Nathan R Kett

Discovery of the first M5-selective and CNS penetrant negative allosteric modulator (NAM) of a muscarinic acetylcholine receptor: (S)-9b-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one (ML375).

Peter Chase, P Jeffrey Conn, Craig W Lindsley, 2013, Journal of medicinal chemistry.

Imidazopyridine CB2 agonists: optimization of CB2/CB1 selectivity and implications for in vivo analgesic efficacy.

K. K. Nanda, D. Henze, Suzie Yeh, 2011, Bioorganic & medicinal chemistry letters.

Further optimization of the K-Cl cotransporter KCC2 antagonist ML077: development of a highly selective and more potent in vitro probe.

A. Waterson, C. Lindsley, E. Delpire, 2012, Bioorganic & medicinal chemistry letters.

Synthesis and biological characterization of a series of novel diaryl amide M₁ antagonists.

D. Sheffler, C. Lindsley, P. Conn, 2012, Bioorganic & medicinal chemistry letters.