B. Chakravarthy

发表

Hippocampal membrane-associated p75NTR levels are increased in Alzheimer's disease.

U. Armato, J. Whitfield, B. Chakravarthy, 2012, Journal of Alzheimer's disease : JAD.

Evidence that the activation of an inactive pool of membrane-associated protein kinase C is linked to the IL-2-dependent survival of T lymphocytes.

R. Tremblay, J. Durkin, B. Chakravarthy, 1994, Journal of immunology.

Rapid isolation of neuroblastoma plasma membranes on Percoll gradients. Characterization and lipid composition.

J. Clarke, B. Chakravarthy, H. W. Cook, 1985, Biochimica et biophysica acta.

Ca2+–calmodulin and protein kinase Cs: a hypothetical synthesis of their conflicting convergences on shared substrate domains

J. Whitfield, B. Chakravarthy, P. Morley, 1999, Trends in Neurosciences.

Ca2+·Calmodulin Prevents Myristoylated Alanine-rich Kinase C Substrate Protein Phosphorylation by Protein Kinase Cs in C6 Rat Glioma Cells (*)

R. Isaacs, J. Whitfield, B. Chakravarthy, 1995, The Journal of Biological Chemistry.

Stimulation of protein kinase C during Ca(2+)-induced keratinocyte differentiation. Selective blockade of MARCKS phosphorylation by calmodulin.

R. Isaacs, J. Durkin, J. Whitfield, 1995, The Journal of biological chemistry.

A synthetic peptide corresponding to a region of the human pericentriolar material 1 (PCM‐1) protein binds β‐amyloid (Aβ1‐42) oligomers

J. Whitfield, B. Chakravarthy, Michel Ménard, 2013, Journal of neurochemistry.

Amyloid-β(25-35), an amyloid-β(1-42) surrogate, and proinflammatory cytokines stimulate VEGF-A secretion by cultured, early passage, normoxic adult human cerebral astrocytes.

U. Armato, J. Whitfield, B. Chakravarthy, 2010, Journal of Alzheimer's disease : JAD.

Association of Gap-43 (neuromodulin) with microtubule-associated protein MAP-2 in neuronal cells.

J. Kelly, B. Chakravarthy, Michel Ménard, 2008, Biochemical and biophysical research communications.

The Possible Roles of the Dentate Granule Cell’s Leptin and Other Ciliary Receptors in Alzheimer’s Neuropathology

U. Armato, J. Whitfield, B. Chakravarthy, 2015, Cells.

Involvement of insulin-like growth factor 1 receptor signaling in the amyloid-β peptide oligomers-induced p75 neurotrophin receptor protein expression in mouse hippocampus.

J. Whitfield, B. Chakravarthy, Michel Ménard, 2012, Journal of Alzheimer's disease : JAD.

Transient NMDA Receptor Inactivation Provides Long-Term Protection to Cultured Cortical Neurons from a Variety of Death Signals

R. Tremblay, J. Tauskela, J. Durkin, 2000, The Journal of Neuroscience.

Co-localization and interaction of DPYSL3 and GAP43 in primary cortical neurons.

B. Chakravarthy, Michel Ménard, L. Brown, 2007, Biochemical and biophysical research communications.

Early Cellular Responses to the Activation of a Mitogenic/Oncogenic Viral K‐RAS Protein

J. Schwartz, D. Franks, R. Tremblay, 1988, Annals of the New York Academy of Sciences.

Parathyroid hormone stimulates protein kinase C but not adenylate cyclase in mouse epidermal keratinocytes

M. Sikorska, R. Isaacs, J. Durkin, 1992, Journal of cellular physiology.

Identification of protein kinase C inhibitory activity associated with a polypeptide isolated from a phage display system with homology to PCM-1, the pericentriolar material-1 protein.

J. Whitfield, B. Chakravarthy, Michel Ménard, 2012, Biochemical and biophysical research communications.

Evidence that the Modulation of Membrane‐Associated Protein Kinase C Activity by an Endogenous Inhibitor Plays a Role in N1E‐115 Murine Neuroblastoma Cell Differentiation

J. Durkin, B. Chakravarthy, J. Wong, 1995, Journal of neurochemistry.

NMR analysis of the correlation of metabolic changes in blood and cerebrospinal fluid in Alzheimer model male and female mice

Junzhou Huang, M. Čuperlović-Culf, B. Chakravarthy, 2020, bioRxiv.

Parathyroid hormone fragments may stimulate bone growth in ovariectomized rats by activating adenylyl cyclase

R. Isaacs, W. Sung, S. Maclean, 1994, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Comparison of the changes in protein kinase C induced by glutamate in primary cortical neurons and by in vivo cerebral ischaemia.

A. Buchan, R. Tremblay, J. Durkin, 1998, Cellular signalling.

Glucose, potassium, and CCK-8 induce increases in membrane-associated PKC activity that correspond to increases in [Ca2+]i in islet cells from neonatal rats.

J. Durkin, J. Whitfield, B. Chakravarthy, 1996, Cellular signalling.

The Aβ Peptides-Activated Calcium-Sensing Receptor Stimulates the Production and Secretion of Vascular Endothelial Growth Factor-A by Normoxic Adult Human Cortical Astrocytes

F. Chioffi, R. Pacchiana, U. Armato, 2014, NeuroMolecular Medicine.

Stimulation of Protein Kinase C Activity in Cells Expressing Human Parathyroid Hormone Receptors by C‐ and N‐Terminally Truncated Fragments of Parathyroid Hormone 1–34

R. Isaacs, S. Maclean, J. Whitfield, 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Membrane protein kinase C activity rapidly increases in quiescent tsRSV-infected NRK cells upon reactivation of the mitogenic v-src protein kinase.

R. Tremblay, J. Durkin, J. Whitfield, 1990, Cellular signalling.

C‐terminal fragment of parathyroid hormone‐related protein, PTHrP‐(107–111), stimulates membrane‐associated protein kinase C activity and modulates the proliferation of human and murine skin keratinocytes

E. Regalia, U. Armato, R. Isaacs, 1996, Journal of cellular physiology.

The role of signal-transducing events in the proliferative response of cells to a mitogenic viral K-ras protein.

J. Schwartz, G. Mealing, D. Franks, 1990, Cellular signalling.

A novel method for measuring protein kinase C activity in a native membrane-associated state.

D. Franks, J. Durkin, J. Whitfield, 1989, Biochemical and biophysical research communications.

PLA2 signaling is involved in calpain-mediated degradation of synaptic dihydropyrimidinase-like 3 protein in response to NMDA excitotoxicity

B. Chakravarthy, R. Kowara, Kristoffer Laser Moraleja, 2008, Neuroscience Letters.

Activation of DNA‐Dependent Protein Kinase May Play a Role in Apoptosis of Human Neuroblastoma Cells

B. Chakravarthy, I. Rasquinha, J. Macmanus, 1999, Journal of neurochemistry.

Calcium—cell cycle regulator, differetiator, killer, chemopreventor, and maybe, tumor promoter

R. Isaacs, J. Whitfield, B. Chakravarthy, 1995, Journal of cellular biochemistry. Supplement.

The amyloid-β₄₂ proxy, amyloid-β(25-35), induces normal human cerebral astrocytes to produce amyloid-β₄₂.

R. Pacchiana, U. Armato, A. Talacchi, 2011, Journal of Alzheimer's disease : JAD.

Further definition of the protein kinase C activation domain of the parathyroid hormone

R. Isaacs, S. Maclean, L. Gagnon, 1994, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Mechanisms of 1S,3R-ACPD-induced neuroprotection in rat hippocampal slices subjected to oxygen and glucose deprivation

G. Mealing, A. Buchan, D. Small, 1996, Neuropharmacology.

Role of protein kinase C in the regulation of ATP-triggered intracellular Ca2+ oscillations in chicken granulosa cells.

G. Mealing, B. Tsang, J. Whitfield, 1996, European journal of endocrinology.

The effect of cholecystokinin on intracellular Ca2+, membrane-associated protein kinase-C activity, and progesterone production in chicken granulosa cells.

B. Vanderhyden, J. Durkin, B. Chakravarthy, 1993, Endocrinology.

Calcium-sensing receptor antagonist (calcilytic) NPS 2143 specifically blocks the increased secretion of endogenous Aβ42 prompted by exogenous fibrillary or soluble Aβ25-35 in human cortical astrocytes and neurons-therapeutic relevance to Alzheimer's disease.

Enzo Colarusso, F. Chioffi, R. Pacchiana, 2013, Biochimica et biophysica acta.

Leptin, Sonic Hedgehogs, and Neurogenesis- A Primary Cilium’s Tale

F. Chioffi, U. Armato, J. Whitfield, 2011 .

The activation of inactive membrane-associated protein kinase C is associated with DMSO-induced erythroleukemia cell differentiation.

R. Tremblay, J. Durkin, J. Whitfield, 1992, Biochimica et biophysica acta.

An Early Loss in Membrane Protein Kinase C Activity Precedes the Excitatory Amino Acid‐Induced Death of Primary Cortical Neurons

G. Mealing, A. Buchan, R. Tremblay, 1996, Journal of neurochemistry.

The p75 neurotrophin receptor is localized to primary cilia in adult murine hippocampal dentate gyrus granule cells.

J. Whitfield, B. Chakravarthy, Michel Ménard, 2010, Biochemical and biophysical research communications.

The gas7 protein potentiates NGF-mediated differentiation of PC12 cells

S. Lin-Chao, B. Chakravarthy, S. Hou, 2005, Brain Research.

Neuroprotective gene expression profiles in ischemic cortical cultures preconditioned with IGF-1 or bFGF.

B. Chakravarthy, T. Atkinson, E. Yoshida, 2004, Brain research. Molecular brain research.

Amyloid-beta peptides stimulate the expression of the p75(NTR) neurotrophin receptor in SHSY5Y human neuroblastoma cells and AD transgenic mice.

F. LaFerla, U. Armato, J. Whitfield, 2010, Journal of Alzheimer's disease : JAD.

Preclinical in vivo longitudinal assessment of KG207-M as a disease-modifying Alzheimer’s disease therapeutic

M. Chakravarty, K. Blennow, S. Gauthier, 2021, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Alzheimer's disease: an update of the roles of receptors, astrocytes and primary cilia (review).

R. Pacchiana, U. Armato, J. Whitfield, 2013, International journal of molecular medicine.

Reduction of the immunostainable length of the hippocampal dentate granule cells' primary cilia in 3xAD-transgenic mice producing human Aβ(1-42) and tau.

F. LaFerla, U. Armato, J. Whitfield, 2012, Biochemical and biophysical research communications.

The direct measurement of protein kinase C (PKC) activity in isolated membranes using a selective peptide substrate.

M. Sikorska, J. Durkin, J. Whitfield, 1991, Analytical biochemistry.

Preferential accumulation of Abeta(1-42) on gel phase domains of lipid bilayers: an AFM and fluorescence study.

L. Johnston, J. Katsaras, B. Chakravarthy, 2007, Biochimica et biophysica acta.

Evidence that the Early Loss of Membrane Protein Kinase C Is a Necessary Step in the Excitatory Amino Acid‐Induced Death of Primary Cortical Neurons

G. Mealing, D. Small, R. Tremblay, 1997, Journal of neurochemistry.

Calcium-sensing receptor (CaSR) in human brain's pathophysiology: roles in late-onset Alzheimer's disease (LOAD).

U. Armato, J. Whitfield, B. Chakravarthy, 2009, Current pharmaceutical biotechnology.

Evidence from cultured rat cortical neurons of differences in the mechanism of ischemic preconditioning of brain and heart

Yizheng Wang, A. Hakim, J. Tauskela, 1999, Brain Research.

Emerging concepts of how β-amyloid proteins and pro-inflammatory cytokines might collaborate to produce an 'Alzheimer brain' (Review).

R. Pacchiana, U. Armato, J. Whitfield, 2008, Molecular medicine reports.

Evidence that a synthetic amyloid-ß oligomer-binding peptide (ABP) targets amyloid-ß deposits in transgenic mouse brain and human Alzheimer's disease brain.

J. Whitfield, B. Chakravarthy, Michel Ménard, 2014, Biochemical and biophysical research communications.

Turnover of phospholipid fatty acyl chains in cultured neuroblastoma cells: involvement of deacylation-reacylation and de novo synthesis in plasma membranes.

B. Chakravarthy, H. W. Cook, M. W. Spence, 1986, Biochimica et biophysica acta.

Calpain‐mediated truncation of dihydropyrimidinase‐like 3 protein (DPYSL3) in response to NMDA and H2O2 toxicity

Q. Chen, B. Chakravarthy, M. Milliken, 2005, Journal of neurochemistry.

Preventing the spread of Alzheimer's disease neuropathology: a role for calcilytics?

U. Armato, E. Gardenal, J. Whitfield, 2015, Current pharmaceutical biotechnology.

Inactive membrane protein kinase Cs: a possible target for receptor signalling.

J. Durkin, J. Whitfield, B. Chakravarthy, 1994, The Biochemical journal.

The protein kinase-C activation domain of the parathyroid hormone.

R. Isaacs, S. Maclean, L. Gagnon, 1992, Endocrinology.

C‐terminal fragments of parathyroid hormone‐related protein, PTHrP‐(107‐111) and (107‐139), and the N‐terminal PTHrP‐(1‐40) fragment stimulate membrane‐associated protein kinase C activity in rat spleen lymphocytes

R. Isaacs, J. Durkin, R. Rixon, 1994, Journal of cellular physiology.

Parathyroid hormone fragment [3-34] stimulates protein kinase C (PKC) activity in rat osteosarcoma and murine T-lymphoma cells.

J. Durkin, J. Whitfield, R. Rixon, 1990, Biochemical and biophysical research communications.

Calcium-Sensing Receptors of Human Astrocyte-Neuron Teams: Amyloid-β-Driven Mediators and Therapeutic Targets of Alzheimer’s Disease

R. Pacchiana, U. Armato, E. Gardenal, 2014, Current neuropharmacology.

Relative expression of the p75 neurotrophin receptor, tyrosine receptor kinase A, and insulin receptor in SH-SY5Y neuroblastoma cells and hippocampi from Alzheimer's disease patients

J. Whitfield, B. Chakravarthy, Michel Ménard, 2016, Neurochemistry International.

Hippocampal slice cultures integrated with multi‐electrode arrays: a model for study of long‐term drug effects on synaptic activity

G. Mealing, B. Chakravarthy, J. Mielke, 2007 .

Identification of okadaic acid-induced phosphorylation events by a mass spectrometry approach.

J. Kelly, B. Chakravarthy, Jennifer J. Hill, 2006, Biochemical and biophysical research communications.

The Aβ Peptides-Activated Calcium-Sensing Receptor Stimulates the Production and Secretion of Vascular Endothelial Growth Factor-A by Normoxic Adult Human Cortical Astrocytes

F. Chioffi, R. Pacchiana, U. Armato, 2014, NeuroMolecular Medicine.

The calcium-sensing receptor: A novel Alzheimer's disease crucial target?

R. Pacchiana, U. Armato, J. Whitfield, 2012, Journal of the Neurological Sciences.

Cytoskeletal, synaptic, and nuclear protein changes associated with rat interface organotypic hippocampal slice culture development.

G. Mealing, J. Woulfe, R. Monette, 2005, Brain research. Developmental brain research.

Do Astrocytes Collaborate with Neurons in Spreading the “Infectious” Aβ and Tau Drivers of Alzheimer’s Disease?

R. Pacchiana, U. Armato, E. Gardenal, 2015, The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.

Pharmacokinetics and Pharmacodynamic Effect of a Blood-Brain Barrier-Crossing Fusion Protein Therapeutic for Alzheimer’s Disease in Rat and Dog

J. Gillard, B. Chakravarthy, A. Haqqani, 2022, Pharmaceutical Research.

Alzheimer’s Disease and Its Possible Evolutionary Origin: Hypothesis

B. Chakravarthy, K. Rennie, J. Whitfield, 2023, Cells.

Alzheimer's Disease & Parkinsonism

U. Armato, J. Whitfield, B. Chakravarthy, 2011 .

Protein kinase C‐activating domains of parathyroid hormone‐related protein

S. Maclean, L. Gagnon, J. Durkin, 1993, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Evidence that a novel human differentiation-inhibiting protein blocks the dimethyl sulfoxide-induced differentiation of erythroleukemia cells by inhibiting the activation of membrane protein kinase C.

R. Tremblay, J. Durkin, J. Whitfield, 1992, Cancer research.

Involvement of nitric oxide synthase and ROS-mediated activation of L-type voltage-gated Ca2+ channels in NMDA-induced DPYSL3 degradation

B. Chakravarthy, R. Kowara, Kristoffer Laser Moraleja, 2006, Brain Research.

The phosphatase inhibitor, okadaic acid, strongly protects primary rat cortical neurons from lethal oxygen-glucose deprivation.

J. Whitfield, B. Chakravarthy, T. Atkinson, 2009, Biochemical and biophysical research communications.

A Protein Kinase C Substrate Peptide Derived from MARCKS Protein

M. Sikorska, J. Durkin, J. Whitfield, 1992 .

The neuronal primary cilium: driver of neurogenesis and memory formation in the hippocampal dentate gyrus?

J. Whitfield, B. Chakravarthy, 2009, Cellular signalling.