Jaclyn L Henderson

发表

Mechanism-based inactivation (MBI) of cytochrome P450 enzymes: structure-activity relationships and discovery strategies to mitigate drug-drug interaction risks.

Hao Sun, A. Kalgutkar, R. Obach, 2012, Journal of medicinal chemistry.

Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor.

R. Kurumbail, B. L. Kormos, M. Hayward, 2015, Journal of medicinal chemistry.

Palladium-Catalyzed Coupling of Functionalized Primary and Secondary Amines with Aryl and Heteroaryl Halides: Two Ligands Suffice in Most Cases.

S. Buchwald, D. Maiti, Jaclyn L Henderson, 2010, Chemical science.

Discovery of hydroxamate bioisosteres as KAT II inhibitors with improved oral bioavailability and pharmacokinetics

J. Pandit, R. Obach, Ji-Young Kim, 2013 .

Kinase domain inhibition of leucine rich repeat kinase 2 (LRRK2) using a [1,2,4]triazolo[4,3-b]pyridazine scaffold.

R. Kurumbail, B. L. Kormos, P. Verhoest, 2014, Bioorganic & medicinal chemistry letters.

Acute inhibition of the CNS-specific kinase TTBK1 significantly lowers tau phosphorylation at several disease relevant sites

J. A. Joyce, D. Rabah, Jaclyn L Henderson, 2020, PloS one.

Mechanisms of Regulation and Diverse Activities of Tau-Tubulin Kinase (TTBK) Isoforms

Jaclyn L Henderson, D. Marcotte, B. Gao, 2020, Cellular and Molecular Neurobiology.

Benzyne in synthesis : a search for palladium catalysed three-component couplings

Jaclyn L Henderson, 2008 .

Biaryl synthesis via palladium-catalyzed aryne multicomponent coupling.

M. Greaney, Jaclyn L Henderson, Andrew S. Edwards, 2007, Organic letters.

Three-component coupling of benzyne: domino intermolecular carbopalladation.

M. Greaney, Jaclyn L Henderson, Andrew S. Edwards, 2006, Journal of the American Chemical Society.

Palladium-catalyzed amination of unprotected halo-7-azaindoles.

S. Buchwald, Jaclyn L Henderson, Sarah M. McDermott, 2010, Organic letters.

Berichtigung: The Benzyne Aza‐Claisen Reaction

G. Bertrand, M. Greaney, Jaclyn L Henderson, 2012 .

Corrigendum: The Benzyne Aza‐Claisen Reaction

G. Bertrand, M. Greaney, Jaclyn L Henderson, 2012 .

The benzyne aza-Claisen reaction.

G. Bertrand, M. Greaney, Jaclyn L Henderson, 2009, Angewandte Chemie.

Three-component coupling of benzyne: domino intermolecular carbopalladation.

M. Greaney, Jaclyn L Henderson, Andrew S. Edwards, 2006, Journal of the American Chemical Society.

Palladium-catalyzed N-arylation of 2-aminothiazoles.

S. Buchwald, Jaclyn L Henderson, Meredeth A. McGowan, 2012, Organic letters.

Synthesis of ortho-substituted nitroaromatics via improved Negishi coupling conditions

Ji-Young Kim, P. Verhoest, Jaclyn L Henderson, 2011 .

Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors

B. L. Kormos, W. Hirst, Jaclyn L Henderson, 2014 .

Chapter Four - Development of LRRK2 Kinase Inhibitors for Parkinson's Disease

B. L. Kormos, W. Hirst, Jaclyn L Henderson, 2014 .

Palladium‐Catalyzed Coupling of Functionalized Primary and Secondary Amines with Aryl and Heteroaryl Halides: Two Ligands Suffice in Most Cases.

S. Buchwald, D. Maiti, Jaclyn L Henderson, 2011 .

Palladium-Catalyzed N-Arylation of 2-Aminothiazoles

S. Buchwald, Jaclyn L Henderson, Meredeth A. McGowan, 2012 .

Efficient Pd-catalyzed amination reactions for heterocycle functionalization.

S. Buchwald, Jaclyn L Henderson, 2010, Organic letters.

Design and optimization of selective protein kinase C θ (PKCθ) inhibitors for the treatment of autoimmune diseases.

L. Settimo, A. Tanner, Jaclyn L Henderson, 2013, Journal of medicinal chemistry.

Tandem thia-Fries rearrangement--cyclisation of 2-(trimethylsilyl)phenyl trifluoromethanesulfonate benzyne precursors.

M. Greaney, Jaclyn L Henderson, G. Ernouf, 2013, Chemical communications.