R Pauwels

发表

Synthesis and anti-HIV-1 activity of 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-on e (TIBO) derivatives. 2.

R. Pauwels, M. Miranda, C. Ho, 1991, Journal of medicinal chemistry.

Crystal structures of 8-Cl and 9-Cl TIBO complexed with wild-type HIV-1 RT and 8-Cl TIBO complexed with the Tyr181Cys HIV-1 RT drug-resistant mutant.

A. D. Clark, Jianping Ding, R. Pauwels, 1996, Journal of molecular biology.

Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-tetraazamacrocycles that inhibit HIV replication. Effects of macrocyclic ring size and substituents on the aromatic linker.

R. Pauwels, G. Bridger, M. Abrams, 1995, Journal of medicinal chemistry.

Synthesis and anti-HIV activity of various 2'- and 3'-substituted 2',3'-dideoxyadenosines: a structure-activity analysis.

E. De Clercq, R. Pauwels, P. Herdewijn, 1987, Journal of medicinal chemistry.

Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds.

J Desmyter, E. De Clercq, R. Pauwels, 1988, Journal of virological methods.

Mechanism of inhibitory effect of dextran sulfate and heparin on replication of human immunodeficiency virus in vitro.

J Desmyter, E. De Clercq, R. Pauwels, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Highly specific inhibition of human immunodeficiency virus type 1 by a novel 6-substituted acyclouridine derivative.

R T Walker, R. T. Walker, E. De Clercq, 1989, Biochemical and biophysical research communications.

Synthesis and anti-HIV activity of different sugar-modified pyrimidine and purine nucleosides.

E. De Clercq, R. Pauwels, P. Herdewijn, 1988, Journal of medicinal chemistry.

Both 2',3'-dideoxythymidine and its 2',3'-unsaturated derivative (2',3'-dideoxythymidinene) are potent and selective inhibitors of human immunodeficiency virus replication in vitro.

J Desmyter, E. De Clercq, R. Pauwels, 1987, Biochemical and biophysical research communications.

Evolution of anti-HIV drug candidates. Part 2: Diaryltriazine (DATA) analogues.

R. Pauwels, E. Arnold, F. Daeyaert, 2001, Bioorganic & medicinal chemistry letters.

Synthesis and anti-HIV-1 activity of 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin- 2(1H)-one (TIBO) derivatives.

R. Pauwels, M. Miranda, M. Kukla, 1991, Journal of medicinal chemistry.

Potent and highly selective human immunodeficiency virus type 1 (HIV-1) inhibition by a series of alpha-anilinophenylacetamide derivatives targeted at HIV-1 reverse transcriptase.

R. Pauwels, A. Vandamme, E. Clercq, 1993, Proceedings of the National Academy of Sciences of the United States of America.