James A Wells

发表

Substrates of IAP ubiquitin ligases identified with a designed orthogonal E3 ligase, the NEDDylator.

Alma L Burlingame, Min Zhuang, S. Guan, 2013, Molecular cell.

Time-Resolved Proteomics Extends Ribosome Profiling-Based Measurements of Protein Synthesis Dynamics.

Hector H. Huang, Yun S. Song, Yun S Song, 2017, Cell systems.

Turning enzymes ON with small molecules.

J. Zorn, James A Wells, Julie A Zorn, 2010, Nature chemical biology.

Engineering a light-activated caspase-3 for precise ablation of neurons in vivo

Tanja Kortemme, Roland A. Pache, G. Davis, 2017, Proceedings of the National Academy of Sciences.

Discovery of an allosteric site in the caspases.

J. Wells, J. Hardy, Joni W. Lam, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Disulfide trapping to localize small-molecule agonists and antagonists for a G protein-coupled receptor.

Elizabeth Buck, James A Wells, E. Buck, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Sampling the N-terminal proteome of human blood

James A Wells, David Wildes, J. Wells, 2010, Proceedings of the National Academy of Sciences.

Fibrils Colocalize Caspase-3 with Procaspase-3 to Foster Maturation*

Dennis W Wolan, D. Wolan, J. Zorn, 2012, The Journal of Biological Chemistry.

A common allosteric site and mechanism in caspases

J. Wells, James A Wells, M. J. Romanowski, 2006, Proceedings of the National Academy of Sciences of the United States of America.

A Split-Abl Kinase for Direct Activation in Cells.

Joshua J Coon, J. Coon, J. E. Díaz, 2017, Cell chemical biology.

Turning a protein kinase on or off from a single allosteric site via disulfide trapping

Matthew P Jacobson, Christopher L. McClendon, Dennis W Wolan, 2011, Proceedings of the National Academy of Sciences.

Potent small-molecule binding to a dynamic hot spot on IL-2.

M. Randal, James A Wells, Mike Randal, 2003, Journal of the American Chemical Society.

Mechanistic Diversity of Cytokine Receptor Signaling Across Cell Membranes

Robert M Stroud, R. Stroud, James A Wells, 2004, Science's STKE.

Structure-Activity Relationship and Molecular Mechanics Reveal the Importance of Ring Entropy in the Biosynthesis and Activity of a Natural Product.

Matthew P Jacobson, Katrina W Lexa, Katrina W. Lexa, 2017, Journal of the American Chemical Society.

An allosteric circuit in caspase-1.

Debajyoti Datta, J. Wells, James A Wells, 2008, Journal of molecular biology.

Redox-based reagents for chemoselective methionine bioconjugation

F Dean Toste, Christopher J Chang, Shixian Lin, 2017, Science.

Searching for new allosteric sites in enzymes.

J. Wells, J. Hardy, James A Wells, 2004, Current opinion in structural biology.

Tethering: fragment-based drug discovery.

Daniel A Erlanson, D. Erlanson, A. Braisted, 2004, Annual review of biophysics and biomolecular structure.

Computational approach to site‐directed ligand discovery

Gergely Tóth, Kiran Mukhyala, James A Wells, 2007, Proteins.

An improved single-chain Fab platform for efficient display and recombinant expression.

J. T. Koerber, James A Wells, James T Koerber, 2015, Journal of molecular biology.

Site-specific Disulfide Capture of Agonist and Antagonist Peptides on the C5a Receptor*

Elizabeth Buck, H. Bourne, James A Wells, 2005, Journal of Biological Chemistry.

An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering

Frank von Delft, James S Fraser, Daniel A Keedy, 2018, eLife.

Targeting RAS-driven human cancer cells with antibodies to upregulated and essential cell-surface proteins

Max A. Horlbeck, Sourav Bandyopadhyay, Josip Blonder, 2018, eLife.

CryptoSite: Expanding the Druggable Proteome by Characterization and Prediction of Cryptic Binding Sites.

Julie C. Mitchell, Andrej Sali, Dina Schneidman-Duhovny, 2016, Journal of molecular biology.