M. B. Finn

发表

Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo.

David M Holtzman, Steven Mennerick, D. Holtzman, 2005, Neuron.

Synaptic Activity Regulates Interstitial Fluid Amyloid-β Levels In Vivo

Steven Mennerick, D. Holtzman, R. S. Sloviter, 2005, Neuron.

R-isomers of Arg-Gly-Asp (RGD) mimics as potent αvβ3 inhibitors

D. Griggs, J. Malecha, J. Collins, 2007 .

Discovery of +(2-{4-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]phenyl}-cyclopropyl)acetic acid as potent and selective alphavbeta3 inhibitor: design, synthesis, and optimization.

I. Khanna, M. A. Russell, T. E. Rogers, 2007, Bioorganic & medicinal chemistry.

Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer’s disease

D. Holtzman, D. Holtzman, L. Lecea, 2014, The Journal of experimental medicine.

Integrin-associated Protein Is a Receptor for the C-terminal Domain of Thrombospondin (*)

E. Brown, S. Blystone, F. Lindberg, 1996, The Journal of Biological Chemistry.

Convergent, parallel synthesis of a series of β-substituted 1,2,4-oxadiazole butanoic acids as potent and selective αvβ3 receptor antagonists

Sarah A. Norring, Hongwei Wu, I. Khanna, 2006 .

Synthesis of pyrazoles and isoxazoles as potent αvβ3 receptor antagonists

T. Penning, M. B. Finn, W. Westlin, 2006 .

Synthesis of 2,5-thiazole butanoic acids as potent and selective αvβ3 integrin receptor antagonists with improved oral pharmacokinetic properties

Hongwei Wu, T. Penning, M. Westlin, 2006 .

Anti-tau antibody administration increases plasma tau in transgenic mice and patients with tauopathy

D. Holtzman, N. Cairns, A. Boxer, 2017, Science Translational Medicine.

apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain.

Katie Hamm, David M Holtzman, D. Holtzman, 2008, The Journal of clinical investigation.

ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

A. Fagan, J. Morris, D. Holtzman, 2017, Nature.

Apolipoprotein E4 Reduction with Antisense Oligonucleotides Decreases Neurodegeneration in a Tauopathy Model

Rosemary J. Jackson, D. Holtzman, B. Hyman, 2021, Annals of neurology.

The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans

D. Holtzman, P. Fuller, Joel C Geerling, 2019, Science.

P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model.

A. Fagan, D. Holtzman, S. Paul, 2005, The Journal of clinical investigation.

Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy

D. Holtzman, Jasmin Herz, I. Smirnov, 2023, Nature.

Apolipoprotein E4 Reduction with Antisense Oligonucleotides Decreases Neurodegeneration in a Tauopathy Model

Rosemary J. Jackson, D. Holtzman, B. Hyman, 2021 .

Lack of hepatic apoE does not influence early Aβ deposition: observations from a new APOE knock-in model

D. Holtzman, R. Tanzi, J. Ulrich, 2019, Molecular Neurodegeneration.

TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy

D. Holtzman, M. Colonna, J. Ulrich, 2017, Proceedings of the National Academy of Sciences.

Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation

Adam P. Silverman, Jennifer A. Getz, D. Holtzman, 2018, The Journal of clinical investigation.

Age-Dependent Effects of apoE Reduction Using Antisense Oligonucleotides in a Model of β-amyloidosis

D. Holtzman, T. Esparza, J. Ulrich, 2017, Neuron.

Rapid Microglial Response Around Amyloid Pathology after Systemic Anti-Aβ Antibody Administration in PDAPP Mice

D. Holtzman, B. Hyman, M. Meyer-Luehmann, 2008, The Journal of Neuroscience.

Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer’s disease

D. Holtzman, D. Holtzman, L. Lecea, 2014, The Journal of experimental medicine.

In Vivo Microdialysis Reveals Age-Dependent Decrease of Brain Interstitial Fluid Tau Levels in P301S Human Tau Transgenic Mice

D. Holtzman, V. Lee, E. Mandelkow, 2011, The Journal of Neuroscience.

Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2

D. Holtzman, L. Piccio, M. Colonna, 2014, Molecular Neurodegeneration.

Lack of hepatic apoE does not influence early Aβ deposition: observations from a new APOE knock-in model

D. Holtzman, R. Tanzi, J. Ulrich, 2019, Molecular Neurodegeneration.

Apolipoprotein E, Especially Apolipoprotein E4, Increases the Oligomerization of Amyloid β Peptide

D. Holtzman, B. Hyman, M. Frosch, 2012, The Journal of Neuroscience.

Haploinsufficiency of Human APOE Reduces Amyloid Deposition in a Mouse Model of Amyloid-β Amyloidosis

D. Holtzman, Hong Jiang, Hyejin Yoon, 2011, The Journal of Neuroscience.

Nicotinamide mononucleotide adenylyl transferase 1 protects against acute neurodegeneration in developing CNS by inhibiting excitotoxic-necrotic cell death

D. Holtzman, J. Milbrandt, J. Neil, 2011, Proceedings of the National Academy of Sciences.

Obstructive sleep apnea decreases central nervous system–derived proteins in the cerebrospinal fluid

A. Fagan, D. Holtzman, J. Ladenson, 2016, Annals of neurology.

Obstructive sleep apnea treatment, slow wave activity, and amyloid‐β

A. Fagan, D. Holtzman, M. B. Finn, 2019, Annals of neurology.

Neurobiology of Disease Apolipoprotein E , Especially Apolipoprotein E 4 , Increases the Oligomerization of Amyloid Peptide

D. Holtzman, B. Hyman, M. Frosch, 2017 .

Brief Definitive Report

D. Holtzman, B. J. Snider, M. Yanagisawa, 2003 .

Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2

D. Holtzman, L. Piccio, M. Colonna, 2014, Molecular Neurodegeneration.

R-isomers of Arg-Gly-Asp (RGD) mimics as potent alphavbeta3 inhibitors.

D. Griggs, J. Collins, M. B. Finn, 2007, Bioorganic & medicinal chemistry.