Douglas A Whittington

Structural aspects of isozyme selectivity in the binding of inhibitors to carbonic anhydrases II and IV.

Chu-Young Kim, John Liao, D. Whittington, 2002, Journal of medicinal chemistry.

The discovery and optimization of a novel class of potent, selective, and orally bioavailable anaplastic lymphoma kinase (ALK) inhibitors with potential utility for the treatment of cancer.

Karina Romero, Renee Emkey, Hao Chen, 2012, Journal of medicinal chemistry.

Naphthamides as novel and potent vascular endothelial growth factor receptor tyrosine kinase inhibitors: design, synthesis, and evaluation.

Ling Wang, Kelly Regal, Sesha Neervannan, 2008, Journal of medicinal chemistry.

Discovery and in vivo evaluation of (S)-N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine (AMG319) and related PI3Kδ inhibitors for inflammation and autoimmune disease.

Xiaolin Hao, Ben Fisher, Andreas Reichelt, 2015, Journal of medicinal chemistry.

Evolution of a highly selective and potent 2-(pyridin-2-yl)-1,3,5-triazine Tie-2 kinase inhibitor.

Richard Kendall, P. Gallant, M. Morrison, 2007, Journal of medicinal chemistry.

Pyridyl-pyrimidine benzimidazole derivatives as potent, selective, and orally bioavailable inhibitors of Tie-2 kinase.

Xin Huang, Christopher Mohr, Paul Hughes, 2009, Bioorganic & medicinal chemistry letters.

Bornyl diphosphate synthase: Structure and strategy for carbocation manipulation by a terpenoid cyclase

D. Whittington, R. Croteau, D. Christianson, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Phospshoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitors: discovery and structure-activity relationships of a series of quinoline and quinoxaline derivatives.

Daniel J. Freeman, Hongyu Liao, Nancy Zhang, 2011, Journal of medicinal chemistry.

Rapid development of piperidine carboxamides as potent and selective anaplastic lymphoma kinase inhibitors.

Renee Emkey, Alan C Cheng, A. Cheng, 2012, Journal of medicinal chemistry.

Selective inhibitors of the mutant B-Raf pathway: discovery of a potent and orally bioavailable aminoisoquinoline.

Thomas Nixey, Nick A. Paras, D. Whittington, 2009, Journal of medicinal chemistry.

The R1275Q Neuroblastoma Mutant and Certain ATP-competitive Inhibitors Stabilize Alternative Activation Loop Conformations of Anaplastic Lymphoma Kinase*

Renee Emkey, D. Whittington, L. Epstein, 2012, The Journal of Biological Chemistry.