Sylvia B. Smith

发表

SLC19: the folate/thiamine transporter family

V. Ganapathy, P. Prasad, Sylvia B. Smith, 2004, Pflügers Archiv.

Cloning and functional characterization of the proton-coupled electrogenic folate transporter and analysis of its expression in retinal cell types.

V. Ganapathy, P. Prasad, Pamela M. Martin, 2007, Investigative ophthalmology & visual science.

A Comparison of Caveolae and Caveolin-1 to Folate Receptor α in Retina and Retinal Pigment Epithelium

V. Ganapathy, P. Cameron, Sylvia B. Smith, 2001, The Histochemical Journal.

Molecular Mechanism of SLC5A8 Inactivation in Breast Cancer

Sudha Ananth, L. Hawthorn, V. Ganapathy, 2013, Molecular and Cellular Biology.

Diabetes accelerates retinal ganglion cell dysfunction in mice lacking sigma receptor 1

E. Zorrilla, V. Ganapathy, Sylvia B. Smith, 2012, Molecular vision.

In vivo protection against retinal neurodegeneration by sigma receptor 1 ligand (+)-pentazocine.

V. Ganapathy, Pamela M. Martin, Sylvia B. Smith, 2008, Investigative ophthalmology & visual science.

Prevention of excitotoxicity in primary retinal ganglion cells by (+)-pentazocine, a sigma receptor-1 specific ligand.

V. Ganapathy, M. Thangaraju, P. Prasad, 2007, Investigative ophthalmology & visual science.

The sigma receptor ligand (+)-pentazocine prevents apoptotic retinal ganglion cell death induced in vitro by homocysteine and glutamate.

V. Ganapathy, N. Agarwal, Pamela M. Martin, 2004, Brain research. Molecular brain research.

Comparison of Neuroprotective Effects of Monomethylfumarate to the Sigma 1 Receptor Ligand (+)-Pentazocine in a Murine Model of Retinitis Pigmentosa

Haiyan Xiao, Sylvia B. Smith, A. Saul, 2020, Investigative ophthalmology & visual science.

Expression and functional features of NaCT, a sodium-coupled citrate transporter, in human and rat livers and cell lines.

V. Ganapathy, S. Miyauchi, P. Prasad, 2007, American journal of physiology. Gastrointestinal and liver physiology.

Transcellular transfer of folate across the retinal pigment epithelium

V. Ganapathy, Sylvia B. Smith, M. Ola, 2002, Current eye research.

Sigma receptor 1 activation attenuates release of inflammatory cytokines MIP1γ, MIP2, MIP3α, and IL12 (p40/p70) by retinal Müller glial cells

Richard L. Perry, E. Zorrilla, V. Ganapathy, 2015, Journal of neurochemistry.

Iron-mediated retinal degeneration in haemojuvelin-knockout mice.

V. Ganapathy, Pamela M. Martin, J. Gnana-Prakasam, 2012, The Biochemical journal.

Human sodium-coupled citrate transporter, the orthologue of Drosophila Indy, as a novel target for lithium action.

V. Ganapathy, Katsuhisa Inoue, L. Zhuang, 2003, The Biochemical journal.

Transport of the synthetic opioid peptide DADLE ([D-Ala2,D-Leu5]-enkephalin) in neuronal cells.

V. Ganapathy, Santosh V. Thakkar, Pamela M. Martin, 2012, Journal of pharmaceutical sciences.

Hyperhomocysteinemia Alters Retinal Endothelial Cells Barrier Function and Angiogenic Potential via Activation of Oxidative Stress

I. Sharma, Sylvia B. Smith, S. Fulzele, 2017, Scientific Reports.

Molecular and biochemical characterization of folate transport proteins in retinal Müller cells.

V. Ganapathy, I. Goldman, P. Prasad, 2010, Investigative ophthalmology & visual science.

Alterations of retinal vasculature in cystathionine-β-synthase heterozygous mice: a model of mild to moderate hyperhomocysteinemia.

V. Ganapathy, S. Markand, Sylvia B. Smith, 2014, The American journal of pathology.

Hyperglycemia, p53 and mitochondrial pathway of apoptosis are involved in the susceptibility of diabetic models to ischemic acute kidney injury

Yunchao Su, Z. Dong, Dongshan Zhang, 2014, Kidney international.

Loss of Hfe leads to progression of tumor phenotype in primary retinal pigment epithelial cells.

V. Ganapathy, M. Thangaraju, Pamela M. Martin, 2013, Investigative ophthalmology & visual science.

Pharmacological Inhibition of Spermine Oxidase Reduces Neurodegeneration and Improves Retinal Function in Diabetic Mice

Prahalathan Pichavaram, Sylvia B. Smith, R. Caldwell, 2020, Journal of clinical medicine.

Pigment Epithelium-Derived Factor Delays the Death of Photoreceptors in Mouse Models of Inherited Retinal Degenerations

C. Gravel, M. Cayouette, Sylvia B. Smith, 1999, Neurobiology of Disease.

Photoreceptor degeneration and choroidal neovascularization in aged BALB/c mice following systemic neonatal murine cytomegalovirus infection

Sylvia B. Smith, D. Espinosa-Heidmann, Jinxian Xu, 2020 .

Downregulation of Cystine Transporter xc– by Irinotecan in Human Head and Neck Cancer FaDu Xenografts

M. Yin, Y. Rustum, H. Slocum, 2010, Chemotherapy.

Identity of SMCT1 (SLC5A8) as a neuron‐specific Na+‐coupled transporter for active uptake of l‐lactate and ketone bodies in the brain

V. Ganapathy, L. Zhuang, P. Prasad, 2006, Journal of neurochemistry.

Regulation of vitamin C transporter in the type 1 diabetic mouse bone and bone marrow.

M. Elsalanty, M. Hamrick, C. Isales, 2013, Experimental and molecular pathology.

Chapter 23 – Mechanisms of ER Stress in Retinal Disease

Sylvia B. Smith, 2012 .

Oxidative Stress and Apoptotic Biomarkers in Diabetic Retinopathy

Sylvia B. Smith, M. Al-Shabrawey, 2013 .

Activation of the molecular chaperone, sigma 1 receptor, preserves cone function in a murine model of inherited retinal degeneration

Sylvia B. Smith, P. Roon, A. Saul, 2016, Proceedings of the National Academy of Sciences.

Expression of the sodium-coupled monocarboxylate transporters SMCT1 (SLC5A8) and SMCT2 (SLC5A12) in retina.

V. Ganapathy, Pamela M. Martin, Sylvia B. Smith, 2007, Investigative ophthalmology & visual science.

Comparison of Sigma 1 Receptor Ligands SA4503 and PRE084 to (+)-Pentazocine in the rd10 Mouse Model of RP

Haiyan Xiao, Sylvia B. Smith, Jing Wang, 2020, Investigative ophthalmology & visual science.

p38MAPK plays a critical role in induction of a pro‐inflammatory phenotype of retinal Müller cells following Zika virus infection

A. Barrett, Sylvia B. Smith, Tian Wang, 2017, Antiviral research.

Oral Monomethyl Fumarate Therapy Ameliorates Retinopathy in a Humanized Mouse Model of Sickle Cell Disease.

D. Gutsaeva, M. Bartoli, V. Ganapathy, 2016, Antioxidants & redox signaling.

Expression and function of iron‐regulatory proteins in retina

V. Ganapathy, Pamela M. Martin, J. Gnana-Prakasam, 2010, IUBMB life.

Sigma 1 Receptor Contributes to Astrocyte-Mediated Retinal Ganglion Cell Protection

Graydon B. Gonsalvez, K. Bollinger, Sylvia B. Smith, 2022, Investigative ophthalmology & visual science.

Structure, Function, and Expression Pattern of a Novel Sodium-coupled Citrate Transporter (NaCT) Cloned from Mammalian Brain*

V. Ganapathy, Katsuhisa Inoue, L. Zhuang, 2002, The Journal of Biological Chemistry.

Absence of iron-regulatory protein Hfe results in hyperproliferation of retinal pigment epithelium: role of cystine/glutamate exchanger.

V. Ganapathy, M. Thangaraju, Kebin Liu, 2009, The Biochemical journal.

Transport via SLC 5 A 8 ( SMCT 1 ) Is Obligatory for 2-Oxothiazolidine-4-Carboxylate to Enhance Glutathione Production in Retinal Pigment Epithelial Cells

V. Ganapathy, E. Babu, T. Boettger, 2011 .

Transport via SLC5A8 (SMCT1) is obligatory for 2-oxothiazolidine-4-carboxylate to enhance glutathione production in retinal pigment epithelial cells.

V. Ganapathy, E. Babu, T. Boettger, 2011, Investigative ophthalmology & visual science.

Deletion of hemojuvelin, an iron-regulatory protein, in mice results in abnormal angiogenesis and vasculogenesis in retina along with reactive gliosis.

V. Ganapathy, J. Gnana-Prakasam, Sylvia B. Smith, 2014, Investigative ophthalmology & visual science.

Expression and iron-dependent regulation of succinate receptor GPR91 in retinal pigment epithelium.

V. Ganapathy, P. Prasad, Pamela M. Martin, 2011, Investigative ophthalmology & visual science.

Expression of the iron-regulatory protein haemojuvelin in retina and its regulation during cytomegalovirus infection.

V. Ganapathy, Pamela M. Martin, J. Gnana-Prakasam, 2009, The Biochemical journal.

Expression and polarized localization of the hemochromatosis gene product HFE in retinal pigment epithelium.

V. Ganapathy, Pamela M. Martin, J. Gnana-Prakasam, 2006, Investigative ophthalmology & visual science.

Defining the Ligand-dependent Interactome of the Sigma 1 Receptor

Graydon B. Gonsalvez, K. Bollinger, Sylvia B. Smith, 2022, bioRxiv.

The short variant of the mitochondrial dynamin OPA1 maintains mitochondrial energetics and cristae structure

Y. Yoon, Sylvia B. Smith, Hakjoo Lee, 2017, The Journal of Biological Chemistry.

Excess homocysteine upregulates the NRF2‐antioxidant pathway in retinal Müller glial cells

Jing Zhao, Y. Yoon, Jing Zhao, 2019, Experimental eye research.

Transport of D-serine via the amino acid transporter ATB(0,+) expressed in the colon.

V. Ganapathy, Wei Huang, T. Nakanishi, 2002, Biochemical and biophysical research communications.

Alterations of retinal vasculature in cystathionine-Beta-synthase mutant mice, a model of hyperhomocysteinemia.

V. Ganapathy, Sylvia B. Smith, S. Atherton, 2013, Investigative ophthalmology & visual science.

GPR109A as an anti-inflammatory receptor in retinal pigment epithelial cells and its relevance to diabetic retinopathy.

Julian J. Nussbaum, V. Ganapathy, M. Thangaraju, 2012, Investigative ophthalmology & visual science.

Arginase 1 promotes retinal neurovascular protection from ischemia through suppression of macrophage inflammatory responses

Y. Huo, Sylvia B. Smith, R. Caldwell, 2018, Cell Death & Disease.

Diabetes and Overexpression of proNGF Cause Retinal Neurodegeneration via Activation of RhoA Pathway

M. Abdelsaid, K. Bollinger, Sylvia B. Smith, 2013, PloS one.

Vitamin C Transporters in the Retina

V. Ganapathy, Pamela M. Martin, Sylvia B. Smith, 2008 .

Sigma 1 receptor regulates the oxidative stress response in primary retinal Müller glial cells via NRF2 signaling and system xc(-), the Na(+)-independent glutamate-cystine exchanger.

E. Zorrilla, V. Ganapathy, S. Markand, 2015, Free radical biology & medicine.

Transport of Amino Acid-Based Prodrugs by the Na+- and Cl--Coupled Amino Acid Transporter ATB0,+ and Expression of the Transporter in Tissues Amenable for Drug Delivery

V. Ganapathy, Y. Fei, S. Miyauchi, 2004, Journal of Pharmacology and Experimental Therapeutics.

Immunofluorescence analysis of the expression of Norpeg (Rai14) in retinal Müller and ganglion cells

Sylvia B. Smith, B. Mysona, Y. Dun, 2006, Neuroscience Letters.

Autonomous regulation of retinal insulin biosynthesis in diabetes

M. Bartoli, Jian-Kang Chen, Pamela M. Martin, 2022, Neuropeptides.

Sigma 1 receptor: A novel therapeutic target in retinal disease

K. Bollinger, Sylvia B. Smith, B. Mysona, 2018, Progress in Retinal and Eye Research.

Effects of hyperglycemia and oxidative stress on the glutamate transporters GLAST and system xc− in mouse retinal Müller glial cells

V. Ganapathy, Sylvia B. Smith, B. Mysona, 2009, Cell and Tissue Research.

Osmoregulation of taurine transporter function and expression in retinal pigment epithelial, ganglion, and müller cells.

V. Ganapathy, S. Miyauchi, Pamela M. Martin, 2004, Investigative ophthalmology & visual science.

Analysis of sigma receptor (sigmaR1) expression in retinal ganglion cells cultured under hyperglycemic conditions and in diabetic mice.

V. Ganapathy, Wei Huang, N. Agarwal, 2002, Brain research. Molecular brain research.

Ciliary neurotrophic factor induces glial fibrillary acidic protein in retinal Müller cells through the JAK/STAT signal transduction pathway

J. Ogilvie, Sylvia B. Smith, V. Sarthy, 2002, Current eye research.

JPET #57109 1 Transport of Amino acid-based Prodrugs by the Na- and Cl- coupled Amino Acid Transporter ATB and Expression of the Transporter in Tissues Amenable for Drug Delivery

Seiji, Takahiro, You-jun, 2003 .

Retinal and ciliary body pigment epithelium suppress activation of T lymphocytes via transforming growth factor beta.

M. Mochizuki, S. Sugita, Sylvia B. Smith, 2006, Experimental eye research.

Regulation of reduced-folate transporter-1 (RFT-1) by homocysteine and identity of transport systems for homocysteine uptake in retinal pigment epithelial (RPE) cells.

V. Ganapathy, Y. Fei, Sylvia B. Smith, 2003, Experimental eye research.

Morphological and Biochemical Studies of the Retinal Degeneration in the Vitiligo Mouse

Sylvia B. Smith, B. Wiggert, 1995 .

Hyperhomocysteinemia-induced death of retinal ganglion cells: The role of Müller glial cells and NRF2

W. Bollag, Jing Zhao, K. Bollinger, 2019, Redox biology.

The Role of Caspase-12 in Retinal Bystander Cell Death and Innate Immune Responses against MCMV Retinitis

Sylvia B. Smith, Jinxian Xu, Ming Zhang, 2021, International journal of molecular sciences.

Sensitivity of Staurosporine-Induced Differentiated RGC-5 Cells to Homocysteine

Sylvia B. Smith, Y. Dun, Yonju Ha, 2010, Current eye research.

Downregulation of reduced-folate transporter by glucose in cultured RPE cells and in RPE of diabetic mice.

V. Ganapathy, Wei Huang, Sylvia B. Smith, 2002, Investigative ophthalmology & visual science.

Diclofenac-induced stimulation of SMCT1 (SLC5A8) in a heterologous expression system: a RPE specific phenomenon.

V. Ganapathy, L. Zhuang, Pamela M. Martin, 2010, Biochemical and biophysical research communications.

Sigma-1 receptor agonist, (+)-pentazocine, is neuroprotective in a Brown Norway rat microbead model of glaucoma.

K. Bollinger, Sylvia B. Smith, B. Mysona, 2022, Experimental eye research.

Regulation of proton‐coupled folate transporter in retinal Müller cells by the antipsoriatic drug monomethylfumarate

V. Ganapathy, P. Prasad, Pamela M. Martin, 2012, Glia.

Optimal timing for activation of sigma 1 receptor in the Pde6brd10/J (rd10) mouse model of retinitis pigmentosa.

Haiyan Xiao, Sylvia B. Smith, Jing Wang, 2020, Experimental eye research.

Expression and function of system N glutamine transporters (SN1/SN2 or SNAT3/SNAT5) in retinal ganglion cells.

V. Ganapathy, P. Prasad, Pamela M. Martin, 2008, Investigative ophthalmology & visual science.

Expression and function of glutamine transporters SN1 (SNAT3) and SN2 (SNAT5) in retinal Müller cells.

V. Ganapathy, Weiguo Li, Sylvia B. Smith, 2005, Investigative ophthalmology & visual science.

The role of N-methyl-D-aspartate receptor activation in homocysteine-induced death of retinal ganglion cells.

Richard E. White, S. Black, P. Mcneil, 2011, Investigative ophthalmology & visual science.

Death of retinal neurons in streptozotocin-induced diabetic mice.

V. Ganapathy, Pamela M. Martin, Sylvia B. Smith, 2004, Investigative ophthalmology & visual science.

Iron Overload Accelerates the Progression of Diabetic Retinopathy in Association with Increased Retinal Renin Expression

V. Ganapathy, M. Thangaraju, Pamela M. Martin, 2018, Scientific Reports.

Induction of cystine-glutamate transporter xc- by human immunodeficiency virus type 1 transactivator protein tat in retinal pigment epithelium.

V. Ganapathy, S. Miyauchi, Sylvia B. Smith, 2004, Investigative ophthalmology & visual science.

Retinal and choroidal pathologies in aged BALB/c mice following systemic neonatal murine cytomegalovirus infection.

Sylvia B. Smith, D. Espinosa-Heidmann, Jinxian Xu, 2021, The American journal of pathology.

PPIP5K2 and PCSK1 are Candidate Genetic Contributors to Familial Keratoconus

Ryan P. McNabb, J. Rotter, Y. Rabinowitz, 2019, Scientific Reports.

Depletion of the Receptor-Interacting Protein Kinase 3 (RIP3) Decreases Photoreceptor Cell Death During the Early Stages of Ocular Murine Cytomegalovirus Infection

Sylvia B. Smith, S. Atherton, Jinxian Xu, 2018, Investigative ophthalmology & visual science.

Role of Bax in death of uninfected retinal cells during murine cytomegalovirus retinitis.

Sylvia B. Smith, S. Atherton, Ming Zhang, 2014, Investigative ophthalmology & visual science.

Transport of Nicotinate and Structurally Related Compounds by Human SMCT1 (SLC5A8) and Its Relevance to Drug Transport in the Mammalian Intestinal Tract

V. Ganapathy, S. Miyauchi, Pamela M. Martin, 2007, Pharmaceutical Research.

Sigma receptor 1 modulates endoplasmic reticulum stress in retinal neurons.

V. Ganapathy, M. Thangaraju, Kebin Liu, 2011, Investigative ophthalmology & visual science.

Effect of long-term chronic hyperhomocysteinemia on retinal structure and function in the cystathionine-β-synthase mutant mouse.

Y. Yoon, Sylvia B. Smith, Jing Wang, 2021, Experimental eye research.

Transient overexpression of the Microphthalmia gene in the eyes of Microphthalmia vitiligo mutant mice

S. Conway, Sylvia B. Smith, N. Bora, 1998, Developmental dynamics : an official publication of the American Association of Anatomists.

Reduction of Phagosomes in the Vitiligo ( C 57 BL / V * Mouse Model of Retinal Degeneration

Sylvia B. Smith, D. Defoe, D. McCool, 2005 .

Late-onset inner retinal dysfunction in mice lacking sigma receptor 1 (σR1).

E. Zorrilla, V. Ganapathy, K. Bollinger, 2011, Investigative ophthalmology & visual science.

Prediction of diabetic retinopathy: role of oxidative stress and relevance of apoptotic biomarkers

Sylvia B. Smith, M. Al-Shabrawey, 2010, EPMA Journal.

GPR109A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon.

G. Cresci, N. Lambert, J. Mellinger, 2009, Cancer research.

The cystine/glutamate antiporter system x(c)(-) in health and disease: from molecular mechanisms to novel therapeutic opportunities.

P. Kalivas, V. Ganapathy, P. Maher, 2013, Antioxidants & redox signaling.

The short variant of optic atrophy 1 (OPA1) improves cell survival under oxidative stress

Y. Yoon, S. Sheu, Sylvia B. Smith, 2020, The Journal of Biological Chemistry.

Homocysteine-mediated modulation of mitochondrial dynamics in retinal ganglion cells.

Richard L. Perry, Sylvia B. Smith, Yonju Ha, 2011, Investigative ophthalmology & visual science.

Sigma receptor 1 modulates ER stress and Bcl2 in murine retina

E. Zorrilla, V. Ganapathy, S. Markand, 2014, Cell and Tissue Research.

SLC5A8 triggers tumor cell apoptosis through pyruvate-dependent inhibition of histone deacetylases.

V. Ganapathy, M. Thangaraju, E. Sterneck, 2006, Cancer research.

Enhanced Affinity for 3-Amino-Chromane-Derived σ1 Receptor Ligands

M. Porter, Haiyan Xiao, Sylvia B. Smith, 2020, ACS omega.

Effects of targeted Bcl-2 expression in mitochondria or endoplasmic reticulum on renal tubular cell apoptosis.

Kebin Liu, K. Bhatt, Sylvia B. Smith, 2008, American journal of physiology. Renal physiology.

Progesterone Inhibits Folic Acid Transport in Human Trophoblasts

Sylvia B. Smith, F. Martel, C. Lemos, 2007, Journal of Membrane Biology.

Expression of the extraneuronal monoamine transporter in RPE and neural retina

V. Ganapathy, Sylvia B. Smith, R. Kekuda, 2000, Current eye research.

Interplay of autophagy and apoptosis during murine cytomegalovirus infection of RPE cells

Sylvia B. Smith, S. Atherton, Ming Zhang, 2014, Molecular vision.

Retinal expression of the serine protease matriptase-2 (Tmprss6) and its role in retinal iron homeostasis

V. Ganapathy, Pamela M. Martin, J. Gnana-Prakasam, 2014, Molecular vision.

Hepcidin expression in mouse retina and its regulation via lipopolysaccharide/Toll-like receptor-4 pathway independent of Hfe.

V. Ganapathy, Pamela M. Martin, J. Gnana-Prakasam, 2008, The Biochemical journal.

Inactivation in Breast Cancer Molecular Mechanism of SLC5A8

L. Hawthorn, V. Ganapathy, E. Babu, 2014 .

Mthfr as a modifier of the retinal phenotype of Crb1(rd8/rd8) mice.

R. Rozen, S. Markand, Sylvia B. Smith, 2016, Experimental eye research.

Arginase 1 promotes retinal neurovascular protection from ischemia through suppression of macrophage inflammatory responses

Y. Huo, Sylvia B. Smith, R. Caldwell, 2018, Cell Death & Disease.

Cystathionine Beta Synthase Expression in Mouse Retina

V. Ganapathy, N. Sen, M. Xian, 2013, Current eye research.

Expression and Differential Polarization of the Reduced-folate Transporter-1 and the Folate Receptor α in Mammalian Retinal Pigment Epithelium*

V. Ganapathy, F. Sirotnak, P. Prasad, 2000, The Journal of Biological Chemistry.

A role for macroautophagy in protection against 4-hydroxytamoxifen–induced cell death and the development of antiestrogen resistance

Sylvia B. Smith, D. Browning, Jennifer Duplantier, 2008, Molecular Cancer Therapeutics.

Effects of hydroxyl radical scavenging on cisplatin-induced p53 activation, tubular cell apoptosis and nephrotoxicity.

G. Dong, Tianxin Yang, Sylvia B. Smith, 2007, Biochemical pharmacology.

Diabetic Retinopathy and the NMDA Receptor.

Sylvia B. Smith, 2002, Drug news & perspectives.

Deletion of Arginase 2 Ameliorates Retinal Neurodegeneration in a Mouse Model of Multiple Sclerosis

Sylvia B. Smith, R. Caldwell, Zhimin Xu, 2019, Molecular Neurobiology.

Cutting Edge: IRF8 Regulates Bax Transcription In Vivo in Primary Myeloid Cells

Xiaoling Hu, Dafeng Yang, Kebin Liu, 2011, The Journal of Immunology.

The Impact of Diabetes on Neuronal, Glial, and Vascular Cells of the Retina

Sylvia B. Smith, 2007 .

Transport of N-acetylaspartate via murine sodium/dicarboxylate cotransporter NaDC3 and expression of this transporter and aspartoacylase II in ocular tissues in mouse.

V. Ganapathy, Wei Huang, Sylvia B. Smith, 2004, Biochimica et biophysica acta.

Identification of Estrogen Signaling in a Prioritization Study of Intraocular Pressure-Associated Genes

L. Pasquale, M. Hauser, J. Wiggs, 2021, International journal of molecular sciences.

Analysis of MTHFR, CBS, Glutathione, Taurine, and Hydrogen Sulfide Levels in Retinas of Hyperhomocysteinemic Mice

Wei Chen, M. Xian, Sylvia B. Smith, 2017, Investigative ophthalmology & visual science.

3-Amino-chromanes and Tetrahydroquinolines as Selective 5-HT2B, 5-HT7, or σ1 Receptor Ligands.

M. Porter, Haiyan Xiao, Sylvia B. Smith, 2019, ACS medicinal chemistry letters.

Folate Transport in Retina and Consequences on Retinal Structure and Function of Hyperhomocysteinemia

V. Ganapathy, Sylvia B. Smith, Preethi S. Ganapathy, 2014 .

Hyperhomocysteinemia disrupts retinal pigment epithelial structure and function with features of age-related macular degeneration

Sylvia B. Smith, A. Ibrahim, M. Al-Shabrawey, 2016, Oncotarget.

A Novel Mechanism of Sigma 1 Receptor Neuroprotection: Modulation of miR-214-3p.

Sylvia B. Smith, Jing Wang, 2019, Advances in experimental medicine and biology.

Generation of Sigmar1 conditional knockout mouse using CRISPR‐Cas9 gene targeting

Lin Gan, Sylvia B. Smith, Xiaoling Xie, 2022, Genesis.

Sigma 1 receptor regulates ERK activation and promotes survival of optic nerve head astrocytes

Graydon B. Gonsalvez, Jing Zhao, K. Bollinger, 2017, PloS one.

Absence of Sigma 1 Receptor Accelerates Photoreceptor Cell Death in a Murine Model of Retinitis Pigmentosa

Sylvia B. Smith, P. Roon, A. Saul, 2017, Investigative ophthalmology & visual science.

The Role of Sigma1R in Mammalian Retina.

Sylvia B. Smith, P. Roon, A. Saul, 2017, Advances in experimental medicine and biology.

Role of Sigma 1 Receptor in Retinal Degeneration of the Ins2Akita/+ Murine Model of Diabetic Retinopathy

Sylvia B. Smith, P. Roon, Jing Wang, 2016, Investigative ophthalmology & visual science.

Sigma receptor ligand, (+)-pentazocine, suppresses inflammatory responses of retinal microglia.

Graydon B. Gonsalvez, Jing Zhao, K. Bollinger, 2014, Investigative ophthalmology & visual science.

Sigma Receptors: Their Role in Disease and as Therapeutic Targets

T. Su, Sylvia B. Smith, 2017 .

Sigma receptor 1 modulates ER stress and Bcl2 in murine retina

J. Borge-Holthoefer, Y. Moreno, E. Zorrilla, 2014, Cell and Tissue Research.

Protective effects of agonists of growth hormone-releasing hormone (GHRH) in early experimental diabetic retinopathy

D. Gutsaeva, Julian J. Nussbaum, M. Bartoli, 2017, Proceedings of the National Academy of Sciences.

Expression, subcellular localization, and regulation of sigma receptor in retinal muller cells.

V. Ganapathy, Weiguo Li, J. Gnana-Prakasam, 2006, Investigative ophthalmology & visual science.

c/ebpδ Null Mouse as a Model for the Double Knock-out of slc5a8 and slc5a12 in Kidney*

V. Ganapathy, M. Thangaraju, E. Sterneck, 2006, Journal of Biological Chemistry.

Monomethylfumarate induces γ-globin expression and fetal hemoglobin production in cultured human retinal pigment epithelial (RPE) and erythroid cells, and in intact retina.

B. Pace, V. Ganapathy, Biaoru Li, 2014, Investigative ophthalmology & visual science.

Transport of hepcidin, an iron-regulatory peptide hormone, into retinal pigment epithelial cells via oligopeptide transporters and its relevance to iron homeostasis.

V. Ganapathy, D. Hinton, Pamela M. Martin, 2011, Biochemical and biophysical research communications.

Progesterone Receptor Membrane Component 1 (PGRMC1) Expression in Murine Retina

E. Zorrilla, V. Ganapathy, S. Markand, 2016, Current eye research.

Regulation of reduced-folate transporter-1 (RFT-1) in retinal pigment epithelial cells by folate

V. Ganapathy, Sylvia B. Smith, Hany Naggar, 2013 .

Regulation of Reduced-Folate Transporter-1 in Retinal Pigment Epithelial Cells by Folate

V. Ganapathy, Sylvia B. Smith, Tracy K Van Ells, 2005 .

Regulation of the cholesterol efflux transporters ABCA1 and ABCG1 in retina in hemochromatosis and by the endogenous siderophore 2,5-dihydroxybenzoic acid.

Y. Bhutia, V. Ganapathy, Pamela M. Martin, 2014, Biochimica et biophysica acta.

Expression of slc5a8 in Kidney and Its Role in Na+-coupled Transport of Lactate*

V. Ganapathy, Y. Fei, L. Zhuang, 2004, Journal of Biological Chemistry.

Pigment epithelium-derived factor inhibits retinal microvascular dysfunction induced by 12/15-lipoxygenase-derived eicosanoids.

E. Duh, S. Markand, Sylvia B. Smith, 2015, Biochimica et biophysica acta.

Reduced-folate carrier (RFC) is expressed in placenta and yolk sac, as well as in cells of the developing forebrain, hindbrain, neural tube, craniofacial region, eye, limb buds and heart

V. Ganapathy, P. Prasad, Sylvia B. Smith, 2003, BMC Developmental Biology.

Increased ER stress as a mechanism of retinal neurovasculopathy in mice with severe hyperhomocysteinemia.

Sylvia B. Smith, A. Tawfik, 2014, Austin journal of clinical ophthalmology.

Sigma 1 Receptor Co-Localizes with NRF2 in Retinal Photoreceptor Cells

Haiyan Xiao, Sylvia B. Smith, Jing Wang, 2021, Antioxidants.

Relationship between Sigma‐1 receptor and BDNF in the visual system

Jing Zhao, K. Bollinger, Sylvia B. Smith, 2018, Experimental eye research.

A lipidomic screen of hyperglycemia-treated HRECs links 12/15-Lipoxygenase to microvascular dysfunction during diabetic retinopathy via NADPH oxidase

M. Abdelsaid, Sylvia B. Smith, N. Rizk, 2015, Journal of Lipid Research.

Activation of Sigma 1 Receptor Extends Survival of Cones and Improves Visual Acuity in a Murine Model of Retinitis Pigmentosa

Sylvia B. Smith, A. Saul, Jing Wang, 2019, Investigative ophthalmology & visual science.

Detailed electroretinographic findings in rd8 mice

S. Markand, Sylvia B. Smith, A. Saul, 2017, Documenta Ophthalmologica.

Retinal Ganglion Cell Loss and Mild Vasculopathy in Methylene Tetrahydrofolate Reductase (Mthfr)-Deficient Mice: A Model of Mild Hyperhomocysteinemia.

R. Rozen, V. Ganapathy, S. Markand, 2015, Investigative ophthalmology & visual science.

(+)-Pentazocine Reduces NMDA-Induced Murine Retinal Ganglion Cell Death Through a σR1-Dependent Mechanism

Graydon B. Gonsalvez, Jing Zhao, K. Bollinger, 2016, Investigative ophthalmology & visual science.

N. Peachey, Gwen M. Sturgill-Short, Sylvia B. Smith, 2012, Experimental eye research.

Endogenous elevation of homocysteine induces retinal neuron death in the cystathionine-beta-synthase mutant mouse.

Kebin Liu, P. Prasad, Sylvia B. Smith, 2009, Investigative ophthalmology & visual science.

Expression and localization of GPR109A (PUMA-G/HM74A) mRNA and protein in mammalian retinal pigment epithelium

G. Cresci, V. Ganapathy, Pamela M. Martin, 2009, Molecular vision.

Hyperhomocysteinemia Alters Retinal Endothelial Cells Barrier Function and Angiogenic Potential via Activation of Oxidative Stress

I. Sharma, Sylvia B. Smith, S. Fulzele, 2017, Scientific Reports.

Diabetes Accelerates Retinal Neuronal Cell Death In A Mouse Model of Endogenous Hyperhomocysteinemia

Sylvia B. Smith, B. Mysona, P. Roon, 2009, Ophthalmology and eye diseases.

Identification of a novel sodium-coupled oligopeptide transporter (SOPT2) in mouse and human retinal pigment epithelial cells.

V. Ganapathy, Santosh V. Thakkar, D. Hinton, 2010, Investigative ophthalmology & visual science.

Polarized distribution of heme transporters in retinal pigment epithelium and their regulation in the iron-overload disease hemochromatosis.

V. Ganapathy, Pamela M. Martin, J. Gnana-Prakasam, 2011, Investigative ophthalmology & visual science.

Induction of cystine-glutamate transporter xc- by human immunodeficiency virus type 1 transactivator protein tat in retinal pigment epithelium.

V. Ganapathy, S. Miyauchi, Sylvia B. Smith, 2004, Investigative Ophthalmology and Visual Science.

Identification of a novel Na+- and Cl--coupled transport system for endogenous opioid peptides in retinal pigment epithelium and induction of the transport system by HIV-1 Tat.

V. Ganapathy, S. Miyauchi, Sylvia B. Smith, 2003, The Biochemical journal.

Polarized distribution of heme transporters in retinal pigment epithelium and their regulation in the iron-overload disease hemochromatosis.

V. Ganapathy, Pamela M. Martin, Sylvia B. Smith, 2011, Investigative ophthalmology & visual science.

Sigma 1 Receptor Modulates Optic Nerve Head Astrocyte Reactivity

Graydon B. Gonsalvez, M. Bartoli, K. Bollinger, 2021, Investigative ophthalmology & visual science.

Sigma receptor ligand, (+)-pentazocine, suppresses inflammatory responses of retinal microglia.

Graydon B. Gonsalvez, Jing Zhao, K. Bollinger, 2014, Investigative ophthalmology & visual science.

Ciliary neurotrophic factor (CNTF) induces reactive gliosis and gfap expression in müller cells

Sylvia B. Smith, V. Sarthy, S. Brodjian, 1997 .

Introduction to Sigma Receptors: Their Role in Disease and as Therapeutic Targets.

Sylvia B. Smith, 2017, Advances in experimental medicine and biology.

Dysregulation of system xc − expression induced by mutant huntingtin in a striatal neuronal cell line and in R6/2 mice

P. Rosenberg, Sylvia B. Smith, Ekaterina Bakradze, 2014, Neurochemistry International.

Iron-mediated retinal degeneration in haemojuvelin-knockout mice.

V. Ganapathy, Pamela M. Martin, Sylvia B. Smith, 2012, The Biochemical journal.

Late-onset inner retinal dysfunction in mice lacking sigma receptor 1 (σR1).

E. Zorrilla, V. Ganapathy, K. Bollinger, 2011, Investigative ophthalmology & visual science.