S. Bhattacharya

发表

Discovery of Orally Bioavailable Selective Inhibitors of the Sodium-Phosphate Cotransporter NaPi2a (SLC34A1).

P. Loria, M. Boehm, H. Jüppner, 2018, ACS medicinal chemistry letters.

Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based Antidiabetic Treatment.

M. Ammirati, A. Carlo, A. Mathiowetz, 2015, ACS medicinal chemistry letters.

MAP4K4 Is a Threonine Kinase That Phosphorylates FARP1.

L. Buckbinder, K. Stone, Adam G Schwaid, 2015, ACS chemical biology.

Design and synthesis of truncated EGF-A peptides that restore LDL-R recycling in the presence of PCSK9 in vitro.

M. Ammirati, D. Craik, David A. Price, 2014, Chemistry & biology.

Pharmacological characterization of the first in class clinical candidate PF‐05190457: a selective ghrelin receptor competitive antagonist with inverse agonism that increases vagal afferent firing and glucose‐dependent insulin secretion ex vivo

P. Loria, S. V. Straub, S. Bhattacharya, 2016, British journal of pharmacology.

Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors.

Jacquelyn L. Klug-McLeod, Daniel P. Walker, David A. Price, 2012, Bioorganic & medicinal chemistry letters.

The Total Synthesis of Eleutherobin: A Surprise Ending.

Xiao-tao Chen, S. Danishefsky, T. Pettus, 1998, Angewandte Chemie.

Endothelial protein kinase MAP 4 K 4 promotes vascular inflammation and atherosclerosis Citation

L. Buckbinder, M. Czech, R. Flach, 2015 .

PF-03814735, an Orally Bioavailable Small Molecule Aurora Kinase Inhibitor for Cancer Therapy

L. Pustilnik, J. Christensen, B. D. Cohen, 2010, Molecular Cancer Therapeutics.

Stereoselective synthesis of a synthon for the A-ring of taxol from R-(+)-verbenone

J. Winkler, R. Batey, R. Kelly, 1995 .

The Total Synthesis of Eleutherobin

Xiao-tao Chen, S. Danishefsky, S. Bhattacharya, 1999 .

Evaluation and synthesis of polar aryl- and heteroaryl spiroazetidine-piperidine acetamides as ghrelin inverse agonists.

P. Loria, D. Hepworth, S. Bhattacharya, 2015, ACS Medicinal Chemistry Letters.

Synthesis of a taxinine analog via the intramolecular Diels-Alder cycloaddition

J. Winkler, R. Batey, S. Bhattacharya, 1996 .

Small molecule ghrelin receptor inverse agonists and antagonists.

A. Loomis, S. Bhattacharya, K. O. Cameron, 2014, Journal of medicinal chemistry.

A CONVERGENT ROUTE FOR THE TOTAL SYNTHESIS OF THE ELEUTHESIDES

S. Danishefsky, T. Pettus, S. Bhattacharya, 1998 .

A total synthesis of the methyl glycoside of ganglioside GM(1).

S. Danishefsky, S. Bhattacharya, 2000, The Journal of organic chemistry.

Lead-like Drugs: A Perspective.

S. Bhattacharya, Samit K Bhattacharya, Brian Raymer, 2018, Journal of medicinal chemistry.

Understanding the Impact of the P-loop Conformation on Kinase Selectivity

Cristiano R. W. Guimaraes, Brajesh K. Rai, Michael J. Munchhof, 2011, J. Chem. Inf. Model..

2-Aminopyridine-Based Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Inhibitors: Assessment of Mechanism-Based Safety.

M. Ammirati, L. Buckbinder, A. El‐Kattan, 2018, Journal of medicinal chemistry.

Achieving selectivity between highly homologous tyrosine kinases: a novel selective erbB2 inhibitor.

A. Mathiowetz, L. Pustilnik, Joel Morris, 2003, Biochemical and biophysical research communications.

Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy.

Jessica Ward, Jun Xiao, David Hepworth, 2016, Journal of medicinal chemistry.

Discovery and pharmacologic characterization of CP-724,714, a selective ErbB2 tyrosine kinase inhibitor.

R. D. Connell, L. Pustilnik, Joel Morris, 2007, Cancer research.

The discovery of novel calcium sensing receptor negative allosteric modulators.

J. Bauman, David A. Price, A. Kalgutkar, 2009, Bioorganic & medicinal chemistry letters.

Structure-activity profiles of eleutherobin analogs and their cross-resistance in Taxol-resistant cell lines

Xiao-tao Chen, S. Danishefsky, S. Horwitz, 1999, Cancer Chemotherapy and Pharmacology.

Endothelial protein kinase MAP4K4 promotes vascular inflammation and atherosclerosis

L. Buckbinder, M. Czech, M. Aouadi, 2015, Nature Communications.

Structural studies identify angiotensin II receptor blocker-like compounds as branched-chain ketoacid dehydrogenase kinase inhibitors

B. L. Kormos, P. Sahasrabudhe, R. Sommese, 2023, The Journal of biological chemistry.

Identification of potent, selective, CNS-targeted inverse agonists of the ghrelin receptor.

L. Michael, T. Goosen, M. Tu, 2013, Bioorganic & medicinal chemistry letters.

Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5'-Adenosine Monophosphate-Activated Protein Kinase (AMPK).

R. Kurumbail, A. Kalgutkar, B. Feng, 2018, Journal of medicinal chemistry.

Discovery of PF-5190457, a Potent, Selective, and Orally Bioavailable Ghrelin Receptor Inverse Agonist Clinical Candidate.

P. Loria, D. Hepworth, S. Bhattacharya, 2014, ACS medicinal chemistry letters.

A remarkable pyranose to furanose isomerization mediated by an “anomeric" silyloxy function

Xiao-tao Chen, S. Danishefsky, S. Bhattacharya, 1999 .

Evaluating the use of Desmodium gangeticum as Alpha Glucosidase and DPP-IV Inhibitor for Type-II Diabetes

S. Bhattacharya, S. Bhattacharya, R. Bisht, 2014 .

Small molecule branched-chain ketoacid dehydrogenase kinase (BDK) inhibitors with opposing effects on BDK protein levels

Jake E. Delmore, A. Kalgutkar, B. L. Kormos, 2023, Nature communications.

The discovery of novel calcium sensing receptor negative allosteric modulators.

J. Bauman, A. Kalgutkar, V. Paralkar, 2009, Bioorganic & medicinal chemistry letters.

The discovery of highly selective erbB2 (Her2) inhibitors for the treatment of cancer.

L. Pustilnik, S. Bhattacharya, J. Chen, 2007, Bioorganic & medicinal chemistry letters.

Spiroazetidine–piperidine bromoindane as a key modular template to access a variety of compounds via C–C and C–N bond-forming reactions

S. Bhattacharya, K. McClure, Wenhua Jiao, 2012 .