Kyeong-Ok Chang

L. Saif, Kyeong-Ok Chang, A. Hoet, 2003, Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc.

The Effects of Simvastatin or Interferon-α on Infectivity of Human Norovirus Using a Gnotobiotic Pig Model for the Study of Antivirals

Qiuhong Wang, L. Saif, Yunjeong Kim, 2012, PloS one.

Potent Protease Inhibitors of Highly Pathogenic Lagoviruses: Rabbit Hemorrhagic Disease Virus and European Brown Hare Syndrome Virus

W. Groutas, Yunjeong Kim, Kyeong-Ok Chang, 2022, Microbiology spectrum.

Structure-based design and synthesis of triazole-based macrocyclic inhibitors of norovirus protease: Structural, biochemical, spectroscopic, and antiviral studies

G. Lushington, K. Battaile, W. Groutas, 2016, European Journal of Medicinal Chemistry.

Development of a Reverse Transcription-Nested Polymerase Chain Reaction Assay for Differential Diagnosis of Transmissible Gastroenteritis Virus and Porcine Respiratory Coronavirus from Feces and Nasal Swabs of Infected Pigs

A. Parwani, L. Saif, L. Kim, 2000, Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc.

Expression and stability of foreign tags inserted into nsp2 of porcine reproductive and respiratory syndrome virus (PRRSV).

R. Rowland, J. Calvert, Kyeong-Ok Chang, 2007, Virus research.

Potent inhibition of enterovirus D68 and human rhinoviruses by dipeptidyl aldehydes and α-ketoamides

W. Groutas, Yunjeong Kim, Kyeong-Ok Chang, 2015, Antiviral Research.

Role of Cholesterol Pathways in Norovirus Replication (cid:1)

Kyeong-Ok Chang, 2009 .

Expression and Self-Assembly in Baculovirus of Porcine Enteric Calicivirus Capsids into Virus-Like Particles and Their Use in an Enzyme-Linked Immunosorbent Assay for Antibody Detection in Swine

L. Saif, Y. Qian, Kyeong-Ok Chang, 2001, Journal of Clinical Microbiology.

Reverse Genetics System for Porcine Enteric Calicivirus, a Prototype Sapovirus in the Caliciviridae

Qiuhong Wang, L. Saif, G. Belliot, 2005, Journal of Virology.

Efficacy of a 3C-like protease inhibitor in treating various forms of acquired feline infectious peritonitis

N. Pedersen, Hongwei Liu, W. Groutas, 2017, Journal of feline medicine and surgery.

Caspase-Mediated Cleavage of Nucleocapsid protein of a Protease-Independent Porcine Epidemic Diarrhea Virus Strain

Yunjeong Kim, Kyeong-Ok Chang, C. Oh, 2020, Virus Research.

Novel triacsin C analogs as potential antivirals against rotavirus infections.

D. Hua, Yunjeong Kim, Kyeong-Ok Chang, 2012, European journal of medicinal chemistry.

Inhibitory Effects of Bile Acids and Synthetic Farnesoid X Receptor Agonists on Rotavirus Replication

Yunjeong Kim, Kyeong-Ok Chang, 2011, Journal of Virology.

Systemic and intestinal antibody secreting cell responses and protection in gnotobiotic pigs immunized orally with attenuated Wa human rotavirus and Wa 2/6-rotavirus-like-particles associated with immunostimulating complexes.

L. Saif, Lijuan Yuan, Yunjeong Kim, 2002, Vaccine.

Nitazoxanide Inhibits Human Norovirus Replication and Synergizes with Ribavirin by Activation of Cellular Antiviral Response

M. Peppelenbosch, Lei Xu, Q. Pan, 2018, Antimicrobial Agents and Chemotherapy.

IRF‐1, RIG‐I and MDA5 display potent antiviral activities against norovirus coordinately induced by different types of interferons

M. Peppelenbosch, Lei Xu, Q. Pan, 2018, Antiviral research.

Trypsin-independent porcine epidemic diarrhea virus US strain with altered virus entry mechanism

R. Hesse, Yunjeong Kim, Kyeong-Ok Chang, 2017, BMC Veterinary Research.

Bile Acids Promote the Expression of Hepatitis C Virus in Replicon-Harboring Cells

Kyeong-Ok Chang, D. George, 2007, Journal of Virology.

Caspase-mediated cleavage of nucleocapsid protein of a protease-independent porcine epidemic diarrhea virus strain

Yunjeong Kim, Kyeong-Ok Chang, C. Oh, 2020, Virus research.

Synthesis and antiviral activity of substituted quercetins.

D. Hua, Yunjeong Kim, Kyeong-Ok Chang, 2012, Bioorganic & medicinal chemistry letters.

Potent norovirus inhibitors based on the acyclic sulfamide scaffold.

W. Groutas, Yunjeong Kim, K. Tiew, 2012, Bioorganic & medicinal chemistry.

Inhibition of norovirus replication by morpholino oligomers targeting the 5′-end of the genome

P. Iversen, K. Bok, A. Campbell, 2008, Virology.

SARS-CoV-2 Omicron (B.1.1.529) Infection of Wild White-Tailed Deer in New York City

James J. Davis, C. Maranas, R. Olsen, 2022, Viruses.

Magnitude of Serum and Intestinal Antibody Responses Induced by Sequential Replicating and Nonreplicating Rotavirus Vaccines in Gnotobiotic Pigs and Correlation with Protection

L. Saif, Lijuan Yuan, Yunjeong Kim, 2004, Clinical Diagnostic Laboratory Immunology.

Potent inhibition of norovirus by dipeptidyl α-hydroxyphosphonate transition state mimics.

G. Lushington, W. Groutas, Yunjeong Kim, 2013, Bioorganic & medicinal chemistry letters.

Inhibition of norovirus 3CL protease by bisulfite adducts of transition state inhibitors.

D. Hua, W. Groutas, Yunjeong Kim, 2013, Bioorganic & medicinal chemistry letters.

Synthesis and anti-norovirus activity of pyranobenzopyrone compounds.

D. Hua, Yunjeong Kim, Kyeong-Ok Chang, 2012, Bioorganic & medicinal chemistry letters.

Replication of Norovirus in Cell Culture Reveals a Tropism for Dendritic Cells and Macrophages

Larissa B. Thackray, H. Virgin, L. Thackray, 2004, PLoS biology.

Inhibition of influenza virus replication by plant-derived isoquercetin.

S. Narayanan, Yunjeong Kim, Kyeong-Ok Chang, 2010, Antiviral research.

Inhibition of Calcineurin or IMP Dehydrogenase Exerts Moderate to Potent Antiviral Activity against Norovirus Replication

M. Koopmans, M. Peppelenbosch, H. Metselaar, 2017, Antimicrobial Agents and Chemotherapy.

Enteric and nasal shedding of bovine torovirus (Breda virus) in feedlot cattle.

L. Saif, S. Loerch, Kyeong-Ok Chang, 2002, American journal of veterinary research.

Anti-norovirus therapeutics: a patent review (2010-2015)

W. Groutas, Yunjeong Kim, Kyeong-Ok Chang, 2016, Expert opinion on therapeutic patents.

Cleavage Map and Proteolytic Processing of the Murine Norovirus Nonstructural Polyprotein in Infected Cells

H. Virgin, L. Thackray, C. Wobus, 2006, Journal of Virology.

Role of Cholesterol Pathways in Norovirus Replication

Kyeong-Ok Chang, 2009, Journal of Virology.

Nucleotidylylation of the VPg protein of a human norovirus by its proteinase-polymerase precursor protein.

G. Belliot, K. Green, Kyeong-Ok Chang, 2008, Virology.

Interferons and Ribavirin Effectively Inhibit Norwalk Virus Replication in Replicon-Bearing Cells

Kyeong-Ok Chang, D. George, 2007, Journal of Virology.

Stable expression of a Norwalk virus RNA replicon in a human hepatoma cell line.

G. Belliot, K. Green, Kyeong-Ok Chang, 2006, Virology.

Antiviral Activity of a Small Molecule Deubiquitinase Inhibitor Occurs via Induction of the Unfolded Protein Response

N. Donato, H. Showalter, C. Wobus, 2012, PLoS pathogens.

Inhibition of noroviruses by piperazine derivatives.

Guijia He, W. Groutas, Yunjeong Kim, 2012, Bioorganic & medicinal chemistry letters.

Biodegradable nanogels for oral delivery of interferon for norovirus infection.

D. Hua, Yunjeong Kim, Kyeong-Ok Chang, 2011, Antiviral research.

Calicivirus 3C-Like Proteinase Inhibits Cellular Translation by Cleavage of Poly(A)-Binding Protein

R. Lloyd, G. Belliot, K. Green, 2004, Journal of Virology.

Potent protease inhibitors of deadly lagoviruses: rabbit hemorrhagic disease virus and European brown hare syndrome virus

W. Groutas, Yunjeong Kim, Kyeong-Ok Chang, 2022, bioRxiv.

Norovirus Proteinase-Polymerase and Polymerase Are Both Active Forms of RNA-Dependent RNA Polymerase

J. Arnold, C. Cameron, G. Belliot, 2005, Journal of Virology.

Molecular characterization of murine norovirus isolates from South Korea.

Kyeong-Ok Chang, Heetae Lee, Misoon Kim, 2010, Virus research.

3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV–infected mice

S. Perlman, D. Meyerholz, K. Battaile, 2020, Science Translational Medicine.

Leader of the Capsid Protein in Feline Calicivirus Promotes Replication of Norwalk Virus in Cell Culture

K. Green, Kyeong-Ok Chang, S. Sosnovtsev, 2008, Journal of Virology.

Feline Calicivirus VP2 Is Essential for the Production of Infectious Virions

G. Belliot, K. Green, Kyeong-Ok Chang, 2005, Journal of Virology.

The crucial role of bile acids in the entry of porcine enteric calicivirus

Yunjeong Kim, Kyeong-Ok Chang, Vinay Shivanna, 2014, Virology.

Protease inhibitors broadly effective against feline, ferret and mink coronaviruses

W. Groutas, Yunjeong Kim, Kyeong-Ok Chang, 2018, Antiviral Research.

Interleukin-1β expression by a recombinant porcine reproductive and respiratory syndrome virus

David E. B. Knudsen, J. Christopher-Hennings, E. Nelson, 2011, Virus Research.

Structural and inhibitor studies of norovirus 3C-like proteases.

D. Takahashi, W. Groutas, Yunjeong Kim, 2013, Virus research.

Cyclosulfamide-based derivatives as inhibitors of noroviruses.

W. Groutas, Yunjeong Kim, S. R. Mandadapu, 2012, European journal of medicinal chemistry.

Protein disulfide isomerases as potential therapeutic targets for influenza A and B viruses.

Yunjeong Kim, Kyeong-Ok Chang, 2018, Virus research.

Fexaramine as an entry blocker for feline caliciviruses

Yunjeong Kim, Kyeong-Ok Chang, 2018, Antiviral Research.

Syntheses of 3-[(Alkylamino)methylene]-6-methylpyridine-2,4(1H,3H)-diones, 3-Substituted 7-Methyl-2H-pyrano[3,2-c]pyridine-2,5(6H)-dione Fluorescence Probes, and Tetrahydro-1H,9H-2,10-dioxa-9-azaanthracen-1-ones

D. Hua, Izumi Maezawa, Yunjeong Kim, 2014, Synthesis.

Structural and dynamics characterization of norovirus protease

Y. Hiromasa, D. Takahashi, Yunjeong Kim, 2013, Protein science : a publication of the Protein Society.

Recent Advances in the Discovery of Norovirus Therapeutics.

W. Groutas, Yunjeong Kim, Kyeong-Ok Chang, 2015, Journal of medicinal chemistry.

Design, Synthesis, and Evaluation of Novel Prodrugs of Transition State Inhibitors of Norovirus 3CL Protease.

W. Groutas, Yunjeong Kim, K. Alliston, 2017, Journal of medicinal chemistry.

Characterization of amino acid substitutions in feline coronavirus 3C-like protease from a cat with feline infectious peritonitis treated with a protease inhibitor

N. Pedersen, Hongwei Liu, W. Groutas, 2019, Veterinary Microbiology.

Characterization of Group C Rotaviruses Associated with Diarrhea Outbreaks in Feeder Pigs

L. Saif, Yunjeong Kim, Kyeong-Ok Chang, 1999, Journal of Clinical Microbiology.

Production of hybrid double- or triple-layered virus-like particles of group A and C rotaviruses using a baculovirus expression system.

L. Saif, Yunjeong Kim, Kyeong-Ok Chang, 2002, Virology.

Modulation of Mitochondrial Complex I Activity Averts Cognitive Decline in Multiple Animal Models of Familial Alzheimer's Disease

G. Bu, Y. Pang, P. Dzeja, 2015, EBioMedicine.

Modulation of CD163 receptor expression and replication of porcine reproductive and respiratory syndrome virus in porcine macrophages.

R. Rowland, D. Yoo, Kyeong-Ok Chang, 2009, Virus research.

Bile acids are essential for porcine enteric calicivirus replication in association with down-regulation of signal transducer and activator of transcription 1.

L. Saif, G. Belliot, K. Green, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Nasal Swabs of Infected Pigs Diagnosis of Transmissible Gastroenteritis Virus and Porcine Respiratory Coronavirus from Feces and Development of a Reverse Transcription-Nested Polymerase Chain Reaction Assay for Differential

A. Parwani, L. Saif, L. Kim, 2013 .

Broad-Spectrum Inhibitors against 3C-Like Proteases of Feline Coronaviruses and Feline Caliciviruses

D. Hua, S. Narayanan, W. Groutas, 2015, Journal of Virology.

Proteases facilitate the endosomal escape of porcine epidemic diarrhea virus during entry into host cells

Yunjeong Kim, Kyeong-Ok Chang, C. Oh, 2019, Virus Research.

Antiviral Drug Discovery: Norovirus Proteases and Development of Inhibitors

W. Groutas, Yunjeong Kim, S. Lovell, 2019, Viruses.

Characterization and inhibition of norovirus proteases of genogroups I and II using a fluorescence resonance energy transfer assay

D. Takahashi, Yunjeong Kim, Kyeong-Ok Chang, 2011, Virology.

Ceramide formation mediated by acid sphingomyelinase facilitates endosomal escape of caliciviruses.

Yunjeong Kim, Kyeong-Ok Chang, Vinay Shivanna, 2015, Virology.

Macrocyclic inhibitors of 3C and 3C-like proteases of picornavirus, norovirus, and coronavirus

G. Lushington, D. Hua, W. Groutas, 2013, Bioorganic & Medicinal Chemistry Letters.

Roles of host proteases in the entry of SARS-CoV-2

Yunjeong Kim, Kyeong-Ok Chang, Alexandria Zabiegala, 2023, Animal Diseases.

Bile Acids Promote HCV Replication through the EGFR/ERK Pathway in Replicon-Harboring Cells

Kyeong-Ok Chang, J. Patton, D. George, 2011, Intervirology.

Corrigendum to “Modulation of mitochondrial complex I activity averts cognitive decline in multiple animal models of familial Alzheimer's disease” [EBioMedicine 2 (2015) 294–305]

G. Bu, Y. Pang, P. Dzeja, 2019, EBioMedicine.

Broad-spectrum inhibitors against 3 C-like proteases of feline coronaviruses

D. Hua, S. Narayanan, Yunjeong Kim, 2015 .

Cell-culture propagation of porcine enteric calicivirus mediated by intestinal contents is dependent on the cyclic AMP signaling pathway.

L. Saif, K. Green, Yunjeong Kim, 2002, Virology.

Design, synthesis, and evaluation of inhibitors of Norwalk virus 3C protease.

G. Lushington, W. Groutas, Yunjeong Kim, 2011, Bioorganic & medicinal chemistry letters.

Structure-Guided Design of Conformationally Constrained Cyclohexane Inhibitors of Severe Acute Respiratory Syndrome Coronavirus-2 3CL Protease

S. Perlman, K. Battaile, W. Groutas, 2021, Journal of medicinal chemistry.

Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element

S. Perlman, Anthony R. Fehr, G. Lushington, 2018, European Journal of Medicinal Chemistry.

Effects of Spike Mutations in SARS-CoV-2 Variants of Concern on Human or Animal ACE2-Mediated Virus Entry and Neutralization

J. Richt, Yunjeong Kim, Kyeong-Ok Chang, 2021, bioRxiv.

Mechanism of Cell Culture Adaptation of an Enteric Calicivirus, the Porcine Sapovirus Cowden Strain

T. Oka, Qiuhong Wang, L. Saif, 2015, Journal of Virology.

Structure-guided design and optimization of dipeptidyl inhibitors of norovirus 3CL protease. Structure-activity relationships and biochemical, X-ray crystallographic, cell-based, and in vivo studies.

K. Battaile, W. Groutas, Yunjeong Kim, 2015, Journal of medicinal chemistry.

Broad-Spectrum Cyclopropane-Based Inhibitors of Coronavirus 3C-like Proteases: Biochemical, Structural, and Virological Studies.

K. Battaile, Alexandra J Machen, W. Groutas, 2022, ACS pharmacology & translational science.

Molecular virology of feline calicivirus.

Kyeong-Ok Chang, J. S. Parker, P. Pesavento, 2008, The Veterinary clinics of North America. Small animal practice.

Potent inhibition of norovirus 3CL protease by peptidyl α-ketoamides and α-ketoheterocycles.

G. Lushington, W. Groutas, Yunjeong Kim, 2012, Bioorganic & medicinal chemistry letters.

Structure-based exploration and exploitation of the S4 subsite of norovirus 3CL protease in the design of potent and permeable inhibitors.

G. Lushington, K. Battaile, W. Groutas, 2017, European journal of medicinal chemistry.

Design and synthesis of inhibitors of noroviruses by scaffold hopping.

W. Groutas, Yunjeong Kim, S. R. Mandadapu, 2011, Bioorganic & medicinal chemistry.

Structure-guided design of direct-acting antivirals that exploit the gem-dimethyl effect and potently inhibit 3CL proteases of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) and middle east respiratory syndrome coronavirus (MERS-CoV)

K. Battaile, Alexandra J Machen, W. Groutas, 2023, European Journal of Medicinal Chemistry.

Design, synthesis, and evaluation of a novel series of macrocyclic inhibitors of norovirus 3CL protease.

G. Lushington, K. Battaile, W. Groutas, 2017, European journal of medicinal chemistry.

Oxadiazole-Based Cell Permeable Macrocyclic Transition State Inhibitors of Norovirus 3CL Protease.

G. Lushington, K. Battaile, W. Groutas, 2016, Journal of medicinal chemistry.

Modulation of CD163 receptor expression and replication of porcine reproductive and respiratory syndrome virus in porcine macrophages.

R. Rowland, D. Yoo, Kyeong-Ok Chang, 2009, Virus research.

Inhibition of Calcineurin or IMP Dehydrogenase Exerts Moderate to Potent Antiviral Activity against Norovirus Replication

M. Koopmans, M. Peppelenbosch, H. Metselaar, 2017, Antimicrobial Agents and Chemotherapy.

Inhibitory Effects of Bile Acids and Synthetic Farnesoid X Receptor Agonists on Rotavirus Replication

Yunjeong Kim, Kyeong-Ok Chang, 2011, Journal of Virology.

Intestinal colonization with Escherichia fergusonii enhances infectivity of GII.12 human norovirus in gnotobiotic pigs

Qiuhong Wang, L. Saif, Kyeong-Ok Chang, 2023, Virus research.

Post-infection treatment with a protease inhibitor increases survival of mice with a fatal SARS-CoV-2 infection

S. Perlman, D. Meyerholz, K. Battaile, 2021, bioRxiv.

Oxadiazole-Based Cell Permeable Macrocyclic Transition State Inhibitors of Norovirus 3CL Protease.

G. Lushington, K. Battaile, W. Groutas, 2016, Journal of medicinal chemistry.

Structure-guided design, synthesis and evaluation of oxazolidinone-based inhibitors of norovirus 3CL protease.

G. Lushington, K. Battaile, W. Groutas, 2018, European journal of medicinal chemistry.

Ceramide formation mediated by acid sphingomyelinase facilitates endosomal escape of caliciviruses.

Yunjeong Kim, Kyeong-Ok Chang, Vinay Shivanna, 2015, Virology.

Molecular virology of feline calicivirus.

Kyeong-Ok Chang, J. S. Parker, P. Pesavento, 2008, The Veterinary clinics of North America. Small animal practice.

Correction: Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease Inhibitor

N. Pedersen, D. Hua, Hongwei Liu, 2016, PLoS pathogens.

The smallest functional antibody fragment: Ultralong CDR H3 antibody knob regions potently neutralize SARS-CoV-2

H. Dyson, R. Stanfield, J. Torres, 2023, Proceedings of the National Academy of Sciences of the United States of America.

Synthesis and antiviral activity of substituted quercetins.

D. Hua, Yunjeong Kim, Kyeong-Ok Chang, 2012, Bioorganic & medicinal chemistry letters.