R. Pepinsky

发表

A DR6/p75NTR complex is responsible for β-amyloid-induced cortical neuron death

S. Mi, X. Lee, Y. Hu, 2013, Cell Death and Disease.

TAJ/TROY, an Orphan TNF Receptor Family Member, Binds Nogo-66 Receptor 1 and Regulates Axonal Regeneration

John M. McCoy, Vincent Jung, Norm Allaire, 2005, Neuron.

Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins.

A. Whitty, M. Sanicola, R. Tizard, 1997, Proceedings of the National Academy of Sciences of the United States of America.

IGF-1:Tetanus toxin fragment C fusion protein improves delivery of IGF-1 to spinal cord but fails to prolong survival of ALS mice

I. Ay, R. Bronson, P. Fishman, 2009, Brain Research.

Death receptor 6 negatively regulates oligodendrocyte survival, maturation and myelination

K. Rhodes, Robert H Miller, S. Mi, 2011, Nature Medicine.

Death receptor 6 (DR6) antagonist antibody is neuroprotective in the mouse SOD1G93A model of amyotrophic lateral sclerosis

S. Mi, X. Lee, Z. Shao, 2013, Cell Death and Disease.

GFRalpha3 is expressed predominantly in nociceptive sensory neurons

M. Sanicola, R. Pepinsky, D. Sah, 2001, The European journal of neuroscience.

Nomenclature of GPI-Linked Receptors for the GDNF Ligand Family

L. M. Goodman, J. Treanor, J. Milbrandt, 1997, Neuron.

Sphingosine 1-phosphate receptor modulator fingolimod (FTY720) does not promote remyelination in vivo

K. Guckian, Robert H Miller, S. Mi, 2011, Molecular and Cellular Neuroscience.

Disulfide structure of the leucine-rich repeat C-terminal cap and C-terminal stalk region of Nogo-66 receptor.

L. Silvian, C. Wildes, S. Mi, 2005, Biochemistry.

LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex

J. Relton, S. Perrin, J. Mccoy, 2004, Nature Neuroscience.

LINGO-1 negatively regulates myelination by oligodendrocytes

B. Trapp, M. Scott, Zhigang He, 2005, Nature Neuroscience.

Constitutive negative regulation in the processing of the anti-Müllerian hormone receptor II

N. Smorodinsky, M. Ehrlich, J. Picard, 2015, Journal of Cell Science.

NGF Regulates the Expression of Axonal LINGO-1 to Inhibit Oligodendrocyte Differentiation and Myelination

J. Chan, Robert H Miller, S. Mi, 2007, The Journal of Neuroscience.

LINGO-1 antagonist promotes functional recovery and axonal sprouting after spinal cord injury

J. Relton, K. So, J. Mccoy, 2006, Molecular and Cellular Neuroscience.

A glial cell line-derived neurotrophic factor (GDNF):tetanus toxin fragment C protein conjugate improves delivery of GDNF to spinal cord motor neurons in mice

I. Ay, D. Sulzer, M. Remington, 2006, Brain Research.

Tetanus toxin fragment C fusion facilitates protein delivery to CNS neurons from cerebrospinal fluid in mice

I. Ay, P. Fishman, E. Bastia, 2005, Journal of neurochemistry.

Characterization of trisulfide modification in antibodies.

Rashmi Kshirsagar, Werner Meier, P. Weinreb, 2010, Analytical biochemistry.

Development and validation of immunoassays to quantify the half-antibody exchange of an IgG4 antibody, natalizumab (Tysabri®) with endogenous IgG4.

R. Motter, T. Yednock, N. Wehner, 2011, Journal of pharmaceutical and biomedical analysis.

Lipocortin-1 (annexin-1) suppresses activation of autoimmune T cell lines in the Lewis rat

H. Hartung, R. Gold, K. Toyka, 1996, Journal of Neuroimmunology.

Resistance of primary isolates of human immunodeficiency virus type 1 to neutralization by soluble CD4 is not due to lower affinity with the viral envelope glycoprotein gp120.

R. Schooley, R. Tizard, R. Pepinsky, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Resolution of disulfide heterogeneity in Nogo receptor 1 fusion proteins by molecular engineering

J. Relton, P. Weinreb, L. Silvian, 2010, Biotechnology and applied biochemistry.

Functional activity of anti-LINGO-1 antibody opicinumab requires target engagement at a secondary binding site

Richelle Sopko, S. Mi, X. Lee, 2020, mAbs.

Structure of the LINGO-1–Anti-LINGO-1 Li81 Antibody Complex Provides Insights into the Biology of LINGO-1 and the Mechanism of Action of the Antibody Therapy

S. Mi, X. Lee, Omar Quintero-Monzon, 2014, The Journal of Pharmacology and Experimental Therapeutics.

Blocking LINGO-1 function promotes retinal ganglion cell survival following ocular hypertension and optic nerve transection.

Wutian Wu, K. So, S. Mi, 2008, Investigative ophthalmology & visual science.

Effect of combined treatment with methylprednisolone and soluble Nogo‐66 receptor after rat spinal cord injury

T. Engber, J. Relton, S. Strittmatter, 2005, The European journal of neuroscience.

Recombinant GDNF: tetanus toxin fragment C fusion protein produced from insect cells.

I. Ay, M. Remington, P. Fishman, 2009, Biochemical and biophysical research communications.

Production of a PEGylated Fab' of the anti-LINGO-1 Li33 antibody and assessment of its biochemical and functional properties in vitro and in a rat model of remyelination.

S. Mi, X. Lee, E. Garber, 2011, Bioconjugate chemistry.

Long-acting forms of Sonic hedgehog with improved pharmacokinetic and pharmacodynamic properties are efficacious in a nerve injury model.

T. Engber, R. Pepinsky, D. Lepage, 2002, Journal of pharmaceutical sciences.

Exposure Levels of Anti-LINGO-1 Li81 Antibody in the Central Nervous System and Dose-Efficacy Relationships in Rat Spinal Cord Remyelination Models after Systemic Administration

Christilyn P. Graff, R. Pepinsky, S. Mi, 2011, Journal of Pharmacology and Experimental Therapeutics.

Stimulation of pancreatic islet beta-cell replication by oncogenes.

D. Steiner, P. Berggren, P. Arkhammar, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Constitutive negative regulation in the processing of the anti-Müllerian hormone receptor II

N. Smorodinsky, M. Ehrlich, J. Picard, 2015, Journal of Cell Science.

Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-β

P. Weinreb, T. Walz, K. P. Kilambi, 2018, Scientific Reports.