J. Knipe

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Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect

Min Gao, Nicholas A. Meanwell, Lawrence G. Hamann, 2010, Nature.

HCV NS5A replication complex inhibitors. Part 5: discovery of potent and pan-genotypic glycinamide cap derivatives.

A. Good, N. Meanwell, J. Lemm, 2013, Bioorganic & medicinal chemistry letters.

Syntheses and initial evaluation of a series of indolo-fused heterocyclic inhibitors of the polymerase enzyme (NS5B) of the hepatitis C virus.

Carl T. Bergstrom, Chong-Hwan Chang, M. Witmer, 2011, Bioorganic & medicinal chemistry letters.

Discovery of BMS-961955, an allosteric inhibitor of the hepatitis C virus NS5B polymerase.

A. Mathur, J. Cutrone, N. Meanwell, 2017, Bioorganic & medicinal chemistry letters.

Preclinical Profile and Characterization of the Hepatitis C Virus NS3 Protease Inhibitor Asunaprevir (BMS-650032)

N. Meanwell, R. Colonno, Chaoqun Chen, 2012, Antimicrobial Agents and Chemotherapy.

New hydrazone derivatives of adriamycin and their immunoconjugates--a correlation between acid stability and cytotoxicity.

T. Kaneko, J. Knipe, D. Vyas, 1991, Bioconjugate chemistry.

The discovery and optimization of naphthalene-linked P2-P4 Macrocycles as inhibitors of HCV NS3 protease.

H. Klei, N. Meanwell, R. Rajamani, 2018, Bioorganic & medicinal chemistry letters.

Hepatitis C virus NS5A replication complex inhibitors: the discovery of daclatasvir.

L. Hamann, A. Fura, N. Meanwell, 2014, Journal of medicinal chemistry.

Effect of linker variation on the stability, potency, and efficacy of carcinoma-reactive BR64-doxorubicin immunoconjugates.

P. Trail, T. Doyle, I. Hellstrom, 1997, Cancer research.

Disposition of conjugate-bound and free doxorubicin in tumor-bearing mice following administration of a BR96-doxorubicin immunoconjugate (BMS 182248)

J. Knipe, L. Klunk, K. Mosure, 1997, Cancer Chemotherapy and Pharmacology.

Cathepsin B-labile dipeptide linkers for lysosomal release of doxorubicin from internalizing immunoconjugates: model studies of enzymatic drug release and antigen-specific in vitro anticancer activity.

P. Trail, J. Knipe, G. Dubowchik, 2002, Bioconjugate chemistry.

Cathepsin B-sensitive dipeptide prodrugs. 2. Models of anticancer drugs paclitaxel (Taxol), mitomycin C and doxorubicin.

J. Knipe, G. Dubowchik, R. Firestone, 1998, Bioorganic & medicinal chemistry letters.

Synthesis of water-soluble prodrugs of BMS-191011: a maxi-K channel opener targeted for post-stroke neuroprotection.

Astrid A. Ortiz, V. Gribkoff, J. Knipe, 2003, Bioorganic & medicinal chemistry letters.

The synthesis and structure-activity relationships of 4-aryl-3-aminoquinolin-2-ones: a new class of calcium-dependent, large conductance, potassium (maxi-K) channel openers targeted for post-stroke neuroprotection.

V. Gribkoff, C. Boissard, J. Knipe, 2002, Bioorganic & medicinal chemistry letters.

Synthesis and antitumor evaluation of paclitaxel phosphonooxymethyl ethers: a novel class of water soluble paclitaxel pro-drugs

T. Doyle, W. Rose, J. Knipe, 1996 .

Oxidation of pteridine derivatives in mice.

J. Knipe, J. McCormack, 1977, Biochemical pharmacology.

Novel water soluble phosphate prodrugs of taxol® possessing in vivo antitumor activity

W. Rose, J. Knipe, A. Casazza, 1993 .

Discovery of a Potent Acyclic, Tripeptidic, Acyl Sulfonamide Inhibitor of Hepatitis C Virus NS3 Protease as a Back-up to Asunaprevir with the Potential for Once-Daily Dosing.

L. Mueller, K. Kish, H. Klei, 2016, Journal of medicinal chemistry.

An automated liquid chromatography-mass spectrometry process to determine metabolic stability half-life and intrinsic clearance of drug candidates by substrate depletion.

James V Belcastro, C. Mcnaney, D. Drexler, 2008, Assay and drug development technologies.

Synthesis and structure-activity relationships of 3-aryloxindoles: a new class of calcium-dependent, large conductance potassium (maxi-K) channel openers with neuroprotective properties.

V. Gribkoff, Stella Huang, N. Meanwell, 2002, Journal of medicinal chemistry.

N-[2-[2-(4-Phenylbutyl)benzofuran-4-yl]cyclopropylmethyl]acetamide: an orally bioavailable melatonin receptor agonist.

Jie Chen, C. D. Mahle, K. Takaki, 2004, Bioorganic & medicinal chemistry letters.

An orally active corticotropin releasing factor 1 receptor antagonist from 8-aryl-1,3a,7,8-tetraaza-cyclopenta[a]indenes.

K. Browman, J. Knipe, G. Dubowchik, 2007, Bioorganic & medicinal chemistry letters.

Discovery and early clinical evaluation of BMS-605339, a potent and orally efficacious tripeptidic acylsulfonamide NS3 protease inhibitor for the treatment of hepatitis C virus infection.

A. Good, H. Klei, A. Cocuzza, 2014, Journal of medicinal chemistry.

The discovery of asunaprevir (BMS-650032), an orally efficacious NS3 protease inhibitor for the treatment of hepatitis C virus infection.

Qi Gao, Huabin Sun, Hong Shi, 2014, Journal of medicinal chemistry.

Discovery and preclinical characterization of the cyclopropylindolobenzazepine BMS-791325, a potent allosteric inhibitor of the hepatitis C virus NS5B polymerase.

Chong-Hwan Chang, M. Witmer, B. Beno, 2014, Journal of medicinal chemistry.

The synthesis and characterization of BMS-204352 (MaxiPost) and related 3-fluorooxindoles as openers of maxi-K potassium channels.

V. Gribkoff, R. Perrone, N. Meanwell, 2002, Bioorganic & medicinal chemistry letters.

Synthesis of etoposide phosphate, BMY-40481: A water-soluble clinically active prodrug of etoposide

D. Langley, J. Kadow, T. Doyle, 1994 .

Identification of a novel series of potent HCV NS5B Site I inhibitors.

N. Meanwell, J. Lemm, J. Kadow, 2014, Bioorganic & medicinal chemistry letters.

Biaryl isoxazolinone antibacterial agents.

Dennis K. Taylor, G. Warr, A. Marinier, 2005, Bioorganic & medicinal chemistry letters.

Synthesis and SAR studies of novel heteroaryl fused tetracyclic indole-diamide compounds: potent allosteric inhibitors of the hepatitis C virus NS5B polymerase.

B. Beno, M. Poss, J. Lemm, 2012, Bioorganic & medicinal chemistry letters.

Retention behavior of pteroyl-oligo-γ-l-glutamates in reversed-phase chromatography

J. Bertino, J. Frenz, C. Horváth, 1979 .

Phosphonooxymethyl prodrugs of the broad spectrum antifungal azole, ravuconazole: synthesis and biological properties.

Qi Gao, Mandar Dali, Srini Venkatesh, 2003, Bioorganic & medicinal chemistry letters.

Hepatitis C virus NS5A replication complex inhibitors. Part 6: Discovery of a novel and highly potent biarylimidazole chemotype with inhibitory activity toward genotypes 1a and 1b replicons.

A. Good, N. Meanwell, J. Lemm, 2014, Journal of medicinal chemistry.

Nonclinical pharmacokinetics of BMS‐292655, a water‐soluble prodrug of the antifungal ravuconazole

J. Knipe, K. Mosure, Kathy Mosure, 2008, Biopharmaceutics & drug disposition.

Adriamycin(hydrazone)-antibody conjugates require internalization and intracellular acid hydrolysis for antitumor activity

Mary Edson, Robert S. Greenfield, Takushi Kaneko, 2005, Cancer Immunology, Immunotherapy.

Preclinical Characterization of BMS-791325, an Allosteric Inhibitor of Hepatitis C Virus NS5B Polymerase

N. Meanwell, J. Lemm, R. Colonno, 2014, Antimicrobial Agents and Chemotherapy.

Role of buffers in a methylase model reaction. General base catalysis by oxyanions vs. nucleophilic dealkylation by amines

J. Knipe, J. Coward, 1979 .

N‐{2‐[2‐(4‐Phenylbutyl)benzofuran‐4‐yl]cyclopropylmethyl}acetamide: An Orally Bioavailable Melatonin Receptor Agonist.

C. D. Mahle, K. Takaki, J. Knipe, 2005 .

Synthesis and antitumor evaluation of water soluble taxol phosphates

T. Doyle, J. Knipe, H. Wong, 1993 .

Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies.

Qi Gao, Min Gao, Steven Sheriff, 2017, Journal of medicinal chemistry.

Discovery and preclinical evaluation of potent, orally bioavailable, metabolically stable cyclopropylindolobenzazepine acylsulfonamides as thumb site 1 inhibitors of the hepatitis c virus NS5B RNA-dependent, RNA polymerase.

N. Meanwell, J. Lemm, J. Kadow, 2016, Bioorganic & medicinal chemistry letters.

Separation of pteroyl-oligo-gamma-L-glutamates by high-performance liquid-chromatography.

J. Bertino, C. Horváth, J. Knipe, 1980, Methods in enzymology.

P3-P4 ureas and reverse carbamates as potent HCV NS3 protease inhibitors: Effective transposition of the P4 hydrogen bond donor.

A. Good, N. Meanwell, R. Rajamani, 2018, Bioorganic & medicinal chemistry letters.

Preclinical Pharmacokinetics and In Vitro Metabolism of Asunaprevir (BMS-650032), a Potent Hepatitis C Virus NS3 Protease Inhibitor.

Y. Shu, V. Arora, Anand Balakrishnan, 2015, Journal of pharmaceutical sciences.

Pharmacokinetics and oral bioavailability of exogenous melatonin in preclinical animal models and clinical implications

J. Knipe, K. Yeleswaram, L. McLaughlin, 1997, Journal of pineal research.

.alpha.-Deuterium isotope effects and transition-state structure in an intramolecular model system for methyl-transfer enzymes

R. Schowen, J. Knipe, J. Coward, 1979 .

In vivo disposition and in vitro metabolism of an anxiolytic compound, BMS-184111, in rats.

R. Rourick, K. Volk, R. Mattson, 1995, Research Communications in Molecular Pathology and Pharmacology.

Potent Inhibitors of Hepatitis C Virus NS3 Protease: Employment of a Difluoromethyl Group as a Hydrogen-Bond Donor.

A. Good, K. Kish, H. Klei, 2018, ACS medicinal chemistry letters.

Novel, water-soluble phosphate derivatives of 2′-ethoxy carbonylpaclitaxel as potential prodrugs of paclitaxel: Synthesis and antitumor evaluation

W. Rose, J. Knipe, V. Farina, 1995 .

Preclinical pharmacokinetics and in vitro metabolism of BMS-605339: a novel HCV NS3 protease inhibitor.

V. Arora, J. Knipe, F. Mcphee, 2014, Journal of pharmaceutical sciences.

HCV NS5A replication complex inhibitors. Part 2: investigation of stilbene prolinamides.

N. Meanwell, J. Lemm, M. Gao, 2012, Bioorganic & medicinal chemistry letters.

Discovery and early clinical evaluation of BMS-605339, a potent and orally efficacious tripeptidic acylsulfonamide NS3 protease inhibitor for the treatment of hepatitis C virus infection.

A. Good, H. Klei, A. Cocuzza, 2014, Journal of medicinal chemistry.