Paul Saftig

发表

The "a disintegrin and metalloprotease" (ADAM) family of sheddases: physiological and cellular functions.

P. Saftig, K. Reiss, Karina Reiss, 2009, Seminars in cell & developmental biology.

Cathepsin K: a cysteine protease with unique kinin-degrading properties.

P. Saftig, S. Duchêne, D. Brömme, 2004, The Biochemical journal.

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

Hugo Vanderstichele, Wim Annaert, H. Vanderstichele, 1998, Nature.

A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain

William J. Ray, Michael S. Wolfe, Wim Annaert, 1999, Nature.

Autophagy: a lysosomal degradation pathway with a central role in health and disease.

Eeva-Liisa Eskelinen, P. Saftig, E. Eskelinen, 2009, Biochimica et biophysica acta.

LIMP-2 Is a Receptor for Lysosomal Mannose-6-Phosphate-Independent Targeting of β-Glucocerebrosidase

P. Saftig, M. Schwake, H. Hughes, 2007, Cell.

Phenotypic and Biochemical Analyses of BACE1- and BACE2-deficient Mice*

Rudi D'Hooge, Jos Tournoy, Tobias Huth, 2005, Journal of Biological Chemistry.

Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy

Laurence Zitvogel, Sebastian Amigorena, Antoine Tesniere, 2007, Nature Medicine.

Stimulation of Platelet-derived Growth Factor Receptor β (PDGFRβ) Activates ADAM17 and Promotes Metalloproteinase-dependent Cross-talk between the PDGFRβ and Epidermal Growth Factor Receptor (EGFR) Signaling Pathways*

C. Blobel, P. Saftig, S. Swendeman, 2010, The Journal of Biological Chemistry.

The proteome of lysosomes

P. Saftig, B. Schröder, A. Hasilik, 2010, Proteomics.

Cytoplasmic Relaxation of Active Eph Controls Ephrin Shedding by ADAM10

Achilleas S. Frangakis, Martin Lackmann, Markus Grabenbauer, 2009, PLoS biology.

Breaking up the tie: disintegrin-like metalloproteinases as regulators of cell migration in inflammation and invasion.

P. Saftig, K. Reiss, A. Ludwig, 2006, Pharmacology & therapeutics.

Implication of APP secretases in notch signaling

Jos Tournoy, Wim Annaert, B. Strooper, 2001, Journal of Molecular Neuroscience.

β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment

Alonso Emilio, Catherine Bowes Rickman, B. de Strooper, 2012, EMBO molecular medicine.

Guidelines for the use and interpretation of assays formonitoring autophagy (3rd edition)

Sangeeta Khare, Xin Qi, Ying Wang, 2016 .

Destabilization of β-catenin by mutations in presenilin-1 potentiates neuronal apoptosis

Hans Clevers, Marc van de Wetering, Bruce A. Yankner, 1998, Nature.

Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36

Peter Loppnau, Sergio Grinstein, Richard F. Collins, 2013, Nature.

Cathepsin K deficiency partially inhibits, but does not prevent, bone destruction in human tumor necrosis factor-transgenic mice.

George Kollias, Georg Schett, Felix Beckmann, 2008, Arthritis and rheumatism.

Cellular Cholesterol Depletion Triggers Shedding of the Human Interleukin-6 Receptor by ADAM10 and ADAM17 (TACE)*

Stefan Rose-John, S. Rose-John, D. Hartmann, 2003, Journal of Biological Chemistry.

The "A Disintegrin And Metalloproteases" ADAM10 and ADAM17: novel drug targets with therapeutic potential?

P. Saftig, K. Reiss, Karina Reiss, 2011, European journal of cell biology.

ADAM10 Regulates Endothelial Permeability and T-Cell Transmigration by Proteolysis of Vascular Endothelial Cadherin

C. Blobel, P. Saftig, K. Reiss, 2008, Circulation research.