I. Kawahata

发表

Single Administration of the T-Type Calcium Channel Enhancer SAK3 Reduces Oxidative Stress and Improves Cognition in Olfactory Bulbectomized Mice

K. Fukunaga, Jing Xu, Dian Yuan, 2021, International journal of molecular sciences.

Accumulation of phosphorylated tyrosine hydroxylase into insoluble protein aggregates by inhibition of an ubiquitin–proteasome system in PC12D cells

H. Parvez, H. Ichinose, I. Kawahata, 2009, Journal of Neural Transmission.

An α-synuclein decoy peptide prevents cytotoxic α-synuclein aggregation caused by fatty acid binding protein 3

K. Fukunaga, Y. Kawata, N. Fukui, 2021, The Journal of biological chemistry.

Two Distinct Mechanisms for Actin Capping Protein Regulation—Steric and Allosteric Inhibition

M. Ota, R. Koike, S. Takeda, 2010, PLoS biology.

Fatty acid-binding protein 7 triggers α-synuclein oligomerization in glial cells and oligodendrocytes associated with oxidative stress

K. Fukunaga, Y. Kawata, An Cheng, 2021, Acta Pharmacologica Sinica.

Epsin2, a novel target for multiple system atrophy therapy via regulating α-synuclein propagation associated with FABP7

K. Fukunaga, D. Finkelstein, An Cheng, 2022 .

Case Report: Guitarist’s cramp as the initial manifestation of dopa-responsive dystonia with a novel heterozygous GCH1 mutation

M. Aoki, N. Sugeno, A. Kikuchi, 2021, F1000Research.

Pathogenic Impact of α-Synuclein Phosphorylation and Its Kinases in α-Synucleinopathies

K. Fukunaga, D. Finkelstein, I. Kawahata, 2022, International journal of molecular sciences.

A novel fatty acid-binding protein 5 and 7 inhibitor ameliorates oligodendrocyte injury in multiple sclerosis mouse models

K. Fukunaga, An Cheng, I. Kawahata, 2021, EBioMedicine.

Music and Dopamine – Potential in Movement Disorders

K. Hasegawa, I. Kawahata, R. Kase, 2020 .

Epsin2, a novel target for multiple system atrophy therapy via α-synuclein/FABP7 propagation

K. Fukunaga, N. Stefanova, D. Finkelstein, 2022, bioRxiv.

Intranasal Administration of Conditioned Medium from Cultured Mesenchymal Stem Cells Improves Cognitive Impairment in Olfactory Bulbectomized Mice

K. Fukunaga, I. Kawahata, Hisanao Izumi, 2020, Advances in Alzheimer's Disease.

Dopamine D2 Long Receptors Are Critical for Caveolae-Mediated α-Synuclein Uptake in Cultured Dopaminergic Neurons

K. Fukunaga, Yanyan Wang, Y. Kawata, 2021, Biomedicines.

Fatty Acid-Binding Proteins: Their Roles in Ischemic Stroke and Potential as Drug Targets

K. Fukunaga, An Cheng, I. Kawahata, 2022, International journal of molecular sciences.

Fatty Acid-Binding Proteins Aggravate Cerebral Ischemia-Reperfusion Injury in Mice

K. Fukunaga, I. Kawahata, Y. Ikeda-Matsuo, 2021, Biomedicines.

Dopamine or biopterin deficiency potentiates phosphorylation at (40)Ser and ubiquitination of tyrosine hydroxylase to be degraded by the ubiquitin proteasome system.

H. Ichinose, Y. Tomioka, I. Kawahata, 2015, Biochemical and biophysical research communications.

Oral sinensetin, but not nobiletin alone, prevents MK801‐induced impairment of memory formation in mice, like nobiletin‐rich chinpi, a kampo medicine

I. Kawahata, Y. Mimaki, Masaaki Yoshida, 2017 .

SLC10A4 is a protease-activated transporter that transports bile acids.

T. Hishinuma, Y. Tomioka, I. Kawahata, 2013, Journal of biochemistry.

Imidacloprid, a neonicotinoid insecticide, facilitates tyrosine hydroxylase transcription and phenylethanolamine N-methyltransferase mRNA expression to enhance catecholamine synthesis and its nicotine-evoked elevation in PC12D cells.

I. Kawahata, T. Yamakuni, 2018, Toxicology.

Epidermal Fatty Acid-Binding Protein 5 (FABP5) Involvement in Alpha-Synuclein-Induced Mitochondrial Injury under Oxidative Stress

K. Fukunaga, An Cheng, I. Kawahata, 2021, Biomedicines.

Fatty Acid-Binding Protein 3 is Critical for α-Synuclein Uptake and MPP+-Induced Mitochondrial Dysfunction in Cultured Dopaminergic Neurons

K. Fukunaga, I. Kawahata, R. Melki, 2019, International journal of molecular sciences.

Royal jelly coordinately enhances hippocampal neuronal expression of somatostatin and neprilysin genes conferring neuronal protection against toxic soluble amyloid-β oligomers implicated in Alzheimer’s disease pathogenesis

I. Kawahata, K. Yamaguchi, T. Yamakuni, 2018, Journal of Functional Foods.

Degradation of Tyrosine Hydroxylase by the Ubiquitin-Proteasome System in the Pathogenesis of Parkinson’s Disease and Dopa-Responsive Dystonia

K. Fukunaga, I. Kawahata, 2020, International journal of molecular sciences.

Fatty acid-binding proteins 3 and 5 are involved in the initiation of mitochondrial damage in ischemic neurons

K. Fukunaga, H. Yoshino, An Cheng, 2022, Redox biology.

Extracellular α‐synuclein enters dopaminergic cells by modulating flotillin‐1–assisted dopamine transporter endocytosis

H. Okano, A. Takeda, M. Kanzaki, 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Impact of Fatty Acid-Binding Proteins in α-Synuclein-Induced Mitochondrial Injury in Synucleinopathy

K. Fukunaga, An Cheng, I. Kawahata, 2021, Biomedicines.

T-type Ca2+ channel enhancer SAK3 administration improves the BPSD-like behaviors in AppNL-G-F/NL-G-F knock-in mice.

K. Fukunaga, I. Kawahata, Hisanao Izumi, 2021, Journal of pharmacological sciences.

Fatty Acid Binding Protein 5 Mediates Cell Death by Psychosine Exposure through Mitochondrial Macropores Formation in Oligodendrocytes

K. Fukunaga, An Cheng, I. Kawahata, 2020, Biomedicines.

Plasma sphingolipid abnormalities in neurodegenerative diseases

K. Fukunaga, A. Takeda, T. Baba, 2022, PloS one.

Ginsenoside Rg1-induced antidepressant effects involve the protection of astrocyte gap junctions within the prefrontal cortex

N. Chen, Heng Zhou, I. Kawahata, 2017, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Impaired Acquisition of Nicotine-Induced Conditioned Place Preference in Fatty Acid-Binding Protein 3 Null Mice

K. Fukunaga, An Cheng, I. Kawahata, 2021, Molecular Neurobiology.

Potent activity of nobiletin-rich Citrus reticulata peel extract to facilitate cAMP/PKA/ERK/CREB signaling associated with learning and memory in cultured hippocampal neurons: identification of the substances responsible for the pharmacological action

A. Naganuma, Y. Tomioka, I. Kawahata, 2013, Journal of Neural Transmission.

Amelioration of Nicotine-Induced Conditioned Place Preference Behaviors in Mice by an FABP3 Inhibitor

K. Fukunaga, T. Sasaoka, An Cheng, 2023, International journal of molecular sciences.

Novel fatty acid-binding protein 3 ligand inhibits dopaminergic neuronal death and improves motor and cognitive impairments in Parkinson's disease model mice

K. Fukunaga, H. Miyachi, I. Kawahata, 2020, Pharmacology Biochemistry and Behavior.

The Role of CaMKII and ERK Signaling in Addiction

K. Fukunaga, An Cheng, I. Kawahata, 2021, International journal of molecular sciences.

α‐Synuclein decoy peptide protects mice against α‐synuclein‐induced memory loss

K. Fukunaga, N. Shioda, An Cheng, 2023, CNS neuroscience & therapeutics.

Impact of fatty acid-binding proteins and dopamine receptors on α-synucleinopathy.

K. Fukunaga, I. Kawahata, 2021, Journal of pharmacological sciences.

Anti-Epileptic Effects of FABP3 Ligand MF1 through the Benzodiazepine Recognition Site of the GABAA Receptor

K. Fukunaga, N. Shioda, S. Ueno, 2020, International journal of molecular sciences.

Fatty Acid Binding Protein 3 Enhances the Spreading and Toxicity of α-Synuclein in Mouse Brain

K. Fukunaga, N. Shioda, Y. Kawata, 2020, International journal of molecular sciences.

Characterization of design grammar of peptides for regulating liquid droplets and aggregates of FUS

K. Kamagata, Saori Kanbayashi, Hiroto Takahashi, 2021, Scientific Reports.

SAK3 Administration Improves Spine Abnormalities and Cognitive Deficits in AppNL-G-F/NL-G-F Knock-in Mice by Increasing Proteasome Activity through CaMKII/Rpt6 Signaling

K. Fukunaga, F. Helmstetter, I. Kawahata, 2020, International journal of molecular sciences.

Fermented Citrus reticulata (ponkan) fruit squeezed draff that contains a large amount of 4′-demethylnobiletin prevents MK801-induced memory impairment

H. Tamura, I. Kawahata, Tatsuya Suzuki, 2017, Journal of Natural Medicines.

Suppression of α-synuclein propagation after intrastriatal injection in FABP3 null mice

K. Fukunaga, Y. Owada, I. Kawahata, 2021, Brain Research.

Regulation of Gene Expression and Degradation of Tyrosine Hydroxylase in Parkinson?s Disease.

I. Kawahata, 2017 .

T-Type Ca2+ Enhancer SAK3 Activates CaMKII and Proteasome Activities in Lewy Body Dementia Mice Model

K. Fukunaga, I. Kawahata, Hisanao Izumi, 2021, International journal of molecular sciences.

Shishihakuhito, a Kampo medicine for atopic dermatitis, suppresses NGF-induced neurite extension by inhibition of MEK/ERK signaling in PC12D cells

K. Nakanishi, Y. Ohizumi, I. Kawahata, 2011 .

Fermented Citrus reticulata (ponkan) fruit squeezed draff that contains a large amount of 4′-demethylnobiletin prevents MK801-induced memory impairment

H. Tamura, I. Kawahata, Tatsuya Suzuki, 2017, Journal of Natural Medicines.

Pharmacological inhibition of FABP7 by MF 6 counteracts cerebellum dysfunction in an experimental multiple system atrophy mouse model.

K. Fukunaga, N. Stefanova, D. Finkelstein, 2023, Acta Pharmacologica Sinica.

Dopamine or biopterin deficiency potentiates phosphorylation at (40)Ser and ubiquitination of tyrosine hydroxylase to be degraded by the ubiquitin proteasome system.

H. Ichinose, Y. Tomioka, I. Kawahata, 2015, Biochemical and biophysical research communications.

Sigma-1 receptor is involved in modification of ER-mitochondria proximity and Ca2+ homeostasis in cardiomyocytes.

K. Fukunaga, M. Bhuiyan, H. Tagashira, 2022, Journal of pharmacological sciences.

Protein Kinases and Neurodegenerative Diseases

K. Fukunaga, I. Kawahata, 2023, International journal of molecular sciences.

Dopamine D1–D5 Receptors in Brain Nuclei: Implications for Health and Disease

I. Kawahata, David I. Finkelstein, Kohji Fukunaga, 2024, Receptors.