D. Rurak

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Variations from morning to afternoon of middle cerebral and umbilical artery blood flow, and fetal heart rate variability, and fetal characteristics in the normally developing fetus

T. Oberlander, T. Avitan, Ari Sanders, 2018, Journal of clinical ultrasound : JCU.

Maternal Fluoxetine Infusion Does Not Alter Fetal Endocrine and Biophysical Circadian Rhythms in Pregnant Sheep

I. McMillen, D. Kennaway, D. Rurak, 2005, The Journal of the Society for Gynecologic Investigation: JSGI.

Fetal Sleep and Spontaneous Behavior In Utero: Animal and Clinical Studies

D. Rurak, 2016 .

Third Trimester Fetal Heart Rate and Doppler Middle Cerebral Artery Blood Flow Velocity Characteristics During Prenatal Selective Serotonin Reuptake Inhibitor Exposure

T. Oberlander, W. Riggs, Ari Sanders, 2011, Pediatric Research.

Drug accumulation in lung fluid of the fetal lamb after maternal or fetal administration.

D. Rurak, S. Yoo, S. Taylor, 1988, American journal of obstetrics and gynecology.

Drug accumulation in lung fluid of the fetal lamb after accumaternal or fetal administration

D. Rurak, S. Yoo, S. Taylor, 1987 .

Do Commonly Used Oral Antihypertensives Alter Fetal or Neonatal Heart Rate Characteristics? A Systematic Review

L. Magee, P. von Dadelszen, P. Dadelszen, 2004, Hypertension in pregnancy.

Determination of diphenhydramine in biological fluids by capillary gas chromatography using nitrogen-phosphorus detection. Application to placental transfer studies in pregnant sheep.

D. Rurak, S. Yoo, J. Axelson, 1986, Journal of chromatography.

Ontogenesis of phase I hepatic drug metabolic enzymes in sheep.

S. Bandiera, W. Riggs, D. Rurak, 2012, Reproduction, fertility, and development.

Stereoselective disposition of fluoxetine and norfluoxetine during pregnancy and breast-feeding.

R. Grunau, T. Oberlander, C. Fitzgerald, 2006, British journal of clinical pharmacology.

Oxygen consumption in the fetal lamb during sustained hypoxemia with progressive acidemia.

B. Richardson, J. Patrick, L. Carmichael, 1990, The American journal of physiology.

Third trimester fetal pulmonary artery Doppler blood flow velocity characteristics following prenatal selective serotonin reuptake inhibitor (SSRI) exposure.

T. Oberlander, W. Riggs, Ari Sanders, 2012, Early human development.

Changes in fetal lamb arterial blood gas and acid-base status with advancing gestation.

D. Rurak, Natalee W. Bessette, 2013, American journal of physiology. Regulatory, integrative and comparative physiology.

Plasma vasopressin levels during hypoxaemia and the cardiovascular effects of exogenous vasopressin in foetal and adult sheep.

D. Rurak, 1978, The Journal of physiology.

Dose-Dependent Effects of Meloxicam Administration on Cyclooxygenase-1 and Cyclooxygenase-2 Protein Expression in Intrauterine Tissues and Fetal Tissues of a Sheep Model of Preterm Labor

S. Lye, V. Rac, C. Scott, 2007, Reproductive Sciences.

Meloxicam effectively inhibits preterm labor uterine contractions in a chronically catheterized pregnant sheep model: impact on fetal blood flow and fetal-maternal physiologic parameters.

S. Lye, V. Rac, C. Scott, 2006, American journal of obstetrics and gynecology.

The effect of relative hypoxemia on the pattern of breathing movements in fetal lambs.

D. Rurak, C. Cooper, 1984, Respiration physiology.

Sildenafil citrate therapy for severe early‐onset intrauterine growth restriction

A. Gruslin, P. von Dadelszen, P. Dadelszen, 2011, BJOG : an international journal of obstetrics and gynaecology.

An in vivo evaluation of the ontogeny of stereoselective fluoxetine metabolism and disposition in lambs from birth to one year of age

D. Rurak, K. Riggs, Timothy W. Chow, 2019, Xenobiotica; the fate of foreign compounds in biological systems.

Fetal Serotonin Reuptake Inhibitor Antidepressant Exposure: Maternal and Fetal Factors

T. Oberlander, D. Rurak, A. Shea, 2012, Canadian journal of psychiatry. Revue canadienne de psychiatrie.

Chronic Maternal Fluoxetine Infusion in Pregnant Sheep: Effects on the Maternal and Fetal Hypothalamic-Pituitary-Adrenal Axes

I. McMillen, J. Morrison, D. Rurak, 2004, Pediatric Research.

Plasma adrenocorticotropic hormone and cortisol and adrenal blood flow during sustained hypoxemia in fetal sheep.

B. Richardson, J. Patrick, J. Challis, 1986, American journal of obstetrics and gynecology.

Intermittent breathing before death in fetal lambs.

G. Dawes, D. Rurak, R. Chapman, 1978, American journal of obstetrics and gynecology.

The distribution and clearances of hormones and metabolites in the circulation of the foetal sheep.

C. Jones, D. Rurak, C. Jones, 1976, Quarterly Journal of Experimental Physiology and Cognate Medical Sciences.

Absence of a correlation between the secretion of adrenocorticotrophin and vasopressin in foetal sheep.

C. Jones, D. Rurak, 1976, The Journal of endocrinology.

Prolonged Prenatal Psychotropic Medication Exposure Alters Neonatal Acute Pain Response

R. Grunau, T. Oberlander, C. Fitzgerald, 2002, Pediatric Research.

Pain Reactivity in 2-Month-Old Infants After Prenatal and Postnatal Selective Serotonin Reuptake Inhibitor Medication Exposure

R. Grunau, T. Oberlander, C. Fitzgerald, 2005, Pediatrics.

Fluoxetine during pregnancy: impact on fetal development.

J. Morrison, D. Rurak, K. Riggs, 2005, Reproduction, fertility, and development.

Reversed umbilical arterial end diastolic flow, sildenafil treatment and early stillbirths

L. Magee, A. Gruslin, P. von Dadelszen, 2012 .

Sensitive fused-silica capillary gas chromatographic assay using electron-capture detection for indomethacin in ovine fetal fluids.

R. Krishna, D. Rurak, K. Riggs, 1995, Journal of chromatography. B, Biomedical applications.

Altered Fetal Pituitary-Adrenal Function in the Ovine Fetus Treated with RU486 and Meloxicam, an Inhibitor of Prostaglandin Synthase-II1

S. Lye, A. Bocking, J. Challis, 2000, Biology of reproduction.

Disposition of valproic acid in maternal, fetal, and newborn sheep. II: metabolism and renal elimination.

H. Wong, D. Rurak, F. Abbott, 2000, Drug metabolism and disposition: the biological fate of chemicals.

Estimation of transplacental and nonplacental diphenhydramine clearances in the fetal lamb: the impact of fetal first-pass hepatic drug uptake.

G. Tonn, D. Rurak, K. Riggs, 1997, The Journal of pharmacology and experimental therapeutics.

The neuropophysial principles of the western brook lamprey, Lampetra richardisoni: studies in the ammocoete larva.

D. Rurak, A. Perks, 1977, General and comparative endocrinology.

The neurohypophysial principles of the western brook lamprey, Lampetra richardsoni: studies inthe adult.

D. Rurak, A. Perks, 1976, General and comparative endocrinology.

The pharmacological characterization of arginine vasotocin in the pituitary of the pacific hagfish (Polistotrema stoutii).

D. Rurak, A. Perks, 1974, General and comparative endocrinology.

Fetal behavioural state changes following maternal fluoxetine infusion in sheep.

J. Morrison, W. Riggs, D. Rurak, 2001, Brain research. Developmental brain research.

Preoperative dextrose does not affect spinalinduced hypotension in elective Cesarean section

Deborah V. Wilson, D. Rurak, J. Douglas, 1999, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

Pharmacologic factors associated with transient neonatal symptoms following prenatal psychotropic medication exposure.

T. Oberlander, X. Kostaras, C. Fitzgerald, 2004, The Journal of clinical psychiatry.

Fetal oxygen extraction: comparison of the human and sheep.

D. Rurak, B. Wittmann, S. Taylor, 1987, American journal of obstetrics and gynecology.

Metoclopramide pharmacokinetics in pregnant and nonpregnant sheep.

D. Rurak, N. Gruber, K. Riggs, 1988, Journal of pharmaceutical sciences.

Effect of Maternal Fluoxetine Administration on Uterine Blood Flow, Fetal Blood Gas Status, and Growth

J. Morrison, D. Rurak, C. Chien, 2002, Pediatric Research.

Fetal oxygenation measurement using wireless near infrared spectroscopy

Babak Shadgan, Andrew J. Macnab, Patricia A. Janssen, 2012, BiOS.

Comparative formation, distribution, and elimination kinetics of diphenylmethoxyacetic acid (a diphenhydramine metabolite) in maternal and fetal sheep.

D. Rurak, K. Riggs, S. Kumar, 1999, Drug metabolism and disposition: the biological fate of chemicals.

Role of the liver and gut in systemic diphenhydramine clearance in adult nonpregnant sheep.

D. Rurak, K. Riggs, S. Kumar, 1999, Drug metabolism and disposition: the biological fate of chemicals.

Simultaneous analysis of diphenylmethoxyacetic acid, a metabolite of diphenhydramine, and its deuterium-labeled stable isotope analog in ovine plasma and urine.

G. Tonn, D. Rurak, F. Abbott, 1995, Journal of chromatography. B, Biomedical applications.

Transplacental and nonplacental clearances of diphenhydramine in the chronically instrumented pregnant sheep.

D. Rurak, S. Yoo, S. Taylor, 1993, Journal of pharmaceutical sciences.

Simultaneous analysis of diphenhydramine and a stable isotope analog (2H10)diphenhydramine using capillary gas chromatography with mass selective detection in biological fluids from chronically instrumented pregnant ewes.

A. Mutlib, G. Tonn, D. Rurak, 1993, Biological mass spectrometry.

Placental transport of metoclopramide: Assessment of maternal and neonatal effects

D. Rurak, M. Bylsma-Howell, K. Riggs, 1983, Canadian Anaesthetists' Society journal.

Fetal oxygen delivery and consumption and blood gases in relation to gestational age

K. Joseph, D. Rurak, M. Shen, 2021, 2109.11616.

The effect of neuromuscular blockade on oxygen consumption and blood gases in the fetal lamb.

D. Rurak, N. Gruber, 1983, American journal of obstetrics and gynecology.

Increased oxygen consumption associated with breathing activity in fetal lambs.

D. Rurak, N. Gruber, 1983, Journal of applied physiology: respiratory, environmental and exercise physiology.

Measurement of rest and activity in newborn lambs using actigraphy: studies in term and preterm lambs.

D. Rurak, N. Gruber, S. Fay, 2008, Reproduction, fertility, and development.

Ontogenesis of UDP-glucuronosyltransferase enzymes in sheep.

S. Bandiera, W. Riggs, D. Rurak, 2011, Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.

Determination of metoclopramide and two of its metabolites using a sensitive and selective gas chromatographic-mass spectrometric assay.

A. Mutlib, D. Rurak, A. Szeitz, 1994, Journal of chromatography. B, Biomedical applications.

A validated assay to quantitate serotonin in lamb plasma using ultrahigh-performance liquid chromatography-tandem mass spectrometry: applications with LC/MS3

D. Rurak, A. Szeitz, K. Riggs, 2014, Analytical and Bioanalytical Chemistry.

Electron-capture determination of metoclopramide in biological fluids using fused silica capillary columns. Application to placental transport studies in sheep and humans.

D. Hasman, D. Rurak, M. Bylsma-Howell, 1983, Journal of chromatography.

Identification and quantitation of an oxidative metabolite of labetalol in sheep: pharmacokinetic and metabolic implications.

D. Rurak, F. Abbott, J. Axelson, 1992, Biological Mass Spectrometry.

Pharmacokinetics and pharmacodynamics of labetalol in the pregnant sheep.

D. Rurak, J. Axelson, M. Wright, 1992, The Journal of pharmacology and experimental therapeutics.

Effects of diphenhydramine in the fetal lamb after maternal or fetal administration.

D. Rurak, S. Yoo, S. Taylor, 1988, The Journal of pharmacology and experimental therapeutics.

The effect of vasopressin on fetal oxygenation in sheep.

D. Rurak, N. Gruber, 1984, Canadian journal of physiology and pharmacology.

Clearance and disposition of indometacin in chronically instrumented fetal lambs following a 3‐day continuous intravenous infusion

H. Wong, R. Krishna, D. Rurak, 2002, The Journal of pharmacy and pharmacology.

Chronic fetal and maternal instrumentation in pregnant sheep: effect on gestation length and birthweight.

D. Rurak, Natalee W. Bessette, Dan W. Rurak, 2010, Reproduction, fertility, and development.

Tissue blood flow distribution and the effect of chronic vascular catheterization in the hind limb of the fetal lamb.

C. Hall, D. Rurak, K. Knight, 1996, Canadian journal of physiology and pharmacology.

Disposition of valproic acid in maternal, fetal, and newborn sheep. I: placental transfer, plasma protein binding, and clearance.

H. Wong, D. Rurak, F. Abbott, 2000, Drug metabolism and disposition: the biological fate of chemicals.

Stereoselective pharmacokinetics of fluoxetine and norfluoxetine enantiomers in pregnant sheep.

D. Rurak, K. Riggs, John Kim, 2004, Drug metabolism and disposition: the biological fate of chemicals.

Real-Time Ultrasound Assessment of Body and Breathing Movements and Abdominal Diameter in Fetal Lambs From 55 Days of Gestation to Term

D. Rurak, B. Wittman, 2013, Reproductive Sciences.

Placental transfer of diphenhydramine in chronically instrumented pregnant sheep.

D. Rurak, S. Yoo, S. Taylor, 1986, Journal of pharmaceutical sciences.

The Use of Microdialysis for the Study of Drug Kinetics: Central Nervous System Pharmacokinetics of Diphenhydramine in Fetal, Newborn, and Adult Sheep

D. Rurak, N. Gruber, K. Riggs, 2007, Drug Metabolism and Disposition.

The use of microdialysis for the study of drug kinetics : CNS pharmacokinetics of diphenhydramine in fetal , newborn and adult sheep

D. Rurak, N. Gruber, K. Riggs, 2007 .

Diphenhydramine disposition in the sheep maternal-placental-fetal unit: gestational age, plasma drug protein binding, and umbilical blood flow effects on clearance.

G. Tonn, D. Rurak, K. Riggs, 2000, Drug Metabolism And Disposition.

Determination of valproic acid and its metabolites using gas chromatography with mass-selective detection: application to serum and urine samples from sheep.

Jeffrey D. Gordon, D. Rurak, F. Abbott, 1995, Journal of chromatography. B, Biomedical applications.

Pharmacokinetics of diphenhydramine after dose ranging in nonpregnant ewes.

D. Rurak, S. Yoo, J. Axelson, 1990, Journal of pharmaceutical sciences.

A PHARMACOKINETIC STUDY OF DIPHENHYDRAMINE TRANSPORT ACROSS THE BLOOD-BRAIN BARRIER IN ADULT SHEEP: POTENTIAL INVOLVEMENT OF A CARRIER-MEDIATED MECHANISM

D. Rurak, N. Gruber, K. Riggs, 2006, Drug Metabolism and Disposition.

Blood volume restitution and growth in fetal lambs after acute hemorrhage.

D. Rurak, S. Taylor, E. Kwan, 1995, The American journal of physiology.

Fetal and maternal placental and nonplacental clearances of metoclopramide in chronically instrumented pregnant sheep.

D. Rurak, S. Taylor, K. Riggs, 1990, Journal of pharmaceutical sciences.

Drug disposition and effects in the fetus.

D. Rurak, J. Axelson, M. Wright, 1991, Journal of developmental physiology.

Pharmacokinetics and renal excretion of diphenhydramine and its metabolites, diphenylmethoxyacetic acid and diphenhydramine-N-oxide, in developing lambs.

H. Wong, D. Rurak, K. Riggs, 2000, Journal of pharmaceutical sciences.

Postnatal outcomes in lambs exposed antenatally and acutely postnatally to fluoxetine

W. Riggs, D. Rurak, Timothy W. Chow, 2019, Pediatric Research.

Dose-dependent pharmacokinetics and metabolism of valproic acid in newborn lambs and adult sheep.

H. Wong, D. Rurak, F. Abbott, 2001, Drug metabolism and disposition: the biological fate of chemicals.

Kinetics of Valproic Acid Glucuronidation: Evidence for in Vivo Autoactivation

H. Wong, Sanjeev Kumar, D. Rurak, 2007, Drug Metabolism and Disposition.

Ontogeny of valproic acid disposition and metabolism: a developmental study in postnatal lambs and adult sheep.

H. Wong, D. Rurak, F. Abbott, 2000, Drug Metabolism And Disposition.

Simultaneous determination of diphenhydramine, its N-oxide metabolite and their deuterium-labeled analogues in ovine plasma and urine using liquid chromatography/electrospray tandem mass spectrometry.

Sanjeev Kumar, D. Rurak, K. Riggs, 1998, Journal of mass spectrometry : JMS.

Pharmacokinetics of indomethacin in chronically instrumented ovine fetuses following a 3-day intravenous infusion

R. Krishna, K. Riggs, D. Rurak, 1995 .

Linearity of metoclopramide kinetics at doses of 5-20 mg.

Y. Tam, D. Rurak, J. Axelson, 1988, British journal of clinical pharmacology.

Effect of haemodialysis on metoclopramide kinetics in patients with severe renal failure.

Y. Tam, D. Rurak, J. Axelson, 1988, British journal of clinical pharmacology.

Effects of acute moderate hypoxemia on kinetics of metoclopramide and its metabolites in chronically instrumented sheep

D. Rurak, K. Riggs, John Kim, 2002, Archives of pharmacal research.

Maternal Serotonin Reuptake Inhibitor Antidepressants Have Acute Effects on Fetal Heart Rate Variability in Late Gestation

T. Oberlander, M. Irvine, U. Brain, 2021, Frontiers in Psychiatry.

Fetal Effects of In Utero Serotonin Reuptake Inhibitor (SRI) Antidepressant Exposure

T. Oberlander, G. Hanley, D. Rurak, 2016 .

Breathing movements in fetal lambs and the effect of hypercapnia.

G. Dawes, D. Rurak, R. Chapman, 1980, The Journal of physiology.

Hypothalamic-pituitary-adrenal (HPA) axis function in 3-month old infants with prenatal selective serotonin reuptake inhibitor (SSRI) antidepressant exposure.

R. Grunau, T. Oberlander, J. Weinberg, 2008, Early human development.

Sensitive high-performance liquid chromatographic method for direct separation of labetalol stereoisomers in biological fluids using an alpha 1-acid glycoprotein stationary phase.

D. Rurak, F. Abbott, J. Axelson, 1993, Journal of chromatography.

Sensitive microbore high-performance liquid chromatographic assay for labetatol in the fluids of pregnant sheep

D. Rurak, J. Axelson, K. Yeleswaram, 1991 .

Oxygen consumption in fetal lambs after maternal administration of sodium pentobarbital.

D. Rurak, S. Taylor, 1986, American journal of obstetrics and gynecology.

Maternal and Fetal Factors That Influence Prenatal Exposure to Selective Serotonin Reuptake Inhibitor Antidepressants

T. Oberlander, U. Brain, D. Rurak, 2014 .

Plasma vasopressin levels during haemorrhage in mature and immature fetal sheep.

D. Rurak, 1979, Journal of developmental physiology.

The impact of maternal positive and negative affect on fetal physiology and diurnal patterns.

T. Oberlander, G. Hanley, U. Brain, 2014, The Israel journal of psychiatry and related sciences.

Use of an automated fluorescent microsphere method to measure regional blood flow in the fetal lamb.

R. Thies, D. Rurak, K. Riggs, 1997, Canadian journal of physiology and pharmacology.

Cerebral oxidative metabolism during sustained hypoxaemia in fetal sheep.

B. Richardson, J. Patrick, L. Carmichael, 1989, Journal of developmental physiology.

Blood flow and oxygen delivery to fetal organs and tissues during sustained hypoxemia.

B. Richardson, J. Patrick, L. Carmichael, 1990, The American journal of physiology.

A validated enantioselective assay for the simultaneous quantitation of (R)-, (S)-fluoxetine and (R)-, (S)-norfluoxetine in ovine plasma using liquid chromatography with tandem mass spectrometry (LC/MS/MS).

D. Rurak, A. Szeitz, K. Riggs, 2011, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.