B. Darnay

发表

Sanguinarine (Pseudochelerythrine) Is a Potent Inhibitor of NF-κB Activation, IκBα Phosphorylation, and Degradation*

B. Aggarwal, M. Chaturvedi, S. Agarwal, 1997, The Journal of Biological Chemistry.

B. Lamothe, B. Darnay, Jörg J. Jacoby, 2007, Advances in experimental medicine and biology.

A TRAF2 binding independent region of TNFR2 is responsibl for TRAF2 depletion and enhancement of cytotoxicity driven b TNFR1

B. Darnay, Lucía Cabal-Hierro, Artime Noelia, 2013, Oncotarget.

A TRAF 2 binding independent region of TNFR 2 is responsibl for TRAF 2 depletion and enhancement of cytotoxicity driven b TNFR 1

Miguel A. Prado, P. Casado, B. Darnay, 2014 .

Ubiquitin-Specific Protease 25 Regulates TLR4-Dependent Innate Immune Responses Through Deubiquitination of the Adaptor Protein TRAF3

Shao-Cong Sun, C. Dong, Xin Lin, 2013, Science Signaling.

A20 Negatively Regulates T Cell Receptor Signaling to NF-κB by Cleaving Malt1 Ubiquitin Chains1

P. Marynen, J. Ruland, D. Krappmann, 2009, The Journal of Immunology.

Site-specific Tyrosine Phosphorylation of IκBα Negatively Regulates Its Inducible Phosphorylation and Degradation*

B. Aggarwal, Sanjaya Singh, B. Darnay, 1996, The Journal of Biological Chemistry.

Sanguinarine (pseudochelerythrine) is a potent inhibitor of NF-kappaB activation, IkappaBalpha phosphorylation, and degradation.

B. Aggarwal, M. Chaturvedi, S. Agarwal, 1997, The Journal of biological chemistry.

The E3 Ubiquitin Ligase TRAF6 Intercedes in Starvation-Induced Skeletal Muscle Atrophy through Multiple Mechanisms

S. Bhatnagar, Ashok Kumar, Yongwon Choi, 2012, Molecular and Cellular Biology.

Deletion of TAK1 in the Myeloid Lineage Results in the Spontaneous Development of Myelomonocytic Leukemia in Mice

Michael D. Schneider, Jing Wang, Z. Estrov, 2012, PloS one.

Identification of a protein kinase associated with the cytoplasmic domain of the p60 tumor necrosis factor receptor.

B. Aggarwal, B. Darnay, S. Reddy, 1994, The Journal of biological chemistry.

Association between imatinib-resistant BCR-ABL mutation-negative leukemia and persistent activation of LYN kinase.

N. Donato, W. Bornmann, M. Talpaz, 2008, Journal of the National Cancer Institute.

Targeted ablation of TRAF6 inhibits skeletal muscle wasting in mice

S. Bhatnagar, Yongwon Choi, Ashok Kumar, 2010, The Journal of cell biology.

TRAF6 ubiquitin ligase is essential for RANKL signaling and osteoclast differentiation.

B. Lamothe, B. Darnay, Arnaud Besse, 2007, Biochemical and biophysical research communications.

FHL 2 inhibits the activated osteoclast in a TRAF 6-dependent manner

R. Schüle, S. Teitelbaum, F. Ross, 2005 .

FHL2 inhibits the activated osteoclast in a TRAF6-dependent manner.

R. Schüle, S. Teitelbaum, F. Ross, 2005, The Journal of clinical investigation.

Inhibition of protein tyrosine phosphatases causes phosphorylation of tyrosine‐331 in the p60 TNF receptor and inactivates the receptor‐associated kinase

B. Aggarwal, B. Darnay, Bryant G Darnay, 1997, FEBS letters.

The E3 Ubiquitin Ligase TRAF6 Intercedes in Starvation-Induced Skeletal Muscle Atrophy through Multiple Mechanisms any regulatory mediation of ER chaperones in skeletal

S. Bhatnagar, Yongwon Choi, B. Darnay, 2012 .

Site-specific tyrosine phosphorylation of IkappaBalpha negatively regulates its inducible phosphorylation and degradation.

B. Aggarwal, B. Darnay, S. Singh, 1996, The Journal of biological chemistry.

Activation of NF-κB by RANK Requires Tumor Necrosis Factor Receptor-associated Factor (TRAF) 6 and NF-κB-inducing Kinase

B. Aggarwal, P. Moore, J. Ni, 1999, The Journal of Biological Chemistry.

Characterization of the Intracellular Domain of Receptor Activator of NF-κB (RANK)

B. Aggarwal, P. Moore, J. Ni, 1998, The Journal of Biological Chemistry.

Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase.

B. Aggarwal, P. Moore, Jian Ni, 1998, The Journal of biological chemistry.

Nuclear Tumor Necrosis Factor Receptor-associated Factor 6 in Lymphoid Cells Negatively Regulates c-Myb-mediated Transactivation through Small Ubiquitin-related Modifier-1 Modification*

L. Pham, Y. Lin-Lee, Hai-jun Zhou, 2008, Journal of Biological Chemistry.

The RING Domain and First Zinc Finger of TRAF6 Coordinate Signaling by Interleukin-1, Lipopolysaccharide, and RANKL*

B. Lamothe, B. Darnay, Alejandro D. Campos, 2008, Journal of Biological Chemistry.

This information is current as Ubiquitin Chains B by Cleaving Malt 1 κ Signaling to NFA 20 Negatively Regulates T Cell Receptor

P. Marynen, J. Ruland, D. Krappmann, 2009 .

Ubiquitin Chains B by Cleaving Malt 1 κ Signaling to NFA 20 Negatively Regulates T Cell Receptor

P. Marynen, J. Ruland, D. Krappmann, 2009 .

Inhibition of RANKL-mediated osteoclast differentiation by selective TRAF6 decoy peptides.

Sujay K. Singh, B. Darnay, A. Poblenz, 2007, Biochemical and biophysical research communications.

TNF and its receptor antibody agonist differ in mediation of cellular responses.

B. Aggarwal, R. Lapushin, T. Kohno, 1994, Journal of immunology.

Physical and functional association of a serine-threonine protein kinase to the cytoplasmic domain of the p80 form of the human tumor necrosis factor receptor in human histiocytic lymphoma U-937 cells.

B. Aggarwal, B. Darnay, S. Reddy, 1994, The Journal of biological chemistry.

TAK1-dependent Signaling Requires Functional Interaction with TAB2/TAB3*

Su-Chang Lin, Hao Wu, B. Lamothe, 2006, Journal of Biological Chemistry.

3-Hydroxy-3-methylglutaryl-CoA reductase.

M. Hedl, P. Kennelly, K. Bischoff, 2000, Methods in enzymology.

Molecular Basis for the Unique Deubiquitinating Activity of the NF-κ B Inhibitor A 20

Y. Lo, Su-Chang Lin, B. Lamothe, 2008 .

Site-specific Lys-63-linked Tumor Necrosis Factor Receptor-associated Factor 6 Auto-ubiquitination Is a Critical Determinant of IκB Kinase Activation*

Hao Wu, Hao Wu, B. Lamothe, 2006, Journal of Biological Chemistry.

Glioma cells deficient in urokinase plaminogen activator receptor expression are susceptible to tumor necrosis factor-alpha-related apoptosis-inducing ligand-induced apoptosis.

G. Kouraklis, B. Aggarwal, D. Dinh, 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

Distinct molecular mechanism for initiating TRAF6 signalling

Hao Wu, Yongwon Choi, Sujay K. Singh, 2002, Nature.

Signal transduction by tumour necrosis factor and tumour necrosis factor related ligands and their receptors

B. Aggarwal, B. Darnay, Bryant G Darnay, 1999, Annals of the rheumatic diseases.

Overexpression of the p80 TNF receptor leads to TNF-dependent apoptosis, nuclear factor-kappa B activation, and c-Jun kinase activation.

R. Heller, B. Aggarwal, R. Heller, 1998, Journal of immunology.

Early events in TNF signaling: a story of associations and dissociations

B. Aggarwal, B. Darnay, 1997, Journal of leukocyte biology.

CARMA3 deficiency abrogates G protein-coupled receptor-induced NF-κB activation

Y. You, C. Dong, Xin Lin, 2007 .

Evidence that TNF-TNFR1-TRADD-TRAF2-RIP-TAK1-IKK pathway mediates constitutive NF-κB activation and proliferation in human head and neck squamous cell carcinoma

B. Aggarwal, J. Myers, Y. Takada, 2007, Oncogene.

TAK1 Is Essential for Osteoclast Differentiation and Is an Important Modulator of Cell Death by Apoptosis and Necroptosis

M. Xie, B. Lamothe, B. Darnay, 2012, Molecular and Cellular Biology.

An efficient method for pouring sequencing gels.

B. Darnay, M. Engel, 1992, BioTechniques.

Phosphorylation and ubiquitination of the IκB kinase complex by two distinct signaling pathways

J. Penninger, H. Sakurai, Y. You, 2007, The EMBO journal.

A Novel High-Throughput Screening System Identifies a Small Molecule Repressive for Matrix Metalloproteinase-9 Expression

Zhengxin Wang, R. Nair, D. Boyd, 2008, Molecular Pharmacology.

Hypoxia-induced SUMOylation of E3 ligase HAF determines specific activation of HIF2 in clear-cell renal cell carcinoma.

T. Ho, E. Jonasch, G. Powis, 2015, Cancer research.

Hypoxia-Associated Factor, a Novel E3-Ubiquitin Ligase, Binds and Ubiquitinates Hypoxia-Inducible Factor 1α, Leading to Its Oxygen-Independent Degradation

G. Powis, B. Darnay, M. Koh, 2008, Molecular and Cellular Biology.

Cthrc1 Is a Positive Regulator of Osteoblastic Bone Formation

J. Deng, R. Behringer, K. Kwan, 2008, PloS one.

The E3 Ligase TRAF6 Regulates Akt Ubiquitination and Activation

Xin Lin, Chia-Hsin Chan, Hui-Kuan Lin, 2009, Science.

Structural basis for the lack of E2 interaction in the RING domain of TRAF2.

Hao Wu, B. Lamothe, B. Darnay, 2009, Biochemistry.

The p60 Tumor Necrosis Factor (TNF) Receptor-associated Kinase (TRAK) Binds Residues 344–397 within the Cytoplasmic Domain Involved in TNF Signaling (*)

B. Aggarwal, M. Chaturvedi, Sanjaya Singh, 1995, The Journal of Biological Chemistry.

BSTA Promotes mTORC2-Mediated Phosphorylation of Akt1 to Suppress Expression of FoxC2 and Stimulate Adipocyte Differentiation

Milind B. Suraokar, G. Mills, Yiling Lu, 2013, Science Signaling.

E2 interaction and dimerization in the crystal structure of TRAF6

Greg L. Hura, Y. Lo, Su-Chang Lin, 2009, Nature Structural &Molecular Biology.

Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif.

B. Aggarwal, P. Moore, J. Ni, 1999, The Journal of biological chemistry.

Characterization of the M(r) 65,000 lymphokine-activated killer proteins phosphorylated after tumor target binding: evidence that pp65a and pp65b are phosphorylated forms of L-plastin.

D. Johnston, M. Frederick, E. Grimm, 1996, Cancer Research.

Receptor activator of nuclear factor-kappaB ligand-induced nuclear factor of activated T cells (C1) autoregulates its own expression in osteoclasts and mediates the up-regulation of tartrate-resistant acid phosphatase.

Sujay K. Singh, J. Pike, B. Darnay, 2008, Molecular endocrinology.

Multiple functions of Osterix are required for bone growth and homeostasis in postnatal mice

Jian Q. Feng, B. Darnay, K. Sinha, 2010, Proceedings of the National Academy of Sciences.

Cycles of Ubiquitination and Deubiquitination Critically Regulate Growth Factor–Mediated Activation of Akt Signaling

W. Gu, Chien-Feng Li, Y. Jeong, 2013, Science Signaling.

Critical Role of Monoubiquitination of Histone H2AX Protein in Histone H2AX Phosphorylation and DNA Damage Response*

Juan Wu, Y. Jeong, Chia-Hsin Chan, 2011, The Journal of Biological Chemistry.

CARMA3 deficiency abrogates G protein-coupled receptor-induced NF-{kappa}B activation.

Y. You, C. Dong, Xin Lin, 2007, Genes & development.

TRAF6 and the Three C-Terminal Lysine Sites on IRF7 Are Required for Its Ubiquitination-Mediated Activation by the Tumor Necrosis Factor Receptor Family Member Latent Membrane Protein 1

J. Pagano, B. Darnay, S. Ning, 2008, Molecular and Cellular Biology.

TWEAK Mediates Signal Transduction and Differentiation of RAW264.7 Cells in the Absence of Fn14/TweakR

M. Talpaz, B. Darnay, T. C. Polek, 2003, Journal of Biological Chemistry.

NF-κB Signal Triggering and Termination by Tumor Necrosis Factor Receptor 2*

J. Iglesias, B. Darnay, Lucía Cabal-Hierro, 2011, The Journal of Biological Chemistry.

Inhibition of prostate tumor growth and bone remodeling by the vascular targeting agent VEGF121/rGel.

M. Rosenblum, C. Sikes, N. Navone, 2006, Cancer research.

Chapter 9 Human cytokines

B. Aggarwal, B. Darnay, 1996 .

/ rGel 121 by the Vascular Targeting Agent VEGF Inhibition of Prostate Tumor Growth and Bone Remodeling

M. Rosenblum, C. Sikes, N. Navone, 2006 .

Necroptosisof Cell Death by Apoptosis and Differentiation and Is an Important TAK1 Is Essential for Osteoclast

M. Xie, B. Lamothe, B. Darnay, 2014 .

Reconstitution of nuclear factor kappa B activation induced by tumor necrosis factor requires membrane-associated components. Comparison with pathway activated by ceramide.

B. Aggarwal, M. Chaturvedi, B. Darnay, 1994, The Journal of biological chemistry.

Molecular basis for the unique deubiquitinating activity of the NF-kappaB inhibitor A20.

Y. Lo, Su-Chang Lin, Hao Wu, 2008, Journal of molecular biology.

TRAF-interacting protein (TRIP) is a RING-dependent ubiquitin ligase.

B. Darnay, Arnaud Besse, Alejandro D. Campos, 2007, Biochemical and biophysical research communications.

Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) and TGFβ-activated Kinase 1 (TAK1) Play Essential Roles in the C-type Lectin Receptor Signaling in Response to Candida albicans Infection*

Xin Lin, B. Darnay, S. Gorjestani, 2012, The Journal of Biological Chemistry.

Identification of the principal catalytically important acidic residue of 3-hydroxy-3-methylglutaryl coenzyme A reductase.

V. Rodwell, B. Darnay, V W Rodwell, 1990, The Journal of biological chemistry.

Modulation of Syrian hamster 3-hydroxy-3-methylglutaryl-CoA reductase activity by phosphorylation. Role of serine 871.

R. V. Omkumar, V. Rodwell, B. Darnay, 1994, The Journal of biological chemistry.

Identification of the catalytically important histidine of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

V. Rodwell, B. Darnay, V W Rodwell, 1992, The Journal of biological chemistry.

Syrian hamster 3-hydroxy-3-methylglutaryl-coenzyme A reductase expressed in Escherichia coli: production of homogeneous protein.

V. Rodwell, B. Darnay, K. Frimpong, 1993, Protein expression and purification.

Sujay K. Singh, J. Pike, B. Darnay, 2008, Molecular Endocrinology.

Dasatinib inhibits both osteoclast activation and prostate cancer PC-3 cell-induced osteoclast formation

C. Logothetis, F. Lee, Jerry T. Thompson, 2009, Cancer biology & therapy.

Targeted ablation of TRAF6 inhibits skeletal muscle wasting in mice

S. Bhatnagar, Yongwon Choi, Ashok Kumar, 2010, The Journal of cell biology.

His865 is the catalytically important histidyl residue of Syrian hamster 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

V. Rodwell, B. Darnay, 1993, The Journal of biological chemistry.

The p80 TNF receptor‐associated kinase (p80TRAK) associates with residues 354–397 of the p80 cytoplasmic domain: similarity to casein kinase

B. Aggarwal, Sanjaya Singh, B. Darnay, 1997, FEBS letters.

Structural basis for the lack of E2 interaction in the RING domain of TRAF2.

B. Lamothe, B. Darnay, Q. Yin, 2009, Biochemistry.

Structural basis for lack of E 2 interaction in the RING of TRAF 2

B. Lamothe, B. Darnay, Q. Yin, 2010 .