Stephen G Withers

发表

In Situ Extension as an Approach for Identifying Novel α-Amylase Inhibitors*

Christopher M Overall, S. Withers, G. Brayer, 2004, Journal of Biological Chemistry.

Active-site Peptide “Fingerprinting” of Glycosidases in Complex Mixtures by Mass Spectrometry

Spencer J. Williams, Young-Wan Kim, S. Withers, 2005, Journal of Biological Chemistry.

The synthesis of a novel thio-linked disaccharide of chondroitin as a potential inhibitor of polysaccharide lyases.

S. Withers, Stephen G Withers, Carl S Rye, 2004, Carbohydrate research.

High-throughput screening methodology for the directed evolution of glycosyltransferases

Amir Aharoni, S. Withers, N. Strynadka, 2006, Nature Methods.

A xylobiose-derived isofagomine lactam glycosidase inhibitor binds as its amide tautomer.

Stephen G Withers, Gideon J Davies, Spencer J Williams, 2003, Chemical communications.

Novel catalytic mechanism of glycoside hydrolysis based on the structure of an NAD+/Mn2+ -dependent phospho-alpha-glucosidase from Bacillus subtilis.

Wayne F Anderson, Annabelle Varrot, Xiaojing Yang, 2004, Structure.

Probing electrostatic interactions along the reaction pathway of a glycoside hydrolase: histidine characterization by NMR spectroscopy.

S. Withers, J. Nielsen, M. Schubert, 2007, Biochemistry.

Aspartate 313 in the Streptomyces plicatusHexosaminidase Plays a Critical Role in Substrate-assisted Catalysis by Orienting the 2-Acetamido Group and Stabilizing the Transition State*

Spencer J. Williams, S. Withers, M. James, 2002, The Journal of Biological Chemistry.

Expanding the thioglycoligase strategy to the synthesis of alpha-linked thioglycosides allows structural investigation of the parent enzyme/substrate complex.

Young-Wan Kim, S. Withers, L. McIntosh, 2006, Journal of the American Chemical Society.

Crystallographic structure of human beta-hexosaminidase A: interpretation of Tay-Sachs mutations and loss of GM2 ganglioside hydrolysis.

S. Withers, M. James, M. J. Lemieux, 2006, Journal of molecular biology.

Mechanistic analyses of catalysis in human pancreatic alpha-amylase: detailed kinetic and structural studies of mutants of three conserved carboxylic acids.

Christopher M Overall, Chunmin Li, Gary D Brayer, 2002, Biochemistry.

Atomic resolution analyses of the binding of xylobiose-derived deoxynojirimycin and isofagomine to xylanase Xyn10A.

Spencer J. Williams, S. Withers, G. Davies, 2004, Chemical communications.

Teaching old enzymes new tricks: engineering and evolution of glycosidases and glycosyl transferases for improved glycoside synthesis.

S. Withers, Stephen G Withers, F. A. Shaikh, 2008, Biochemistry and cell biology = Biochimie et biologie cellulaire.

Direct observation of the protonation state of an imino sugar glycosidase inhibitor upon binding.

David L Zechel, Annabelle Varrot, S. Withers, 2003, Journal of the American Chemical Society.

Acarbose rearrangement mechanism implied by the kinetic and structural analysis of human pancreatic alpha-amylase in complex with analogues and their elongated counterparts.

S. Withers, G. Brayer, Shin Numao, 2004, Biochemistry.

Structural analysis of the sialyltransferase CstII from Campylobacter jejuni in complex with a substrate analog

Andrew G. Watts, Daniel Lim, S. Withers, 2004, Nature Structural &Molecular Biology.

The structure of the Mycobacterium smegmatis trehalose synthase reveals an unusual active site configuration and acarbose-binding mode.

Ran Zhang, S. Withers, G. Brayer, 2013, Glycobiology.

Engineering of glycosidases and glycosyltransferases.

S. Withers, S. Hancock, Stephen G Withers, 2006, Current opinion in chemical biology.

Structural, Thermodynamic, and Kinetic Analyses of Tetrahydrooxazine-derived Inhibitors Bound to β-Glucosidases*

S. Withers, G. Davies, Stephen G Withers, 2004, Journal of Biological Chemistry.

Thioglycoligases: mutant glycosidases for thioglycoside synthesis.

S. Withers, R. Warren, M. Jahn, 2003, Angewandte Chemie.

Toward Efficient Enzymes for the Generation of Universal Blood through Structure-Guided Directed Evolution.

S. Withers, E. Samain, A. Boraston, 2015, Journal of the American Chemical Society.