S L Schreiber

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A yeast genetic system for selecting small molecule inhibitors of protein-protein interactions in nanodroplets.

S. Schreiber, J. Huang, J Huang, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Solution structure of the SH3 domain of Src and identification of its ligand-binding site.

S. Schreiber, J. Brugge, C. Seidel-Dugan, 1992, Science.

Understanding and controlling the cell cycle with natural products.

S. Schreiber, T. Jamison, D. Hung, 1996, Chemistry & biology.

Atomic structures of the human immunophilin FKBP-12 complexes with FK506 and rapamycin.

R F Standaert, S. Schreiber, P. Karplus, 1993, Journal of molecular biology.

Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity.

Jun O. Liu, S. Schreiber, P. Cohen, 1992, Biochemistry.

Inducible gene expression and protein translocation using nontoxic ligands identified by a mammalian three-hybrid screen.

S. Schreiber, S. Liberles, D. Austin, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Two binding orientations for peptides to the Src SH3 domain: development of a general model for SH3-ligand interactions.

S. Schreiber, Hongtao Yu, J. Chen, 1995, Science.

Three-part inventions: intracellular signaling and induced proximity.

S. Schreiber, G. Crabtree, S L Schreiber, 1996, Trends in biochemical sciences.

Solution structure of FKBP, a rotamase enzyme and receptor for FK506 and rapamycin

M Karplus, M. Karplus, S. Schreiber, 1991, Science.

Complete amino acid sequence of the FK506 and rapamycin binding protein, FKBP, isolated from calf thymus

S. Schreiber, William Arbuthnot Sir Lane, M. Harding, 1991, Journal of protein chemistry.

Small molecule developmental screens reveal the logic and timing of vertebrate development.

J. Dowling, S. Schreiber, R. Peterson, 2000, Proceedings of the National Academy of Sciences of the United States of America.

High-throughput screening of small molecules in miniaturized mammalian cell-based assays involving post-translational modifications.

S. Haggarty, S. Schreiber, B. Stockwell, 1999, Chemistry & biology.

Dimerization as a regulatory mechanism in signal transduction.

S. Schreiber, G. Crabtree, J. Klemm, 1998, Annual review of immunology.

Specific interactions outside the proline-rich core of two classes of Src homology 3 ligands.

S. Schreiber, R. Rickles, S L Schreiber, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Phthalascidin, a synthetic antitumor agent with potency and mode of action comparable to ecteinascidin 743.

S. Schreiber, E. Corey, T. Owa, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small molecules that perturb mitosis.

S. Haggarty, S. Schreiber, T. Mitchison, 2000, Chemistry & biology.

Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin

R F Standaert, S. Schreiber, E. Corey, 1995, Science.

Synthesis of 7200 small molecules based on a substructural analysis of the histone deacetylase inhibitors trichostatin and trapoxin.

S. Schreiber, S. Sternson, J. Wong, 2001, Organic letters.

Nuclear histone acetylases and deacetylases and transcriptional regulation: HATs off to HDACs.

S. Schreiber, C. Hassig, S L Schreiber, 1997, Current opinion in chemical biology.

Atomic structure of FKBP-FK506, an immunophilin-immunosuppressant complex

R F Standaert, P. Karplus, J. Clardy, 1991, Science.

GTP-dependent binding of the antiproliferative agent didemnin to elongation factor 1 alpha.

S. Schreiber, William Arbuthnot Sir Lane, C. Crews, 1994, The Journal of biological chemistry.

Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins.

S. Schreiber, F. Kuruvilla, A. Shamji, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Controlling signal transduction with synthetic ligands.

S. Schreiber, G. Crabtree, T. Wandless, 1993, Science.

Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin.

L A Herzenberg, R F Standaert, S. Schreiber, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Controlling protein association and subcellular localization with a synthetic ligand that induces heterodimerization of proteins.

S. Schreiber, G. Crabtree, P. J. Belshaw, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Molecular basis for the binding of SH3 ligands with non-peptide elements identified by combinatorial synthesis.

S. Schreiber, T. Kapoor, A. Combs, 1996, Chemistry & biology.

cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein.

S. Schreiber, C. Keith, K. Cimprich, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Structure-function analysis of SH3 domains: SH3 binding specificity altered by single amino acid substitutions

S. Schreiber, S. Richard, R. Rickles, 1995, Molecular and cellular biology.

A tricyclic ring system replaces the variable regions of peptides presented by three alleles of human MHC class I molecules.

S. Schreiber, D. Wiley, D. Garboczi, 1995, Chemistry & biology.

Prevention of HIV-1 infection and preservation of CD4 function by the binding of CPFs to gp120.

S. Schreiber, R. Finberg, D. Diamond, 1990, Science.

Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen.

S. Haggarty, S. Schreiber, T. Kapoor, 1999, Science.

Covalent HLA-B27/peptide complex induced by specific recognition of an aziridine mimic of arginine.

S. Schreiber, D. Wiley, William Arbuthnot Sir Lane, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Structure-based design of a cyclophilin-calcineurin bridging ligand.

S. Schreiber, S L Schreiber, D G Alberg, 1993, Science.