F. Sekiguchi

发表

High glucose induces N-linked glycosylation-mediated functional upregulation and overexpression of Cav3.2 T-type calcium channels in neuroendocrine-like differentiated human prostate cancer cells.

A. Kawabata, Kazuki Fukami, Erina Asano, 2017, Journal of pharmacological sciences.

Signal transduction for formation/release of interleukin-8 caused by a PAR2-activating peptide in human lung epithelial cells

A. Kawabata, F. Sekiguchi, H. Nishikawa, 2008, Regulatory Peptides.

Proteinase-Activated Receptor-2–Triggered Prostaglandin E2 Release, but Not Cyclooxygenase-2 Upregulation, Requires Activation of the Phosphatidylinositol 3–Kinase / Akt / Nuclear Factor-κB Pathway in Human Alveolar Epithelial Cells

A. Kawabata, F. Sekiguchi, H. Nishikawa, 2009 .

Hydrogen Sulfide and T-Type Ca2+ Channels in Pain Processing, Neuronal Differentiation and Neuroendocrine Secretion

A. Kawabata, Kazuki Fukami, F. Sekiguchi, 2016, Pharmacology.

Effect of a potent iNOS inhibitor (ONO-1714) on acetaminophen-induced hepatotoxicity in the rat.

A. Kawabata, F. Sekiguchi, N. Kawao, 2003, Life sciences.

Rhythmic spontaneous contractions in the rat proximal colon.

F. Sekiguchi, H. Fukui, M. Kadowaki, 2001, The Japanese journal of physiology.

Involvement of the cystathionine-γ-lyase/Cav3.2 pathway in substance P-induced bladder pain in the mouse, a model for nonulcerative bladder pain syndrome

H. Ishikura, A. Kawabata, F. Sekiguchi, 2018, Neuropharmacology.

Involvement of Voltage-Gated Calcium Channels in Inflammation and Inflammatory Pain.

A. Kawabata, F. Sekiguchi, Maho Tsubota, 2018, Biological & pharmaceutical bulletin.

Role of high‐mobility group box 1 and its modulation by thrombomodulin/thrombin axis in neuropathic and inflammatory pain

R. Tsujita, A. Kawabata, F. Sekiguchi, 2020, British journal of pharmacology.

Effects of Bepridil and Pimozide, Existing Medicines Capable of Blocking T-Type Ca2+ Channels, on Visceral Pain in Mice.

K. Matsui, A. Kawabata, F. Sekiguchi, 2021, Biological & pharmaceutical bulletin.

[Development of agonists/antagonists for protease-activated receptors (PARs) and the possible therapeutic application to gastrointestinal diseases].

F. Sekiguchi, 2005, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Antiallodynic effect of etidronate, a bisphosphonate, in rats with adjuvant-induced arthritis: Involvement of ATP-sensitive K+ channels

A. Kawabata, F. Sekiguchi, N. Kawao, 2006, Neuropharmacology.

Hydrogen sulfide‐induced mechanical hyperalgesia and allodynia require activation of both Cav3.2 and TRPA1 channels in mice

A. Kawabata, F. Sekiguchi, Yuka Aoki, 2012, British journal of pharmacology.

Recombinant human soluble thrombomodulin prevents peripheral HMGB1‐dependent hyperalgesia in rats

H. Ishikura, A. Kawabata, F. Sekiguchi, 2013, British journal of pharmacology.

ENDOTHELIUM-DEPENDENT AND -INDEPENDENT TENSION OSCILLATION OF ARTERIES AND ITS ABNORMALITY IN HYPERTENSIVE ANIMALS

F. Sekiguchi, K. Shimamura, S. Sunano, 1998 .

HYPERPOLARIZATION AND RELAXATION MEDIATED BY ENDOTHELIUM-DERIVED FACTORS AND ABNORMALITIES IN HYPERTENSIVE ANIMALS

F. Sekiguchi, K. Shimamura, S. Sunano, 1997 .

Abnormal response to ryanodine in oesophageal striated muscle of spontaneously hypertensive rats.

F. Sekiguchi, S. Sunano, K. Kawata, 2004, European journal of pharmacology.

Involvement of ERK in NMDA receptor-independent cortical neurotoxicity of hydrogen sulfide.

A. Akaike, A. Kawabata, F. Sekiguchi, 2011, Biochemical and biophysical research communications.

Involvement of Src kinase in T‐type calcium channel‐dependent neuronal differentiation of NG108‐15 cells by hydrogen sulfide

A. Kawabata, Kazuki Fukami, F. Sekiguchi, 2010, Journal of neurochemistry.

Involvement of endothelium-derived factors in controlling the active tone of smooth muscle in aorta from hypertensive rats.

F. Sekiguchi, K. Shimamura, S. Sunano, 1998, Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi.

RagA, an mTORC1 activator, interacts with a hedgehog signaling protein, WDR35/IFT121

T. Ishii, Hideki Kobayashi, N. Furuno, 2019, Genes to cells : devoted to molecular & cellular mechanisms.

Transmural field stimulation-induced relaxation in the rat common hepatic artery.

H. Saito, S. Kimura, F. Sekiguchi, 2000, Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi.

Distinct roles for protease-activated receptors 1 and 2 in vasomotor modulation in rat superior mesenteric artery.

A. Kawabata, F. Sekiguchi, N. Kawao, 2004, Cardiovascular research.

Gastrointestinal roles for proteinase‐activated receptors in health and disease

A. Kawabata, F. Sekiguchi, M. Matsunami, 2008, British journal of pharmacology.

Proteinase-activated receptors in the gastrointestinal system: a functional linkage to prostanoids

A. Kawabata, F. Sekiguchi, K. Takaoka, 2007, Inflammopharmacology.

Mechanisms for modulation of mouse gastrointestinal motility by proteinase-activated receptor (PAR)-1 and -2 in vitro.

T. Kanke, A. Kawabata, F. Sekiguchi, 2006, Life sciences.

A protective role of protease-activated receptor 1 in rat gastric mucosa.

M. Nishida, H. Yamagishi, A. Kawabata, 2004, Gastroenterology.

Modulation of capsaicin-evoked visceral pain and referred hyperalgesia by protease-activated receptors 1 and 2.

A. Kawabata, F. Sekiguchi, K. Kataoka, 2004, Journal of Pharmacological Sciences.

Responses to endothelium‐derived factors and their interaction in mesenteric arteries from Wistar‐Kyoto and stroke‐prone spontaneously hypertensive rats

F. Sekiguchi, S. Sunano, K. Kawata, 2002, Clinical and experimental pharmacology & physiology.

Factors involved in the time course of response to acetylcholine in mesenteric arteries from spontaneously hypertensive rats.

F. Sekiguchi, S. Sunano, K. Kawata, 2001, European journal of pharmacology.

Superoxide dismutase reduces the impairment of endothelium-dependent relaxation in the spontaneously hypertensive rat aorta.

F. Sekiguchi, S. Sunano, A. Yanamoto, 2004, Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi.

[Endothelium-derived factors in hypertensive blood vessels, especially nitric oxide and hypertension].

F. Sekiguchi, S. Sunano, 2003, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Contraction of arterial smooth muscle of normotensive and spontaneously hypertensive rats by manganese(III)tetrakis(1-methyl-4-pyridyl)porphyrin (MnTMPyP).

F. Sekiguchi, S. Sunano, Mikako Seo, 2003, Journal of pharmacological sciences.

Receptor-activating peptides for PAR-1 and PAR-2 relax rat gastric artery via multiple mechanisms.

A. Kawabata, F. Sekiguchi, N. Kawao, 2004, Life sciences.

Attenuation of intrinsic active tone by endothelium-derived nitric oxide in aortae of spontaneously hypertensive rats with different levels of blood pressure.

F. Sekiguchi, K. Shimamura, S. Sunano, 1996, Clinical and experimental hypertension.

Role of non-macrophage cell-derived HMGB1 in oxaliplatin-induced peripheral neuropathy and its prevention by the thrombin/thrombomodulin system in rodents: negative impact of anticoagulants

M. Nishibori, T. Araki, Takaya Miyazaki, 2019, Journal of Neuroinflammation.

Peripheral HMGB1-induced hyperalgesia in mice: Redox state-dependent distinct roles of RAGE and TLR4.

M. Nishibori, Keyue Liu, A. Taga, 2016, Journal of pharmacological sciences.

Peripheral HMGB 1-induced hyperalgesia in mice : Redox state-dependent distinct roles of RAGE and TLR 4

M. Nishibori, Keyue Liu, A. Taga, 2016 .

Inhibition of T-type calcium channels and hydrogen sulfide-forming enzyme reverses paclitaxel-evoked neuropathic hyperalgesia in rats

A. Kawabata, F. Sekiguchi, S. Yoshida, 2011, Neuroscience.

Upregulation of Cav3.2 T-type calcium channels targeted by endogenous hydrogen sulfide contributes to maintenance of neuropathic pain

Y. Maeda, Tomoko Takahashi, A. Kawabata, 2010, PAIN.

Hyperalgesia induced by spinal and peripheral hydrogen sulfide: Evidence for involvement of Cav3.2 T-type calcium channels

Y. Maeda, Tomoko Takahashi, A. Kawabata, 2009, Pain.

Contribution of TRPA1 as a downstream signal of proteinase-activated receptor-2 to pancreatic pain.

A. Kawabata, F. Sekiguchi, Y. Terada, 2013, Journal of pharmacological sciences.

Colonic hydrogen sulfide-induced visceral pain and referred hyperalgesia involve activation of both Ca(v)3.2 and TRPA1 channels in mice.

A. Kawabata, F. Sekiguchi, Yasumasa Okawa, 2012, Journal of pharmacological sciences.

Macrophage as a Peripheral Pain Regulator

A. Kawabata, F. Sekiguchi, Maho Tsubota, 2021, Cells.

Hydrogen sulfide as a novel nociceptive messenger

Y. Maeda, T. Wada, S. Ichida, 2007, Pain.

Ion Channels as Therapeutic Targets for the Immune , Inflammatory , and Metabolic Disorders Review

A. Kawabata, F. Sekiguchi, Maho Tsubota, 2018 .

2‐Furoyl‐LIGRL‐NH2, a potent agonist for proteinase‐activated receptor‐2, as a gastric mucosal cytoprotective agent in mice

T. Kanke, H. Ishiwata, A. Kawabata, 2005, British journal of pharmacology.

Proteinase-Activated Receptor-2 – Triggered Prostaglandin E 2 Release , but Not Cyclooxygenase-2 Upregulation , Requires Activation of the Phosphatidylinositol 3 – Kinase / Akt / Nuclear Factor-κ B Pathway in Human Alveolar Epithelial Cells

A. Kawabata, F. Sekiguchi, H. Nishikawa, 2009 .

Signal Transduction for Proteinase-Activated Receptor-2-Triggered Prostaglandin E2 Formation in Human Lung Epithelial Cells

M. Hollenberg, T. Wada, S. Ichida, 2005, Journal of Pharmacology and Experimental Therapeutics.

The proteinase/proteinase-activated receptor-2/transient receptor potential vanilloid-1 cascade impacts pancreatic pain in mice.

H. Ishikura, A. Kawabata, F. Sekiguchi, 2010, Life sciences.

Suppression of pancreatitis‐related allodynia/hyperalgesia by proteinase‐activated receptor‐2 in mice

T. Kanke, M. Tsutsumi, T. Minami, 2006, British journal of pharmacology.

T-type calcium channels: functional regulation and implication in pain signaling.

A. Kawabata, F. Sekiguchi, 2013, Journal of pharmacological sciences.

Caspase-Dependent HMGB1 Release from Macrophages Participates in Peripheral Neuropathy Caused by Bortezomib, a Proteasome-Inhibiting Chemotherapeutic Agent, in Mice

M. Nishibori, Takaya Miyazaki, A. Kawabata, 2021, Cells.

Bladder pain relief by HMGB1 neutralization and soluble thrombomodulin in mice with cyclophosphamide-induced cystitis

H. Ishikura, A. Kawabata, F. Sekiguchi, 2014, Neuropharmacology.

Hypertension and impairment of endothelium-dependent relaxation of arteries from spontaneously hypertensive and L-NAME-treated Wistar rats.

A. Hirakawa, F. Sekiguchi, K. Shimamura, 2001, Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi.

Evidence that PAR2‐triggered prostaglandin E2 (PGE2) formation involves the ERK‐cytosolic phospholipase A2‐COX‐1‐microsomal PGE synthase‐1 cascade in human lung epithelial cells

A. Kawabata, F. Sekiguchi, Kazumi Moriyuki, 2008, Cell biochemistry and function.

Effects of cyclopiazonic acid and thapsigargin on electromechanical activities and intracellular Ca2+ in smooth muscle of carotid artery of hypertensive rats

F. Sekiguchi, K. Shimamura, S. Sunano, 1996, British journal of pharmacology.

Ca2+-Sensitivity of Portal Vein Circular Muscle from Normotensive and Hypertensive Rats

F. Sekiguchi, K. Shimamura, Kazuo Yamamoto, 1998 .

Involvement of NF‐κB in the upregulation of cystathionine‐γ‐lyase, a hydrogen sulfide‐forming enzyme, and bladder pain accompanying cystitis in mice

A. Kawabata, F. Sekiguchi, Maho Tsubota, 2018, Clinical and experimental pharmacology & physiology.

Polaprezinc attenuates cyclophosphamide-induced cystitis and related bladder pain in mice.

K. Matsuyama, A. Kawabata, F. Sekiguchi, 2015, Journal of pharmacological sciences.

Role of HMGB1 in Chemotherapy-Induced Peripheral Neuropathy

A. Kawabata, F. Sekiguchi, 2020, International journal of molecular sciences.

The potent inducible nitric oxide synthase inhibitor ONO-1714 inhibits neuronal NOS and exerts antinociception in rats

A. Kawabata, F. Sekiguchi, N. Kawao, 2004, Neuroscience Letters.

Endothelium-dependent relaxation in pulmonary arteries of L-NAME-treated Wistar and stroke-prone spontaneously hypertensive rats.

F. Sekiguchi, K. Shinomiya, Kazuo Yamamoto, 2002, Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi.

Distinct Activity of Peptide Mimetic Intracellular Ligands (Pepducins) for Proteinase‐Activated Receptor‐1 in Multiple Cells/Tissues

H. Matsui, A. Kawabata, F. Sekiguchi, 2006, Annals of the New York Academy of Sciences.

The proteinase inhibitor camostat mesilate suppresses pancreatic pain in rodents.

T. Nakatani, H. Ishikura, A. Kawabata, 2007, Life sciences.

Functional upregulation of the H2S/Cav3.2 channel pathway accelerates secretory function in neuroendocrine-differentiated human prostate cancer cells.

A. Kawabata, Kazuki Fukami, Erina Asano, 2015, Biochemical pharmacology.

Unaltered caffeine-induced relaxation in the aorta of stroke-prone spontaneously hypertensive rats (SHRSP).

F. Sekiguchi, S. Sunano, Y. Miyake, 2002, Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi.

Effects of amiloride on the neurally mediated contraction of rat mesenteric artery.

F. Sekiguchi, K. Shimamura, S. Sunano, 1997, European journal of pharmacology.

Biological activity of Helicobacter pylori components in mammalian cells: is it independent of proteinase-activated receptors?

Y. Matsumoto, A. Kawabata, F. Sekiguchi, 2012, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

M. Nishibori, H. Ishikura, H. Wake, 2020, Cells.

Paclitaxel-induced HMGB1 release from macrophages and its implication for peripheral neuropathy in mice: Evidence for a neuroimmune crosstalk

M. Nishibori, H. Wake, A. Kawabata, 2018, Neuropharmacology.

[The effect of an antihypertensive drug budralazine on cerebrovascular lesions in salt-loaded SHR].

S. Tanaka, F. Sekiguchi, S. Shibamura, 1989, Nihon yakurigaku zasshi. Folia pharmacologica Japonica.

Blockade of T-type calcium channels by 6-prenylnaringenin, a hop component, alleviates neuropathic and visceral pain in mice

Mio Ichikawa, A. Kawabata, F. Sekiguchi, 2018, Neuropharmacology.

Discovery of pimozide derivatives as novel T-type calcium channel inhibitors with little binding affinity to dopamine D2 receptors for treatment of somatic and visceral pain.

A. Kawabata, F. Sekiguchi, S. Yoshida, 2022, European journal of medicinal chemistry.

Essential role of Cav3.2 T-type calcium channels in butyrate-induced colonic pain and nociceptor hypersensitivity in mice.

K. Matsui, A. Kawabata, F. Sekiguchi, 2020, European journal of pharmacology.

Prenylflavanones as Novel T-Type Calcium Channel Blockers Useful for Pain Therapy

A. Kawabata, F. Sekiguchi, N. Toyooka, 2019, Natural Product Communications.

Critical role of Cav3.2 T-type calcium channels in the peripheral neuropathy induced by bortezomib, a proteasome-inhibiting chemotherapeutic agent, in mice.

Takaya Miyazaki, A. Kawabata, F. Sekiguchi, 2019, Toxicology.

Design and synthesis of novel anti-hyperalgesic agents based on 6-prenylnaringenin as the T-type calcium channel blockers.

A. Kawabata, F. Sekiguchi, S. Yoshida, 2018, Bioorganic & medicinal chemistry.

Zinc deficiency promotes cystitis-related bladder pain by enhancing function and expression of Cav3.2 in mice.

T. Minami, A. Kawabata, F. Sekiguchi, 2018, Toxicology.

Therapeutic potential of RQ-00311651, a novel T-type Ca2+ channel blocker, in distinct rodent models for neuropathic and visceral pain

A. Kawabata, F. Sekiguchi, S. Yoshida, 2016, Pain.

Endogenous and exogenous hydrogen sulfide facilitates T-type calcium channel currents in Cav3.2-expressing HEK293 cells.

A. Kawabata, F. Sekiguchi, S. Yoshida, 2014, Biochemical and biophysical research communications.

AKAP‐dependent sensitization of Cav3.2 channels via the EP4 receptor/cAMP pathway mediates PGE2‐induced mechanical hyperalgesia

A. Kawabata, F. Sekiguchi, S. Yoshida, 2013, British journal of pharmacology.

Involvement of the endogenous hydrogen sulfide/Cav3.2 T‐type Ca2+ channel pathway in cystitis‐related bladder pain in mice

A. Kawabata, F. Sekiguchi, T. Tsujiuchi, 2012, British journal of pharmacology.

Hydrogen sulfide as a novel mediator for pancreatic pain in rodents

H. Ishikura, A. Kawabata, F. Sekiguchi, 2009, Gut.

Hydrogen sulfide evokes neurite outgrowth and expression of high‐voltage‐activated Ca2+ currents in NG108‐15 cells: involvement of T‐type Ca2+ channels

S. Ichida, A. Kawabata, Kazuki Fukami, 2009, Journal of neurochemistry.

Antihyperalgesic effect of buprenorphine involves nociceptin/orphanin FQ peptide-receptor activation in rats with spinal nerve injury-induced neuropathy.

Tomoko Takahashi, A. Kawabata, F. Sekiguchi, 2013, Journal of pharmacological sciences.

A hydrolysate of poly-trans-[(2-carboxyethyl)germasesquioxane] (Ge-132) suppresses Cav3.2-dependent pain by sequestering exogenous and endogenous sulfide

A. Kawabata, F. Sekiguchi, S. Yoshida, 2022, Redox Biology.

Genetic deletion of Cav3.2 T-type calcium channels abolishes H2S-dependent somatic and visceral pain signaling in C57BL/6 mice.

K. Matsui, H. Masuda, Takaya Miyazaki, 2019, Journal of pharmacological sciences.

Roles of Cav3.2 and TRPA1 channels targeted by hydrogen sulfide in pancreatic nociceptive processing in mice with or without acute pancreatitis

A. Kawabata, F. Sekiguchi, Y. Terada, 2015, Journal of neuroscience research.

Cav3.2 overexpression in L4 dorsal root ganglion neurons after L5 spinal nerve cutting involves Egr-1, USP5 and HMGB1 in rats: An emerging signaling pathway for neuropathic pain.

M. Nishibori, H. Wake, A. Kawabata, 2020, European journal of pharmacology.

TENSION OSCILLATION IN ARTERIES AND ITS ABNORMALITY IN HYPERTENSIVE ANIMALS

F. Sekiguchi, K. Shimamura, S. Sunano, 1999, Clinical and experimental pharmacology & physiology.

SmoothB-Adrenoceptor-Mediated Responses in the Muscle of Hypert nsive Rats Gastric

F. Sekiguchi, K. Shimamura, Kazuo Yamamoto, 2018 .

Altered beta-adrenoceptor-mediated responses in the gastric smooth muscle of hypertensive rats.

F. Sekiguchi, K. Shimamura, S. Sunano, 2000, Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi.

Effects of l-arginine on spontaneous contraction of the rat portal vein

S. Kimura, F. Sekiguchi, K. Shimamura, 2003, Pflügers Archiv.

Macrophage-derived HMGB1 as a Pain Mediator in the Early Stage of Acute Pancreatitis in Mice: Targeting RAGE and CXCL12/CXCR4 Axis

M. Nishibori, Keyue Liu, H. Ishikura, 2017, Journal of Neuroimmune Pharmacology.

Estrogen decline is a risk factor for paclitaxel-induced peripheral neuropathy: Clinical evidence supported by a preclinical study.

A. Kawabata, F. Sekiguchi, Y. Koizumi, 2021, Journal of pharmacological sciences.

HMGB1 and its membrane receptors as therapeutic targets in an intravesical substance P-induced bladder pain syndrome mouse model.

M. Nishibori, H. Ishikura, H. Wake, 2020, Journal of pharmacological sciences.

Human soluble thrombomodulin-induced blockade of peripheral HMGB1-dependent allodynia in mice requires both the lectin-like and EGF-like domains.

R. Tsujita, A. Kawabata, F. Sekiguchi, 2018, Biochemical and biophysical research communications.

Role of Thrombin in Soluble Thrombomodulin-Induced Suppression of Peripheral HMGB1-Mediated Allodynia in Mice

R. Tsujita, A. Kawabata, F. Sekiguchi, 2018, Journal of Neuroimmune Pharmacology.

Proteinase-activated receptor-2-triggered prostaglandin E(2) release, but not cyclooxygenase-2 upregulation, requires activation of the phosphatidylinositol 3-kinase/Akt / nuclear factor-kappaB pathway in human alveolar epithelial cells.

A. Kawabata, F. Sekiguchi, H. Nishikawa, 2009, Journal of pharmacological sciences.

PAR2 triggers IL-8 release via MEK/ERK and PI3-kinase/Akt pathways in GI epithelial cells.

A. Kawabata, F. Sekiguchi, Yusuke Tanaka, 2008, Biochemical and biophysical research communications.

Hydrogen sulfide inhibits activity of three isoforms of recombinant nitric oxide synthase.

T. Masuko, A. Kawabata, F. Sekiguchi, 2007, Toxicology.

Involvement of high mobility group box 1 in the development and maintenance of chemotherapy-induced peripheral neuropathy in rats.

M. Nishibori, Keyue Liu, H. Ishikura, 2016, Toxicology.

Curcumin Inhibits the proteinase-activated receptor-2-triggered prostaglandin E2 production by suppressing cyclooxygenase-2 upregulation and Akt-dependent activation of nuclear factor-κB in human lung epithelial cells.

A. Kawabata, F. Sekiguchi, H. Nishikawa, 2010, Journal of pharmacological sciences.

Blood pressure and age-dependent changes of endothelium-dependent tension oscillations in different strains of spontaneously hypertensive rats.

F. Sekiguchi, K. Shimamura, S. Sunano, 1996, Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi.

Endothelium‐derived relaxing, contracting and hyperpolarizing factors of mesenteric arteries of hypertensive and normotensive rats

S. Tanaka, F. Sekiguchi, K. Shimamura, 1999, British journal of pharmacology.

SPONTANEOUS AND AGONIST‐INDUCED CONTRACTIONS AND ENDOTHELIUM‐DEPENDENT RELAXATION IN AORTAE FROM SHRSP AND WKY RATS UNDER VARIOUS LEVELS OF PASSIVE FORCE

F. Sekiguchi, K. Shimamura, S. Sunano, 1996, Clinical and experimental pharmacology & physiology.

Role of neuron-derived ATP in paclitaxel-induced HMGB1 release from macrophages and peripheral neuropathy

M. Nishibori, A. Kawabata, F. Sekiguchi, 2021, Journal of Pharmacological Sciences.

Influences of endothelium on the time course of noradrenaline-, 5-HT-, prostaglandin F2alpha- and high-K+-induced contractions in aortae of WKY and SHRSP.

F. Sekiguchi, K. Shimamura, S. Sunano, 1998, Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi.

Effects of cyclopiazonic acid on contraction and intracellular Ca2+ in oesophageal striated muscle of normotensive and spontaneously hypertensive rats

F. Sekiguchi, K. Shimamura, S. Sunano, 1999, British journal of pharmacology.

Repeated Cold Stress Reduces Cyclophosphamide-Induced Cystitis/Bladder Pain and Macrophage Activity in Mice

Y. Funakami, Takaya Miyazaki, A. Kawabata, 2017, Pharmacology.

A protective role of hydrogen sulfide against oxidative stress in rat gastric mucosal epithelium.

T. Masuko, A. Kawabata, F. Sekiguchi, 2007, Toxicology.

Endogenous Hydrogen Sulfide Enhances Cell Proliferation of Human Gastric Cancer AGS Cells.

A. Kawabata, F. Sekiguchi, Teruki Sekimoto, 2016, Biological & pharmaceutical bulletin.

Effects of flufenamic acid on smooth muscle of the carotid artery isolated from spontaneously hypertensive rats.

S. Kimura, F. Sekiguchi, K. Shimamura, 2002, Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi.

Effects of Flufenamic Acid on Smooth Muscle

S. Kimura, F. Sekiguchi, K. Shimamura, 2002 .

Proteinase-Activated Receptor-2-Mediated Relaxation in Mouse Tracheal and Bronchial Smooth Muscle: Signal Transduction Mechanisms and Distinct Agonist Sensitivity

M. Hollenberg, T. Kanke, A. Kawabata, 2004, Journal of Pharmacology and Experimental Therapeutics.

Activation of trigeminal nociceptive neurons by parotid PAR-2 activation in rats

K. Iwata, T. Masuko, A. Kawabata, 2004, Neuroreport.

Potent and Metabolically Stable Agonists for Protease-Activated Receptor-2: Evaluation of Activity in Multiple Assay Systems in Vitro and in Vivo

Toru Kanke, R. Plevin, T. Kanke, 2004, Journal of Pharmacology and Experimental Therapeutics.

Effects of chronic treatment with carvedilol on smooth muscle tone and endothelium-dependent relaxation of aorta in stroke-prone spontaneously hypertensive rats.

F. Sekiguchi, K. Shimamura, M. Tanaka, 1997, Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi.

Rhodanese, but not cystathionine-gamma-lyase, is associated with dextran sulfate sodium-evoked colitis in mice: a sign of impaired colonic sulfide detoxification?

H. Ishikura, A. Kawabata, F. Sekiguchi, 2009, Toxicology.

Difference in effects of stretch on depressive effect of endothelium-derived nitric oxide on noradrenaline- and high-K+-induced contractions between the aortae from normotensive and spontaneously hypertensive rats.

S. Nakazumi, F. Sekiguchi, K. Shimamura, 2001, Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi.

Membrane potential of mesenteric artery from carvedilol-treated spontaneously hypertensive rats.

S. Tanaka, F. Sekiguchi, K. Shimamura, 1998, European journal of pharmacology.

Effects of NG-nitro-L-arginine on alpha-agonists-induced contraction of aortae from Wistar Kyoto rats and stroke-prone spontaneously hypertensive rats.

F. Sekiguchi, K. Shimamura, M. Tojo, 1995, Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi.

Opposite effects of two thiazolidinediones, ciglitazone and troglitazone, on proteinase-activated receptor-1-triggered prostaglandin E(2) release.

A. Kawabata, F. Sekiguchi, H. Nishikawa, 2010, Toxicology.

Tacrolimus Triggers Transient Receptor Potential Vanilloid-1-Dependent Relapse of Pancreatitis-Related Pain in Mice

A. Kawabata, F. Sekiguchi, M. Takada, 2017, Pharmacology.

Tacrolimus, a calcineurin inhibitor, promotes capsaicin-induced colonic pain in mice.

K. Matsui, A. Kawabata, F. Sekiguchi, 2020, Journal of pharmacological sciences.

Reduced effect of caffeine on twitch contraction of oesophageal striated muscle from stroke‐prone spontaneously hypertensive rats

F. Sekiguchi, K. Shimamura, S. Sunano, 2003, Clinical and experimental pharmacology & physiology.

Caffeine-induced contracture in oesophageal striated muscle of normotensive and hypertensive rats.

F. Sekiguchi, S. Sunano, K. Kawata, 2003, European journal of pharmacology.

Effect of chronic treatment with perindopril on endothelium-dependent relaxation of aorta and carotid artery in SHRSP.

F. Sekiguchi, K. Shimamura, M. Tanaka, 2000, Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi.

The PAR-1-activating peptide facilitates pepsinogen secretion in rats

A. Kawabata, F. Sekiguchi, N. Kawao, 2003, Peptides.

Mechanisms for prostaglandin E2 formation caused by proteinase-activated receptor-1 activation in rat gastric mucosal epithelial cells.

H. Matsui, Hitomi Hayashi, A. Kawabata, 2007, Biochemical pharmacology.

Endothelium-dependent relaxation by alpha 2-adrenoceptor agonists in spontaneously hypertensive rat aorta.

F. Sekiguchi, K. Shimamura, S. Sunano, 1996, Journal of cardiovascular pharmacology.

Inhibition by hydrogen sulfide of rabbit platelet aggregation and calcium mobilization.

Hitomi Hayashi, A. Kawabata, F. Sekiguchi, 2013, Biological & pharmaceutical bulletin.

NNC 55-0396, a T-type calcium channel blocker, protects against the brain injury induced by middle cerebral artery occlusion and reperfusion in mice.

A. Kawabata, F. Sekiguchi, Yuko Kurokawa, 2019, Journal of pharmacological sciences.

Macrophage-derived HMGB1 as a Pain Mediator in the Early Stage of Acute Pancreatitis in Mice: Targeting RAGE and CXCL12/CXCR4 Axis

M. Nishibori, Keyue Liu, H. Ishikura, 2017, Journal of Neuroimmune Pharmacology.

EFFECTS OF NG-NITRO-L-ARGININE ON THE BLOOD PRESSURE OF SPONTANEOUSLY HYPERTENSIVE RATS WITH DIFFERENT DEGREES OF HYPERTENSION

F. Sekiguchi, K. Shimamura, S. Sunano, 2001, Clinical and experimental hypertension.

Delayed production of arachidonic acid contributes to the delay of proteinase‐activated receptor‐1 (PAR1)‐triggered prostaglandin E2 release in rat gastric epithelial RGM1 cells

A. Kawabata, F. Sekiguchi, H. Nishikawa, 2011, Journal of cellular biochemistry.

Prostanoid-dependent bladder pain caused by proteinase-activated receptor-2 activation in mice: Involvement of TRPV1 and T-type Ca2+ channels.

A. Kawabata, F. Sekiguchi, H. Nishikawa, 2017, Journal of pharmacological sciences.

Protease-Activated Receptors (PARs) as Therapeutic Targets: Development of Agonists / Antagonists and Modulation of Gastrointestinal Functions

F. Sekiguchi, 2004 .

Mechanisms for proteinase-activated receptor 1-triggered prostaglandin E2 generation in mouse osteoblastic MC3T3-E1 cells

A. Kawabata, F. Sekiguchi, H. Nishikawa, 2015, Biological chemistry.

Development of hepatic impairment aggravates chemotherapy-induced peripheral neuropathy following oxaliplatin treatment: Evidence from clinical and preclinical studies.

M. Nishibori, A. Kawabata, F. Sekiguchi, 2022, Journal of pharmacological sciences.

Opioid modulation of T-type Ca2+ channel-dependent neuritogenesis/neurite outgrowth through the prostaglandin E2/EP4 receptor/protein kinase A pathway in mouse dorsal root ganglion neurons.

A. Kawabata, F. Sekiguchi, S. Yoshida, 2023, Biochemical and Biophysical Research Communications - BBRC.

Dietary ascorbic acid restriction in GNL/SMP30-knockout mice unveils the role of ascorbic acid in regulation of somatic and visceral pain sensitivity.

A. Kawabata, F. Sekiguchi, Maho Tsubota, 2019, Biochemical and Biophysical Research Communications - BBRC.

The prostaglandin E2/EP4 receptor/cyclic AMP/T-type Ca(2+) channel pathway mediates neuritogenesis in sensory neuron-like ND7/23 cells.

A. Kawabata, F. Sekiguchi, S. Yoshida, 2016, Journal of pharmacological sciences.

Role of nitric oxide in the contraction of circular muscle in the rat portal vein

F. Sekiguchi, K. Shimamura, Kazuo Yamamoto, 2000, Pflügers Archiv.

Hyperalgesia induced by spinal and peripheral hydrogen sulfide: Evidence for involvement of Cav3.2 T-type calcium channels

Y. Maeda, Tomoko Takahashi, A. Kawabata, 2009, Pain.

Functional upregulation of the H2S/Cav3.2 channel pathway accelerates secretory function in neuroendocrine-differentiated human prostate cancer cells.

A. Kawabata, Kazuki Fukami, Erina Asano, 2015, Biochemical pharmacology.

Unaltered endothelium-dependent modulation of contraction in the pulmonary artery of hypertensive rats.

F. Sekiguchi, K. Shimamura, S. Sunano, 2000, European journal of pharmacology.

Upregulation of Cav3.2 T-type calcium channels targeted by endogenous hydrogen sulfide contributes to maintenance of neuropathic pain

Y. Maeda, Tomoko Takahashi, A. Kawabata, 2010, PAIN.

Sulfide and polysulfide as pronociceptive mediators: Focus on Cav3.2 function enhancement and TRPA1 activation.

F. Sekiguchi, Maho Tsubota, Atsufumi Kawabata, 2024, Journal of pharmacological sciences.