Jeffery W Kelly

发表

Chemical chaperones increase the cellular activity of N370S β-glucosidase: A therapeutic strategy for Gaucher disease

Ernest Beutler, Chi-Huey Wong, Chi‐Huey Wong, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis.

John R Yates, Gerard Manning, Yoshihiro Matsumura, 2010, Nature chemical biology.

Functional Amyloid Formation within Mammalian Tissue

Atanas V Koulov, Douglas M Fowler, D. Fowler, 2005, PLoS biology.

Structural insight into pH-induced conformational changes within the native human transthyretin tetramer.

James C Sacchettini, J. Sacchettini, J. Kelly, 2008, Journal of molecular biology.

An experimental survey of the transition between two-state and downhill protein folding scenarios

Amelia A. Fuller, Martin Gruebele, Peter Wipf, 2008, Proceedings of the National Academy of Sciences.

Determinants for dephosphorylation of the RNA polymerase II C‐terminal domain by Scp1

Yan Zhang, Joseph P Noel, Jianmin Gao, 2006, Molecular cell.

Backbone-Backbone H-Bonds Make Context-Dependent Contributions to Protein Folding Kinetics and Thermodynamics: Lessons from Amide-to-Ester Mutations.

J. Kelly, E. Powers, S. Deechongkit, 2005, Advances in protein chemistry.

Structure-function-folding relationship in a WW domain.

Yan Zhang, Martin Gruebele, Joseph P Noel, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Pharmacologic chaperoning as a strategy to treat Gaucher disease

J. Kelly, Anu R Sawkar, Jeffery W Kelly, 2007, The FEBS journal.

Opposing Activities Protect Against Age-Onset Proteotoxicity

Ehud Cohen, E. Cohen, J. Kelly, 2006, Science.

Temporal requirements of insulin/IGF-1 signaling for proteotoxicity protection

Ehud Cohen, E. Cohen, J. Kelly, 2010, Aging cell.

Kinetic stabilization of an oligomeric protein by a single ligand binding event.

Steven M. Johnson, Ian A Wilson, I. Wilson, 2005, Journal of the American Chemical Society.

Functional amyloid--from bacteria to humans.

Atanas V Koulov, Douglas M Fowler, D. Fowler, 2007, Trends in biochemical sciences.

Beta-sheet folding mechanisms from perturbation energetics.

Martin Gruebele, H. Nguyen, M. Gruebele, 2006, Current opinion in structural biology.

Enhanced Aromatic Sequons Increase Oligosaccharyltransferase Glycosylation Efficiency and Glycan Homogeneity.

Stuart M Haslam, Anne Dell, Wentao Chen, 2015, Chemistry & biology.

Metalloendoprotease cleavage triggers gelsolin amyloidogenesis

John D. Venable, J. Yates, J. Kelly, 2005, The EMBO journal.

Biological and chemical approaches to diseases of proteostasis deficiency.

R. Morimoto, J. Kelly, E. Powers, 2009, Annual review of biochemistry.

Diflunisal analogues stabilize the native state of transthyretin. Potent inhibition of amyloidogenesis.

James C Sacchettini, J. Sacchettini, J. Kelly, 2004, Journal of medicinal chemistry.

Adsorption of beta-hairpin peptides on the surface of water: a neutron reflection study.

Jeffery W Kelly, Shiamalee Perumal, Evan T Powers, 2003, Journal of the American Chemical Society.

Engineering a beta-sheet protein toward the folding speed limit.

Martin Gruebele, Marcus Jäger, H. Nguyen, 2005, The journal of physical chemistry. B.

Chemical chaperones and permissive temperatures alter localization of Gaucher disease associated glucocerebrosidase variants.

Klaus-Peter Zimmer, J. Kelly, W. Balch, 2006, ACS chemical biology.

NMR solution structure of the isolated Apo Pin1 WW domain: comparison to the x-ray crystal structures of Pin1.

J. Kelly, Jeffery W Kelly, Kai Liu, 2002, Biopolymers.

The effect of backbone cyclization on the thermodynamics of beta-sheet unfolding: stability optimization of the PIN WW domain.

J. Kelly, S. Deechongkit, Jeffery W Kelly, 2002, Journal of the American Chemical Society.

ALS mutants of human superoxide dismutase form fibrous aggregates via framework destabilization.

John A Tainer, J. Tainer, E. Getzoff, 2003, Journal of molecular biology.

Amylin proprotein processing generates progressively more amyloidogenic peptides that initially sample the helical state.

Gerard J A Kroon, H Jane Dyson, H. Dyson, 2008, Biochemistry.

Structure-based design of kinetic stabilizers that ameliorate the transthyretin amyloidoses.

Steven M. Johnson, Ian A Wilson, I. Wilson, 2010, Current opinion in structural biology.

Gaucher disease-associated glucocerebrosidases show mutation-dependent chemical chaperoning profiles.

Klaus-Peter Zimmer, Ernest Beutler, Chi-Huey Wong, 2005, Chemistry & biology.