R. Kaufman

发表

A naturally occurring gamma globin gene mutation enhances SP1 binding activity

K. Sykes, R. Kaufman, 1990, Molecular and cellular biology.

Biochemical, immunological, and in vivo functional characterization of B-domain-deleted factor VIII.

A. Giles, R. Kaufman, K. Tomkinson, 1993, Blood.

The effect of plasma von Willebrand factor on the binding of human factor VIII to thrombin-activated human platelets.

A. Giles, M. Nesheim, R. Kaufman, 1991, The Journal of biological chemistry.

Role of the B domain for factor VIII and factor V expression and function.

R. Kaufman, D. Pittman, K. Marquette, 1994, Blood.

Binding of factor VIII to von willebrand factor is enabled by cleavage of the von Willebrand factor propeptide and enhanced by formation of disulfide-linked multimers.

G. E. Gilbert, R. Kaufman, J. A. Morris, 1998, Blood.

Bioengineering of coagulation factor VIII for efficient expression through elimination of a dispensable disulfide loop

S. Pipe, H. Miao, S. Selvaraj, 2012, Journal of thrombosis and haemostasis : JTH.

The binding of 35S-labeled recombinant factor VIII to activated and unactivated human platelets.

A. Giles, M. Nesheim, R. Kaufman, 1988, The Journal of biological chemistry.

Posttranslational sulfation of factor V is required for efficient thrombin cleavage and activation and for full procoagulant activity.

R. Kaufman, D. Michnick, K. Tomkinson, 1994, Biochemistry.

Rare bleeding disorders

P. Mannucci, F. Peyvandi, R. Palla, 2006, Haemophilia : the official journal of the World Federation of Hemophilia.

Identification of individual tyrosine sulfation sites within factor VIII required for optimal activity and efficient thrombin cleavage.

R. Kaufman, R. Kaufman, D. Michnick, 1994, The Journal of biological chemistry.

The factor V B-domain provides two functions to facilitate thrombin cleavage and release of the light chain.

R. Kaufman, D. Pittman, K. Marquette, 1995, Blood.

Effect of von Willebrand factor coexpression on the synthesis and secretion of factor VIII in Chinese hamster ovary cells

A. Dorner, Davies, R. Kaufman, 1989 .

The role of von Willebrand factor multimers and propeptide cleavage in binding and stabilization of factor VIII.

A. Dorner, R. Kaufman, R. Wise, 1991, The Journal of biological chemistry.

Identification and functional importance of tyrosine sulfate residues within recombinant factor VIII.

J. H. Wang, R. Kaufman, R. Kaufman, 1992, Biochemistry.

Post-translational requirements for functional factor V and factor VIII secretion in mammalian cells.

R. Kaufman, K. Tomkinson, D. Pittman, 1994, The Journal of biological chemistry.

A2 domain of human recombinant-derived factor VIII is required for procoagulant activity but not for thrombin cleavage.

K. Bauer, R. Kaufman, D. Pittman, 1992, Blood.

Proteolytic requirements for thrombin activation of anti-hemophilic factor (factor VIII).

R. Kaufman, D. Pittman, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Expression of a human proprotein processing enzyme: correct cleavage of the von Willebrand factor precursor at a paired basic amino acid site.

A. Brake, P. Barr, M. Kiefer, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Site-directed mutagenesis and expression of coagulation factors VIII and V in mammalian cells.

R. Kaufman, R. Kaufman, D. Pittman, 1993, Methods in enzymology.

Cloning and expression in COS-1 cells of a full-length cDNA encoding human coagulation factor X.

T. Messier, G. Long, R. Kaufman, 1991, Gene.

LMAN1 is a molecular chaperone for the secretion of coagulation factor VIII 1

H. Hauri, D. Ginsburg, S. Pipe, 2003, Journal of thrombosis and haemostasis : JTH.

Inhibitors of 2-ketoglutarate-dependent dioxygenases block aspartyl beta-hydroxylation of recombinant human factor IX in several mammalian expression systems.

K. Berkner, P. Walsh, C. Derian, 1989, The Journal of biological chemistry.

Effect of von Willebrand factor coexpression on the synthesis and secretion of factor VIII in Chinese hamster ovary cells.

R. Kaufman, A. Dorner, D. Israel, 1989, Molecular and cellular biology.