Sridhar Mani

发表

Activated Pregnenolone X-Receptor Is a Target for Ketoconazole and Its Analogs

Hao Li, Denise G. Teotico, Hongwei Wang, 2007, Clinical Cancer Research.

Erlotinib (Tarceva®): a promising drug targeting epidermal growth factor receptor tyrosine kinase

Sanjay Goel, R. Perez-soler, S. Mani, 2003, Expert review of anticancer therapy.

Elucidating the ‘Jekyll and Hyde’ Nature of PXR: The Case for Discovering Antagonists or Allosteric Antagonists

Sean Ekins, Matthew D. Krasowski, Matthew R. Redinbo, 2009, Pharmaceutical Research.

A phase I safety and dose escalation trial of docetaxel combined with GEM®231, a second generation antisense oligonucleotide targeting protein kinase A R1α in patients with advanced solid cancers

Sanjay Goel, Gary Goldberg, M. Einstein, 2005, Investigational New Drugs.

Computational Discovery of Novel Low Micromolar Human Pregnane X Receptor Antagonists

Sean Ekins, Ni Ai, Vladyslav Kholodovych, 2008, Molecular Pharmacology.

Phase I and pharmacokinetic study of imatinib mesylate in patients with advanced malignancies and varying degrees of renal dysfunction: a study by the National Cancer Institute Organ Dysfunction Working Group.

Pingfu Fu, C. Takimoto, H. Lenz, 2008, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Human Pregnane X Receptor Antagonists and Agonists Define Molecular Requirements for Different Binding Sites

Sean Ekins, Ni Ai, Rachana Patel, 2007, Molecular Pharmacology.

Alleviating Cancer Drug Toxicity by Inhibiting a Bacterial Enzyme

Matthew R. Redinbo, John E Scott, Hongwei Wang, 2010, Science.

The BCL2-family of protein ligands as cancer drugs: the next generation of therapeutics.

R. Perez-soler, S. Mani, M. Haigentz, 2003, Current medicinal chemistry. Anti-cancer agents.

Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice.

Lei Wang, Hongwei Wang, J. Shay, 2011, The Journal of clinical investigation.

Symbiotic Bacterial Metabolites Regulate Gastrointestinal Barrier Function via the Xenobiotic Sensor PXR and Toll‐like Receptor 4

Sandhya Kortagere, Jeremy K Nicholson, Hongwei Wang, 2014, Immunity.

Phase I Clinical and Pharmacokinetic Study of BMS-247550, a Novel Derivative of Epothilone B, in Solid Tumors

Susan Band Horwitz, Anne Hamilton, D. Lebwohl, 2004, Clinical Cancer Research.