Y. Kido

发表

Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.

Pär Matsson, K. Giacomini, Y. Kido, 2011, Journal of medicinal chemistry.

Limited distribution of new quinolone antibacterial agents into brain caused by multiple efflux transporters at the blood-brain barrier.

Y. Sai, K. Naruhashi, I. Tamai, 2000, The Journal of pharmacology and experimental therapeutics.

Discovery of imidazo[1,2-b]pyridazine derivatives: selective and orally available Mps1 (TTK) kinase inhibitors exhibiting remarkable antiproliferative activity.

Yusuke Nakamura, H. Yoshida, K. Kusakabe, 2015, Journal of medicinal chemistry.

A unique hinge binder of extremely selective aminopyridine-based Mps1 (TTK) kinase inhibitors with cellular activity.

Yusuke Nakamura, K. Kusakabe, Y. Daigo, 2015, Bioorganic & medicinal chemistry.

Identification of Food-Derived Isoflavone Sulfates as Inhibition Markers for Intestinal Breast Cancer Resistance Proteins

Y. Masuo, Y. Kato, R. Agustina, 2021, Drug Metabolism and Disposition.

Species difference in brain penetration of P-gp and BCRP substrates among monkey, dog and mouse.

Y. Kido, T. Matsuzaki, Takanori Akazawa, 2021, Drug metabolism and pharmacokinetics.

Transport of carnitine and acetylcarnitine by carnitine/organic cation transporter (OCTN) 2 and OCTN3 into epididymal spermatozoa.

J. Nezu, Y. Sai, I. Tamai, 2007, Reproduction.

Blood-Brain Barrier Transport of H1-Antagonist Ebastine and its Metabolite Carebastine

Y. Sai, I. Tamai, A. Tsuji, 2000, Journal of drug targeting.

Immunohistochemical and Functional Characterization of pH‐dependent Intestinal Absorption of Weak Organic Acids by the Monocarboxylic Acid Transporter MCT1

H. Takanaga, Y. Sai, I. Tamai, 1999, The Journal of pharmacy and pharmacology.

Highly Conformationally Restricted Cyclopropane Tethers with Three-Dimensional Structural Diversity Drastically Enhance the Cell Permeability of Cyclic Peptides.

S. Shuto, K. Matsui, Y. Kido, 2017, Chemistry.

Glutathione-mediated modulation of tetraplatin activity against sensitive and resistant tumor cells.

A. Khokhar, Z. Siddik, Y. Kido, 1994, Biochemical pharmacology.

Distinct P‐glycoprotein expression in two subclones simultaneously selected from a human colon carcinoma cell line by cis‐diamminedichloroplatinum (II)

Z. Siddik, M. Siciliano, L. Yang, 1993, International journal of cancer.

Evaluation of blood-brain barrier transporters by co-culture of brain capillary endothelial cells with astrocytes.

T. Nakanishi, Y. Sai, I. Tamai, 2002, Drug metabolism and pharmacokinetics.

Molecular and functional identification of large neutral amino acid transporters LAT1 and LAT2 and their pharmacological relevance at the blood‐brain barrier

Y. Sai, I. Tamai, A. Tsuji, 2001, The Journal of pharmacy and pharmacology.

Functional Clarification of MCT1-Mediated Transport of Monocarboxylic Acids at the Blood-Brain Barrier Using In Vitro Cultured Cells and In Vivo BUI Studies

I. Tamai, A. Tsuji, F. Suzuki, 2004, Pharmaceutical Research.

Preparation, characterization, and antitumor activity of new ethylenediamine platinum(IV) complexes containing mixed carboxylate ligands.

A. Khokhar, Z. Siddik, Y. Kido, 1993, Journal of inorganic biochemistry.

Synthesis, characterization, and antitumor activity of new chloroethylamine platinum complexes.

A. Khokhar, Z. Siddik, R. Newman, 1992, Journal of inorganic biochemistry.

Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling.

Andrej Sali, Natalia Khuri, A. Sali, 2013, Journal of medicinal chemistry.

Functional relevance of carnitine transporter OCTN2 to brain distribution of l‐carnitine and acetyl‐l‐carnitine across the blood–brain barrier

J. Nezu, Y. Sai, I. Tamai, 2001, Journal of neurochemistry.

Diaminopyridine-based potent and selective mps1 kinase inhibitors binding to an unusual flipped-Peptide conformation.

Yusuke Nakamura, Takayuki Kanazawa, Kazuo Ueda, 2012, ACS medicinal chemistry letters.

Correlation of total and interstrand DNA adducts in tumor and kidney with antitumor efficacies and differential nephrotoxicities of cis-ammine/cyclohexylamine-dichloroplatinum(II) and cisplatin.

F. Ali-Osman, A. Khokhar, Z. Siddik, 1994, Biochemical pharmacology.

Indazole-based potent and cell-active Mps1 kinase inhibitors: rational design from pan-kinase inhibitor anthrapyrazolone (SP600125).

Yusuke Nakamura, K. Kusakabe, Y. Daigo, 2013, Journal of medicinal chemistry.

Trifluoromethyl Dihydrothiazine‐Based β‐Secretase (BACE1) Inhibitors with Robust Central β‐Amyloid Reduction and Minimal Covalent Binding Burden

K. Kusakabe, Shinji Suzuki, Y. Kido, 2019, ChemMedChem.

Modulation of cytotoxicity and cellular pharmacology of 1,2-diaminocyclohexane platinum (IV) complexes mediated by axial and equatorial ligands.

A. Khokhar, Z. Siddik, Y. Kido, 1993, Cancer research.

Differential cytotoxicity, uptake and DNA binding of tetraplatin and analogous isomers in sensitive and resistant cancer cell lines.

A. Khokhar, Z. Siddik, Y. Kido, 1993, Anti-cancer drugs.

Balancing potency and basicity by incorporating fluoropyridine moieties: Discovery of a 1-amino-3,4-dihydro-2,6-naphthyridine BACE1 inhibitor that affords robust and sustained central Aβ reduction.

K. Kusakabe, Y. Kido, Shiho Yamamoto, 2021, European journal of medicinal chemistry.

Discovery of an Extremely Potent Thiazine-Based β-Secretase (BACE1) Inhibitor with Reduced Cardiovascular and Liver Toxicity at a Low Projected Human Dose.

K. Kusakabe, Shinji Suzuki, N. Asada, 2019, Journal of medicinal chemistry.

Discovery of Potent and Centrally Active 6-Substituted 5-Fluoro-1,3-dihydro-oxazine β-Secretase (BACE1) Inhibitors via Active Conformation Stabilization.

Kenji Nakahara, Takahiko Yamamoto, K. Kusakabe, 2018, Journal of medicinal chemistry.

Rational Design of Novel 1,3-Oxazine Based β-Secretase (BACE1) Inhibitors: Incorporation of a Double Bond To Reduce P-gp Efflux Leading to Robust Aβ Reduction in the Brain.

K. Kusakabe, Y. Kido, T. Fukushima, 2018, Journal of medicinal chemistry.

Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.

K. Giacomini, Y. Kido, P. Matsson, 2011, Journal of medicinal chemistry.