A. Shavnya

发表

Discovery of Orally Bioavailable Selective Inhibitors of the Sodium-Phosphate Cotransporter NaPi2a (SLC34A1).

P. Loria, M. Boehm, H. Jüppner, 2018, ACS medicinal chemistry letters.

Toward the assembly and characterization of an encoded library hit confirmation platform: Bead-Assisted Ligand Isolation Mass Spectrometry (BALI-MS).

Timothy L. Foley, K. Farley, L. Byrnes, 2021, Bioorganic & medicinal chemistry.

Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase (ACC) Inhibitors Through Liver Targeting.

David A. Price, A. Kalgutkar, S. Liras, 2020, Journal of medicinal chemistry.

Discovery and in Vitro Optimization of 3-Sulfamoylbenzamides as ROMK Inhibitors.

A. Carlo, M. Boehm, K. J. Filipski, 2018, ACS medicinal chemistry letters.

Piperazinyl CCR1 antagonists--optimization of human liver microsome stability.

Christopher S. Poss, M. Hayward, J. Driscoll, 2007, Bioorganic & medicinal chemistry letters.

Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK).

J. Pandit, J. Culp, K. Parris, 2017, Journal of medicinal chemistry.

Discovery of PF-04449913, a Potent and Orally Bioavailable Inhibitor of Smoothened.

M. Munchhof, A. Shavnya, N. Patel, 2012, ACS medicinal chemistry letters.

Heterocyclic Allylsulfones as Latent Heteroaryl Nucleophiles in Palladium-Catalyzed Cross-Coupling Reactions.

Philip R. D. Murray, M. Willis, D. Blakemore, 2018, Journal of the American Chemical Society.

Synthesis of sulfones from organozinc reagents, DABSO, and alkyl halides.

A. Shavnya, Christian Perreault, Vincent Mascitti, 2014, Organic letters.

5-Heteroatom-substituted pyrazoles as canine COX-2 inhibitors: Part 2. Structure-activity relationship studies of 5-alkylethers and 5-thioethers.

M. P. Lynch, S. Sakya, Jin Li, 2006, Bioorganic & medicinal chemistry letters.

Design and synthesis of diazatricyclodecane agonists of the G-protein-coupled receptor 119.

Bryan M. Li, David A. Price, A. Kalgutkar, 2013, Journal of medicinal chemistry.

5-heteroatom substituted pyrazoles as canine COX-2 inhibitors. Part 1: Structure-activity relationship studies of 5-alkylamino pyrazoles and discovery of a potent, selective, and orally active analog.

M. P. Lynch, S. Sakya, Jin Li, 2006, Bioorganic & medicinal chemistry letters.

Palladium-Catalyzed Synthesis of (Hetero)Aryl Alkyl Sulfones from (Hetero)Aryl Boronic Acids, Unactivated Alkyl Halides, and Potassium Metabisulfite.

Aaron C. Smith, A. Shavnya, Vincent Mascitti, 2015, Angewandte Chemie.

5-Heteroatom substituted pyrazoles as canine COX-2 inhibitors. Part III: molecular modeling studies on binding contribution of 1-(5-methylsulfonyl)pyrid-2-yl and 4-nitrile.

S. Sakya, Jin Li, Xinjun Hou, 2007, Bioorganic & medicinal chemistry letters.

A Versatile Reagent and Method for Direct Aliphatic Sulfonylation

A. Shavnya, A. Tsai, Kevin D. Hesp, 2018 .

Reaction of Alkyl Halides with Rongalite: One-Pot and Telescoped Syntheses of Aliphatic Sulfonamides, Sulfonyl Fluorides, and Unsymmetrical Sulfones.

A. Shavnya, A. Tsai, S. Coffey, 2016, Organic letters.

Palladium-catalyzed sulfination of aryl and heteroaryl halides: direct access to sulfones and sulfonamides.

Aaron C. Smith, A. Shavnya, Vincent Mascitti, 2013, Organic letters.

Structure-activity relationships and hepatic safety risks of thiazole agonists of the thrombopoietin receptor.

M. Munchhof, T. Harris, J. Driscoll, 2010, Bioorganic & medicinal chemistry letters.

The identification of orally bioavailable thrombopoietin agonists.

A. Marfat, M. Munchhof, T. Harris, 2009, Bioorganic & medicinal chemistry letters.

Pyrimidine benzamide-based thrombopoietin receptor agonists.

M. Munchhof, J. Driscoll, Jonathan L. Doty, 2007, Bioorganic & medicinal chemistry letters.

Efficient fluoride-mediated synthesis of 5-alkyl amino- and ether-substituted pyrazoles

S. Sakya, A. Shavnya, Martha L. Minich, 2005 .

Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy.

Jessica Ward, Jun Xiao, David Hepworth, 2016, Journal of medicinal chemistry.

Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5'-Adenosine Monophosphate-Activated Protein Kinase (AMPK).

R. Kurumbail, A. Kalgutkar, B. Feng, 2018, Journal of medicinal chemistry.

Selective Activation of AMPK β1-Containing Isoforms Improves Kidney Function in a Rat Model of Diabetic Nephropathy

R. Kurumbail, M. Birnbaum, A. Kalgutkar, 2017, The Journal of Pharmacology and Experimental Therapeutics.

Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose.

J. Pandit, K. Parris, David A. Price, 2020, Journal of medicinal chemistry.

Comparative structure-activity relationship studies of 1-(5-methylsulfonylpyrid-2-yl)-5-alkyl and (hetero)aryl triazoles and pyrazoles in canine COX inhibition.

M. P. Lynch, S. Sakya, Jin Li, 2008, Bioorganic & medicinal chemistry letters.

Efficient Synthesis of 4-Amino-2-methoxy-7,8-dihydropyrido[4,3-d]pyrimidin-5-ones: Practical Access to a Novel Chemotype in the Development of DGAT-1 Inhibitors

M. Munchhof, K. Karki, R. L. Dow, 2012, Synthesis.

Discovery of a potent, selective and orally active canine COX-2 inhibitor, 2-(3-difluoromethyl-5-phenyl-pyrazol-1-yl)-5-methanesulfonyl-pyridine.

M. P. Lynch, S. Sakya, Jin Li, 2004, Bioorganic & medicinal chemistry letters.

Discovery of PF-04449913, a Potent and Orally Bioavailable Inhibitor of Smoothened.

M. Munchhof, A. Shavnya, N. Patel, 2012, ACS medicinal chemistry letters.

Base‐Activated Latent Heteroaromatic Sulfinates as Nucleophilic Coupling Partners in Palladium‐Catalyzed Cross‐Coupling Reactions

N. Sach, M. Willis, D. Blakemore, 2021, Angewandte Chemie.