Manuela Bartolini

发表

Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: new disease-modifying agents for Alzheimer's disease.

F. J. Luque, Modesto Orozco, F Javier Luque, 2005, Journal of medicinal chemistry.

Multi-target-directed drug design strategy: from a dual binding site acetylcholinesterase inhibitor to a trifunctional compound against Alzheimer's disease.

Maurizio Recanatini, Maria Laura Bolognesi, Andrea Cavalli, 2007, Journal of medicinal chemistry.

A small molecule targeting the multifactorial nature of Alzheimer's disease.

Maurizio Recanatini, Maria Laura Bolognesi, Andrea Cavalli, 2007, Angewandte Chemie.

Kinetic characterization of amyloid-beta 1-42 aggregation with a multimethodological approach.

Fabio Biscarini, Marina Naldi, Vincenza Andrisano, 2011, Analytical biochemistry.

Disease‐Modifying Anti‐Alzheimer's Drugs: Inhibitors of Human Cholinesterases Interfering with β‐Amyloid Aggregation

Simone Brogi, Stefania Lamponi, Ettore Novellino, 2014, CNS neuroscience & therapeutics.

Novel Huprine Derivatives with Inhibitory Activity toward β‐Amyloid Aggregation and Formation as Disease‐Modifying Anti‐Alzheimer Drug Candidates

F. J. Luque, Vincenza Andrisano, Albert Badia, 2010, ChemMedChem.

Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds.

F. J. Luque, F Javier Luque, Vincenza Andrisano, 2009, Journal of medicinal chemistry.

Development and characterization of an immobilized enzyme reactor based on glyceraldehyde-3-phosphate dehydrogenase for on-line enzymatic studies

Vincenza Andrisano, Irving W. Wainer, V. Andrisano, 2003 .

Multitargeted drugs discovery: balancing anti-amyloid and anticholinesterase capacity in a single chemical entity.

Maria Laura Bolognesi, Vincenza Andrisano, Fabiana Morroni, 2011, Bioorganic & medicinal chemistry letters.

Inhibition of acetylcholinesterase, beta-amyloid aggregation, and NMDA receptors in Alzheimer's disease: a promising direction for the multi-target-directed ligands gold rush.

David W McClymont, Andrea Cavalli, David W. McClymont, 2008, Journal of medicinal chemistry.

Targeting Alzheimer's disease: Novel indanone hybrids bearing a pharmacophoric fragment of AP2238.

Silvia Gobbi, Maurizio Recanatini, Andrea Cavalli, 2010, Bioorganic & medicinal chemistry.

Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents.

F. J. Luque, F Javier Luque, Vincenza Andrisano, 2014, Journal of medicinal chemistry.

Rational approach to discover multipotent anti-Alzheimer drugs.

Vincenza Andrisano, Anna Minarini, Carlo Melchiorre, 2005, Journal of medicinal chemistry.

The role of Li+, Na+, and K+ in the ligand binding inside the human acetylcholinesterase gorge

Francesco Luigi Gervasio, Michele Parrinello, Maurizio Recanatini, 2008, Proteins.

Characterization of reversible and pseudo-irreversible acetylcholinesterase inhibitors by means of an immobilized enzyme reactor.

Vincenza Andrisano, V. Andrisano, V. Cavrini, 2007, Journal of chromatography. A.

Novel class of quinone-bearing polyamines as multi-target-directed ligands to combat Alzheimer's disease.

Maurizio Recanatini, Maria Laura Bolognesi, Andrea Cavalli, 2007, Journal of medicinal chemistry.

Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease.

Xavier Barril, F. J. Luque, F Javier Luque, 2009, Journal of medicinal chemistry.