R. DeBose-Boyd

发表

Transport-Dependent Proteolysis of SREBP Relocation of Site-1 Protease from Golgi to ER Obviates the Need for SREBP Transport to Golgi

P. Espenshade, J. Goldstein, Michael S. Brown, 1999, Cell.

Hypoxia Stimulates Degradation of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase through Accumulation of Lanosterol and Hypoxia-Inducible Factor-mediated Induction of Insigs*

J. McDonald, R. Bruick, R. DeBose-Boyd, 2007, Journal of Biological Chemistry.

Protein Sensors for Membrane Sterols

Joseph L. Goldstein, J. Goldstein, Michael S. Brown, 2006, Cell.

Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA in rat hepatoma cells requires endogenous LXR ligands.

M. Brown, J. Goldstein, Michael S. Brown, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR

B. Shan, J. Goldstein, Michael S. Brown, 2001, Proceedings of the National Academy of Sciences of the United States of America.

UbiA prenyltransferase domain–containing protein-1 modulates HMG-CoA reductase degradation to coordinate synthesis of sterol and nonsterol isoprenoids

D. Jun, R. DeBose-Boyd, M. Schumacher, 2017, The Journal of Biological Chemistry.

Schnyder corneal dystrophy-associated UBIAD1 is defective in MK-4 synthesis and resists autophagy-mediated degradation[S]

N. Grishin, L. Kinch, D. Jun, 2020, Journal of Lipid Research.

Insig-dependent Ubiquitination and Degradation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Stimulated by δ- and γ-Tocotrienols*

B. Song, R. DeBose-Boyd, 2006, Journal of Biological Chemistry.

Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol.

B. Song, R. DeBose-Boyd, N. Javitt, 2005, Cell metabolism.

Failure to Cleave Sterol Regulatory Element-binding Proteins (SREBPs) Causes Cholesterol Auxotrophy in Chinese Hamster Ovary Cells with Genetic Absence of SREBP Cleavage-activating Protein*

M. Brown, J. Goldstein, Michael S. Brown, 1999, The Journal of Biological Chemistry.

Sterols regulate cycling of SREBP cleavage-activating protein (SCAP) between endoplasmic reticulum and Golgi.

M. S. Brown, M. Brown, J. Goldstein, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Sterol-regulated Degradation of Insig-1 Mediated by the Membrane-bound Ubiquitin Ligase gp78*

Joon-No Lee, Jin Ye, B. Song, 2006, Journal of Biological Chemistry.

Hypoxia-inducible factor 1α activates insulin-induced gene 2 (Insig-2) transcription for degradation of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase in the liver

J. Brugarolas, Y. Jo, R. DeBose-Boyd, 2017, The Journal of Biological Chemistry.

Schistosoma mansoni: characterization of an alpha 1-3 fucosyltransferase in adult parasites.

R. Cummings, R. DeBose-Boyd, A. Nyame, 1996, Experimental parasitology.

Regulation of cholesterol and fatty acid synthesis.

Jin Ye, R. DeBose-Boyd, 2011, Cold Spring Harbor perspectives in biology.

Underlying mechanisms for sterol-induced ubiquitination and ER-associated degradation of HMG CoA reductase.

R. DeBose-Boyd, Brittany M. Johnson, 2018, Seminars in cell & developmental biology.

A helping hand for cytochrome p450 enzymes.

R. DeBose-Boyd, 2007, Cell metabolism.

Enhanced ER-associated degradation of HMG CoA reductase causes embryonic lethality associated with Ubiad1 deficiency

Xueyan Fu, S. Booth, Y. Jo, 2020, eLife.

Schnyder corneal dystrophy-associated UBIAD1 inhibits ER-associated degradation of HMG CoA reductase in mice

J. McDonald, Bonne M. Thompson, Y. Jo, 2019, eLife.

Sufficient production of geranylgeraniol is required to maintain endotoxin tolerance in macrophages

Joon-No Lee, Jin Ye, R. DeBose-Boyd, 2013, Journal of Lipid Research.

Intramembrane glycine mediates multimerization of Insig-2, a requirement for sterol regulation in Chinese hamster ovary cells

R. DeBose-Boyd, P. C. Lee, 2010, Journal of Lipid Research.

Insig-mediated, Sterol-accelerated Degradation of the Membrane Domain of Hamster 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase in Insect Cells*

R. DeBose-Boyd, S. Lee, Andrew D. Nguyen, 2009, The Journal of Biological Chemistry.

Amplification of the gene for SCAP, coupled with Insig-1 deficiency, confers sterol resistance in mutant Chinese hamster ovary cells Published, JLR Papers in Press, June 22, 2007.

Pingsheng Liu, Wei-ping Li, R. DeBose-Boyd, 2007, Journal of Lipid Research.

Contribution of Accelerated Degradation to Feedback Regulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase and Cholesterol Metabolism in the Liver*

J. McDonald, Matthew A. Mitsche, R. DeBose-Boyd, 2016, The Journal of Biological Chemistry.

Isolation of Mutant Cells Lacking Insig-1 through Selection with SR-12813, an Agent That Stimulates Degradation of 3-Hydroxy-3-methylglutaryl-Coenzyme A Reductase*

R. B. Rawson, B. Song, R. DeBose-Boyd, 2004, Journal of Biological Chemistry.

Regulated degradation of HMG CoA reductase requires conformational changes in sterol-sensing domain

R. DeBose-Boyd, Xiaochun Li, Xiaofeng Qi, 2022, Nature Communications.

Isolation of Sterol-resistant Chinese Hamster Ovary Cells with Genetic Deficiencies in Both Insig-1 and Insig-2*

R. DeBose-Boyd, P. C. Lee, Navdar Sever, 2005, Journal of Biological Chemistry.

Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8

Y. Jo, R. DeBose-Boyd, Peter V. Sguigna, 2011, Proceedings of the National Academy of Sciences.

Lipid-regulated degradation of HMG-CoA reductase and Insig-1 through distinct mechanisms in insect cells

Y. Jo, R. DeBose-Boyd, Rebecca A. Faulkner, 2013, Journal of Lipid Research.

Membrane Extraction of HMG CoA Reductase as Determined by Susceptibility of Lumenal Epitope to In Vitro Protease Digestion.

R. DeBose-Boyd, Lindsey L. Morris, 2017, Methods in molecular biology.

Geranylgeranyl-regulated transport of the prenyltransferase UBIAD1 between membranes of the ER and Golgi[S]

D. Jun, Y. Jo, R. DeBose-Boyd, 2016, Journal of Lipid Research.

Knowing when to let go: endosomal release of LDL from the LDL-Receptor.

R. DeBose-Boyd, 2004, Molecular cell.

Geranylgeranyl-Mediated Control of HMG CoA Reductase

D. Jun, Y. Jo, R. DeBose-Boyd, 2022 .

Sequential Actions of the AAA-ATPase Valosin-containing Protein (VCP)/p97 and the Proteasome 19 S Regulatory Particle in Sterol-accelerated, Endoplasmic Reticulum (ER)-associated Degradation of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase*

D. Jun, R. DeBose-Boyd, J. Seemann, 2014, The Journal of Biological Chemistry.

Sterol-induced dislocation of 3-hydroxy-3-methylglutaryl coenzyme A reductase from membranes of permeabilized cells

Y. Jo, R. DeBose-Boyd, T. T. Dinh, 2013, Molecular biology of the cell.

Membrane-associated Ubiquitin Ligase Complex Containing gp78 Mediates Sterol-accelerated Degradation of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase*

Y. Jo, R. DeBose-Boyd, Peter V. Sguigna, 2011, The Journal of Biological Chemistry.

Synergistic Impact of d‐δ‐Tocotrienol and Geranylgeraniol on the Growth and HMG CoA Reductase of Human DU145 Prostate Carcinoma Cells

H. Mo, B. McFarlin, Hoda Yeganehjoo, 2016, Nutrition and cancer.

Geranylgeraniol suppresses the viability of human DU145 prostate carcinoma cells and the level of HMG CoA reductase

H. Mo, Hoda Yeganehjoo, Zhi-Ling Yu, 2013, Experimental biology and medicine.

Opening up new fronts in the fight against cholesterol

J. Horton, R. DeBose-Boyd, 2013, eLife.

Feedback regulation of cholesterol synthesis: sterol-accelerated ubiquitination and degradation of HMG CoA reductase

R. DeBose-Boyd, 2008, Cell Research.

Significance and regulation of lipid metabolism.

R. DeBose-Boyd, 2018, Seminars in cell & developmental biology.

SREBPs in Lipid Metabolism, Insulin Signaling, and Beyond.

Jin Ye, R. DeBose-Boyd, 2018, Trends in biochemical sciences.

Insig-dependent Ubiquitination and Degradation of Mammalian 3-Hydroxy-3-methylglutaryl-CoA Reductase Stimulated by Sterols and Geranylgeraniol*

Joseph L Goldstein, J. Goldstein, Michael S. Brown, 2003, Journal of Biological Chemistry.

Schistosoma mansoni:Characterization of an α1–3 Fucosyltransferase in Adult Parasites

R. Cummings, R. DeBose-Boyd, A. Nyame, 1996 .

Expression of Lex antigen in Schistosoma japonicum and S.haematobium and immune responses to Lex in infected animals: lack of Lex expression in other trematodes and nematodes.

R. Cummings, V. Tsang, R. DeBose-Boyd, 1998, Glycobiology.

Molecular cloning and characterization of an alpha1,3 fucosyltransferase, CEFT-1, from Caenorhabditis elegans.

R. Cummings, R. DeBose-Boyd, A. Nyame, 1998, Glycobiology.

The prenyltransferase UBIAD1 is the target of geranylgeraniol in degradation of HMG CoA reductase

Y. Jo, R. DeBose-Boyd, J. Seemann, 2015, eLife.

Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain.

J. Goldstein, Michael S. Brown, R. DeBose-Boyd, 2003, Molecular cell.

Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase.

B. Song, R. DeBose-Boyd, Navdar Sever, 2005, Molecular cell.

Multiple Dietary Vitamin K Forms Are Converted to Tissue Menaquinone-4 in Mice.

Xueyan Fu, S. Booth, J. Mason, 2021, The Journal of nutrition.

Transcription Factor Hepatocyte Nuclear Factor-1β Regulates Renal Cholesterol Metabolism.

P. Igarashi, M. Pontoglio, K. Aboudehen, 2015, Journal of the American Society of Nephrology : JASN.

Membrane Topology of UbiA Prenyltransferase Domain-Containing Protein-1 (UBIAD1), a Novel Regulator of Cholesterol Homeostasis

R. DeBose-Boyd, Brittany M. Johnson, Dong-Jae Jun, 2023, bioRxiv.

In mammalian cells, the endoplasmic reticulum-associated degradation (ERAD) pathway controls levels of two integral membrane proteins that play important roles in the main- tenance of lipid homeostasis, 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase and Insig-1. HMG-CoA reductase catalyzes the r

Y. Jo, R. DeBose-Boyd, Rebecca A. Faulkner, 2013 .

Ubiquitination of 3-Hydroxy-3-methylglutaryl-CoA Reductase in Permeabilized Cells Mediated by Cytosolic E1 and a Putative Membrane-bound Ubiquitin Ligase*

B. Song, R. DeBose-Boyd, 2004, Journal of Biological Chemistry.

Post-Translational Regulation of HMG CoA Reductase.

Y. Jo, R. DeBose-Boyd, 2022, Cold Spring Harbor perspectives in biology.

Type 1 polyisoprenoid diphosphate phosphatase modulates geranylgeranyl-mediated control of HMG CoA reductase and UBIAD1

Y. Jo, R. DeBose-Boyd, Seonghwan Hwang, 2021, eLife.

Posttranslational Regulation of HMG CoA Reductase, the Rate-Limiting Enzyme in Synthesis of Cholesterol.

R. DeBose-Boyd, M. Schumacher, 2021, Annual review of biochemistry.

Sterol-induced Dislocation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase from Endoplasmic Reticulum Membranes into the Cytosol through a Subcellular Compartment Resembling Lipid Droplets*

Richard G. W. Anderson, Pingsheng Liu, Y. Jo, 2010, The Journal of Biological Chemistry.

Uncoupling hypoxia signaling from oxygen sensing in the liver results in hypoketotic hypoglycemic death

J. Brugarolas, S. Peña-Llopis, N. Sunny, 2011, Oncogene.

Insig-dependent ubiquitination and degradation of 3-hydroxy-3-methylglutaryl coenzyme a reductase stimulated by delta- and gamma-tocotrienols.

B. Song, R. DeBose-Boyd, 2006, The Journal of biological chemistry.

Ancient ubiquitous protein-1 mediates sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl CoA reductase in lipid droplet–associated endoplasmic reticulum membranes

Y. Jo, R. DeBose-Boyd, I. Hartman, 2013, Molecular biology of the cell.

Control of cholesterol synthesis through regulated ER-associated degradation of HMG CoA reductase

Y. Jo, R. DeBose-Boyd, 2010, Critical reviews in biochemistry and molecular biology.

Structures of dimeric human NPC1L1 provide insight into mechanisms for cholesterol absorption

R. DeBose-Boyd, Xiaochun Li, T. Long, 2021, Science Advances.

Ufd1 is a cofactor of gp78 and plays a key role in cholesterol metabolism by regulating the stability of HMG-CoA reductase.

Liang Ge, Bo-Liang Li, B. Song, 2007, Cell metabolism.

Mutations within the membrane domain of HMG-CoA reductase confer resistance to sterol-accelerated degradation Published, JLR Papers in Press, November 7, 2006.

R. DeBose-Boyd, P. C. Lee, Andrew D. Nguyen, 2007, Journal of Lipid Research.

Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8

Y. Jo, R. DeBose-Boyd, Peter V. Sguigna, 2011, Proceedings of the National Academy of Sciences.

Contribution of Accelerated Degradation to Feedback Regulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase and Cholesterol Metabolism in Liver*

Matthew A. Mitsche, R. DeBose-Boyd, Seonghwan Hwang, 2016 .

Regulation of cholesterol and fatty acid synthesis.

Jin Ye, R. DeBose-Boyd, 2011, Cold Spring Harbor perspectives in biology.