P E Nielsen

发表

Double duplex invasion by peptide nucleic acid: a general principle for sequence-specific targeting of double-stranded DNA.

P. Nielsen, J Lohse, O Dahl, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Quinoxaline antibiotics enhance peptide nucleic acid binding to double-stranded DNA.

M. Waring, C. Bailly, P. Nielsen, 2000, Biochemistry.

Peptide nucleic acids (PNA): synthesis, properties and potential applications.

P. Nielsen, P E Nielsen, B Hyrup, 1996, Bioorganic & medicinal chemistry.

Sequence specific inhibition of DNA restriction enzyme cleavage by PNA.

M. Egholm, P. Nielsen, O. Buchardt, 1993, Nucleic acids research.

Evidence for (PNA)2/DNA triplex structure upon binding of PNA to dsDNA by strand displacement

M. Egholm, P. Nielsen, O. Buchardt, 1994, Journal of molecular recognition : JMR.

Sequence-specific purification of nucleic acids by PNA-controlled hybrid selection.

Christopher B. Stanley, P. Nielsen, H. Ørum, 1995, BioTechniques.

An experimental study of mechanism and specificity of peptide nucleic acid (PNA) binding to duplex DNA.

V V Demidov, P. Nielsen, M. Frank-Kamenetskii, 1999, Journal of molecular biology.

Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide.

M. Egholm, P. Nielsen, O. Buchardt, 1991, Science.

Applications of peptide nucleic acids.

P. Nielsen, P E Nielsen, 1999, Current opinion in biotechnology.

Sequence-specific protection of duplex DNA against restriction and methylation enzymes by pseudocomplementary PNAs.

V V Demidov, P. Nielsen, M. Frank-Kamenetskii, 2000, Biochemistry.

Solid‐Phase synthesis of peptide nucleic acids

R. H. Berg, M. Egholm, P. Nielsen, 1995, Journal of peptide science : an official publication of the European Peptide Society.

Peptide nucleic acid (PNA). A DNA mimic with a peptide backbone.

M. Egholm, P. Nielsen, O. Buchardt, 1994, Bioconjugate chemistry.

DNA unwinding upon strand-displacement binding of a thymine-substituted polyamide to double-stranded DNA.

M. Egholm, P. Nielsen, M. Frank-Kamenetskii, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Progress in developing PNA as a gene-targeted drug.

P. Nielsen, L. Good, P E Nielsen, 1997, Antisense & nucleic acid drug development.

Efficient pH-independent sequence-specific DNA binding by pseudoisocytosine-containing bis-PNA.

M. Egholm, P. Nielsen, O. Buchardt, 1995, Nucleic acids research.

Kinetics for hybridization of peptide nucleic acids (PNA) with DNA and RNA studied with the BIAcore technique.

B. Nordén, P. Nielsen, H. Ørum, 1997, Biochemistry.

An introduction to peptide nucleic acid.

M. Egholm, P. Nielsen, P E Nielsen, 1999, Current issues in molecular biology.

Thermodynamics of sequence-specific binding of PNA to DNA.

B. Nordén, P. Nielsen, A. Holmen, 2000, Biochemistry.

Identification and characterization of genomic nucleosome-positioning sequences.

D M Crothers, D. Crothers, J. Kahn, 1997, Journal of molecular biology.

Kinetic sequence discrimination of cationic bis-PNAs upon targeting of double-stranded DNA.

V V Demidov, P. Nielsen, M. Frank-Kamenetskii, 1998, Nucleic acids research.

A formula for thermal stability (Tm) prediction of PNA/DNA duplexes.

P. Nielsen, C. Berding, H. Ørum, 1998, Nucleic acids research.

Peptide nucleic acid: a versatile tool in genetic diagnostics and molecular biology.

P. Nielsen, P E Nielsen, 2001, Current opinion in biotechnology.

Electron microscopy mapping of oligopurine tracts in duplex DNA by peptide nucleic acid targeting.

V V Demidov, P. Nielsen, D. Cherny, 1994, Nucleic acids research.

Peptide nucleic acid.DNA strand displacement loops as artificial transcription promoters.

M. Egholm, P. Nielsen, O. Buchardt, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Sequence-selective DNA recognition by synthetic ligands.

P. Nielsen, P E Nielsen, Peter E. Nielsen, 1991, Bioconjugate chemistry.

PD-loop: a complex of duplex DNA with an oligonucleotide.

V V Demidov, P. Nielsen, M. Frank-Kamenetskii, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Stability of peptide nucleic acids in human serum and cellular extracts.

V V Demidov, M. Egholm, P. Nielsen, 1994, Biochemical pharmacology.

Label-free DNA electrochemical sensor based on a PNA-functionalized conductive polymer.

P. Nielsen, B. Piro, M. Pham, 2008, Talanta.

Effect of secondary structure on the thermodynamics and kinetics of PNA hybridization to DNA hairpins.

P. Nielsen, J. Seifert, B. Armitage, 2001, Journal of the American Chemical Society.

Enhanced peptide nucleic acid binding to supercoiled DNA: possible implications for DNA "breathing" dynamics.

P. Nielsen, P E Nielsen, T Bentin, 1996, Biochemistry.

Peptide nucleic acids (PNAs): potential antisense and anti-gene agents.

M. Egholm, P. Nielsen, O. Buchardt, 1993, Anti-cancer drug design.

Kinetics and mechanism of polyamide ("peptide") nucleic acid binding to duplex DNA.

V V Demidov, P. Nielsen, M. Frank-Kamenetskii, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Investigating the kinetics of DNA-DNA and PNA-DNA interactions using surface plasmon resonance-enhanced fluorescence spectroscopy.

W. Knoll, P. Nielsen, D. Kambhampati, 2001, Biosensors & bioelectronics.

Peptide nucleic acids and their potential applications in biotechnology.

R. H. Berg, M. Egholm, P. Nielsen, 1993, Trends in biotechnology.

Hybridization of peptide nucleic acid.

B. Nordén, P. Nielsen, L. Christensen, 1998, Biochemistry.

DNA analogues with nonphosphodiester backbones.

P. Nielsen, P E Nielsen, P. Nielsen, 1995, Annual review of biophysics and biomolecular structure.

Strand displacement recognition of mixed adenine-cytosine sequences in double stranded DNA by thymine-guanine PNA (peptide nucleic acid).

M. Egholm, P. Nielsen, P E Nielsen, 2001, Bioorganic & medicinal chemistry.

Transcription-mediated binding of peptide nucleic acid (PNA) to double-stranded DNA: sequence-specific suicide transcription.

P. Nielsen, P E Nielsen, H J Larsen, 1996, Nucleic acids research.