic glycinamide cap derivatives.

A. Good, N. Meanwell, J. Lemm, 2013, Bioorganic & medicinal chemistry letters.

Hepatitis C virus NS5A replication complex inhibitors: the discovery of daclatasvir.

L. Hamann, A. Fura, N. Meanwell, 2014, Journal of medicinal chemistry.

Synthesis of enantiomerically pure hydrinden-2-ones and benz[e]inden-2-ones via asymmetric alkylations of chiral bicyclic lactams

L. Snyder, A. Meyers, 1993 .

HCV NS5A replication complex inhibitors. Part 4. Optimization for genotype 1a replicon inhibitory activity.

N. Meanwell, J. Lemm, B. Pearce, 2014, Journal of medicinal chemistry.

Inhibitors of HCV NS5A: From Iminothiazolidinones to Symmetrical Stilbenes.

N. Meanwell, M. Deshpande, Scott W. Martin, 2011, ACS medicinal chemistry letters.

The synthesis of aracemic 4-substituted pyrrolidinones and 3-substituted pyrrolidines. An asymmetric synthesis of (-)-rolipram

L. Snyder, A. Meyers, 1993 .

Discovery of the first antibacterial small molecule inhibitors of MurB.

M. Pucci, P. Falk, H. Ho, 2003, Bioorganic & medicinal chemistry letters.

Synthesis of 18-Noranhydrocamptothecin Analogs Which Retain Topoisomerase I Inhibitory Function

W. Bornmann, S. Danishefsky, L. Snyder, 1994 .

Biaryl isoxazolinone antibacterial agents.

Dennis K. Taylor, G. Warr, A. Marinier, 2005, Bioorganic & medicinal chemistry letters.

Asymmetric conjugate additions to chiral bicyclic lactams. Synthesis of aracemic trans-2,3-disubstituted pyrrolidines

L. Snyder, A. Meyers, 1992 .

HCV NS5A replication complex inhibitors. Part 3: discovery of potent analogs with distinct core topologies.

A. Good, N. Meanwell, J. Lemm, 2013, Bioorganic & medicinal chemistry letters.

Hepatitis C virus NS5A replication complex inhibitors. Part 6: Discovery of a novel and highly potent biarylimidazole chemotype with inhibitory activity toward genotypes 1a and 1b replicons.

A. Good, N. Meanwell, J. Lemm, 2014, Journal of medicinal chemistry.

A practical, enantioselective synthesis of SK&F 104353

W. Mendelson, L. Snyder, I. Lantos, 1993 .

Discovery and Preclinical Evaluation of BMS-955829, a Potent Positive Allosteric Modulator of mGluR5.

J. Macor, Amy Easton, Anand Balakrishnan, 2016, ACS medicinal chemistry letters.

Chapter 22. Non-HIV antiviral agents

N. Meanwell, L. Snyder, M. Serrano-Wu, 2003, Annual Reports in Medicinal Chemistry.

Electrostatic interaction of pi-acidic amides with hydrogen-bond acceptors.

D. Langley, L. Snyder, Yi Li, 2003, Bioorganic & medicinal chemistry letters.

Oxazolidinone-based allosteric modulators of mGluR5: Defining molecular switches to create a pharmacological tool box.

J. Macor, Amy Easton, Anand Balakrishnan, 2016, Bioorganic & medicinal chemistry letters.

Identification of Glutathione Conjugates of Acetylene-Containing Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5

Yue-Zhong Shu, Y. Shu, L. Snyder, 2015, Drug Metabolism and Disposition.

3-Substituted 4-pyranones: a rapid approach using microwave heating

D. LopezOmar, L. Snyder, Fukang Yang, 2007 .

Identification of Hepatitis C Virus NS5A Inhibitors

N. Meanwell, M. Deshpande, Scott W. Martin, 2009, Journal of Virology.

Discovery of isoxazolinone antibacterial agents. Nitrogen as a replacement for the stereogenic center found in oxazolidinone antibacterials.

A. Marinier, L. Snyder, J. Barrett, 2004, Bioorganic & Medicinal Chemistry Letters.

The effects of NS5A inhibitors on NS5A phosphorylation, polyprotein processing and localization.

L. Hamann, N. Meanwell, J. Lemm, 2011, The Journal of general virology.

HCV NS5A replication complex inhibitors. Part 2: investigation of stilbene prolinamides.

N. Meanwell, J. Lemm, M. Gao, 2012, Bioorganic & medicinal chemistry letters.

Targeting the BACE1 Active Site Flap Leads to a Potent Inhibitor That Elicits Robust Brain Aβ Reduction in Rodents.

Andrea Mcclure, J. Macor, H. Lewis, 2016, ACS medicinal chemistry letters.

Discovery of Potent Hepatitis C Virus NS5A Inhibitors with Dimeric Structures

N. Meanwell, Scott W. Martin, Joseph L. Cantone, 2011, Antimicrobial Agents and Chemotherapy.

Identification of Glutathione Conjugates of Acetylene-Containing Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5

Y. Shu, L. Snyder, Benjamin M. Johnson, 2015, Drug Metabolism and Disposition.

Targeting the BACE1 Active Site Flap Leads to a Potent Inhibitor That Elicits Robust Brain Aβ Reduction in Rodents.

Andrea Mcclure, J. Macor, H. Lewis, 2016, ACS medicinal chemistry letters.

Synthesis of β-disubstituted β-amino isoxazolyl ketones by addition of ketimines with isoxazolyl methyl ketone enolates

L. Snyder, L. Thompson, Yong-Jin Wu, 2014 .

Synthesis of β‐Disubstituted β‐Amino Isoxazolyl Ketones by Addition of Ketimines with Isoxazolyl Methyl Ketone Enolates.

L. Snyder, L. Thompson, Yong-Jin Wu, 2014 .

Chemistry in the Pharmaceutical Industry

M. Deshpande, L. Snyder, G. Poindexter, 2007 .